Article
Medicine, General & Internal
Layla Damen, Melitza S. M. Elizabeth, Stephany H. Donze, Sjoerd A. A. van den Berg, Laura C. G. de Graaff, Anita C. S. Hokken-Koelega
Summary: In children with Prader-Willi syndrome receiving GH treatment, high immunoreactive IGF-I levels are often observed, while free IGF-I levels are low, indicating a significant discrepancy between the two.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Joseph A. M. J. L. Janssen
Summary: Hyperinsulinemia may be a significant factor in causing obesity, metabolic syndrome, cardiovascular disease, cancer, and premature mortality. Strategies for managing hyperinsulinemia include reducing insulin secretion, increasing hepatic insulin clearance, and maximizing insulin sensitivity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Mengyang Li
Summary: The GH/IGF system plays a role in growth regulation in the body. By studying the basal chordate amphioxus, it was discovered that most members of the GH/IGF system are present in amphioxus, providing strong evidence for the origin of this system in amphioxus.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Pharmacology & Pharmacy
Kazuki Kurihara, Hajime Moteki, Mitsutoshi Kimura, Masahiko Ogihara
Summary: The mechanism of GH-induced hepatocyte DNA synthesis and proliferation is mainly mediated through the JAK2/PLC pathway leading to autocrine secretion of IGF-I, which then activates the IGF-I receptor tyrosine kinase signaling pathway. Blocking antibodies to IGF-I, but not transforming growth factor alpha, inhibit GH-induced hepatocyte DNA synthesis and proliferation.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Cell Biology
Hiroki Nishi, Kaito Uchida, Maki Saito, Daisuke Yamanaka, Haruka Nagata, Hinako Tomoshige, Ichiro Miyata, Koichi Ito, Yuka Toyoshima, Shin-Ichiro Takahashi, Fumihiko Hakuno, Asako Takenaka
Summary: This study evaluates the contribution of protein nutrition and the GH/IGF-I system to body growth regulation. The results show that a reduction in serum EAA concentration hinders Igf1 transcription and decreases serum IGF-I levels. Restoring serum IGF-I levels through recombinant IGF-I infusion rescues body growth, indicating the importance of EAAs for animal growth.
Review
Multidisciplinary Sciences
Samia S. Barrera, Juan S. Naranjo-Gomez, Iang S. Rondon-Barragan
Summary: Heat stress has negative effects on the welfare and productivity of cattle, leading to economic losses. Supplementation of the culture medium with insulin-like growth factor-1 (IGF-1) can protect the oocyte maturation process and improve thermotolerance of oocytes exposed to high temperatures.
Review
Pediatrics
Guyeol Jeong, Hongyong Jung, Wi-Young So, Buongo Chun
Summary: This meta-analysis examined the effects of taekwondo on growth factors in children and adolescents. The results showed that taekwondo significantly increased levels of growth hormones and insulin-like growth factors in Korean children and adolescents. However, further research is needed to determine its impact on height. These findings suggest that taekwondo can be recommended as a suitable physical exercise for promoting normal growth in this population.
Article
Biochemistry & Molecular Biology
Lu Wen, Cheng Chen, Keji Zhou
Summary: This experiment investigated the correlation between abdominal obesity and insulin resistance, growth hormone, and insulin-like growth factor-1 in patients with type 2 diabetes mellitus. The results showed that abdominal obesity was positively associated with insulin resistance, and negatively correlated with growth hormone and insulin-like growth factor-1 levels. Improving insulin resistance and regulating the levels of growth hormone and insulin-like growth factor-1 may play crucial roles in the early prevention and efficient clinical treatment of type 2 diabetes mellitus patients with abdominal obesity.
CELLULAR AND MOLECULAR BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Kangkang Chen, Xiaoyi Dou, Jai Hoon Eum, Ruby E. Harrison, Mark R. Brown, Michael R. Strand
Summary: This study assessed the expression of insulin-like peptides (ILPs) and ovary ecdysteroidogenic hormone (OEH) in Aedes aegypti during a gonadotrophic cycle and further functionally characterized these peptides to understand their roles in regulating egg formation. The results showed that all ILPs and OEH were expressed during the cycle, and there were differences in their biological activities and insulin- insulin growth factor signaling (IIS) phosphorylation levels.
INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY
(2023)
Review
Endocrinology & Metabolism
Dorit Koren
Summary: This review aims to summarize the current literature on linear growth in children and adolescents with or at risk for type 1 diabetes mellitus (T1DM). It is found that poor glycemic control in T1DM is associated with growth hormone resistance, and improving glycemic control can improve linear growth. Other factors such as celiac disease and dietary alterations may also affect linear growth in T1DM.
CURRENT OPINION IN ENDOCRINOLOGY DIABETES AND OBESITY
(2022)
Review
Endocrinology & Metabolism
Haim Werner, Zvi Laron
Summary: The GH-IGF1 signaling pathway plays a key role in aging and longevity. Patients with LS, a congenital IGF1 deficiency, seem to be protected from cancer. Aging and cancer may be different manifestations of the same underlying processes. Genome-wide screenings have identified genes associated with aging and longevity in LS patients.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Oncology
Eirini-Maria Giatagana, Aikaterini Berdiaki, Margrethe Gaardlos, Sergey A. Samsonov, George N. Tzanakakis, Dragana Nikitovic
Summary: Osteosarcoma is an aggressive bone cancer, and biglycan plays a role in promoting its growth and resistance to chemotherapy by activating the IGF-IR signaling pathway. This mechanism varies in different levels of differentiation in osteosarcoma cells.
Article
Endocrinology & Metabolism
In-Ho Jung, Seonah Choi, Cheol Ryong Ku, Sang-Guk Lee, Eun Jig Lee, Sun Ho Kim, Eui Hyun Kim
Summary: This study evaluated the reliability of IGF-1 levels as an alternative for disease monitoring after surgical treatment of acromegaly. The results showed that IGF-1 levels can serve as a reliable alternative to OGTT and play a valuable role in monitoring acromegaly status.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2021)
Review
Genetics & Heredity
Qiaoli Zeng, Dehua Zou, Qiaodi Zeng, Xiaoming Chen, Yue Wei, Runmin Guo
Summary: The meta-analysis revealed a significant association between IGF-1 rs35767 and an increased risk of type 2 diabetes (T2DM) in various genetic models, especially in homozygote comparisons and after excluding the study by Gouda et al. Additionally, the gene also increased the risk of T2DM in the Uyghur population subgroup. However, overall, there was not enough evidence to suggest a statistically significant association between the rs35767 SNP and type 2 diabetes.
FRONTIERS IN GENETICS
(2021)
Review
Endocrinology & Metabolism
Derek LeRoith, Jeff M. P. Holly, Briony E. Forbes
Summary: The IGF family of ligands, receptors, and binding proteins play critical roles in normal human physiology and disease states. IGF-I regulates cellular growth, differentiation, and survival to control overall body growth, while IGF-II has important effects prenatally and in tissue-specific roles in adults.
MOLECULAR METABOLISM
(2021)
Article
Endocrinology & Metabolism
Carla J. Greenbaum, Cate Speake, Jeffrey Krischer, Jane Buckner, Peter A. Gottlieb, Desmond A. Schatz, Kevan C. Herold, Mark A. Atkinson
Article
Endocrinology & Metabolism
Michael J. Haller, Desmond A. Schatz, Jay S. Skyler, Jeffrey P. Krischer, Brian N. Bundy, Jessica L. Miller, Mark A. Atkinson, Dorothy J. Becker, David Baidal, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Jennifer B. Marks, Antoinette Moran, Henry Rodriguez, William Russell, Darrell M. Wilson, Carla J. Greenbaum
Article
Endocrinology & Metabolism
Jane L. Chiang, David M. Maahs, Katharine C. Garvey, Korey K. Hood, Lori M. Laffel, Stuart A. Weinzimer, Joseph I. Wolfsdorf, Desmond Schatz
Article
Endocrinology & Metabolism
Michael J. Haller, S. Alice Long, J. Lori Blanchfield, Desmond A. Schatz, Jay S. Skyler, Jeffrey P. Krischer, Brian N. Bundy, Susan M. Geyer, Megan V. Warnock, Jessica L. Miller, Mark A. Atkinson, Dorothy J. Becker, David A. Baidal, Linda A. DiMeglio, Stephen E. Gitelman, Robin Goland, Peter A. Gottlieb, Kevan C. Herold, Jennifer B. Marks, Antoinette Moran, Henry Rodriguez, William E. Russell, Darrell M. Wilson, Carla J. Greenbaum
Article
Endocrinology & Metabolism
Irina Kusmartseva, Maria Beery, Helmut Hiller, Myriam Padilla, Stephen Selman, Amanda Posgai, Harry S. Nick, Martha Campbell-Thompson, Desmond A. Schatz, Michael J. Haller, Clive H. Wasserfall, Mark A. Atkinson
Article
Endocrinology & Metabolism
Melanie R. Shapiro, Clive H. Wasserfall, Sean M. McGrail, Amanda L. Posgai, Rhonda Bacher, Andrew Muir, Michael J. Haller, Desmond A. Schatz, Johnna D. Wesley, Matthias von Herrath, William A. Hagopian, Cate Speake, Mark A. Atkinson, Todd M. Brusko
Article
Endocrinology & Metabolism
Kendra Vehik, Ezio Bonifacio, Ake Lernmark, Liping Yu, Alistair Williams, Desmond Schatz, Marian Rewers, Jin-Xiong She, Jorma Toppari, William Hagopian, Beena Akolkar, Anette G. Ziegler, Jeffrey P. Krischer
Article
Medical Informatics
Heather Lynne Morris, William Troy Donahoo, Brittany Bruggeman, Chelsea Zimmerman, Paul Hiers, Victor W. Zhong, Desmond Schatz
JMIR MEDICAL INFORMATICS
(2020)
Article
Endocrinology & Metabolism
Michael J. Haller, Laura M. Jacobsen, Amanda L. Posgai, Desmond A. Schatz
Summary: Research-based immunotherapy trials for autoimmune diseases like type 1 diabetes have been suspended due to the COVID-19 pandemic, but studies show children and adolescents with diabetes may not have increased risk. It is important to carefully resume these trials and take measures to mitigate infection risks.
Article
Endocrinology & Metabolism
Helmut Hiller, Changjun Yang, Dawn E. Beachy, Irina Kusmartseva, Eduardo Candelario-Jalil, Amanda L. Posgai, Harry S. Nick, Desmond Schatz, Mark A. Atkinson, Clive H. Wasserfall
Summary: This study evaluated the localization and trafficking of PrPC in human pancreases and identified its interaction with proteins involved in cyto-protection, signaling, differentiation, and morphogenesis. The expression of both PRNP and STIP1 genes, encoding PrPC and its interacting partner STI1, were found to be significantly altered in type 1 diabetic and autoantibody-positive pancreases.
Article
Endocrinology & Metabolism
Suzanne Bennett Johnson, Kristian F. Lynch, Roswith Roth, Desmond Schatz
Article
Education, Scientific Disciplines
Ashby F. Walker, Mark A. Atkinson, Alexandra M. Lee, Gina Aulisio, Todd M. Brusko, Michael J. Haller, Desmond A. Schatz
MEDICAL SCIENCE EDUCATOR
(2020)
