Polymerase pausing induced by sequence-specific RNA-binding protein drives heterochromatin assembly

Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control

(2018) Pamela S. Gallagher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Iron homeostasis regulates facultative heterochromatin assembly in adaptive genome control

(2018) Pamela S. Gallagher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Spt5 Plays Vital Roles in the Control of Sense and Antisense Transcription Elongation

(2017) Ameet Shetty et al.   MOLECULAR CELL

The conserved protein Seb1 drives transcription termination by binding RNA polymerase II and nascent RNA

(2017) Sina Wittmann et al.   Nature Communications

Architecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex

(2017) Youwei Xu et al.   Nature Communications

Replication stress affects the fidelity of nucleosome-mediated epigenetic inheritance

(2017) Wenzhu Li et al.   PLoS Genetics

Mec1, INO80, and the PAF1 complex cooperate to limit transcription replication conflicts through RNAPII removal during replication stress

(2016) Jérôme Poli et al.   GENES & DEVELOPMENT

The Nrd1-like protein Seb1 coordinates cotranscriptional 3′ end processing and polyadenylation site selection

(2016) Jean-François Lemay et al.   GENES & DEVELOPMENT

Phospho-site mutants of the RNA Polymerase II C-terminal domain alter subtelomeric gene expression and chromatin modification state in fission yeast

(2016) Maki Inada et al.   NUCLEIC ACIDS RESEARCH

A Novel Epigenetic Silencing Pathway Involving the Highly Conserved 5’-3’ Exoribonuclease Dhp1/Rat1/Xrn2 in Schizosaccharomyces pombe

(2016) James Franklin Tucker et al.   PLoS Genetics

The Paf1 complex factors Leo1 and Paf1 promote local histone turnover to modulate chromatin states in fission yeast

(2015) L. Sadeghi et al.   EMBO REPORTS

Expanded GAA repeats impede transcription elongation through theFXNgene and induce transcriptional silencing that is restricted to theFXNlocus

(2015) Yanjie Li et al.   HUMAN MOLECULAR GENETICS

The Paf1 complex represses small-RNA-mediated epigenetic gene silencing

(2015) Katarzyna Maria Kowalik et al.   NATURE

Conserved factor Dhp1/Rat1/Xrn2 triggers premature transcription termination and nucleates heterochromatin to promote gene silencing

(2015) Venkata R. Chalamcharla et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Restricted epigenetic inheritance of H3K9 methylation

(2015) P. N. C. B. Audergon et al.   SCIENCE

Global regulation of heterochromatin spreading by Leo1

(2015) L. Verrier et al.   Open Biology

Rapid epigenetic adaptation to uncontrolled heterochromatin spreading

(2015) Jiyong Wang et al.   eLife

Determinants of Heterochromatic siRNA Biogenesis and Function

(2014) Ruby Yu et al.   MOLECULAR CELL

The RNA exosome promotes transcription termination of backtracked RNA polymerase II

(2014) Jean-François Lemay et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A pause sequence enriched at translation start sites drives transcription dynamics in vivo

(2014) M. H. Larson et al.   SCIENCE

A conserved ncRNA-binding protein recruits silencing factors to heterochromatin through an RNAi-independent mechanism

(2013) D. B. Marina et al.   GENES & DEVELOPMENT

HDAC-mediated suppression of histone turnover promotes epigenetic stability of heterochromatin

(2013) Ozan Aygün et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microprocessor, Setx, Xrn2, and Rrp6 Co-operate to Induce Premature Termination of Transcription by RNAPII

(2012) Alexandre Wagschal et al.   CELL

Intrinsic Translocation Barrier as an Initial Step in Pausing by RNA Polymerase II

(2012) Masahiko Imashimizu et al.   JOURNAL OF MOLECULAR BIOLOGY

RNAi triggered by specialized machinery silences developmental genes and retrotransposons

(2012) Soichiro Yamanaka et al.   NATURE

Transcription in the maintenance of centromere chromatin identity

(2012) F. L. Chan et al.   NUCLEIC ACIDS RESEARCH

New clues to understand the role of THO and other functionally related factors in mRNP biogenesis

(2011) Rosa Luna et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

DREME: motif discovery in transcription factor ChIP-seq data

(2011) Timothy L. Bailey   BIOINFORMATICS

Tight protein-DNA interactions favor gene silencing

(2011) M. Dubarry et al.   GENES & DEVELOPMENT

RNAi promotes heterochromatic silencing through replication-coupled release of RNA Pol II

(2011) Mikel Zaratiegui et al.   NATURE

Coordination of DNA replication and histone modification by the Rik1–Dos2 complex

(2011) Fei Li et al.   NATURE

Nascent transcript sequencing visualizes transcription at nucleotide resolution

(2011) L. Stirling Churchman et al.   NATURE

Defects in RNA quality control factors reveal RNAi-independent nucleation of heterochromatin

(2011) Francisca E Reyes-Turcu et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

PomBase: a comprehensive online resource for fission yeast

(2011) V. Wood et al.   NUCLEIC ACIDS RESEARCH

RNA Elimination Machinery Targeting Meiotic mRNAs Promotes Facultative Heterochromatin Formation

(2011) M. Zofall et al.   SCIENCE

PARalyzer: definition of RNA binding sites from PAR-CLIP short-read sequence data

(2011) David L Corcoran et al.   GENOME BIOLOGY

Stc1: A Critical Link between RNAi and Chromatin Modification Required for Heterochromatin Integrity

(2010) Elizabeth H. Bayne et al.   CELL

Transcriptome-wide Identification of RNA-Binding Protein and MicroRNA Target Sites by PAR-CLIP

(2010) Markus Hafner et al.   CELL

Long intronic GAA repeats causing Friedreich ataxia impede transcription elongation

(2010) Tanel Punga et al.   EMBO Molecular Medicine

Hairpin RNA induces secondary small interfering RNA synthesis and silencing in trans in fission yeast

(2010) Femke Simmer et al.   EMBO REPORTS

Sex-induced silencing defends the genome of Cryptococcus neoformans via RNAi

(2010) X. Wang et al.   GENES & DEVELOPMENT

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

(2010) Stefan Sigurdsson et al.   MOLECULAR CELL

TopHat: discovering splice junctions with RNA-Seq

(2009) Cole Trapnell et al.   BIOINFORMATICS

Identification of protein binding sites on U3 snoRNA and pre-rRNA by UV cross-linking and high-throughput analysis of cDNAs

(2009) S. Granneman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ultrafast and memory-efficient alignment of short DNA sequences to the human genome

(2009) Ben Langmead et al.   GENOME BIOLOGY

Cell cycle control of centromeric repeat transcription and heterochromatin assembly

(2008) Ee Sin Chen et al.   NATURE

RNAi, heterochromatin and the cell cycle

(2008) Anna Kloc et al.   TRENDS IN GENETICS

Mutations in deoxyribonucleotide biosynthesis pathway cause spreading of silencing across heterochromatic barriers at the mating-type region of the fission yeast

(2007) Gurjeet Singh et al.   YEAST