Article
Immunology
Ee Von Woon, Dimitrios Nikolaou, Kate MacLaran, Julian Norman-Taylor, Priya Bhagwat, Antonia O. O. Cuff, Mark R. R. Johnson, Victoria Male
Summary: A significant proportion of unexplained reproductive failure is associated with immunological dysfunction at the maternal-fetal interface. Uterine Natural Killer cells (uNK) play a crucial role in successful pregnancy by regulating EVT invasion and spiral artery remodeling. This study explores the frequency, phenotype, and function of uNK subsets in women with unexplained reproductive failure and reveals a global reduction in expression of uNK receptors important for interaction with HLA-C and HLA-G, leading to reduced uNK activation.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Jia Mao, Ying Feng, Xiaofeng Zhu, Fang Ma
Summary: Human leukocyte antigen-G (HLA-G) is a non-classical major histocompatibility complex molecule that plays a crucial role in immune regulation at the maternal-fetal interface. This review highlights the different molecular mechanisms by which HLA-G modulates the immune function of NK cells, including the suppression of cytotoxicity and the stimulation of growth factor secretion. The interaction between HLA-G and NK cells also promotes senescence signaling and inhibits the function of other immune cells, contributing to spiral artery remodeling and maintaining immune balance during pregnancy.
Article
Oncology
Fei Gao, Mauricio Campos Mora, Michael Constantinides, Lois Coenon, Caroline Multrier, Loic Vaillant, Tianxiang Zhang, Martin Villalba
Summary: This study found significant phenotypical and functional differences between g-NK cells in umbilical cord blood and peripheral blood. Unlike g-NK cells in peripheral blood, g-NK cells in umbilical cord blood do not show heightened cytokine production upon CD16 engagement. However, they exhibit elevated levels of IFN-gamma production after in vitro activation, particularly when co-cultured with human cytomegalovirus and plasma from g-NK positive adults.
Article
Immunology
Songchen Cai, Rong Lin, Su Liu, Xiaohui Wang, Hongxia Wei, Chunyu Huang, Yuye Li, Xian Chen, Longfei Li, Yong Zeng, Ruochun Lian, Lianghui Diao
Summary: Intrauterine infusion of hCG can effectively increase the level of Tregs and improve the pregnancy success rate, making it a potential treatment for infertile patients with low Tregs levels.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Obstetrics & Gynecology
Li Jiang, Xi Wang, Tingting Zhang, Huan Chen, Zhangming Wei, Tianjiao Li, Yuqing Wu, Zeying Li, Xiaoling Fang
Summary: HLA-DRA may serve as an independent predictor of endometrial infertility, while the down-regulation of HLA-DRs and HLA-DPs may be a common biomarker for this condition.
Article
Immunology
Rajeev K. Tyagi, Justin Jacobse, Jing Li, Margret M. Allaman, Kevin L. Otipoby, Erik R. Sampson, Keith T. Wilson, Jeremy A. Goettel
Summary: Regulatory T cells play a crucial role in maintaining immune homeostasis in the intestine, and dysfunction of T-reg cells is linked to various inflammatory and autoimmune disorders. Treatment with low-dose IL-2 may be a promising therapeutic strategy for inflammatory conditions, but its effectiveness in treating IBD is still uncertain.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Oncology
Rui Jing, Shukun Bai, Peipei Zhang, Hao Ren, Lintao Jia, Weimiao Li, Guoxu Zheng
Summary: This study found that TNBC cells induce dysfunction of NK cells through an IFN-gamma/IDO-1/HLA-G pathway, impairing the normal immune response. Therefore, targeted therapy against IDO-1 and HLA-G could be a potential treatment strategy for TNBC.
Article
Immunology
Karolina Piekarska, Pawel Radwan, Agnieszka Tarnowska, Andrzej Wisniewski, Rafal Krasinski, Michal Radwan, Jacek R. Wilczynski, Andrzej Malinowski, Izabela Nowak
Summary: Male factors play an important role in infertility of couples. HLA-G gene polymorphisms in seminal plasma may influence the secretion of soluble HLA-G protein in semen and affect male fertility. The G-C-ins haplotype may reduce sperm parameters.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Diana Tronik-Le Roux, Marina Daouya, Alix Jacquier, Chantal Schenowitz, Francois Desgrandchamps, Nathalie Rouas-Freiss, Edgardo D. Carosella
Summary: The heterogeneity of cancer cells poses challenges in therapeutic approaches, and the newly discovered isoform HLA-G increment alpha 1 has immune-stimulatory activity in ccRCC and trophoblasts. Unlike other HLA-G isoforms, HLA-G increment alpha 1 does not associate with beta 2-microglobulin and may not present antigens to T cells. It exerts individual dependent immune-stimulatory effects on peripheral blood NK cells and might have potential antitumor effects.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2022)
Article
Immunology
Yelei Guo, Beilei Xu, Zhiqiang Wu, Jian Bo, Chuan Tong, Deyun Chen, Jin Wang, Haoyi Wang, Yao Wang, Weidong Han
Summary: Recent studies have shown that UCAR T cells lacking endogenous T cell receptors and beta-2 microglobulin, but engineered with mutant B2M-HLA-E and B2M-HLA-G fusion proteins, are effective in resisting allogeneic NK cell-mediated lysis and have specific anti-tumor activity. Additional experiments, including animal models and clinical trials, are needed to further evaluate the safety and efficacy of these modified UCAR T cells.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Immunology
Ching-Lien Wu, Julien Caumartin, Giada Amodio, Francois Anna, Maria Loustau, Silvia Gregori, Pierre Langlade-Demoyen, Joel LeMaoult
Summary: Invariant Natural Killer T (iNKT) cells, when activated by exogenic glycolipid antigen, can release cytokines rapidly to enhance anti-tumor activity. The presence of the tolerogenic molecule HLA-G in humans may impact the function of iNKT cells, potentially affecting the outcome of clinical trials.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ryan M. Marquardt, Tae Hoon Kim, Jung-Yoon Yoo, Hanna E. Teasley, Asgerally T. Fazleabas, Steven L. Young, Bruce A. Lessey, Ripla Arora, Jae-Wook Jeong
Summary: The research reveals the important role of ARID1A in the endometrial epithelium, supporting early pregnancy establishment through the maintenance of gland function. Lack of ARID1A in endometrial epithelium leads to defects in implantation, decidualization, and endometrial receptivity, possibly through disruption of the LIF-STAT3-EGR1 pathway.
Article
Medicine, General & Internal
Mihai Surcel, Iulia Adina Neamtiu, Daniel Muresan, Iulian Goidescu, Adelina Staicu, Monica Mihaela Marta, Georgiana Nemeti, Radu Harsa, Bogdan Doroftei, Mihai Emil Capilna, Gabriela Caracostea
Summary: There is increasing evidence that endometrial immune disorders may be responsible for gynecological and obstetrical pathology. This study explored the potential relationship between different killer cell immunoglobulin-like receptor (KIR) genotypes and reproductive outcomes, and found that the KIR AA genotype population subgroups may be more susceptible to developing chronic endometritis.
Review
Plant Sciences
Kannan Maharajan, Qing Xia, Xiuying Duan, Pengfei Tu, Yun Zhang, Kechun Liu
Summary: Zishen Yutai Pill (ZYP) is a widely used Traditional Chinese Medicine in Assisted Reproductive Technology (ART) medications, and has shown potential therapeutic effects in improving fertility and pregnancy rates. Clinical studies have demonstrated its curative effects on various reproductive disorders by regulating reproductive functions such as ovulation, follicle development, and hormonal balance.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Lenka Lapides, Ivan Varga, Maria Csobonyeiova, Martin Klein, Lada Pavlikova, Kristina Visnyaiova, Pavel Babal, Renata Mikusova
Summary: Reproductive immunology focuses on understanding the immune regulation during pregnancy, with uterine natural killer (uNK) cells playing a key role in supporting and maintaining pregnancy. However, uNK cells are often overlooked and neglected in medical teaching, despite their crucial importance in clinical research and practice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Urology & Nephrology
Peter Humaidan, Thor Haahr, Betina Boel Povlsen, Louise Kofod, Rita Jakubcionyte Laursen, Birgit Alsbjerg, Helle Olesen Elbaek, Sandro C. Esteves
Summary: This study evaluated the impact of lifestyle changes and oral antioxidant intake on sperm DNA fragmentation index (DFI) and static oxidation-reduction potential (sORP) in male factor infertility. The intervention program, combined with antioxidant therapy, significantly reduced DFI but did not affect sperm parameters and sORP. There was no correlation between DFI and sORP.
INTERNATIONAL BRAZ J UROL
(2022)
Meeting Abstract
Immunology
Ole B. Christiansen, Caroline Norgaard-Pedersen, Rudi Steffensen, Astrid Petersen, Lise H. Thomsen, Louise M. Kofod, Pernille B. Koefoed-Nielsen
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2023)
Article
Immunology
Louise Kofod, Anette Lindhard, Michael Bzorek, Jens Ole Eriksen, Lise Grupe Larsen, Thomas Vauvert F. Hviid
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2017)