Article
Biochemical Research Methods
Anna Karlund, Teemu Kaariainen, Vili M. Kostamo, Tarja Kokkola, Marjukka Kolehmainen, Timo A. Lakka, Jussi Pihlajamaki, Albert Manninen
Summary: Analyzing the isotopic composition of exhaled carbon dioxide may help screen for prediabetes, but further research is needed to apply this method in Finnish individuals with prediabetes. While C-13/C-12 isotopes may assist in identifying prediabetic individuals in some cases, they are not yet reliable as a sole marker for screening prediabetes.
JOURNAL OF BREATH RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Xiaojing Huang, Daniel Winter, Dominic. J. J. Glover, Claudiu. T. T. Supuran, William. A. A. Donald
Summary: Carbonic anhydrases (CAs) are metalloenzymes that play important roles in cellular processes and have been implicated in various diseases. Phosphorylation, a common post-translational modification of CAs, can significantly impact their catalytic activity and drug-binding capabilities. This study highlights the potential regulatory role of phosphorylation in CA activity and its effect on small molecule drug binding.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Geochemistry & Geophysics
Ellen K. Olsen, James M. Watkins, Laurent S. Devriendt
Summary: Background electrolytes can affect the precipitation and dissolution rates of calcite, potentially impacting the kinetic isotope fractionation between calcite and dissolved inorganic carbon (DIC). In this study, inorganic calcite was grown from NaCl-CaCl2 solutions to examine the effects of ionic strength on the oxygen isotope fractionation. The results showed no significant ionic strength effect on the fractionation. However, at NaCl concentrations above 0.35M, the isotopic equilibrium between DIC and water could not be maintained due to the inhibitory effect of NaCl on the enzyme carbonic anhydrase. The efficacy of the enzyme decreased exponentially with increasing NaCl concentration. The findings provide insights into oxygen isotope vital effects in marine organisms.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2022)
Article
Chemistry, Multidisciplinary
Ferran Esteve, Fidan Rahmatova, Jean-Marie Lehn
Summary: This study reveals the remarkable effect of supramolecular multivalency on increasing imine stability. By synthesizing a series of reactive aldehydes bearing supramolecularly-active sites, it was found that decreasing the degree of supramolecular multivalency significantly decreased imine yields. Preliminary results on protein bioconjugation demonstrated the ability to dynamically inhibit the activity of carbonic anhydrase and recover its initial activity with a suitable chemical effector.
Article
Multidisciplinary Sciences
Daily Zuniga-Rios, Roman Manuel Vasquez-Elizondo, Edgar Caamal, Daniel Robledo
Summary: The study evaluated the interactive effects of temperature, pH, and nutrients on photosynthetic performance in a calcareous tropical macroalga. The highest values of gross photosynthesis were found at the highest temperature, pH, and nutrient enrichment levels. The absorption of bicarbonate was assessed through carbon stable isotope content and inhibitors assays, confirming the algae's use of both CO2 and HCO3- forms of carbon.
Article
Marine & Freshwater Biology
Ryotaro Izumi, Ee Suan Tan, Hinako Higa, Zongyan Shi, Yuki Takeuchi, Naoko Isomura, Akihiro Takemura
Summary: Light conditions (photoperiod, intensity, and spectrum) affect coral growth. Longer photoperiods and higher light intensities promote coral growth. Changes in light spectrum affect symbiotic algae density and chlorophyll content, but not growth. Light accelerates coral calcification through photosynthesis by algal symbionts.
Editorial Material
Multidisciplinary Sciences
Martin Thibault, Anne Lorrain, Fanny Houlbreque
Summary: In an era of significant environmental changes, understanding corals' resistance to bleaching is crucial. A new framework for inferring corals' trophic strategies has been proposed, but a potential bias risk was identified in its application, leading to the proposal of three alternative adjustments.
Article
Biochemistry & Molecular Biology
Hasan Yakan, Gurkan Bilir, Sukriye Cakmak, Omer Tas, Nalan Turkoz Karakullukcu, Ercan Soydan, Halil Kutuk, Coskun Guclu, Murat Senturk, Tayfun Arslan, Seyhan Ozturk, Ercument Aksakal, Deniz Ekinci
Summary: A series of sulfenimide derivatives were synthesized via an efficient, simple and eco-friendly method and were found to be effective inhibitors of human and bovine carbonic anhydrase enzymes. The structures of the derivatives were confirmed by various techniques. These compounds showed strong inhibitory activity at low micromolar concentrations on human isoforms, while only four derivatives inhibited the bovine enzyme. One of the derivatives, the bromo derivative, was found to be the strongest inhibitor for all three enzymes. This study provides valuable contributions to further investigations on carbonic anhydrase inhibition in medicinal chemistry.
JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
(2023)
Article
Environmental Sciences
Juliana Lemos Dal Pizzol, Joseane Aparecida Marques, Juliana da Silva Fonseca, Patricia Gomes Costa, Adalto Bianchini
Summary: This study evaluated the influence of metal accumulation on the oxidative status and enzyme activity in coral and hydrocoral species in Abrolhos Reef Banks. The results indicated that the hydrocoral M. alcicornis was more affected by metals than the coral M. harttii, and CA activity can serve as a complementary biomarker for assessing the physiological impacts of environmental metal contamination in reefs. The findings also provide reference data for monitoring reef health impacted by a relevant dam rupture.
Article
Geochemistry & Geophysics
Joji Uchikawa, Sang Chen, John M. Eiler, Jess F. Adkins, Richard E. Zeebe
Summary: This study investigates the abundance of O-18 isotopes and C-13-O-18 isotopic clumps in carbonate minerals for inferring mineral formation temperatures. It reveals that isotopic equilibrium during mineral formation is not always achieved. Analyzing inorganic BaCO3 samples precipitated at different times, it was found that while the timescales for delta O-18 and Delta(47) equilibrium are similar, the equilibration trajectories are notably different, possibly due to differences in exchange rates for oxygen isotopes bound to C-12 versus C-13.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2021)
Article
Biochemistry & Molecular Biology
Saeid Hadi Ali Janvand, Lucy Kate Ladefoged, Asta Zubriene, Andrius Sakalauskas, Gunna Christiansen, Virginija Dudutiene, Birgit Schiott, Daumantas Matulis, Vytautas Smirnovas, Daniel E. Otzen
Summary: Fluorinated sulfonamide compounds can inhibit the formation of amyloid fibrils, potentially providing therapeutic effects against amyloid-related disorders such as Parkinson's, Alzheimer's, and type 2 diabetes, possibly by maintaining insulin in its native monomeric state.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Biochemistry & Molecular Biology
Necla Oztaskin, Suleyman Goksu, Yeliz Demir, Ahmet Maras, Ilhami Gulcin
Summary: Nine new bromophenol derivatives were designed and synthesized in this study, showing effective inhibition effects on metabolic enzymes. These compounds may be used for the treatment of various diseases.
Article
Neurosciences
Mogens Andreasen, Steen Nedergaard
Summary: This study investigated the effects of acetazolamide on the axonal compound action potential in hippocampal slices and found that carbonic anhydrase-dependent pH regulation can counteract the activity-induced reduction of excitability in Schaffer collateral axons in CA1.
Review
Biochemistry & Molecular Biology
Hatice Zehra Ozsoy
Summary: Acetazolamide and other CA inhibitors have potential benefits in treating epilepsy and other neurological disorders, but their specific mechanisms are still unclear. These drugs work by influencing the balance of substances like CO2, H+, and HCO3-, as well as modulating the activity of neurons and ion channels.
NEUROCHEMICAL RESEARCH
(2021)
Article
Geochemistry & Geophysics
Sang Chen, Eloise F. M. Littley, James W. B. Rae, Christopher D. Charles, Yunbin Guan, Jess F. Adkins
Summary: Deep-sea corals serve as an important record of past oceans and studying their vital effects is crucial for paleoceanographic applications. By analyzing stable isotopes, minor and trace metals, we observed spatially coherent tracer correlations in individual corals. Our findings provide insights into the biomineralization mechanisms and the response of marine calcification to environmental stress. Understanding these mechanisms is essential for accurate use of deep-sea coral tracers and predicting the impact of ocean acidification.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2023)
Article
Geochemistry & Geophysics
Anthony J. Giuffre, Alexander C. Gagnon, James J. De Yoreo, Patricia M. Dove
GEOCHIMICA ET COSMOCHIMICA ACTA
(2015)
Article
Geochemistry & Geophysics
Sang Chen, Sharon S. Hoffmann, David C. Lund, Kim M. Cobb, Julien Emile-Geay, Jess F. Adkins
EARTH AND PLANETARY SCIENCE LETTERS
(2016)
Article
Multidisciplinary Sciences
Oscar Branson, Elisa A. Bonnin, Daniel E. Perea, Howard J. Spero, Zihua Zhu, Maria Winters, Barbel Honisch, Ann D. Russell, Jennifer S. Fehrenbacher, Alexander C. Gagnon
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Article
Multidisciplinary Sciences
Jennifer S. Fehrenbacher, Ann D. Russell, Catherine V. Davis, Alexander C. Gagnon, Howard J. Spero, John B. Cliff, Zihua Zhu, Pamela Martin
NATURE COMMUNICATIONS
(2017)
Article
Geochemistry & Geophysics
Elisa A. Bonnin, Zihua Zhu, Jennifer S. Fehrenbacher, Ann D. Russell, Barbel Honisch, Howard J. Spero, Alexander C. Gagnon
GEOCHIMICA ET COSMOCHIMICA ACTA
(2019)
Article
Geochemistry & Geophysics
Sang Chen, Uri Ryb, Alison M. Piasecki, Max K. Lloyd, Michael B. Baker, John M. Eiler
GEOCHIMICA ET COSMOCHIMICA ACTA
(2019)
Article
Optics
Samuel C. Johnson, Eric A. Muller, Omar Khatib, Elisa A. Bonnin, Alexander C. Gagnon, Markus B. Raschke
Article
Chemistry, Multidisciplinary
Isaiah W. Bolden, Julian P. Sachs, Alexander C. Gagnon
Article
Geochemistry & Geophysics
Alexander C. Gagnon, Anne M. Gothmann, Oscar Branson, James W. B. Rae, Joseph A. Stewart
Summary: Research on coral calcification reveals the sensitivity to environmental change and the ability of physiological processes to buffer biomineralization. Boron isotopes have been shown to be a useful proxy for past seawater pH, and new findings demonstrate their sensitivity to seawater dissolved inorganic carbon. The introduction of boric acid diffusion as a new flux within a geochemical model helps explain the observed sensitivity of coral delta B-11 to multiple factors, including pH and DIC.
EARTH AND PLANETARY SCIENCE LETTERS
(2021)
Article
Environmental Sciences
Eileen H. Bates, Lindsay Alma, Tamas Ugrai, Alexander Gagnon, Michael Maher, Paul McElhany, Jacqueline L. Padilla-Gamino
Summary: The study compared trace metal concentrations in tissue of Mediterranean mussels and Olympia oysters at different sites in Puget Sound, Washington to understand differences in bioaccumulation based on species, location, and shellfish size. The research found that metal concentrations in shellfish varied between sites and were influenced by factors such as water chemistry and shellfish size.
FRONTIERS IN MARINE SCIENCE
(2021)
Article
Multidisciplinary Sciences
Shuaifeng Li, Liza M. Roger, Lokender Kumar, Nastassja A. Lewinski, Judith Klein-Seetharaman, Alex Gagnon, Hollie M. Putnam, Jinkyu Yang
Summary: Coral reef ecosystems are under threat due to human activities and climate change, while the behavioral trait of coral motion plays a crucial role in survival. However, the subtle tissue motion in scleractinian corals is hard to detect. Researchers have proposed a systematic approach to quantify and visualize minute coral motion in different light conditions for Montipora capricornis.
SCIENTIFIC REPORTS
(2021)
Article
Geochemistry & Geophysics
Anne M. Gothmann, Alex C. Gagnon
Summary: Culture experiments with cold-water coral reveal that U/Ca and Sr/Ca ratios are most strongly correlated with solution DIC, rather than pH or [CO32-]. The study suggests that changes in seawater exchange rates and calcifying fluid pH play important roles in the biomineralization process of the coral species studied.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2021)
Article
Geosciences, Multidisciplinary
Daniel Vielzeuf, Alexander C. Gagnon, Angele Ricolleau, Jean-Luc Devidal, Catherine Balme-Heuze, Nassima Yahiaoui, Claire Fonquernie, Jonathan Perrin, Joaquim Garrabou, Jean-Marc Montel, Nicole Floquet
FRONTIERS IN EARTH SCIENCE
(2018)
Article
Geochemistry & Geophysics
Xinze Lu, Geoffrey J. Gilleaudeau, Brian Kendall
Summary: The Late Ordovician mass extinction is the first major extinction event in the Phanerozoic, but the reasons for the decline in global biodiversity before the extinction are not well understood.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2024)
Article
Geochemistry & Geophysics
Junyao Kang, Daniel D. Gregory, Benjamin Gill, Shiqiang Huang, Changxin Lai, Zhaoshan Chang, Huan Cui, Ivan Belousov, Shuhai Xiao
Summary: Sedimentary pyrite is an important geological archive, but it can be altered by diagenetic and hydrothermal processes. This study successfully trained machine learning algorithms to distinguish pyrite origins using trace element data. The approach was validated and applied to identify the origins of pyrite in two sedimentary successions in South China.
GEOCHIMICA ET COSMOCHIMICA ACTA
(2024)