Review
Nutrition & Dietetics
Ryota Matsui, Kazuma Rifu, Jun Watanabe, Noriyuki Inaki, Tetsu Fukunaga
Summary: This study aimed to clarify the impact of GLIM-defined malnutrition on the treatment outcomes of patients with cancer. The study found that GLIM-defined malnutrition may worsen the overall survival and increase the risk of postoperative complications in patients with cancer.
CLINICAL NUTRITION
(2023)
Article
Multidisciplinary Sciences
Muhammad Osman, Cari van Schalkwyk, Pren Naidoo, James A. Seddon, Rory Dunbar, Sicelo S. Dlamini, Alex Welte, Anneke C. Hesseling, Mareli M. Claassens
Summary: The mortality rate of TB patients in South Africa during treatment has decreased, but factors such as older age, male gender, previous TB history, and HIV infection increase the risk of death. Young women aged 15-24 with TB experience disproportionately high mortality rates and require targeted interventions.
SCIENTIFIC REPORTS
(2021)
Article
Cell Biology
Tingxin Zhang, Aksheev Bhambri, Yihe Zhang, Daniela Barbosa, Han-Gyu Bae, Jumin Xue, Sabeen Wazir, Sara B. Mulinyawe, Jun Hee Kim, Lu O. Sun
Summary: Oligodendrocytes are the only cells responsible for producing myelin in the central nervous system. The number of oligodendrocytes is tightly regulated in different brain regions to match the type and quantity of local axons, but the underlying mechanisms are still unclear. This study shows that autophagy, a cellular process that promotes cell survival under normal conditions, leads to apoptosis of premyelinating oligodendrocytes during development. Autophagy functions autonomously in premyelinating oligodendrocytes to trigger cell apoptosis, and it interacts with the TFEB pathway to control the number of oligodendrocytes in diverse brain regions. These findings provide in vivo evidence that autophagy plays a role in promoting apoptosis in mammalian cells under physiological conditions and uncover important intrinsic mechanisms governing oligodendrogenesis.
Article
Endocrinology & Metabolism
Hongying He, Rilige Wu, Jiahang Zhao, Qing Song, Yan Zhang, Yukun Luo
Summary: The study compared the efficacy and safety of radiofrequency ablation (RFA) and surgical resection (SR) in patients with T1bN0M0 papillary thyroid carcinoma (PTC) in different age groups. Results showed that RFA had similar prognosis as SR but with lower overall cost, making it a potential alternative treatment for patients with T1bN0M0 PTC.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Editorial Material
Hematology
Miriam Erlacher, Verena Labi
Summary: BCL-2, the first oncogene described to promote cell survival, continues to be a popular therapeutic agent in oncology as the prime target of venetoclax. However, in hematology, its pro-survival sibling MCL-1 is now taking the spotlight, as elegantly demonstrated in the latest issue of Blood.
Article
Multidisciplinary Sciences
Mariel F. Schwietzer, Sonja Thoelmann, Daniel Kummer, Anne Kaschler, Lilo Greune, Eva-Maria Thuering, M. Alexander Schmidt, Volker Gerke, Klaus Ebnet
Summary: Entosis is a cell competition process where tumor cells engulf other tumor cells. Depletion of the cell adhesion receptor JAM-A increases the rate of entosis and is associated with dysregulation of CIL.
Article
Oncology
Malek Shatila, Weijie Ma, Yantong Cui, Sidra Naz, Anusha S. Thomas, Enrico N. De Toni, Helga-Paula Toeroek, Najib Ben Khaled, Mehmet Altan, Bryan Schneider, Yinghong Wang
Summary: This study aims to explore the impact of immunosuppression use and duration on cancer progression and progression-free survival (PFS). The results showed that shorter duration of steroid treatment for colitis may be associated with less cancer progression, while immunosuppression had no effect on PFS. Therefore, it may be preferable to limit long-term immunosuppression in the treatment of immune-mediated colitis.
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
(2023)
Article
Oncology
Toru Aoyama, Koji Oba, Michitaka Honda, Masaru Muto, Shuhei Mayanagi, Hiromichi Maeda, Mitsuro Kanda, Kosuke Kashiwabara, Junichi Sakamoto, Takaki Yoshikawa
Summary: This study investigated the impact of postoperative complications (POCs) on survival and the potential influence on adjuvant chemotherapy. The results showed that POCs were associated with poor prognosis but did not affect the intensity of adjuvant chemotherapy.
INTERNATIONAL JOURNAL OF CLINICAL ONCOLOGY
(2023)
Article
Engineering, Biomedical
Zhongyun Chen, Yingying Su, Gang Liu, Linlin Fan, Yan Zhang, Weibi Chen, Hong Ye, Huijing Huang
Summary: Apnea testing (AT) is a key step in brain death diagnosis in China, but completion rates are not ideal. This study analyzed completion rates of AT in potential BD patients from 2013 to 2019, finding lower rates in both adult and pediatric groups. Factors such as PaO2 and A-a gradient are crucial for successful completion of AT and should be optimized beforehand.
Article
Radiology, Nuclear Medicine & Medical Imaging
Tze Min Wah, James Lenton, Jonathan Smith, Paul Bassett, Satinder Jagdev, Christy Ralph, Naveen Vasudev, Selina Bhattarai, Michael Kimuli, Jon Cartledge
Summary: The study evaluated the safety and efficacy of CT-guided IRE for cT1a renal tumors close to vital structures. The primary technical success rate was 73.3% and all patients preserved renal function without the need for dialysis. The 2- and 3-year cancer-specific survival rates were 89% and 87%.
EUROPEAN RADIOLOGY
(2021)
Article
Surgery
Yi Liu, Yi-fan Liu, Hong-zheng Meng, Tao Sun, Ping Gao, Zhao-zhi Li, Wen-qiang Zhang
Summary: This study aimed to determine the long-term clinical efficacy of TKA in hemophilia patients with stiff knees, assess the prosthesis survival in hemophilia, and determine the impact of preoperative stiffness severity on postoperative outcomes. The clinical data of 71 patients with hemophilia and knee stiffness who underwent TKA were analyzed retrospectively. The study found that TKA showed satisfactory long-term efficacy in patients with hemophilic knee joint disease involving stiffness, with significant improvements in function and reduced pain.
FRONTIERS IN SURGERY
(2023)
Article
Biochemistry & Molecular Biology
Omar A. Itani, Xuefei Zhong, Xiaoting Tang, Barbara A. Scott, Jun Yi Yan, Stephane Flibotte, Yiting Lim, Andrew C. Hsieh, James E. Bruce, Marc Van Gilst, C. Michael Crowder
Summary: Our study reveals an unrecognized higher-order-translation regulatory mechanism in a metazoan, where ribosome biogenesis genes communicate with genes controlling tRNA abundance to match the global rate of protein synthesis with available resources.
Article
Oncology
A. Broadbent, S. Rahman, B. Grace, R. Walker, F. Noble, J. Kelly, J. Byrne, T. Underwood
Summary: Complications have a significant impact on long-term survival after oesophagectomy for cancer, especially the cumulative effect of multiple complications. Interestingly, multiple minor complications have a worse effect on survival than major complications.
Article
Gastroenterology & Hepatology
Yasmina Chouik, Olivier Chazouilleres, Claire Francoz, Eleonora De Martin, Olivier Guillaud, Armand Abergel, Mario Altieri, Louise Barbier, Camille Besch, Filomena Conti, Christophe Corpechot, Sebastien Dharancy, Francois Durand, Christophe Duvoux, Jean Gugenheim, Jean Hardwigsen, Marie-Noelle Hilleret, Pauline Houssel-Debry, Nassim Kamar, Delphine Maucort-Boulch, Anne Minello, Martine Neau-Cransac, Georges-Philippe Pageaux, Sylvie Radenne, Olivier Roux, Faouzi Saliba, Olivier Seree, Didier Samuel, Claire Vanlemmens, Marie-Lorraine Woehl-Jaegle, Vincent Leroy, Jean-Charles Duclos-Vallee, Jerome Dumortier
Summary: This study evaluated long-term survival and prognostic factors for patients with autoimmune hepatitis (AIH) after liver transplantation (LT), particularly the impact of recurrent AIH (rAIH). The results showed that AIH patients had excellent survival rates after LT, but disease recurrence and chronic rejection reduced graft survival.
LIVER INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Arintaya Phrommintikul, Piyameth Dilokthornsakul, Unchalee Permsuwan
Summary: This study estimated the real-world financial burden of type 2 diabetes treatment, complications, and cardiovascular death. The findings indicate that diabetes and its complications incur a substantial financial burden, necessitating a multi-sectoral effort from government, providers, patients, and private sector for effective management of diabetes.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Letter
Gastroenterology & Hepatology
Joshua Quan, Christopher Ma, Remo Panaccione, Lindsay Hracs, Nastaran Sharifi, Michelle Herauf, Ante Makovinovic, Stephanie Coward, Joseph W. Windsor, Lea Caplan, Richard J. M. Ingram, Jamil N. Kanji, Graham Tipples, Jessalyn K. Holodinsky, Charles N. Bernstein, Douglas J. Mahoney, Sasha Bernatsky, Eric Benchimol, Gilaad G. Kaplan
Article
Gastroenterology & Hepatology
Bradley G. Goodyear, Faranak Heidari, Richard J. M. Ingram, Filomeno Cortese, Nastaran Sharifi, Gilaad G. Kaplan, Christopher Ma, Remo Panaccione, Keith A. Sharkey, Mark G. Swain
Summary: Magnetic resonance imaging revealed structural and functional changes within the brains of inflammatory bowel disease patients, in regions known to be involved in processing brain signals associated with behavioral symptoms, anxiety, pain, stress, and cognitive deficits.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
William J. Sandborn, Geert R. D'Haens, Bruce E. Sands, Remo Panaccione, Siew C. Ng, Nervin Lawendy, Nicole Kulisek, Irene Modesto, Xiang Guo, Rajiv Mundayat, Chinyu Su, Ivana Vranic, Julian Panes
Summary: This study provides a summary of tofacitinib safety in the treatment of ulcerative colitis. The results showed a low incidence of adverse events, with stable rates in patients treated for at least 7.8 years. The incidence rates of important safety events were generally below 2.0, except for herpes zoster.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Christopher Ma, Remo Panaccione, Yasi Xiao, Yuvan Khandelwal, Sanjay K. Murthy, Emily C. L. Wong, Neeraj Narula, Catherine Tsai, Farhad Peerani, Marica Reise-Filteau, Brian Bressler, Samantha Y. Starkey, Dustin Loomes, Rocio Sedano, Vipul Jairath, Talat Bessissow
Summary: This Canadian multicenter cohort study evaluated the real-world effectiveness and safety of tofacitinib for the treatment of ulcerative colitis (UC). The study found that one-third of UC patients achieved clinical remission with few serious adverse events. However, half of the patients lost response with dose de-escalation, highlighting the importance of counseling patients with negative prognostic factors about the risks and benefits of continuing high doses of tofacitinib.
AMERICAN JOURNAL OF GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Michael J. Buie, Stephanie Coward, Abdel-Aziz Shaheen, Jayna Holroyd-Leduc, Lindsay Hracs, Christopher Ma, Remo Panaccione, Eric Benchimol, Charles N. Bernstein, Alain Bitton, Anthony R. Otley, Jennifer L. Jones, Sanjay K. Murthy, M. Ellen Kuenzig, Juan-Nicolas Pena-Sanchez, Laura E. Targownik, Harminder Singh, Antonio Avina-Zubieta, Gilaad G. Kaplan
Summary: Recent advances in IBD management have led to a decrease in hospitalization rates for IBD-related and non-IBD-related causes. The study observed a decline in all-cause hospitalization rates as well.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Florence-Damilola Odufalu, Marla C. Dubinsky, Laurent Peyrin-Biroulet, Karoliina Ylanne, Allyson Sipes, Joseph C. Cappelleri, Leo J. Russo, Michelle Segovia, Sean Gardiner, Edward P. Johnson, Amy Mulvey, Remo Panaccione
Summary: This study investigated the impact of patient demographics and psychological comorbidities on disease management and health care experience in patients with ulcerative colitis, highlighting the need for better understanding and improvement of patient care.
INFLAMMATORY BOWEL DISEASES
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Jacinda Tran, Geert D'Haens, David T. Rubin, Nobuo Aoyama, Wen Zhou, Dapo Ilo, Xuan Yao, Yuri Sanchez Gonzalez, Remo Panaccione
Summary: This post hoc analysis evaluated the effects of upadacitinib on fatigue, bowel urgency, and abdominal pain in patients with ulcerative colitis. The results showed that upadacitinib induction treatment significantly reduced abdominal pain and bowel urgency, and also improved fatigue symptoms.
INFLAMMATORY BOWEL DISEASES
(2023)
Review
Gastroenterology & Hepatology
Harris A. Ahmad, James E. East, Remo Panaccione, Simon Travis, James B. Canavan, Keith Usiskin, Michael F. Byrne
Summary: Artificial intelligence has the potential to improve clinical research in inflammatory bowel disease endoscopy. It can enhance the efficiency and accuracy of assessing endoscopic activity in patients with inflammatory bowel disease and the impact of therapeutic interventions. This review discusses the current state of endoscopic assessment in inflammatory bowel disease clinical trials, highlighting the potential for artificial intelligence to transform the current paradigm and suggesting steps for implementation. By incorporating artificial intelligence into quality evaluation and patient progress monitoring, precision endoscopy and clinical trial recruitment in inflammatory bowel disease can be advanced.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Eric B. Collins, Gil Y. Melmed, Severine Vermeire, Silvio Danese, Peter D. R. Higgins, Christina S. Kwon, Wen Zhou, Dapo Ilo, Dolly Sharma, Yuri Sanchez Gonzalez, Si-Tien Wang
Summary: Indirect evidence suggests that Upadacitinib may be more effective than other advanced therapies in achieving clinical response, clinical remission, and endoscopic response in patients with moderately to severely active ulcerative colitis over a one-year period, with similar safety profiles across different therapies.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Jamie M. Horrigan, Edouard Louis, Antonino Spinelli, Simon Travis, Bjorn Moum, Jessica Salwen-Deremer, Jonas Halfvarson, Remo Panaccione, Marla C. Dubinsky, Pia Munkholm, Corey A. Siegel
Summary: This study investigated the global use and barriers to using patient-reported outcomes (PROs) in clinical practice for inflammatory bowel disease (IBD). The majority of healthcare providers use PROs in clinical practice, but there are variations in which PROs are used and how they influence management. Barriers to using PROs include lack of familiarity, integration issues, and time constraints. Education about PROs and the use of an accepted set of PROs can help overcome these barriers and achieve global harmonization.
CROHNS & COLITIS 360
(2023)
Article
Gastroenterology & Hepatology
Silvio Danese, Remo Panaccione, Maria T. Abreu, David T. Rubin, Subrata Ghosh, Axel Dignass, Anita Afzali, Douglas C. Wolf, Michael Chiorean, Severine Vermeire, Anjali Jain, Lorna Charles, Garrett Lawlor, Mark T. Osterman, Hsiuanlin Wu, James B. Canavan, Annkatrin Petersen, Jean-Frederic Colombel, Miguel Regueiro
Summary: This interim analysis examines the efficacy and safety of ozanimod treatment in patients with ulcerative colitis over a period of approximately 3 years. The results show that a high percentage of patients maintain clinical and mucosal efficacy during the treatment. No new safety concerns arise from long-term use of ozanimod.
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Marc Ferrante, Peter M. Irving, Maria T. Abreu, Jeffrey Axler, Xiang Gao, Qian Cao, Toshimitsu Fujii, Astrid Rausch, Joana Torres, Ezequiel Neimark, Alexandra Song, Kori Wallace, Kristina Kligys, Sofie Berg, Xiaomei Liao, Qing Zhou, Jasmina Kalabic, Brian Feagan, Remo Panaccione
Summary: This post-hoc analysis found that maintenance therapy with risankizumab can lead to durable improvement in clinical and endoscopic outcomes for patients with moderately to severely active Crohn's disease, achieving the treatment goals of durable clinical remission, endoscopic healing, and biomarker normalization.
JOURNAL OF CROHNS & COLITIS
(2023)
Meeting Abstract
Gastroenterology & Hepatology
J. Panes, R. Panaccione, B. Sands, C. Gasink, C. Marano, T. Ma, T. Hoops
JOURNAL OF CROHNS & COLITIS
(2023)
Article
Gastroenterology & Hepatology
Remo Panaccione, Silvio Danese, Wen Zhou, Justin Klaff, Dapo Ilo, Xuan Yao, Gweneth Levy, Peter D. R. Higgins, Edward V. Loftus Jr, Su Chen, Yuri Sanchez Gonzalez, Carolyn Leonard, Xavier Hebuterne, James O. Lindsay, Qian Cao, Hiroshi Nakase, Jean-Frederic Colombel, Severine Vermeire
Summary: Upadacitinib demonstrates efficacy and safety for 16-week induction and 52-week maintenance therapy in patients with moderately to severely active ulcerative colitis. Patients without clinical response after 8 weeks' upadacitinib 45 mg induction therapy may benefit from an additional 8 weeks of therapy.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS
(2023)
Correction
Gastroenterology & Hepatology
William J. Sandborn, Geert R. D'Haens, Bruce E. Sands, Remo Panaccione, Siew C. Ng, Nervin Lawendy, Nicole Kulisek, Irene Modesto, Xiang Guo, Rajiv Mundayat, Chinyu Su, Ivana Vranic, Julian Panes
JOURNAL OF CROHNS & COLITIS
(2023)