Article
Endocrinology & Metabolism
Guoying Wang, Jessie P. Buckley, Tami R. Bartell, Xiumei Hong, Colleen Pearson, Xiaobin Wang
Summary: The study aimed to identify a lipidomic signature associated with gestational diabetes mellitus (GDM) in the postpartum period and investigate its role in the progression to type 2 diabetes (T2D). A cohort of 1,409 women who delivered a singleton baby was followed up prospectively, and their lipidome was analyzed using liquid chromatography-tandem mass spectrometry. 33 postpartum lipid species were identified to be associated with GDM, and 4 of them were also associated with incident T2D, mediating the progression from GDM to T2D. Including these lipid species improved the prediction of T2D when considering the entire follow-up period.
Article
Endocrinology & Metabolism
Francisco Visiedo, Luis Vazquez-Fonseca, Jessica Abalos-Martinez, J. Roman Broullon-Molanes, Rocio Quintero-Prado, Rosa Maria Mateos, Fernando Bugatto
Summary: This study investigated the impact of maternal circulating inflammatory mediators on placental fatty acid metabolism in women with gestational diabetes mellitus (GDM). The results showed that GDM patients had higher levels of inflammatory cytokines and lower fatty acid oxidation capacity in the placenta, along with increased triglyceride levels. The findings suggest that the maternal inflammatory status may interfere with the delivery of maternal fat to the fetus via the placenta.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Nutrition & Dietetics
Shuxian Wang, Yu Liu, Shengtang Qin, Huixia Yang
Summary: This study found that circulating short-chain fatty acid levels decrease in gestational diabetes mellitus (GDM) patients. These fatty acids are associated with clinical parameters and metabolic indicators, and can also impact placental function and fetal development. These findings provide more evidence for the therapeutic potential of short-chain fatty acids in GDM treatment.
Review
Plant Sciences
Samuel Scott, Edgar B. Cahoon, Lucas Busta
Summary: Plants have the ability to produce lineage-specific natural products from their core metabolic pathways. However, little attention has been given to natural products derived from fatty acids. Recent studies have shown that plants can produce structurally diverse compounds from fatty acids, some of which have unique structural features and novel functionalities. This review aims to summarize the current knowledge of fatty acid-derived natural products and their biosynthesis, and suggest future research priorities.
Article
Plant Sciences
Jiadi Zhang, Jia Yao, Linli Mao, Qingpeng Li, Lixia Wang, Qing Lin
Summary: This study found that low temperature storage prevented the formation of healing periderm in wounded potatoes and led to a decrease in hydrogen peroxide content, inhibition of starch-to-sugar conversion, reduction in soluble sugar and sucrose content, decrease in lignin accumulation, and lower suberin deposition due to down-regulation of phenylpropanoid metabolism and fatty acid biosynthesis in potato tubers.
FRONTIERS IN PLANT SCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Serhii Chornyi, Rob Ofman, Janet Koster, Hans R. Waterham
Summary: The aim of this study was to determine the origin of long-chain acyl-CoAs required for ether lipid synthesis. The researchers found that these acyl-CoAs can be imported from the cytosol by peroxisomal ABCD proteins, particularly ABCD3. Additionally, they discovered that chain shortening of CoA esters of very long-chain fatty acids via beta-oxidation can also produce these acyl-CoAs within the peroxisomes. These findings demonstrate the close connection between peroxisomal beta-oxidation and ether lipid synthesis, and the crucial role of peroxisomal ABC transporters in de novo ether lipid synthesis.
JOURNAL OF LIPID RESEARCH
(2023)
Article
Nutrition & Dietetics
Xiangju Kong, Qiushuang Zhu, Yuanjie Dong, Yuqiao Li, Jinxiao Liu, Qingna Yan, Mingli Huang, Yucun Niu
Summary: This study investigated the metabolite differences between hypertensive disorders of pregnancy (HP) and gestational diabetes mellitus (GDM) in pregnant women. The findings suggest that both conditions are associated with dysregulated glucose and lipid metabolism, which may lead to oxidative stress.
FRONTIERS IN NUTRITION
(2022)
Article
Pharmacology & Pharmacy
Donglei Sun, Tianhe Zhao, Keyan Long, Mei Wu, Zunzhen Zhang
Summary: Triclosan downregulates FASN expression through upregulating miRNAs, leading to inhibition of lipid metabolism and cell growth in human hepatoma cells via apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Amelie I. S. Sobczak, Samantha J. Pitt, Terry K. Smith, Ramzi A. Ajjan, Alan J. Stewart
Summary: This study investigated the plasma concentrations of free fatty acid species in individuals with Type-1 diabetes mellitus (T1DM) compared to healthy controls. The results showed reduced concentrations of specific FFA species in the T1DM group, along with increased saturated/unsaturated FFA ratio and other indices related to lipid metabolism. Age and HbA1c levels were found to have correlations with certain FFA concentrations and indices in T1DM patients.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS
(2021)
Review
Medicine, General & Internal
Wenqian Lu, Cheng Hu
Summary: This review summarizes recent studies on biomolecules associated with GDM and postpartum diabetes, focusing on their predictive value in screening and diagnosis.
CHINESE MEDICAL JOURNAL
(2022)
Article
Nutrition & Dietetics
Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D. Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N. Baker
Summary: The study suggests a relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM) subtypes, with different fatty acid levels observed in different GDM subtypes during pregnancy. Specifically, higher levels of ALA and DHA in early pregnancy are associated with an increased risk of fasting plasma glucose (FPG) GDM subtype.
CLINICAL NUTRITION
(2021)
Article
Gastroenterology & Hepatology
Lea Henneke, Kristina Schlicht, Nadia A. Andreani, Tim Hollstein, Tobias Demetrowitsch, Carina Knappe, Katharina Hartmann, Julia Jensen-Kroll, Nathalie Rohmann, Daniela Pohlschneider, Corinna Geisler, Dominik M. Schulte, Ute Settgast, Kathrin Tuerk, Johannes Zimmermann, Christoph Kaleta, John F. Baines, Jane Shearer, Shrushti Shah, Grace Shen-Tu, Karin Schwarz, Andre Franke, Stefan Schreiber, Matthias Laudes
Summary: Recent research has found that Parasutterella plays an important role in the development of type 2 diabetes and obesity. This study analyzed a European cohort and validated the results in a Canadian cohort. The findings showed that Parasutterella was positively associated with BMI and type 2 diabetes, and its abundance was related to the intake of carbohydrates. Furthermore, the study found a reduction in L-cysteine and activation of the fatty acid biosynthesis pathway, suggesting potential mechanisms for the development of type 2 diabetes and obesity.
Article
Chemistry, Medicinal
Anna-Kay R. West, Constance B. Bailey
Summary: The article discusses the interconnected biosynthesis between fatty acid synthases (FASs) and polyketide synthases (PKSs) in primary and secondary metabolism. Understanding the linkage between polyketide biosynthesis and fatty acid biosynthesis may lead to the discovery and production of novel drug leads from polyketide metabolites.
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
(2023)
Article
Nutrition & Dietetics
Peiyun Li, Shan Hu, Yalun Zhu, Taoping Sun, Yue Huang, Zihui Xu, Hongjie Liu, Cheng Luo, Shiqiong Zhou, Aijun Tan, Liegang Liu
Summary: This study identified two novel fatty acid patterns that were inversely associated with the odds of gestational diabetes mellitus (GDM). The combination of circulating fatty acids may be a more significant marker for GDM development than individual fatty acids or their subgroups.
FRONTIERS IN NUTRITION
(2022)
Article
Endocrinology & Metabolism
Yi Wang, Ping Wu, Yichao Huang, Yi Ye, Xue Yang, Fengjiang Sun, Yi-Xiang Ye, Yuwei Lai, Jing Ouyang, Linjing Wu, Yue Li, Yanqin Li, Bin Zhao, Yixin Wang, Gang Liu, Xiong-Fei Pan, Da Chen, An Pan
Summary: Higher BMI in early pregnancy is associated with altered lipid metabolism that may contribute to the increased risk of GDM.
Article
Medical Laboratory Technology
Erik Orro, Kristi Alnek, Tiia Reimand, Koit Reimand, Oivi Uibo, Tiina Talvik, Kadri Haller-Kikkataloa, Kalle Kisand, Raivo Uibo
CLINICA CHIMICA ACTA
(2019)
Correction
Microbiology
Tommi Vatanen, Damian R. Plichta, Juhi Somani, Philipp C. Munch, Timothy D. Arthur, Andrew Brantley Hall, Sabine Rudolf, Edward J. Oakeley, Xiaobo Ke, Rachel A. Young, Henry J. Haiser, Raivo Kolde, Moran Yassour, Kristiina Luopajarvi, Heli Siljander, Suvi M. Virtanen, Jorma Ilonen, Raivo Uibo, Vallo Tillmann, Sergei Mokurov, Natalya Dorshakova, Jeffrey A. Porter, Alice C. McHardy, Harri Lahdesmaki, Hera Vlamakis, Curtis Huttenhower, Mikael Knip, Ramnik J. Xavier
NATURE MICROBIOLOGY
(2019)
Article
Immunology
Tamara Vorobjova, Aili Tagoma, Astrid Oras, Kristi Alnek, Kalle Kisand, Ija Talja, Oivi Uibo, Raivo Uibo
JOURNAL OF IMMUNOLOGY RESEARCH
(2019)
Article
Immunology
A. Oras, A. Peet, T. Giese, V. Tillmann, R. Uibo
CLINICAL AND EXPERIMENTAL IMMUNOLOGY
(2019)
Article
Immunology
Aili Tagoma, Kadri Haller-Kikkatalo, Kristine Roos, Astrid Oras, Anne Kirss, Jorma Ilonen, Raivo Uibo
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Immunology
Marina Sunina, Kristi Alnek, Kai Kisand, Raivo Uibo
Summary: This study showed that in healthy blood donors, most T cells did not express CD226 and TIGIT before and after stimulation, instead predominantly upregulating activating receptors post-stimulation. Memory CD4(+) T cells displayed a balance of activating and inhibitory receptor expression before and after stimulation, while memory CD8(+) T cells predominantly expressed TIGIT. The rs763361 TT genotype was associated with reduced CD226 expression on CD4(+) memory T cells and increased interleukin-17A secretion from activated T cells.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Natalia Pervjakova, Gunn-Helen Moen, Maria-Carolina Borges, Teresa Ferreira, James P. Cook, Catherine Allard, Robin N. Beaumont, Mickael Canouil, Gad Hatem, Anni Heiskala, Anni Joensuu, Ville Karhunen, Soo Heon Kwak, Frederick T. J. Lin, Jun Liu, Sheryl Rifas-Shiman, Claudia H. Tam, Wing Hung Tam, Gudmar Thorleifsson, Toby Andrew, Juha Auvinen, Bishwajit Bhowmik, Amelie Bonnefond, Fabien Delahaye, Ayse Demirkan, Philippe Froguel, Kadri Haller-Kikkatalo, Hildur Hardardottir, Sandra Hummel, Akhtar Hussain, Eero Kajantie, Elina Keikkala, Amna Khamis, Jari Lahti, Tove Lekva, Sanna Mustaniemi, Christine Sommer, Aili Tagoma, Evangelia Tzala, Raivo Uibo, Marja Vaarasmaki, Pia M. Villa, Kare Birkeland, Luigi Bouchard, Cornelia M. Duijn, Sarah Finer, Leif Groop, Esa Hamalainen, Geoffrey M. Hayes, Graham A. Hitman, Hak C. Jang, Marjo-Riitta Jarvelin, Anne Karen Jenum, Hannele Laivuori, Ronald C. Ma, Olle Melander, Emily Oken, Kyong Soo Park, Patrice Perron, Rashmi B. Prasad, Elisabeth Qvigstad, Sylvain Sebert, Kari Stefansson, Valgerdur Steinthorsdottir, Tiinamaija Tuomi, Marie-France Hivert, Paul W. Franks, Mark McCarthy, Cecilia M. Lindgren, Rachel M. Freathy, Deborah A. Lawlor, Andrew P. Morris, Reedik Magi
Summary: The study found that gestational diabetes mellitus (GDM) and type 2 diabetes (T2D) share the same underlying pathology, but there are also genetic determinants specific to glucose regulation in pregnancy.
HUMAN MOLECULAR GENETICS
(2022)
Article
Endocrinology & Metabolism
Aili Tagoma, Kadri Haller-Kikkatalo, Astrid Oras, Kristine Roos, Anne Kirss, Raivo Uibo
Summary: This study found that plasma adiponectin and CCL2 concentrations can distinguish women with GDM, and IL-27 and IL-22 levels may be associated with autoimmune reactions.
JOURNAL OF DIABETES INVESTIGATION
(2022)
Correction
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
SCIENTIFIC REPORTS
(2022)
Article
Multidisciplinary Sciences
Jelena Stsepetova, Kart Simre, Aili Tagoma, Oivi Uibo, Aleksandr Peet, Heli Siljander, Vallo Tillmann, Mikael Knip, Reet Mandar, Raivo Uibo
Summary: This study compared the microbiota composition and immune markers concentration in breast milk from mothers of children with genetic predisposition to celiac disease (CD) and mothers of unaffected children. The breast milk of mothers with genetically predisposed offspring who developed CD showed higher bacterial phylotype abundance and diversity, as well as a different bacterial composition. The immune markers were associated with specific bacterial genera and species, and may influence the risk for development of CD beyond early childhood.
SCIENTIFIC REPORTS
(2022)
Article
Biotechnology & Applied Microbiology
Kristi Alnek, Ija Talja, Brita Laht, Kaja Metskuela, Maire Mandel, Ingrid Reppo, Maire Lubi, Raivo Uibo
Summary: This study found a significant association between enterovirus antibodies and type 1 diabetes in both children and young adults, suggesting that enterovirus infections may be an important disease-promoting factor. However, further virological studies are needed to confirm this association.
BIOMED RESEARCH INTERNATIONAL
(2022)
Article
Endocrinology & Metabolism
Efe Ergur, Ege Ergur, Kristi Alnek, Kaja Metskula, Aleksandr Peet, Maire Lubi, Kaire Heilman, Raivo Uibo
Summary: The distribution of TCF7L2 polymorphism was assessed and associations between TCF7L2 and characteristics of type 1 diabetes were explored. The study found that TCF7L2 polymorphism is associated with zinc transporter 8 and islet antigen-2 autoantibodies and C-peptide levels in patients with type 1 diabetes.
JOURNAL OF DIABETES INVESTIGATION
(2023)
Article
Multidisciplinary Sciences
Astrid Oras, Henna Kallionpa, Tomi Suomi, Satu Koskinen, Asta Laiho, Laura L. Elo, Mikael Knip, Riitta Lahesmaa, Alar Aints, Raivo Uibo
Summary: A study on the gene expression in B-cells from children developing CoD early in life revealed gene expression changes associated with CoD development, indicating the important role of B-cells in CoD development.
Article
Endocrinology & Metabolism
Tamara Vorobjova, Aili Tagoma, Ija Talja, Helis Janson, Anne Kirss, Raivo Uibo
Summary: This study aimed to compare FABP4 and I-FABP levels in pregnant women with GDM and healthy pregnant controls, and to investigate their relationship with BMI, enterovirus exposure, and adipokines. The results showed that FABP4 and I-FABP levels were not associated with the diagnosis of GDM, but rather with BMI. In women with GDM, I-FABP was positively correlated with adiponectin and resistin levels.
JOURNAL OF DIABETES RESEARCH
(2022)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.