Article
Gastroenterology & Hepatology
Hiroyuki Hisada, Yosuke Tsuji, Miho Obata, Rina Cho, Sayaka Nagao, Yuko Miura, Hiroya Mizutani, Daisuke Ohki, Seiichi Yakabi, Yu Takahashi, Yoshiki Sakaguchi, Naomi Kakushima, Nobutake Yamamichi, Mitsuhiro Fujishiro
Summary: This study investigated the association between sarcopenia and endoscopic submucosal dissection (ESD) outcomes for early gastric cancer (EGC). The results showed that patients with sarcopenia had significantly more adverse events and shorter overall survival (OS). Evaluation of a patient's general condition, including sarcopenia, before ESD is important.
JOURNAL OF GASTROENTEROLOGY
(2022)
Article
Oncology
Ji Eun Na, Hyuk Lee, Yang Won Min, Byung-Hoon Min, Jun Haeng Lee, Poong-Lyul Rhee, Kyoung-Mee Kim, Jae J. Kim
Summary: Primary endoscopic submucosal dissection is clinically feasible and oncologically safe for cT1bN0M0 gastric cancer, with a high curative resection rate. It can potentially eliminate unnecessary surgery and further management can be based on post-procedure pathology results.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2021)
Article
Medicine, General & Internal
Dae-Gon Ryu, Su-Jin Kim, Cheol-Woong Choi, Su-Bum Park, Hyeong-Seok Nam, Si-Hak Lee, Sun-Hwi Hwang
Summary: Endoscopic submucosal dissection (ESD) is the preferred treatment for early gastric cancer (EGC) with low risk of lymph node metastasis. Predicting the risk of local recurrence after ESD is crucial for management and prevention. Factors associated with a higher risk of local recurrence include lesion size >= 15 mm, incomplete histologic resection, undifferentiated adenocarcinoma, scar, and the absence of erythema of the surface. Regular endoscopic surveillance is important to predict local recurrence, especially in patients with larger lesions, incomplete histologic resection, surface changes of scars, and no surface erythema.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Surgery
Jeong Ho Song, Sejin Lee, Sung Hyun Park, Anastasios Kottikias, Aleisa Abdulmohsen, Nasser Alrashidi, Minah Cho, Yoo Min Kim, Hyoung-Il Kim, Woo Jin Hyung
Summary: This study suggests that patients with early gastric cancer who meet the surgical indications can be treated with endoscopic submucosal dissection. The location of the tumor, as well as its size and histological features, are key factors in determining whether curative resection can be achieved with ESD.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Pradeep Bhandari, Mohamed Abdelrahim, Asma A. Alkandari, Piera Alessia Galtieri, Marco Spadaccini, Stefan Groth, Nastazja D. Pilonis, Sharmila Subhramaniam, Kesavan Kandiah, Ejaz Hossain, Sophie Arndtz, Paul Bassett, Katie Siggens, Hein Htet, Roberta Maselli, Michal F. Kaminski, Stefan Seewald, Alessandro Repici
Summary: This study aimed to determine long-term outcomes of gastric endoscopic submucosal dissection (ESD) in Western settings based on the latest Japanese indication criteria, and to examine predictors of outcomes and complications. The results showed that gastric ESD is safe and effective in the Western setting.
Article
Medicine, General & Internal
Xing Xu, Guoliang Zheng, Na Gao, Zhichao Zheng
Summary: This study evaluated the clinical outcomes and safety of ESD versus SR for EGC with expanded indications and found that ESD provided favorable results. Further randomized controlled trials are needed to confirm these findings.
Article
Oncology
Toshio Watanabe, Yuji Nadatani, Wataru Suda, Akira Higashimori, Koji Otani, Shusei Fukunaga, Shuhei Hosomi, Fumio Tanaka, Yasuaki Nagami, Koichi Taira, Tetsuya Tanigawa, Geicho Nakatsu, Masahira Hattori, Yasuhiro Fujiwara
Summary: The gastric microbiome, aside from H. pylori, plays a role in the tumorigenesis of gastric cancer. Patients with early GC who undergo endoscopic submucosal dissection have a high risk of developing metachronous GC even after successful H. pylori eradication. H. pylori eradication partially restores microbial diversity in these patients, but dysbiosis may persist long after eradication and be involved in the development of both primary and metachronous GC.
Article
Gastroenterology & Hepatology
Takuya Satomi, Seiji Kawano, Tomoki Inaba, Masahiro Nakagawa, Hirokazu Mouri, Masao Yoshioka, Shoichi Tanaka, Tatsuya Toyokawa, Sayo Kobayashi, Takehiro Tanaka, Hiromitsu Kanzaki, Masaya Iwamuro, Yoshiro Kawahara, Hiroyuki Okada
Summary: This study retrospectively analyzed the efficacy and safety of endoscopic submucosal dissection (ESD) for gastric tube cancer (GTC) in patients after esophagectomy. The results showed that ESD was safe and effective with an en bloc resection rate of 91.7%, curative resection rate of 79%, and 5-year survival rate of 59.5%.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Medicine, General & Internal
Yu-Lan Gao, Yue-han Zhang, Meng Cao
Summary: This study retrospectively analyzed the preoperative endoscopic evaluation in endoscopic submucosal dissection (ESD) for early gastric cancer and precancerous lesions. Accurate preoperative assessment of lesion type, extent, and depth of invasion is helpful in improving the complete resection rate and reducing the risk of additional surgery in ESD.
Article
Medicine, General & Internal
Shan-Shan Xu, Ning-Li Chai, Xiao-Wei Tang, En-Qiang Linghu, Sha-Sha Wang, Bao Li
Summary: This study analyzed the characteristics, risk factors, treatment, and follow-up outcomes of patients with metachronous gastric neoplasms (MGN) following curative endoscopic submucosal dissection (ESD). It found that initial multiplicity was the sole independent risk factor of MGN, and patients with MGN had significantly lower disease-specific survival rate compared to those without MGN. Regular and long-term surveillance endoscopy may be beneficial for patients with initial multiple neoplasms.
CHINESE MEDICAL JOURNAL
(2021)
Article
Surgery
Shungo Goto, Jun Arimoto, Takuma Higurashi, Kota Takahashi, Naoki Ohkubo, Nobuyoshi Kawamura, Tetsuya Tamura, Hisakuni Tomonari, Akito Iwasaki, Leo Taniguchi, Hideyuki Chiba, Kazuhiro Atsukawa, Yusuke Saigusa, Atsushi Nakajima
Summary: This study aimed to compare the outcomes of colorectal ESD in patients with and without sarcopenia. The results showed that the presence of sarcopenia did not influence the rate of complications after ESD, indicating that colorectal ESD is safe and effective even in patients with sarcopenia. Prospective multicenter studies are needed to confirm these results.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2021)
Article
Surgery
Hideyuki Takashiro, Hirofumi Saito, Katsunobu Tawada, Yuhei Oyama, Shinichi Tazawa, Masatoshi Usui, Hiromasa Nomoto, Kazuhiko Kita
Summary: The study retrospectively compared the efficacy and safety of the early clip-with-line (ECL) method with the conventional method for colorectal endoscopic submucosal dissection (ESD). It was found that the ECL group had significantly shorter procedure time and no perforation events occurred. There were no significant differences in clinical characteristics between the two groups.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Gastroenterology & Hepatology
Waku Hatta, Yosuke Tsuji, Toshiyuki Yoshio, Naomi Kakushima, Shu Hoteya, Hisashi Doyama, Yasuaki Nagami, Takuto Hikichi, Masakuni Kobayashi, Yoshinori Morita, Tetsuya Sumiyoshi, Mikitaka Iguchi, Hideomi Tomida, Takuya Inoue, Tomoyuki Koike, Tatsuya Mikami, Kenkei Hasatani, Jun Nishikawa, Tomoaki Matsumura, Hiroko Nebiki, Dai Nakamatsu, Ken Ohnita, Haruhisa Suzuki, Hiroya Ueyama, Yoshito Hayashi, Mitsushige Sugimoto, Shinjiro Yamaguchi, Tomoki Michida, Tomoyuki Yada, Yoshiro Asahina, Toshiaki Narasaka, Shiko Kuribasyashi, Shu Kiyotoki, Katsuhiro Mabe, Tomohiro Nakamura, Naoki Nakaya, Mitsuhiro Fujishiro, Atsushi Masamune
Summary: A prediction model for bleeding after endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) was developed and externally validated, showing moderately good discrimination and good calibration.
Article
Oncology
Meng Qian, Yuan Sheng, Min Wu, Song Wang, Kaiguang Zhang
Summary: This retrospective case-control study compared the clinical outcomes of endoscopic submucosal dissection (ESD) and surgical resection for early gastric cancer (EGC). After propensity score-matching, the ESD group showed comparable overall survival, disease-specific survival, and recurrence-free survival with the surgery group. The ESD group also had less blood loss, fewer adverse events, lower hospital cost, and a shorter operative time and hospital duration. Therefore, ESD can be considered as a first-line treatment for EGC.
Article
Gastroenterology & Hepatology
Kazunori Tsuda, Shinwa Tanaka, Tetsuya Yoshizaki, Yoshinobu Yamamoto, Takayuki Ose, Tsukasa Ishida, Yasuaki Kitamura, Daisuke Obata, Mineo Iwatate, Atsushi Ikeda, Ryusuke Ariyoshi, Fumiaki Kawara, Hiroshi Takihara, Hirofumi Abe, Toshitatsu Takao, Yoshinori Morita, Yasushi Sano, Eiji Umegaki, Hogara Nishisaki, Takashi Toyonaga, Yuzo Kodama
Summary: This study examined the long-term outcomes of endoscopic submucosal dissection (ESD) for early remnant gastric cancer (ERGC) using a large multicenter database. The results showed favorable survival rates for ERGC patients and suggested that the hospital case volume does not affect the outcomes.
