Review
Cardiac & Cardiovascular Systems
Sergio Jansen-Chaparro, Maria D. Lopez-Carmona, Lidia Cobos-Palacios, Jaime Sanz-Canovas, M. Rosa Bernal-Lopez, Ricardo Gomez-Huelgas
Summary: PAD is a common atherosclerotic condition that can lead to decreased quality of life and increased risk of cardiac or cerebrovascular events. Statins are recommended for reducing cardiovascular events and mortality in PAD patients, but the prescribing rate is lower than in patients with coronary heart disease.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2021)
Review
Cardiac & Cardiovascular Systems
Saul Penin-Grandes, Susana Lopez-Ortiz, Sergio Maroto-Izquierdo, Hector Menendez, Jose Pinto-Fraga, Juan Martin-Hernandez, Simone Lista, Alejandro Lucia, Alejandro Santos-Lozano
Summary: This systematic review evaluates the effects of regular exercise in patients with peripheral arterial disease (PAD) by summarizing published meta-analyses. The review finds that exercise has a positive impact on functional parameters and health-related quality of life in PAD patients. Supervised aerobic exercise is particularly effective in improving walking-related outcomes and pain, while resistance exercise is more effective for improving lower limb strength.
EUROPEAN JOURNAL OF PREVENTIVE CARDIOLOGY
(2023)
Review
Obstetrics & Gynecology
E. G. Mulder, S. de Haas, Z. Mohseni, N. Schartmann, F. Abo Hasson, F. Alsadah, S. M. J. van Kuijk, J. van Drongelen, M. E. A. Spaanderman, C. Ghossein-Doha
Summary: During normotensive pregnancy, cardiac output gradually increases to its peak in early third trimester, while vascular resistance decreases until early third trimester before slightly increasing at term. In hypertensive pregnancies, initial increase in cardiac output is higher and vascular resistance remains stable throughout gestation compared to reference values. Monitoring haemodynamic changes in pregnancy can help identify women at risk for hypertensive complications.
BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY
(2022)
Article
Medicine, General & Internal
Gabriela Goncalves-Martins, Daniel Gil-Sala, Cristina Tello-Diaz, Xavier Tenezaca-Sari, Carlos Marrero, Teresa Puig, Raquel Gayarre, Joan Fite, Sergi Bellmunt-Montoya
Summary: The study found independent strong associations between male smokers and diabetes, as well as female smokers and hypertension, with peripheral arterial disease (PAD) prevalence. Male subjects presented with higher REGICOR scores and should be considered high-risk groups for screening programs.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Endocrinology & Metabolism
Martine Paquette, Sophie Bernard, Alexis Baass
Summary: This study found that patients with DBL have a significantly higher risk of ASCVD and PVD compared to normolipidemic controls, as well as a higher risk of PVD compared to patients with FH. Adequate screening for DBL is vital to improve the clinical care and prevent the development of ASCVD in these patients.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Cardiac & Cardiovascular Systems
Christine Espinola-Klein, Gerhard Weisser, Volker Schmitt, Melanie Schwaderlapp, Thomas Munzel
Summary: Antithrombotic therapy is highly effective in reducing major adverse cardiovascular events (MACE) and major adverse limb events (MALE) in patients with peripheral arterial disease (PAD). Dual pathway inhibition with low-dose rivaroxaban and acetylic salicylic acid (ASA) has demonstrated superiority in preventing MACE and MALE compared to ASA alone. However, it also increases the risk of major bleeding. Current guidelines recommend the combination of low-dose rivaroxaban and ASA for PAD patients with low bleeding risk, while a single antiplatelet drug, preferably clopidogrel, is indicated for those with high bleeding risk. For patients with atherosclerotic vascular disease requiring oral anticoagulation, additional antiplatelet therapy is not necessary to avoid an increased risk of bleeding without improving prognosis.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Article
Cardiac & Cardiovascular Systems
Marco Witkowski, Mario Witkowski, Julian Friebel, Jennifer A. Buffa, Xinmin S. Li, Zeneng Wang, Naseer Sangwan, Lin Li, Joseph A. DiDonato, Caroline Tizian, Arash Haghikia, Daniel Kirchhofer, Francois Mach, Lorenz Raeber, Christian M. Matter, W. H. Wilson Tang, Ulf Landmesser, Thomas F. Luescher, Ursula Rauch, Stanley L. Hazen
Summary: The study demonstrates that TMAO increases the risk of cardiovascular events and affects platelets and vascular tissue factor TF. Experimental results indicate that TMAO enhances arterial thrombosis potential by inducing the expression of TF and VCAM1.
CARDIOVASCULAR RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Larissa Schawe, Ben Raude, Jan Christoph Carstens, Irene Hinterseher, Raphael Donatus Hein, Safwan Omran, Gilles Berger, Nina A. Hering, Matthias Buerger, Andreas Greiner, Jan Paul Frese
Summary: The study investigated the role of vascular endothelial growth factor (VEGF) in ischemic and non-ischemic skeletal muscle in patients with peripheral arterial disease (PAD). The results showed that preoperative VEGF levels were significantly higher in ischemic muscles compared to controls, and postoperative values decreased significantly. There was no significant change in VEGF levels in the non-ischemic muscle. This suggests impaired angiogenesis mechanisms in PAD patients.
Review
Surgery
Samick Sofat, Xiaoyu Chen, Mohammed M. Chowdhury, Patrick A. Coughlin
Summary: The study investigated the impact of statin therapy and dosage on PAD patients' outcomes and found that high-dose statins significantly improved patient outcomes, especially in terms of all-cause mortality and amputations.
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
(2021)
Review
Pharmacology & Pharmacy
Xiaopeng Ai, Peiling Yu, Lixia Peng, Liuling Luo, Jia Liu, Shengqian Li, Xianrong Lai, Fei Luan, Xianli Meng
Summary: Traditional Chinese medicine, particularly berberine, has shown promise as an alternative therapeutic strategy for vascular diseases, with identified cellular and molecular targets indicating its potential benefits. Berberine exhibits remarkable anti-inflammatory, antioxidant, antiapoptotic, and antiautophagic activity through various signaling pathways, but limitations in treatment effectiveness exist and further research is needed to explore novel drugs.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Medicine, General & Internal
Andrea Grillo, Vincenzo Barbato, Roberta Maria Antonello, Marco Fabio Cola, Gianfranco Parati, Paolo Salvi, Bruno Fabris, Stella Bernardi
Summary: Growing evidence suggests that arterial stiffness measurement plays an important role in the diagnosis and prognosis of thyroid and parathyroid diseases. Despite methodological heterogeneity, studies indicate a relationship between arterial stiffness and hypothyroidism, hyperthyroidism, and primary hyperparathyroidism.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Hematology
Sanny Scheffer, Dorien M. A. Hermkens, Louise van der Weerd, Helga E. de Vries, Mat J. A. P. Daemen
Summary: Alzheimer's disease is characterized by neurodegeneration, neuroinflammation, and cognitive decline. Cardiovascular disease has been identified as an important contributor to the development and progression of AD, known as the vascular hypothesis. Vascular risk factors are associated with an increased chance of developing AD, with chronic cerebral hypoperfusion suggested to play a key role in disease onset.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2021)
Review
Public, Environmental & Occupational Health
Samantha Huo Yung Kai, Jean Ferrieres, Camille Carles, Marion Turpin, Francois-Xavier Lapebie, Frederic Dutheil, Alessandra Bura-Riviere, Yolande Esquirol
Summary: This systematic review examines the relationships between lower limb peripheral venous and arterial diseases and occupational constraints. Prolonged standing is significantly associated with varicose veins, while there is insufficient evidence linking prolonged sitting at work to VTE. Further research is needed to explore the impact of carrying heavy loads, work stress, and exposure to high temperatures on varicose veins.
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE
(2021)
Article
Cardiac & Cardiovascular Systems
Mette Sogaard, Peter Bronnum Nielsen, Flemming Skjoth, Nikolaj Eldrup, Torben Bjerregaard Larsen
Summary: This study investigated the temporal changes in medical prevention and adverse outcomes in patients with symptomatic PAD who underwent revascularization. The results showed that medication use increased over time, leading to reduced adverse outcomes, except for major amputations. These improvements were seen across all strata of patients undergoing different procedures, regardless of age, sex, or comorbidity.
Review
Dermatology
Tai-Li Chen, Ling-Ling Lee, Huei-Kai Huang, Jen-Hung Wang, Li-Yu Chen, Hou-Ren Tsai, Ching-Hui Loh, Ching-Chi Chi
Summary: This systematic review and meta-analysis revealed an increased risk of incident VTE and PVD among patients with psoriatic disease. Typical presentations of VTE or PVD should not be overlooked in patients with psoriasis. Risk factors such as obesity, physical inactivity, smoking, and varicose veins should be identified and treated in patients with psoriasis, and caution should be exercised in prescribing hormone-related therapies.
