Article
Oncology
Ken Saito, Ayaka Mitsui, I. Wayan Sumardika, Yusuke Yokoyama, Masakiyo Sakaguchi, Eisaku Kondo
Summary: This study reveals the relationship between high PLOD2 expression and integrin beta 1 signaling in promoting invasion and metastasis of oral SCC, as well as the role of IL-6 in triggering this process. It shows that IL-6 activates STAT3 to increase PLOD2 expression, particularly in M2 macrophages in the tumor microenvironment, contributing to tumor aggressiveness.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2021)
Article
Multidisciplinary Sciences
Matthew E. Cockman, Yoichiro Sugimoto, Hamish B. Pegg, Norma Masson, Eidarus Salah, Anthony Tumber, Helen R. Flynn, Joanna M. Kirkpatrick, Christopher J. Schofield, Peter J. Ratcliffe
Summary: JMJD6 is a 2-oxoglutarate-dependent dioxygenase involved in various cellular processes. Through mass spectrometry analysis, we identified 150 lysine hydroxylation sites on 48 protein substrates catalyzed by JMJD6, including 19 hydroxylation sites on BRD4. Most of these substrates are associated with membraneless organelle formation, suggesting a potential role for JMJD6 in regulating subcellular partitioning in response to stress.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Oncology
Qi Qi, Wuhao Huang, Hua Zhang, Bin Zhang, Xiaoyan Sun, Jun Ma, Chaonan Zhu, Changli Wang
Summary: This study demonstrated that PLODs are highly expressed in NSCLC tissues, with high expression being associated with poor prognosis in LUAD but not in LUSC. PLOD1 and PLOD3 were identified as independent risk factors for relapse-free survival and overall survival in LUAD, while genetic alterations of PLODs in LUSC patients were associated with favorable OS. Additionally, PLODs were significantly linked to tumor immunity in lung cancer.
TRANSLATIONAL CANCER RESEARCH
(2021)
Article
Oncology
Baijun Li, Hao Yang, Bin Shen, Jianwei Huang, Zhiqiang Qin
Summary: PLOD1 is an enzyme that plays a significant role in stabilizing intermolecular crosslinks in collagen-like peptides. High levels of PLOD1 mRNA have prognostic significance in various human malignancies. This study investigated the impact of PLOD1 in lung adenocarcinoma (LUAD) and lung squamous cell carcinoma (LUSC) and found that PLOD1 promotes lung cancer through E2F1 activation, suggesting potential targeting of the PLOD1/E2F1 axis for lung cancer treatment.
Article
Oncology
Chun Zhuang, Xiaoqi Li, Linxi Yang, Xinli Ma, Yanying Shen, Chen Huang, Tao Pan, Jianzhi Cui, Bo Ni, Ming Wang
Summary: This study analyzed the expression of ferroptosis-related genes in gastrointestinal stromal tumor (GIST) and found that transferrin receptor (TFRC) was significantly upregulated in high-risk patients. Further enrichment analysis revealed that TFRC expression was closely associated with cell growth pathways and metabolism-related pathways. High TFRC expression in GIST patients indicated an unfavorable state of patient relapse and could serve as a powerful independent predictor of recurrence-free survival.
FRONTIERS IN ONCOLOGY
(2023)
Article
Medicine, General & Internal
Anna Starzynska, Bartosz Kamil Sobocki, Monika Sakowicz-Burkiewicz, Barbara Alicja Jereczek-Fossa, Daniela Alterio, Olga Szot, Aleksandra Korwat, Rafal Peksa
Summary: In this study, the potential prognostic factor VISTA was investigated in oral squamous cell carcinoma patients. The results showed a strong correlation between VISTA expression and Il-33 levels in tumor cells and lymphocytes, as well as PD-L1 levels in tumor cells. While the impact on overall survival was limited, a significant association was found in the 5-year survival rate. Further evaluation and investigation of the combination of VISTA with Il-33 or PD-L1 in OSCC is warranted.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Genetics & Heredity
Guoshun Zhang, Bin Liu, Hua Shang, Guikai Wu, Diyang Wu, Liuqing Wang, Shengnan Li, Zhiyuan Wang, Suying Wang, Juxiang Yuan
Summary: This study revealed that SRSF9 is overexpressed in HCC and negatively regulated by methylation. Low SRSF9 expression and hypermethylation of cg06116271 were associated with longer overall survival. The knockdown of SRSF9 inhibited HCC cell proliferation and migration, affecting the expression of proteins in the Wnt signaling and cell cycle pathways, and identified potential drugs targeting SRSF9.
BMC MEDICAL GENOMICS
(2022)
Article
Oncology
Miao Xu, Shuo Fang, Xiaorong Ma
Summary: This study found that CD73(+) AMSCs have better therapeutic effects compared to CD73(-) AMSCs, inhibiting scar formation by indirectly reducing PLOD1. Co-immunoprecipitation results showed no direct protein interaction between CD73 and PLOD1.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Oncology
Miao Xu, Shuo Fang, Xiaorong Ma
Summary: CD73(+) AMSCs are a subgroup of AMSCs with better therapeutic effects on wound healing and can inhibit scar formation through reducing PLOD1 in an indirect manner.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Genetics & Heredity
Wen Gao, Zhe-Wen Zhang, Hong-Yi Wang, Xin-Di Li, Wei-Ting Peng, Hao-Yu Guan, Yu-Xuan Liao, An Liu
Summary: The study found that TMED2/9/10 and related genes may jointly affect the prognosis of HNSC, providing specific clues for further experimental research, personalized diagnosis strategies, and targeted clinical therapy for HNSC.
FRONTIERS IN GENETICS
(2022)
Article
Oncology
Kotaro Sato, Kshitij Parag-Sharma, Masahiko Terajima, Adele M. Musicant, Ryan M. Murphy, Matthew R. Ramsey, Hideharu Hibi, Mitsuo Yamauchi, Antonio L. Amelio
Summary: Head and neck squamous cell carcinoma (HNSCC) is the 6th most common cancer globally, with patient prognosis closely related to tumor metastases and the role of collagen in the tumor microenvironment (TME). Lysyl hydroxylase 2 (LH2) is key in modifying collagen cross-links, affecting HNSCC tumor invasion and metastasis.
Article
Cell Biology
Svetlana I. Galkina, Natalia V. Fedorova, Alexander L. Ksenofontov, Marina V. Serebryakova, Ekaterina A. Golenkina, Vladimir I. Stadnichuk, Ludmila A. Baratova, Galina F. Sud'ina
Summary: This study discovered that the release of hydroxylysine by neutrophils during adhesion is influenced by various inhibitors, revealing the interaction of hydroxylysine release with lysyl hydroxylase, matrix metalloproteinase, PI3K/Akt pathway, and actin cytoskeleton. These factors play important roles in recruiting neutrophils into tissue through extracellular matrix remodeling.
Article
Clinical Neurology
Edward R. Bader, Tiberiu A. Pana, Raphae S. Barlas, Anthony K. Metcalf, John F. Potter, Phyo K. Myint
Summary: This study investigates the association between admission inflammatory biomarkers and adverse outcomes in spontaneous intracerebral hemorrhage (ICH) using a stroke register in the United Kingdom. The results show that elevated inflammatory biomarkers are associated with poor outcomes in ICH, highlighting the importance of inflammation in this condition.
JOURNAL OF NEUROLOGY
(2022)
Article
Oncology
Miao Xu, Shuo Fang, Aiguo Xie
Summary: Inhibiting PLOD1 levels in AMSCs significantly reduces fibrosis in the injured region of mice, leading to altered macrophage polarization and decreased ROS levels and myofibroblast activation.
ANNALS OF TRANSLATIONAL MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Miguel A. Ortega, Oscar Fraile-Martinez, Leonel Pekarek, Cielo Garcia-Montero, Miguel Angel Alvarez-Mon, Alejandro J. Castellanos, Natalio Garcia-Honduvilla, Julia Bujan, Melchor Alvarez-Mon, Miguel A. Saez, Luis G. Guijarro, Angel Asunsolo
Summary: Pancreatic cancer is a malignancy that is becoming more prevalent, especially in developed countries due to dietary patterns and sedentary lifestyles. It is expected to become the second leading cause of cancer-related deaths in the near future. The low survival rate is attributed to the lack of symptoms in the early stages, leading to metastasis in advanced stages. This study evaluates molecular biomarkers and finds a correlation between their high expression and low survival rate in pancreatic cancer patients.
