Article
Cardiac & Cardiovascular Systems
David G. Rosenthal, Christina D. Fang, Christopher A. Groh, Gregory Nah, Eric Vittinghoff, Thomas A. Dewland, Vasanth Vedantham, Gregory M. Marcus
Summary: Sarcoidosis is strongly associated with heart failure, atrioventricular block, and ventricular tachycardia, surpassing established risk factors for these cardiovascular outcomes. The presence of any cardiac involvement is the best predictor of these outcomes. Cardiovascular complications in sarcoidosis patients explain a significant proportion of the increased mortality risk.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Medicine, General & Internal
Ameenathul M. M. Fawzy, Arnaud Bisson, Alexandre Bodin, Julien Herbert, Gregory Y. H. Lip, Laurent Fauchier
Summary: This study investigated the association between atrial fibrillation (AF) and ventricular arrhythmias (VAs) and sudden death in hospitalized patients in France. The results showed that AF patients had significantly higher incidence and risk of VAs and cardiac arrest compared to non-AF patients. This association remained significant after adjusting for confounders, indicating a clear association between AF and VAs and sudden death.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Peripheral Vascular Disease
Antonis A. Manolis, Theodora A. Manolis, Helen Melita, Antonis S. Manolis
Summary: Takotsubo syndrome, triggered by intense emotional or physical stress, is a cardiovascular disease that mainly occurs in post-menopausal women. Its prognosis is not as benign as previously thought, as it can cause mechanical complications, lethal arrhythmias, and sudden cardiac death. There are risk factors that increase the risk of sudden cardiac death in Takotsubo syndrome patients.
Article
Emergency Medicine
Stephen Gyung Won Lee, Jeong Ho Park, Young Sun Ro, Ki Jeong Hong, Kyoung Jun Song, Sang Do Shin
Summary: This study found a significant association between the time from collapse to first defibrillation and good neurological recovery in OHCA patients, indicating that a shorter time interval is associated with higher likelihood of recovery.
AMERICAN JOURNAL OF EMERGENCY MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Hilmi Alnsasra, Gal Tsaban, Jean Marc Weinstein, Mhamad Nasasra, Tal Ovdat, Roy Beigel, Katia Orvin, Moti Haim
Summary: Among patients with AMI, women are more likely to have atrial fibrillation and HAVB, but lower rates of early ventricular tachyarrhythmia compared to men. Early and late VTAs, AF, and HAVB are associated with increased 30-day mortality, while only late VTA and AF are linked to post-30-day mortality.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jassin Hamidi, Joachim Winter, Rene Weber, Sven Dittmann, Eric Schulze-Bahr
Summary: In this study, we reported a rare case of a female patient with non-obstructive HCM who presented with VF as the first clinical manifestation and received successful cardiopulmonary resuscitation. Subsequently, an ICD was implanted for secondary VF prevention, but additional episodes of VF occurred, accompanied by SAN arrest. This case highlights the importance of considering SAN arrest in HCM patients when implanting a specific ICD device.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cardiac & Cardiovascular Systems
Jason Coult, Betty Y. Yang, Heemun Kwok, J. Nathan Kutz, Patrick M. Boyle, Jennifer Blackwood, Thomas D. Rea, Peter J. Kudenchuk
Summary: This study developed an ECG-based algorithm that can predict patients with refractory ventricular fibrillation (VF). The algorithm has shown high predictive accuracy, which can help rescuers take targeted interventions in advance and improve the resuscitation outcome.
Review
Cardiac & Cardiovascular Systems
Min-Shan Tsai, Chien-Hua Huang, Chen-Hsu Wang, Hsaio-Ju Cheng, Shih-Ni Wu, Wei-Tien Chang, Wen-Jone Chen
Summary: The use of hydrocortisone after cardiac arrest can mitigate myocardial injury and cardiac mitochondrial damage, improving survival, neurological, and histological outcomes in a rat model of ventricular fibrillation cardiac arrest.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Review
Biochemistry & Molecular Biology
Stephane Zaffran, Lilia Kraoua, Hager Jaouadi
Summary: This review discusses the genetic etiology of cardiac diseases related to calcium mishandling, focusing on catecholaminergic polymorphic ventricular tachycardia (CPVT) as a cardiac channelopathy and hypertrophic cardiomyopathy (HCM) as a primary cardiomyopathy. It emphasizes that calcium-handling perturbations are the common pathophysiological mechanism despite the genetic heterogeneity of cardiac defects.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Letter
Cardiac & Cardiovascular Systems
Adi Lador, John R. Giudicessi, Walid M. Barake, Peter A. Noseworthy, Suraj Kapa, Christopher J. McLeod, Bryan C. Cannon, Samuel J. Asirvatham, Michael J. Ackerman
Summary: Sudden cardiac arrest (SCA) and death account for approximately 350,000 deaths annually in the United States. The majority of cases occur in older individuals with underlying coronary artery disease. Short-coupled premature ventricular contractions (PVCs) can trigger ventricular fibrillation (VF) and ventricular tachycardia (VT) in structurally normal hearts. Electrophysiological mapping and targeted PVC ablation may eliminate VF recurrences. However, the contribution of PVC-triggered ventricular fibrillation (PTVF) to sudden cardiac arrest in the young population and the outcomes of targeted ablation in this patient population require further investigation.
JACC-CLINICAL ELECTROPHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Jarieke C. Hoogendoorn, Jeroen Venlet, Yannick N. J. Out, Sumche Man, Saurabh Kumar, Marek Sramko, Dirk G. Dechering, Ikutaro Nakajima, Konstantinos C. Siontis, Masaya Watanabe, Yoshinori Nakamura, Usha B. Tedrow, Frank Bogun, Lars Eckardt, Petr Peichl, William G. Stevenson, Katja Zeppenfeld
Summary: CS with RV involvement can mimic ARVC, but with different patterns of electrical activation. Evaluating the distinct terminal activation patterns of R' waves in leads V1-V3 can differentiate between CS and ARVC.
Article
Cardiac & Cardiovascular Systems
Ankur N. Shah, Justin Field, Brad A. Clark, Jeffrey A. Olson, Saarik Gupta, Girish V. Nair, Sandeep A. Joshi, Asim S. Ahmed, Jasen L. Gilge, Leonard A. Steinberg, Eric N. Prystowsky, Parin J. Patel, Benzy J. Padanilam
Summary: The study aimed to test the hypothesis that an early premature ventricular complex always shows a difference of more than 35 ms in its advancement of the next atrial activation during tachycardia. The results indicated that an accessory pathway response to premature ventricular complexes (A1A2 < H1S2+35 ms) is 100% specific for the presence of an accessory pathway, serving as a predictor for AVRT.
Article
Medicine, General & Internal
Min-Tsun Liao, Cho-Kai Wu, Jyh-Ming Jimmy Juang, Ting-Tse Lin, Chih-Cheng Wu, Lian-Yu Lin
Summary: Incident AF is associated with an increased risk of SCA and NSCD in the HCM population, suggesting early detection of AF may provide more comprehensive risk stratification of SCD in this population.
Article
Physiology
Shin-Huei Liu, Li-Wei Lo, Yu-Hui Chou, Wei-Lun Lin, Tsung-Ying Tsai, Wen-Han Cheng, Yenn-Jiang Lin, Shih-Lin Chang, Yu-Feng Hu, Fa-Po Chung, Hui-Chun Huang, Shih-Ann Chen
Summary: Early LC presents with increased ventricular vulnerability, structural heterogeneity, and sympathetic innervation. Close monitoring for fatal arrhythmias is warranted in patients with early stages of LC.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Genetics & Heredity
Yuriy Vakhrushev, Alexandra Kozyreva, Andrey Semenov, Polina Sokolnikova, Tamara Lubimtseva, Dmitry Lebedev, Natalia Smolina, Sergey Zhuk, Lubov Mitrofanova, Elena Vasichkina, Anna Kostareva
Summary: RBM20 is a splicing factor that can cause different types of cardiomyopathies. Initially discovered in dilated cardiomyopathy, it has also been associated with arrhythmogenic cardiomyopathy.
Letter
Cardiac & Cardiovascular Systems
Antonin Trimaille, Benjamin Marchandot, Walid Oulehri, Adrien Carmona, Olivier Vollmer, Vincent Poindron, Kensuke Matsushita, Laurent Sattler, Lelia Grunebaum, Anne-Sophie Korganow, Valerie Schini-Kerth, Olivier Morel
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Kensuke Matsushita, Marion Kibler, Floriane Zeyons, Sebastien Hess, Olivier Morel, Patrick Ohlmann
CANADIAN JOURNAL OF CARDIOLOGY
(2022)
Review
Hematology
Antoine Caillon, Antonin Trimaille, Julie Favre, Laurence Jesel, Olivier Morel, Gilles Kauffenstein
Summary: This study explores the impact of neutrophils, platelets, and extracellular vesicles on the thromboinflammatory process in COVID-19 patients. The article emphasizes the crucial role of the immune system in inflammation and thrombosis, and discusses potential therapeutic strategies focusing on modulating purinergic signaling.
JOURNAL OF THROMBOSIS AND HAEMOSTASIS
(2022)
Letter
Cardiac & Cardiovascular Systems
Benjamin Marchandot, Adrien Carmona, Olivier Morel
JOURNAL OF THROMBOSIS AND THROMBOLYSIS
(2022)
Article
Medicine, General & Internal
Laurent Dietrich, Marion Kibler, Kensuke Matsushita, Benjamin Marchandot, Antonin Trimaille, Antje Reydel, Bamba Diop, Phi Dinh Truong, Anh Mai Trung, Annie Trinh, Adrien Carmona, Sebastien Hess, Laurence Jesel, Patrick Ohlmann, Olivier Morel
Summary: This study evaluated the impact of ongoing primary hemostasis disorders among anticoagulated AF patients after TAVR. It found that a post-procedural CT-ADP > 180 s was identified as a strong independent predictor of late major/life-threatening bleeding complications. These findings suggest that persistent primary hemostasis disorders contribute to a higher risk of late bleeding events.
JOURNAL OF CLINICAL MEDICINE
(2022)
Letter
Cardiac & Cardiovascular Systems
Antonin Trimaille, Sandy Hmadeh, Olivier Morel
Article
Cardiac & Cardiovascular Systems
Jean-Philippe Collet, Eric Van Belle, Holger Thiele, Sergio Berti, Thibault Lhermusier, Thibault Manigold, Franz-Josef Neumann, Martine Gilard, David Attias, Farzin Beygui, Angel Cequier, Fernando Alfonso, Pierre Aubry, Flore Baronnet, Stephane Ederhy, Mohamad El Kasty, Mathieu Kerneis, Olivier Barthelemy, Thierry Lefevre, Pascal Leprince, Alban Redheuil, Patrick Henry, Jean-Jacques Portal, Eric Vicaut, Gilles Montalescot
Summary: This study aimed to compare the effectiveness of oral anticoagulation and antiplatelet therapy after TAVI surgery and found that apixaban was not superior to standard treatment, regardless of the indication for oral anticoagulation.
EUROPEAN HEART JOURNAL
(2022)
Article
Cardiac & Cardiovascular Systems
Kensuke Matsushita, Benjamin Marchandot, Marion Kibler, Joe Heger, Marilou Peillex, Antonin Trimaille, Sebastien Hess, Lelia Grunebaum, Mickael Ohana, Antje Reydel, Laurence Jesel, Patrick Ohlmann, Olivier Morel
Summary: Appropriate P2Y12 inhibition by clopidogrel is a major determinant of MACCE at 90 days after TAVR.
INTERNATIONAL JOURNAL OF CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Clemence Delhomme, Marina Urena, Oualid Zouaghi, Francisco Campelo-Parada, Patrick Ohlmann, Gilles Rioufol, Eric Van Belle, Frederic Pinaud, Nicolas Meneveau, Patrick Staat, Olivier Morel, Francois Derimay, Flavien Vincent, Frederic Rouleau, Eric Brochet, Caroline Chong-Nguyen, Dominique Himbert
Summary: This study evaluated the effectiveness of transcatheter aortic valve implantation using the SAPIEN 3 transcatheter heart valve in patients with pure aortic regurgitation. The results showed a device success rate of 94.6%, a 30-day all-cause mortality rate of 8.1%, and a one-year all-cause mortality rate of 16.2%. This method appears promising for treating high-risk patients with pure aortic regurgitation, but further research is needed.
ARCHIVES OF CARDIOVASCULAR DISEASES
(2023)
Letter
Cardiac & Cardiovascular Systems
Kensuke Matsushita, Antonin Trimaille, Benjamin Marchandot, Patrick Ohlmann, Olivier Morel
JACC-CARDIOVASCULAR INTERVENTIONS
(2022)
Editorial Material
Cardiac & Cardiovascular Systems
Antonin Trimaille, Benjamin Marchandot, Olivier Morel
EUROPEAN HEART JOURNAL
(2023)
Letter
Cardiac & Cardiovascular Systems
Benjamin Marchandot, Antonin Trimaille, Olivier Morel
EUROPEAN JOURNAL OF HEART FAILURE
(2023)
Article
Medicine, General & Internal
Valerie Wilme, Sebastien Harscoat, Francois Severac, Adrien Carmona, Pierrick Le Borgne, Pascal Bilbault, Olivier Morel, Sabrina Kepka
Summary: This retrospective single-center study aimed to estimate the frequency of serious heart rhythm disorders (SHRDs) among 480 patients with non-ST elevation acute coronary syndrome (NSTE-ACS) and identify associated factors. The results showed that the occurrence rate of SHRDs during the first 48 hours of hospital care was 2.3%, with 0.4% of patients requiring immediate treatment and no deaths. Age, anticoagulant medication, decreased glomerular filtration rate, decreased hemoglobin and left ventricle ejection fraction (LVEF), and increased troponin, BNP, and CRP levels were significantly associated with SHRDs. Higher hemoglobin level (>12 g/dL) appeared to be a protective factor for SHRDs.
JOURNAL OF CLINICAL MEDICINE
(2023)
Review
Cardiac & Cardiovascular Systems
Kensuke Matsushita, Olivier Morel, Patrick Ohlmann
Summary: The latest clinical trials have shown positive outcomes of TAVR in low surgical risk patients with severe aortic stenosis. However, there are unresolved concerns for younger patients with longer life expectancy. Factors such as prosthesis-patient mismatch, heart failure hospitalization, subclinical thrombosis, future coronary access, and valve durability can affect long-term clinical outcomes. This review examines the available evidence and discusses potential treatment strategies for the lifetime management of TAVR patients.
CARDIOVASCULAR INTERVENTION AND THERAPEUTICS
(2023)
Article
Cardiac & Cardiovascular Systems
Adrien Carmona, Benjamin Marchandot, Mylene Sagnard, Olivier Morel
Summary: This case highlights the complexity of cardio-renal interaction in patients with CSSS causing ACS. Revascularization of the proximal left subclavian artery with a stent was performed, enabling instant recovery of distal coronary flows. Treatment options for CSSS include secondary prevention measures and revascularization through endovascular approaches if indicated.
EUROPEAN HEART JOURNAL-CASE REPORTS
(2022)