Article
Gastroenterology & Hepatology
Jing Hu, Juan Wu, Peipei Zhang, Naizhong Hu, Qiao Mei, Xingwang Wu, Wei Han
Summary: This study evaluated the efficacy of double-balloon endoscopy (DBE) in detecting small-bowel strictures in Crohn's disease. The results showed that DBE had a higher diagnostic yield compared to computed tomography enterography (CTE), and the diagnostic yield was not influenced by the severity of the stricture. This suggests that DBE is an effective method for detecting small bowel strictures in CD patients.
BMC GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Gilles Boschetti, Maria Nachury, David Laharie, Xavier Roblin, Cyrielle Gilletta, Alexandre Aubourg, Arnaud Bourreille, Camille Zallot, Xavier Hebuterne, Anthony Buisson, Jean-Charles Grimaud, Yoram Bouhnik, Matthieu Allez, Romain Altwegg, Stephanie Viennot, Lucine Vuitton, Franck Carbonnel, Stephane Paul, Kristell Desseaux, Jerome Lambert, Laurent Peyrin-Biroulet
Summary: This study aimed to investigate the efficacy and safety of infliximab (IFX) reintroduction in Crohn's disease (CD) after discontinuation due to loss of response or intolerance. The results showed that IFX retreatment was effective and safe in approximately one-third of patients with CD, regardless of the reason for prior discontinuation. Early detection of anti-drug antibodies could predict subsequent failure of IFX reintroduction and infusion reactions.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Surgery
Michael F. Bath, Aman Malhi, Ruth M. Ayling, Edward Seward, Kathy Pritchard-Jones, Helga E. Laszlo, Allan Hackshaw, Michael R. Machesney
Summary: Faecal immunochemistry testing has low sensitivity for detecting adenomas, and if used as the only test, the opportunity to prevent colorectal cancer progression would be lost.
Article
Biochemistry & Molecular Biology
Giammarco Mocci, Giorgia Bodini, Leonardo Allegretta, Alessia Immacolata Cazzato, Stefania Chiri, Giovanni Aragona, Patrizia Perazzo, Antonio Ferronato, Maria Giovanna Graziani, Cristiano Pagnini, Costantino Zampaletta, Camilla Graziosi, Marcello Picchio, Walter Elisei, Giovanni Maconi, Antonio Tursi
Summary: This study compared the efficacy and safety of GP2017 and its originator in IBD patients in a real-life setting, and the results showed that both GP2017 and its originator were equally effective and safe for the treatment of IBD.
Article
Respiratory System
Thomas Sonnweber, Sabina Sahanic, Alex Pizzini, Anna Luger, Christoph Schwabl, Bettina Sonnweber, Katharina Kurz, Sabine Koppelstatter, David Haschka, Verena Petzer, Anna Boehm, Magdalena Aichner, Piotr Tymoszuk, Daniela Lener, Markus Theurl, Almut Lorsbach-Koehler, Amra Tancevski, Anna Schapfl, Marc Schaber, Richard Hilbe, Manfred Nairz, Bernhard Puchner, Doris Huettenberger, Christoph Tschurtschenthaler, Malte Asshoff, Andreas Peer, Frank Hartig, Romuald Bellmann, Michael Joannidis, Can Gollmann-Tepekoylu, Johannes Holfeld, Gudrun Feuchtner, Alexander Egger, Gregor Hoermann, Andrea Schroll, Gernot Fritsche, Sophie Wildner, Rosa Bellmann-Weiler, Rudolf Kirchmair, Raimund Helbok, Helmut Prosch, Dietmar Rieder, Zlatko Trajanoski, Florian Kronenberg, Ewald Woell, Gunter Weiss, Gerlig Widmann, Judith Loeffler-Ragg, Ivan Tancevski
Summary: A study found that some COVID-19 patients still experienced persistent symptoms and lung function impairment 100 days after the onset of the disease, but there was significant improvement in symptoms and cardiopulmonary status over time.
EUROPEAN RESPIRATORY JOURNAL
(2021)
Article
Gastroenterology & Hepatology
Fabio Salvatore Macaluso, Maria Cappello, Anita Busacca, Walter Fries, Anna Viola, Giuseppe Costantino, Antonio Magnano, Elisa Vinci, Concetta Ferracane, Antonino Carlo Privitera, Giovita Piccillo, Nunzio Belluardo, Emiliano Giangreco, Claudio Romano, Michele Citrano, Francesco Graziano, Serena Garufi, Carmelo Bertolami, Marco Ventimiglia, Barbara Scrivo, Giulia Teresi, Sara Renna, Giulia Rizzuto, Angelo Casa, Ambrogio Orlando
Summary: This study aimed to evaluate the safety and effectiveness of ADA biosimilar ABP 501 in patients with inflammatory bowel disease. The results showed that the safety and effectiveness of ABP 501 were overall similar to those of the ADA originator, indicating that switching from the originator to ABP 501 was safe and effective.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Livia Lontai, Lorant Gonczi, Fruzsina Balogh, Nora Komlodi, Tamas Resal, Klaudia Farkas, Tamas Molnar, Pal Miheller, Petra A. Golovics, Eszter Schafer, Tamas Szamosi, Akos Ilias, Peter L. Lakatos
Summary: This study evaluated the medium-term clinical efficacy, drug sustainability, and safety of non-medical switches between adalimumab biosimilars. The results showed no significant difference in clinical remission rates or drug survival between non-medical switches from the originator to biosimilar ADA or between ADA biosimilars. The study concludes that clinical benefit can be sustained following non-medical switches in adalimumab-treated patients with inflammatory bowel disease.
DIGESTIVE AND LIVER DISEASE
(2022)
Article
Anesthesiology
A. Cumberworth, H. Lewith, A. Sud, H. Jefferson, V Athanassoglou, J. J. Pandit
Summary: This observational study in four hospitals in the UK found that the incidence of serious airway complications is similar to previous research, despite the use of airway prediction not affecting subsequent management.
Article
Anesthesiology
J. Gibson, T. Leckie, J. Hayward, L. Hodgson, South East Anaesthet Res Chain
Summary: This study reports the incidence and nature of non-theatre emergency airway management events in eight acute NHS hospitals in southeast England. The study found that these events are common, unpredictable, and associated with high complication rates. Senior personnel were often present during advanced airway management episodes, and videolaryngoscopy and capnography were frequently used. However, adverse outcomes such as hypoxia and hypotension still occurred.
Article
Medicine, General & Internal
Rory J. Piper, Fardad T. Afshari, Wai Cheong Soon, Angelos G. Kolias, Edward W. Dyson, Laurence Watkins, Rodney Laing, William B. Lo, Jayaratnam Jayamohan
Summary: The UK Chiari 1 Study (UKC1S) aims to investigate the health-related quality of life and complications in patients with Chiari 1 malformation (CM1) in the UK, as well as to compare the outcomes of conservative and surgical management. It also seeks to determine the variation within UK practice in referral patterns, patient pathways, investigations, and surgical decisions.
Article
Gastroenterology & Hepatology
Foong Way D. Tai, Pierre Ellul, Alfonso Elosua, Ignacio Fernandez-Urien, Gian E. Tontini, Luca Elli, Rami Eliakim, Uri Kopylov, Sara Koo, Clare Parker, Simon Panter, Reena Sidhu, Mark McAlindon
Summary: This study demonstrates that panenteric capsule endoscopy is feasible in routine clinical practice and may lead to changes in management decisions, especially for patients with active Crohn's disease. It also suggests that capsule endoscopy can provide valuable information for assessing disease severity and guiding treatment strategies.
UNITED EUROPEAN GASTROENTEROLOGY JOURNAL
(2021)
Article
Medicine, General & Internal
Davide Giuseppe Ribaldone, Elisa Tribocco, Chiara Rosso, Angelo Armandi, Marta Vernero, Elisabetta Bugianesi, Marco Astegiano, Giorgio Maria Saracco, Gian Paolo Caviglia
Summary: The study aimed to provide real-world data on switching from biosimilar adalimumab to another biosimilar, including multiple switches. Results showed that most patients continued SB5 therapy after 6 months of follow-up, with a high success rate of switch completion.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Federica Branchi, Rolf Klingenberg-Noftz, Kristina Friedrich, Nataly Burgel, Severin Daum, Juliane Buchkremer, Elena Sonnenberg, Michael Schumann, Christoph Treese, Hanno Troger, Donata Lissner, Hans-Jorg Epple, Britta Siegmund, Andrea Stroux, Andreas Adler, Winfried Veltzke-Schlieker, Daniel Autenrieth, Silke Leonhardt, Andreas Fischer, Christian Jurgensen, Ulrich-Frank Pape, Bertram Wiedenmann, Oliver Moschler, Maximilian Schreiner, Mathias Z. Strowski, Volkmar Hempel, Yvonne Huber, Helmut Neumann, Christian Bojarski
Summary: PuraStat gel is an effective tool for treating gastrointestinal bleeding, safely applicable as both primary and secondary therapy, and can serve as a bridge to surgery for temporary haemostasis. It shows high efficacy with low rebleeding rates.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Critical Care Medicine
Florian Reizine, Sarah Le Marec, Anthony Le Meur, Maelys Consigny, Florian Berteau, Laetitia Bodenes, Marie Geslain, Zoe McQuilten, Catherine Le Niger, Julien Huntzinger, Philippe Seguin, Jean-Baptiste Thibert, David Simon, Jean Reignier, Pierre-Yves Egreteau, Jean-Marc Tadie, Olivier Huet, Pierre Asfar, Stephan Ehrmann, Cecile Aubron
Summary: This study aimed to investigate the response of prophylactic platelet transfusion in critically ill patients and to identify factors associated with a poor response. The results showed that nearly two-thirds of prophylactic platelet transfusions led to suboptimal platelet increment, which was associated with the storage duration of platelets.
Review
Gastroenterology & Hepatology
Bo Shen
Summary: Endoscopic therapy has become the main treatment for inflammatory bowel diseases and associated complications, such as strictures, fistulas, abscesses, bleeding lesions, and polyps. The development of interventional IBD is supported by a better understanding of the disease process, advancements in endoscopic technology, and the training of next-generation specialists.
GASTROENTEROLOGY REPORT
(2022)
