Journal
GASTRIC CANCER
Volume 19, Issue 3, Pages 1016-1022Publisher
SPRINGER
DOI: 10.1007/s10120-015-0558-0
Keywords
Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR); Atrophic gastritis; Enlarged gastric folds; Gastric cancer; Helicobacter pylori
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Funding
- Japan Society for the Promotion of Science [25460381]
- Grants-in-Aid for Scientific Research [25460381] Funding Source: KAKEN
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Double-contrast upper gastrointestinal barium X-ray radiography (UGI-XR) is the standard gastric cancer screening method in Japan. Atrophic gastritis and enlarged gastric folds are considered the two major features of Helicobacter pylori-induced chronic gastritis, but the clinical meaning of evaluating them by UGI-XR has not been elucidated. We analyzed healthy UGI-XR examinees without a history of gastrectomy, previous Helicobacter pylori eradication and usage of gastric acid suppressants. Of the 6433 subjects, 1936 (30.1 %) had atrophic gastritis and 1253 (19.5 %) had enlarged gastric folds. During the 3-year prospective observational follow-up, gastric cancer developed in seven subjects, six of whom (85.7 %) had atrophic gastritis with H. pylori infection and five of whom (71.4 %) had enlarged gastric folds with H. pylori infection. The Kaplan-Meier method with log-rank testing revealed that both UGI-XR-based atrophic gastritis (p = 0.0011) and enlarged gastric folds (p = 0.0003) are significant predictors for future gastric cancer incidence.
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