A solvent-free, base-catalyzed domino reaction towards trifluoromethylated benzenes from bio-based methyl coumalate

The formation of p-toluic acid from coumalic acid: a reaction network analysis

(2017) Toni Pfennig et al.   GREEN CHEMISTRY

A new selective route towards benzoic acid and derivatives from biomass-derived coumalic acid

(2017) Toni Pfennig et al.   GREEN CHEMISTRY

Preparation of Substituted 2H-Pyrans via a Cascade Reaction from Methyl Coumalate and Activated Methylene Nucleophiles

(2017) Liang Chang et al.   JOURNAL OF ORGANIC CHEMISTRY

Catalyst-Free and Redox-Neutral Innate Trifluoromethylation and Alkylation of Aromatics Enabled by Light

(2017) Peng Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Regio- and Stereoselective Preparation of β,γ-Unsaturated Carboxylic Acids by One-Pot Sequential Double 1,6-Addition of Grignard Reagents to Methyl Coumalate

(2016) Kristína Plevová et al.   ADVANCED SYNTHESIS & CATALYSIS

Highly mono-selective ortho-trifluoromethylation of benzamides via 8-aminoquinoline assisted Cu-promoted C–H activations

(2016) Liang Hu et al.   CHEMICAL COMMUNICATIONS

Methyl fluorosulfonyldifluoroacetate (MFSDA): An Underutilised Reagent for Trifluoromethylation

(2016) Sarah L. Clarke et al.   CHEMISTRY-A EUROPEAN JOURNAL

5-Position-selective C–H trifluoromethylation of 8-aminoquinoline derivatives

(2016) Yoichiro Kuninobu et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

The role of substituents in retro Diels–Alder extrusion of CO 2 from 2( H )-pyrone cycloadducts

(2016) Mohamed Haji Abdullahi et al.   TETRAHEDRON

Multicomponent Reactions of Phosphines, Enynedioates and Cinnamaldimines Give γ-Lactams with a 1,3,5-Hexatriene Moiety for Facile 6π Electrocyclization: Access to Oxindoles, Isatins and Isoxazolinones

(2015) Jie-Cheng Deng et al.   ADVANCED SYNTHESIS & CATALYSIS

Condensed-Phase, Halogen-Bonded CF3I and C2F5I Adducts for Perfluoroalkylation Reactions

(2015) Filippo Sladojevich et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Synthesis of Trifluoromethyl-Containing Polysubstituted Aromatic Compounds by Diels-Alder Reaction of Ethyl 3-Benz­amido-2-oxo-6-(trifluoromethyl)-2H-pyran-5-carboxylate

(2015) Ivan S. Kondratov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Selective synthesis of fluoroalkyl-containing multisubstituted benzenes through Co-mediated [2+2+2] cycloaddition reaction with fluoroalkylated alkynes

(2015) Yukiho Sakaguchi et al.   JOURNAL OF FLUORINE CHEMISTRY

Understanding the domino reaction between 3-chloroindoles and methyl coumalate yielding carbazoles. A DFT study

(2015) Luis R. Domingo et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

NMR Studies and Crystal Structure Determinations of CF3 Group-containing Bicyclic Phenolates

(2015) Constantin Mamat et al.   ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES

Fluorinated benzophenone derivatives: Balanced multipotent agents for Alzheimer's disease

(2014) Federica Belluti et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Diels-Alder Reaction of Ethyl 3-Benzamido-2-oxo-6-(trifluoromethyl)-2H-pyran-5-carboxylate with Alkoxyalkenes as an Effective Approach to Trifluoromethyl-Containing 3-Aminobenzoic Acid Derivatives

(2014) Ivan S. Kondratov et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

One-pot formal synthesis of biorenewable terephthalic acid from methyl coumalate and methyl pyruvate

(2014) Jennifer J. Lee et al.   GREEN CHEMISTRY

Structural diversity and bioactivities of natural benzophenones

(2014) Shi-Biao Wu et al.   NATURAL PRODUCT REPORTS

First Inverse Electron-Demand Diels–Alder Methodology of 3-Chloroindoles and Methyl Coumalate to Carbazoles

(2014) Tezcan Guney et al.   ORGANIC LETTERS

Upgrading malic acid to bio-based benzoates via a Diels–Alder-initiated sequence with the methyl coumalate platform

(2014) Jennifer J. Lee et al.   RSC Advances

Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001–2011)

(2013) Jiang Wang et al.   CHEMICAL REVIEWS

One-Pot Synthesis of Hypervalent Iodine Reagents for Electrophilic Trifluoromethylation

(2013) Václav Matoušek et al.   JOURNAL OF ORGANIC CHEMISTRY

Divergent Diels–Alder methodology from methyl coumalate toward functionalized aromatics

(2013) Jennifer J. Lee et al.   TETRAHEDRON LETTERS

Aromatics from pyrones: esters of terephthalic acid and isophthalic acid from methyl coumalate

(2013) George A. Kraus et al.   RSC Advances

Stereoselective synthesis of conjugated α-Z/γ-E and α-Z/γ-Z dienoic acids. Kinetic torquoselectivity versus thermodynamic control

(2013) Jyoti Agarwal et al.   RSC Advances

Ortho-Trifluoromethylation of Functionalized Aromatic Triazenes

(2012) Andreas Hafner et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Pd-catalyzed double C–H bond activation of diaryl ketones for the synthesis of fluorenones

(2012) Parthasarathy Gandeepan et al.   CHEMICAL COMMUNICATIONS

Pd(II)-Catalyzed Ortho Trifluoromethylation of Arenes and Insights into the Coordination Mode of Acidic Amide Directing Groups

(2012) Xing-Guo Zhang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis of Fluorenone Derivatives through Pd-Catalyzed Dehydrogenative Cyclization

(2012) Hu Li et al.   ORGANIC LETTERS

A Broadly Applicable Copper Reagent for Trifluoromethylations and Perfluoroalkylations of Aryl Iodides and Bromides

(2011) Hiroyuki Morimoto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Palladium-Catalyzed Cascade Cyclization of Ynamides to Azabicycles

(2011) Rebecca L. Greenaway et al.   CHEMISTRY-A EUROPEAN JOURNAL

Aromatics from pyrones: para-substituted alkyl benzoates from alkenes, coumalic acid and methyl coumalate

(2011) George A. Kraus et al.   GREEN CHEMISTRY

Synthesis of trifluoromethyl-substituted salicylates by cyclocondensation of 1,3-bis(silyloxy)-1,3-butadienes with 4,4-dimethylthio-1,1,1-trifluorobut-3-en-2-one

(2011) Viktor O. Iaroshenko et al.   JOURNAL OF FLUORINE CHEMISTRY

Synopsis of Some Recent Tactical Application of Bioisosteres in Drug Design

(2011) Nicholas A. Meanwell   JOURNAL OF MEDICINAL CHEMISTRY

Room Temperature Aryl Trifluoromethylation via Copper-Mediated Oxidative Cross-Coupling

(2011) Todd D. Senecal et al.   JOURNAL OF ORGANIC CHEMISTRY

Trifluoromethylation of arenes and heteroarenes by means of photoredox catalysis

(2011) David A. Nagib et al.   NATURE

Cooperative Effect of Silver in Copper-Catalyzed Trifluoromethylation of Aryl Iodides Using Me3SiCF3

(2011) Zhiqiang Weng et al.   ORGANOMETALLICS

Pd(II)-Catalyzedortho-Trifluoromethylation of Arenes Using TFA as a Promoter

(2010) Xisheng Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Rhodium-catalyzed [2+2+2] cycloaddition of various fluorine-containing alkynes—novel synthesis of multi-substituted fluoroalkylated aromatic compounds

(2010) Tsutomu Konno et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Copper-Mediated Oxidative Trifluoromethylation of Boronic Acids

(2010) Lingling Chu et al.   ORGANIC LETTERS

First synthesis of functionalized 5-aryl-3-(trifluoromethyl)phenols by regioselective [3+3] cyclocondensations of 1,3-bis(silyloxy)-1,3-butadienes with 3-aryl-3-silyloxy-1-trifluoromethyl-2-en-1-ones

(2009) Stefan Büttner et al.   TETRAHEDRON

Natural and synthetic 2H-pyran-2-ones and their versatility in organic synthesis

(2009) Atul Goel et al.   TETRAHEDRON

Catalysis of 6π Electrocyclizations

(2008) Lee M. Bishop et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Structural Basis for the Improved Drug Resistance Profile of New Generation Benzophenone Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors†

(2008) Jingshan Ren et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Many Roles for Fluorine in Medicinal Chemistry

(2008) William K. Hagmann   JOURNAL OF MEDICINAL CHEMISTRY

Active Trifluoromethylating Agents from Well-Defined Copper(I)−CF3Complexes

(2008) Galyna G. Dubinina et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Fluorine in medicinal chemistry

(2007) Sophie Purser et al.   CHEMICAL SOCIETY REVIEWS

One-Pot Synthesis of Functionalized 3-(Trifluoromethyl)phenols by [3+3] Cyclization of 1,3-Bis(silyl enol ethers) with α,β-Unsaturated Trifluoromethyl Ketones

(2007) Constantin Mamat et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY