Article
Immunology
Lin-Chao Li, Yang Tian, Ji Xiao, Yi Yang, Jin-Ni Wu, Yan Chen, Pu-Hong Zhang, Fang Gao-Smith, Jian-Guang Wang, Sheng-Wei Jin
Summary: The experiment showed that DEX increased the population of F4/80+Ly6G+ macrophages, which further promoted the secretion of TGF-β1, leading to a reduction in cytokine storm and an accelerated resolution of inflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Article
Immunology
Ying Fu, Zhiming Wang, Baichao Yu, Yuli Lin, Enyu Huang, Ronghua Liu, Chujun Zhao, Mingfang Lu, Wei Xu, Hongchun Liu, Yongzhong Liu, Luman Wang, Yiwei Chu
Summary: The study reveals that CD11b(+) B cells play a crucial role in alleviating colitis and producing IgA, with CD11b deficiency leading to loss of this protective function. CD11b(+) B cells promote class switch to IgA by expressing abundant TGF-beta and TGF-beta receptor II.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Norio Okamoto, Hideko Ohama, Masahiro Matsui, Shinya Fukunishi, Kazuhide Higuchi, Akira Asai
Summary: Gut-associated sepsis is a major problem in patients undergoing abdominal radiation therapy, with pathogens translocated from the gut microbiota being the main cause. The hepatic immune response, particularly involving Kupffer cells, plays a crucial role in bacterial clearance during sepsis. Different populations of hepatic macrophages have been identified, with normal mice showing effective immune responses against sepsis, while irradiated mice exhibit altered phenotype and reduced antibacterial activity in hepatic macrophages.
JOURNAL OF LEUKOCYTE BIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Qingjun Lu, Hao Shen, Han Yu, Jing Fu, Hui Dong, Yao Chen, Hongyang Wang
Summary: The role of F4/80(+) Kupffer cells (KCs) in liver regeneration varies at different stages, with their depletion affecting hepatocyte proliferation either delaying or inhibiting it. Depletion of F4/80(+) KCs may impact hepatocyte proliferation by modulating TGF-beta 2 and OSM pathways.
Review
Immunology
Xinru Gong, Zhoutong Han, Hongli Fan, Yuqi Wu, Yuanqiong He, Yijie Fu, Tianmin Zhu, Hui Li
Summary: This review examines the potential role of immune cells and cytokines in regulating inflammation and remodeling of chronic rhinosinusitis (CRS) mucosa. The study highlights the important connection between inflammation and remodeling in CRS and provides novel ideas for future research.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Cell Biology
Casandra Carrillo, Vagisha Ravi, Sarika Tiwari, Ellen A. Chernoff, Teri L. Belecky-Adams
Summary: The factors necessary for cell differentiation in the retina are not fully understood. This study focuses on the potential role of transforming growth factor beta-activated kinase 1 (TAK1) in the differentiation of cell types in the chick retina. The results indicate that TAK1 plays a unique role in differentiating and proliferating retinal cells.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Immunology
Jingjing Zhang, Jinxin Qiu, Wenyong Zhou, Jianping Cao, Xuefei Hu, Wenli Mi, Bing Su, Bin He, Ju Qiu, Lei Shen
Summary: This study identifies neuropilin-1 (Nrp1) as a tissue-specific marker of lung-resident ILC2s, which enhances their function and type 2 immune response by upregulating IL-33 receptor ST2 expression. Inhibition of Nrp1 suppresses IL-5 and IL-13 production by ILC2s and protects mice from the development of pulmonary fibrosis.
Article
Biochemistry & Molecular Biology
Elena Della Morte, Stefania Niada, Chiara Giannasi, Luigi Zagra, Anna Teresa Brini
Summary: This study found that TNF-α can rapidly induce a decrease in Cx43 expression in articular chondrocytes, mainly through the proteasomal pathway. The proteasome inhibitor MG132 and the synthetic factor TGF-β 1 can reverse this decrease. These results suggest a potentially important role of Cx43 perturbation in joint inflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Yonghui Zou, Yi Xu, Xiaofeng Chen, Yaoqi Wu, Longsheng Fu, Yanni Lv
Summary: LRG1 is an important protein involved in normal physiological activities of the nervous system and has been found to affect the development of various diseases. However, research on its role in disease is still in its early stages, and further studies are needed to uncover its potential therapeutic value.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Oncology
Justin Joseph, Capucine R. Magaut, Simon Storevik, Luiz H. Geraldo, Thomas Mathivet, Md Abdul Latif, Justine Rudewicz, Joris Guyon, Matteo Gambaretti, Frida Haukas, Amalie Trones, Lars A. Romo Ystaas, Jubayer A. Hossain, Sandra Ninzima, Sylvain Cuvellier, Wenjing Zhou, Tushar Tomar, Barbara Klink, Lalit Rane, Bronwyn K. Irving, Joanne Marrison, Peter O'Toole, Heiko Wurdak, Jian Wang, Zhang Di, Even Birkeland, Frode S. Berven, Frank Winkler, Frank A. E. Kruyt, Andreas Bikfalvi, Rolf Bjerkvig, Thomas Daubon, Hrvoje Miletic
Summary: Analysis of TCGA data revealed a high activation of the TGF-beta pathway in GBMs compared to oligodendroglial tumors. Stimulation of GBM cell lines with TGF-beta 1 enhanced MT formation and communication via calcium signaling, while inhibition of the TGF-beta pathway significantly reduced MT formation and invasion. Downstream of TGF-beta, thrombospondin 1 (TSP1) was identified as a potential mediator of MT formation in GBM, which was upregulated upon TGF-beta stimulation and inhibited MT formation when knocked down in vitro and in vivo.
Review
Pharmacology & Pharmacy
Yicheng Wei, Jialuo Cai, Ruiqiu Zhu, Ke Xu, Hongchang Li, Jianxin Li
Summary: This review focuses on the role of TRPA1 channel in fibroblasts, exploring its interactions with inflammatory factors and its different functions in the fibrosis process in different organs. The aim of this review is to describe the function of TRP channels in controlling fibrosis through fibroblasts in various inflammatory and immune-mediated diseases.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Tarfah Al-Warhi, Eman Maher Zahran, Samy Selim, Mohammad M. Al-Sanea, Mohammed M. Ghoneim, Sherif A. Maher, Yaser A. Mostafa, Faisal Alsenani, Mahmoud A. Elrehany, Mohammed S. Almuhayawi, Soad K. Al Jaouni, Usama Ramadan Abdelmohsen, Abeer H. Elmaidomy
Summary: This study demonstrates the potential of Vitis vinifera seed extract in promoting wound healing by accelerating wound closure rates, increasing TGF-beta and VEGF levels, and reducing TNF-alpha and IL-1 beta levels. Phytochemical analysis identified multiple compounds, and molecular docking experiments were performed to investigate the mechanisms of action.
Article
Chemistry, Analytical
Giulia Siciliano, Maria Serena Chiriaco, Francesco Ferrara, Antonio Turco, Luciano Velardi, Maria Assunta Signore, Marco Esposito, Giuseppe Gigli, Elisabetta Primiceri
Summary: Oral cancer, a common type of cancer in Europe, necessitates the development of low-cost and reliable portable platforms for its diagnosis. In this study, a molecularly imprinted polymer (MIP)-based electrochemical sensor for TGF-β1 detection was developed and characterized. The optimized biosensor shows potential for early screening of oral cancer. The MIP sensor demonstrates a linear response, high selectivity, and sensitivity in buffer solution and saliva samples, making it suitable for large-scale fast screening in oral cancer diagnosis.
Article
Physiology
Hsiu-Hui Yang, Shih-Han Su, Cheng-Hsuan Ho, Ai-Hsin Yeh, Yi-Jiun Lin, Ming-Jiun Yu
Summary: The expression of the water channel protein AQP2 is regulated by the glucocorticoid receptor and the pituitary hormone vasopressin. Transcriptomic comparison revealed positive and negative regulatory pathways maintained by the glucocorticoid receptor for the vasopressin-induced Aqp2 gene expression.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Immunology
Zhi-wei Liu, Yi-ming Zhang, Li-ying Zhang, Ting Zhou, Yang-yang Li, Gu-cheng Zhou, Zhi-ming Miao, Ming Shang, Jin-peng He, Nan- Ding, Yong-qi Liu
Summary: The tumor microenvironment plays a crucial role in the formation and development of tumors. Cytokines, such as TGF-beta and TNF-alpha, have different effects on tumor growth, metastasis, and prognosis at different stages. Inhibiting TGF-beta can promote tumor formation, while TGF-beta can contribute to tumor malignancy. TNF-alpha, initially identified as a natural immune serum mediator for tumor hemorrhagic necrosis, has broad biological activities and can be targeted for immune diseases and tumors. However, there is limited research on the interaction between these two cytokines in the tumor microenvironment.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Dermatology
Elisabeth Richert, Julia Papenkort, Alexa Klettner, Jan Tode, Stefan Koinzer, Ralf Brinkmann, Christine Fink, Thomas Roeder, Ralph Lucius, Johann Roider
Summary: The study indicates that TSR may serve as a stimulating treatment for dry AMD. TSR did not induce RPE cell death and had no impact on the integrity of the RPE/BrM-complex. TSR increased the basal release of active MMP-2 and promoted the secretion of anti-angiogenic PEDF.
LASERS IN SURGERY AND MEDICINE
(2021)
Article
Ophthalmology
Kumiko Hirayama, Manabu Yamamoto, Takeya Kohno, Akika Kyo, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Shigeru Honda
Summary: The study investigates the effect of selective retina therapy (SRT) for macular serous retinal detachment (MSRD) associated with tilted disc syndrome (TDS). SRT may promote absorption of MSRD and maintenance of best-corrected visual acuity (BCVA) for TDS. Randomized and prospective clinical studies are needed to evaluate the effectiveness of SRT for MSRD associated with TDS.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Multidisciplinary Sciences
Akika Kyo, Manabu Yamamoto, Kumiko Hirayama, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Yoko Miura, Shigeru Honda
Summary: This study investigated the factors influencing the clinical outcome of SRT for CSC, finding that the rate of change in CMT was associated with focal leakage type on FA and baseline CMT, while complete resolution of subretinal fluid was associated with non-smoking history and focal leakage type on FA. These findings may help predict the therapeutic effectiveness of SRT.
SCIENTIFIC REPORTS
(2021)
Article
Optics
Hubertus Hakert, Matthias Eibl, Marie Tillich, Ralph Pries, Gereon Huettmann, Ralf Brinkmann, Barbara Wollenberg, Karl-Ludwig Bruchhage, Sebastian Karpf, Robert Huber
Summary: Stimulated Raman scattering (SRS) microscopy enables biomedical analysis by providing a molecular localization map for inferring tissue changes, with faster imaging speeds and reliable results. By targeting spectral features in the fingerprint region, SRS allows efficient imaging of molecular contrast in unstained head-and-neck biopsies.
Article
Medicine, General & Internal
Konstantin Yashin, Matteo Mario Bonsanto, Ksenia Achkasova, Anna Zolotova, Al-Madhaji Wael, Elena Kiseleva, Alexander Moiseev, Igor Medyanik, Leonid Kravets, Robert Huber, Ralf Brinkmann, Natalia Gladkova
Summary: This review discusses the application of optical coherence tomography (OCT) in brain tumor surgery and its potential benefits. OCT can assist in precise identification and visualization of tumor infiltration in brain tissue, thereby improving the safety and accuracy of surgical procedures. The combination of OCT with traditional imaging methods and intelligent diagnosis can achieve high precision, automation, and intelligence in brain tumor surgery.
Article
Acoustics
Eric Seifert, Jan Tode, Amelie Pielen, Dirk Theisen-Kunde, Carsten Framme, Johann Roider, Yoko Miura, Reginald Birngruber, Ralf Brinkmann
Summary: The study evaluated an optoacoustically based MBF detection algorithm, showing high sensitivity and specificity, which can be used for controlling appropriate radiant exposures during treatments like SRT.
Article
Biology
Yoko Miura, Keiji Inagaki, Alessa Hutfilz, Eric Seifert, Benedikt Schmarbeck, Akira Murakami, Kishiko Ohkoshi, Ralf Brinkmann
Summary: This study compared the effects of continuous wave (CW) and microsecond pulse (MP) laser irradiation on cell damage and laser-induced temperature rise at the retinal pigment epithelium (RPE). The results showed that there was no difference in the average temperature rise between CW and MP modes at the same average power. However, at lower duty cycles, caution is required due to potential mechanical damage caused by microbubble formation.
Article
Biology
Manabu Yamamoto, Yoko Miura, Kumiko Hirayama, Akika Kyo, Takeya Kohno, Dirk Theisen-Kunde, Ralf Brinkmann, Shigeru Honda
Summary: This study compared the safety and efficacy of selective retina therapy (SRT) combined with intravitreal injection of ranibizumab (IVR) in patients with macular edema (ME) secondary to branch retinal vein occlusion (BRVO). The results showed that IVR combined with SRT significantly reduced the number of IVR treatments while maintaining the visual and anatomical improvement effect of IVR monotherapy.
Meeting Abstract
Ophthalmology
Svenja Sonntag, Eric Seifert, Maximilian Hamann, Britta Lewke, Dirk Theisen-Kunde, Ralf Brinkmann, Salvatore Grisanti, Yoko Miura
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Yoko Miura, Britta Lewke, Erdal Ishizuka, Svenja Sonntag, Eric Seifert, Salvatore Grisanti, Ralf Brinkmann
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Proceedings Paper
Automation & Control Systems
Viktoria Kleyman, Manuel Schaller, Mitsuru Wilson, Mario Mordmueller, Ralf Brinkmann, Karl Worthmann, Matthias A. Mueller
Summary: The approach presented in this study focuses on state and parameter estimation in retinal laser treatment using a single laser for both measurement and heating. By applying a model-based approach with a parametric model for a heat diffusion equation, real-time tractability is maintained while estimating the absorption coefficient and system state. Results from simulated and experimental data show that moving horizon estimation slightly outperforms extended Kalman filtering in terms of parameter and state estimation speed.
Meeting Abstract
Ophthalmology
Jan-Erik Fleger, Claus von der Burchard, Christopher Kren, Mario Mordmuller, Dirk Theisen-Kunde, Veit Danicke, Hossam Abbas, Ralf Brinkmann, Johann Roider
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Ralf Brinkmann, Christopher Kren, Veit Danicke, Ahmed Almashharawi, Mario Mordmuller, Dirk Theisen-Kunde, Yoko Miura, Claus von der Burchard, Johann Roider, Hossam Abbas
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Meeting Abstract
Ophthalmology
Richard Foerster, Erdal Tan Ishizuka, Kensuke Shima, Britta Lewke, Svenja Rebecca Sonntag, Jan Rupp, Ralf Brinkmann, Salvatore Grisanti, Yoko Miura
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Ophthalmology
Eric Seifert, Svenja Rebecca Sonntag, Philipp Kleingarn, Dirk Theisen-Kunde, Salvatore Grisanti, Reginald Birngruber, Yoko Miura, Ralf Brinkmann
Summary: The study evaluated the mechanisms and thresholds for RPE cell damage using lasers with different pulse durations, finding that the threshold for microbubble formation was significantly higher than cell damage for pulse durations >= 5 μs.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)