Review
Medicine, General & Internal
Jeremy T. Hines, Woo Lam Jo, Quanjun Cui, Michael A. Mont, Kyung Hoi Koo, Edward Y. Cheng, Stuart B. Goodman, Yong Chan Ha, Phillippe Hernigou, Lynne C. Jones, Shin Yoon Kim, Takashi Sakai, Nobuhiko Sugano, Takuaki Yamamoto, Mel S. Lee, Dewei Zhao, Wolf Drescher, Tae Young Kim, Young Kyun Lee, Byung Ho Yoon, Seung Hoon Baek, Wataru Ando, Hong Seok Kim, Jung Wee Park
Summary: Non-traumatic osteonecrosis of the femoral head (ONFH) predominantly affects adults younger than 50 years, leading to femoral head collapse and hip arthritis. The use of corticosteroids for leukemia and organ transplantation has contributed to the increasing prevalence of ONFH.
JOURNAL OF KOREAN MEDICAL SCIENCE
(2021)
Article
Biotechnology & Applied Microbiology
Sumit Murab, Teresa Hawk, Alexander Snyder, Sydney Herold, Meghana Totapally, Patrick W. Whitlock
Summary: Avascular necrosis (AVN) of the femoral head commonly leads to symptomatic osteoarthritis of the hip. While hip replacement is a viable option for older patients, it poses significant challenges for pediatric, adolescent, and young adult patients. Early detection is vital, but current diagnostic techniques are not sensitive enough. Various surgical techniques exist to prevent disease progression, but their effectiveness is limited, and more research is needed in tissue engineering for a potential long-term solution.
BIOENGINEERING-BASEL
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Julia Crim, Lester J. Layfield, James Derek Stensby, Robert L. Schmidt
Summary: Radiography is useful in depicting osteonecrosis in most patients undergoing femoral head resection, but there are false-positive and false-negative findings. Diagnostic difficulty increases in patients with advanced osteoarthritis or subchondral fractures, leading to increased uncertainty for both radiologic and pathologic evaluations. The accuracy of MRI for osteonecrosis evaluation requires further study due to limited patient numbers.
AMERICAN JOURNAL OF ROENTGENOLOGY
(2021)
Article
Orthopedics
Paul Hoogervorst, Joshua C. Campbell, Natalie Scholz, Edward Y. Cheng
Summary: This study evaluated the outcomes of core decompression (CD) with bone marrow aspiration concentrate (BMAC) in osteonecrosis of the femoral head (ONFH). The results showed no significant differences in radiographic progression or conversion to total hip arthroplasty (THA) between the CD with BMAC group and the control groups. Obesity and the extent of ONFH were identified as predictive factors for progression. Further research is needed with a larger randomized controlled trial.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Orthopedics
Jung-Wee Park, Hong-Seok Kim, Sojeong Park, Sung Hwa Kim, Young-Kyun Lee, Kyung-Hoi Koo
Summary: The number of surgical procedures for ONFH increased in South Korea from 2007 to 2018. Total hip arthroplasty (THA) was the most common procedure with an increasing percentage over the years, while joint preservation procedures decreased.
CLINICS IN ORTHOPEDIC SURGERY
(2022)
Article
Orthopedics
Jingyang Su, Yaojie Zhang, Bin Cao, Xiao Li
Summary: This study found that hormonal osteonecrosis of the femur, extent of necrosis, type C1 and type C2 in the Japanese Society for the Study of Femoral Osteonecrosis staging, and distance of the tip of the tantalum rod from the center of necrosis are risk factors for postoperative FHC in patients with Ficat I, II, and III stages of ANFH.
JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS
(2022)
Review
Environmental Sciences
Wojciech Konarski, Tomasz Pobozy, Andrzej Sliwczynski, Ireneusz Kotela, Jan Krakowiak, Martyna Hordowicz, Andrzej Kotela
Summary: Avascular necrosis of the femoral head is a condition caused by disruption of blood supply. Diagnosis can be established based on patients' complaints, medical history, and radiographic findings. There is currently no consensus on the treatment of this disease, with non-surgical methods recommended for early-stage patients and surgery recommended for advanced cases.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH
(2022)
Article
Orthopedics
Andre L. de Campos Pessoa, Victor H. V. de Oliveira Araujo, Ana L. Rosa Nascimento, Nelson Elias, Jorge J. de Carvalho
Summary: Sildenafil can optimize bone tissue regeneration by increasing VEGF signaling and OPN expression, leading to increased bone formation and potentially improving the prognosis of patients with osteonecrosis.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2021)
Article
Multidisciplinary Sciences
Satoshi Ikemura, Goro Motomura, Ryosuke Yamaguchi, Takeshi Utsunomiya, Satoshi Hamai, Masanori Fujii, Shinya Kawahara, Taishi Sato, Daisuke Hara, Kyohei Shiomoto, Takuaki Yamamoto, Yasuharu Nakashima
Summary: This study aimed to investigate the influence of bone marrow edema (BME) on the assessment of necrotic lesion boundaries in patients with osteonecrosis of the femoral head (ONFH) using unenhanced and contrast-enhanced (CE) magnetic resonance (MR) images. The findings suggest that BME significantly impacts the evaluation of necrotic lesion boundaries, and contrast-enhanced MR images provide clearer visualization of these boundaries.
SCIENTIFIC REPORTS
(2022)
Article
Orthopedics
Chul-Ho Kim, Minkyu Shin, Dongkeun Lee, Se Jin Choi, Dou Hyun Moon
Summary: This study revealed hidden ONFH after femoral neck fractures using MRI, especially in initially displaced fractures. Careful consideration is needed in selecting treatment between internal fixation and hip arthroplasty for these patients.
ARCHIVES OF ORTHOPAEDIC AND TRAUMA SURGERY
(2022)
Review
Surgery
Xiao-Lei Fan, Wen-Tao Wang, Jian Wang, Rui Xiao
Summary: This study aimed to describe the epidemiology, possible risk factors, clinical presentation, diagnostic workup, and treatment of avascular necrosis of the metacarpal head. The literature search revealed 45 studies with 55 patients. Surgical management is based on the patient and lesion characteristics.
INTERNATIONAL JOURNAL OF SURGERY
(2023)
Article
Multidisciplinary Sciences
Lan Tang, Bin Li, Qiuming Su, Xi Chen, Rongxin He
Summary: This study identified 10 hub genes and 85 therapeutic drugs for osteonecrosis of the femoral head (ONFH) through integrated bioinformatics analysis and literature mining. The findings have significant implications for future genetic and related research in ONFH.
SCIENTIFIC REPORTS
(2023)
Review
Orthopedics
Raju Vaishya, Brij Mohan Gupta, Ghouse Modin N. Mamdapur, Abhishek Vaish, Filippo Migliorini
Summary: This study conducted a scientometric analysis to identify the characteristics and research status of highly cited papers (HCPs) in the field of avascular necrosis of the femoral head (AVNFH).
JOURNAL OF ORTHOPAEDICS AND TRAUMATOLOGY
(2023)
Review
Rheumatology
Ahmed Abdelazim A. Hassan, Ahmed A. Khalifa
Summary: The current study aimed to summarize the occurrence and management of femoral head avascular necrosis (FHAVN) following COVID-19 infection. A systematic literature review was conducted, and 14 articles were included. Most of the FHAVN cases were treated with non-surgical methods, including medication and surgical intervention.
RHEUMATOLOGY INTERNATIONAL
(2023)
Article
Orthopedics
Nicole D. Quinlan, Dennis Q. Chen, Brian C. Werner, Quanjun Cui
Summary: Patients with a history of solid organ transplant undergoing total hip arthroplasty for osteonecrosis of the femoral head are not necessarily at an increased risk of early postoperative complications, but they utilize more hospital resources, have longer length of stay, and have a higher risk of hospital readmission.
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME
(2022)
Article
Materials Science, Multidisciplinary
Yuhao Zheng, Qing Han, Dongdong Li, Fan Sheng, Zhiming Song, Jincheng Wang
Summary: No suitable method exists for tendon fixation after artificial prosthetic implantation, but researching optimal factors for biological fixation between the tendon and prosthesis is crucial. Selective laser melting (SLM) 3D printing was used to prepare scaffolds with different actual pore sizes, with 527.15 μm being the most effective in cell experiments. Implantation of these scaffolds in a rabbit model showed that 527.15 μm is the best pore size for promoting tendon ingrowth on a titanium alloy surface.
MATERIALS & DESIGN
(2021)
Article
Engineering, Biomedical
Yue Zhao, Chaohua Gao, Hou Liu, Hangrui Liu, Yubin Feng, Zuhao Li, He Liu, Jincheng Wang, Bai Yang, Quan Lin
Summary: A new scaffold for rheumatoid arthritis management was developed through the integration of infliximab-based hydrogels and 3D printing porous metal scaffolds. The composite scaffold can modulate the survival and differentiation of ADSCs in vitro. In vivo results show that the composite scaffolds, along with ADSCs, are capable of suppressing inflammatory cytokines, rebuilding damaged cartilage, and improving subchondral bone repair.
ACTA BIOMATERIALIA
(2021)
Article
Biology
Hao Chen, Yang Liu, Chenyu Wang, Aobo Zhang, Bingpeng Chen, Qing Han, Jincheng Wang
Summary: This study aimed to design an irregular biomimetic scaffold for use in bone tissue engineering applications. The scaffold was based on the Voronoi tessellation method and a new gradient method, showing good controllability and excellent permeability.
COMPUTERS IN BIOLOGY AND MEDICINE
(2021)
Article
Materials Science, Multidisciplinary
Yutong Chen, Yuzhe Liu, Jiaxin Zhang, He Liu, Jincheng Wang, Qiran Liu, Yan Zhang
Summary: Breast reconstruction is crucial for mental health, current methods have limitations, and 3D bioprinting technology shows promise as an alternative solution.
MATERIALS & DESIGN
(2021)
Review
Materials Science, Biomaterials
Hui Jin, Youbo Ji, Yutao Cui, Li Xu, He Liu, Jincheng Wang
Summary: Simvastatin-incorporated drug delivery systems show potential in enhancing bone regeneration by inducing osteogenesis and angiogenesis, with various loading methods and materials being explored. Further research is needed to address current shortcomings and define future development directions in this field.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chuangang Peng, Baoming Yuan, Jincheng Wang, He Liu, Dongsheng Wang
Summary: The study found that using 2 fluoroscopic devices for percutaneous sacroiliac screw fixation significantly reduces radiation exposure frequency and operation time without increasing radiation dose. There were no significant differences in dislocation reduction quality and functional scores between the two groups during follow-up, and complications were rare in both groups.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2021)
Article
Nanoscience & Nanotechnology
Hou Liu, Zuhao Li, Yue Zhao, Yubin Feng, Andrei Zvyagin, Jincheng Wang, Xiaoyu Yang, Bai Yang, Quan Lin
Summary: This study developed a temperature-tolerant antibacterial hydrogel dressing with excellent properties, effectively promoting the healing of diabetic foot ulcers (DFUs).
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Cell Biology
Qixuan Cai, Xin Zhao, Yanbing Wang, Shuai Li, Jincheng Wang, Zhuoyuan Xin, Fan Li
Summary: The study identified that LINC01614 is significantly upregulated in osteosarcoma tissues and promotes the proliferation and invasion activities of osteosarcoma cells through the miR-520a-3p/SNX3 axis.
CELLULAR SIGNALLING
(2021)
Review
Computer Science, Interdisciplinary Applications
Naichao Wu, Shan Li, Boyan Zhang, Chenyu Wang, Bingpeng Chen, Qing Han, Jincheng Wang
Summary: This article discusses the application of metal implants in the treatment of orthopedic diseases and the topology optimization technique. By optimizing the design with TO technology, stress shielding issues can be more effectively addressed. The article summarizes the characteristics of implants, TO methods, validation methods, and research limitations, and proposes future challenges and research directions.
MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING
(2021)
Article
Materials Science, Multidisciplinary
Yutao Cui, Zhonghan Wang, Zuhao Li, Xuan Ji, Baoming Yuan, Yu Sun, Chuangang Peng, Yi Leng, Minghan Dou, Jincheng Wang, He Liu, Dankai Wu
Summary: This study developed a drug-releasing inorganic-organic bioactive interface to enhance osseointegration in joint replacement for osteoporotic patients, effectively preventing complications such as prosthesis loosening and periprosthetic fractures. The interface improved osteogenic differentiation, inhibited osteoclast-related gene expression, and regulated osteoclastic activity, showing promising results in ameliorating osteoporosis and promoting stable bone integration around the interface.
MATERIALS & DESIGN
(2021)
Review
Biotechnology & Applied Microbiology
Xianggang Wang, Zuhao Li, Chenyu Wang, Haotian Bai, Zhonghan Wang, Yuzhe Liu, Yirui Bao, Ming Ren, He Liu, Jincheng Wang
Summary: The growth plate is vulnerable to damage with limited regenerative ability, leading to difficulties in achieving satisfactory outcomes with current clinical treatment strategies. Tissue engineering approaches, including biocompatible scaffolds with seed cells and growth factors, offer a promising alternative for GP repair and may be enhanced by advancements such as three-dimensional printing technology.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Review
Infectious Diseases
Yang Sun, Yang Yang, Weibo Jiang, Haotian Bai, He Liu, Jincheng Wang
Summary: This study systematically reviewed the in vivo antibacterial efficacy of bionic surface nanopatterns on titanium implant surfaces. The limited literature results suggest poor in vivo antibacterial effectiveness of these nanostructures on Ti substrates' surfaces, posing a challenge for their practical application. Additional high-quality preclinical data are necessary to further investigate the in vivo antibacterial effects of nanopatterns on implant surfaces.
Article
Radiology, Nuclear Medicine & Medical Imaging
Qiang Li, Wenzhuo Yang, Meng Xu, Nan An, Dawei Wang, Xing Wang, Hui Jin, Jiajiong Wang, Jincheng Wang
Summary: This study developed a new artificial intelligence (AI) model to automatically measure the CE angle for the diagnosis of DDH. The AI model showed a high consistency with orthopaedic doctors in measuring CE angles and demonstrated much higher efficiency in terms of time-consumption.
BIOMEDICAL PHYSICS & ENGINEERING EXPRESS
(2021)
Article
Engineering, Biomedical
Yun Pei, Wenzhuo Yang, Shangqing Wei, Rui Cai, Jialin Li, Shuxu Guo, Qiang Li, Jincheng Wang, Xueyan Li
Summary: This study developed and validated a deep learning-based automated method for measuring HKA on unilateral lower limb X-rays, which showed high accuracy and reliability in comparison with manual measurements.
PHYSICAL AND ENGINEERING SCIENCES IN MEDICINE
(2021)
Article
Engineering, Biomedical
Aobo Zhang, Hao Chen, Yang Liu, Naichao Wu, Bingpeng Chen, Xue Zhao, Qing Han, Jincheng Wang
Summary: A novel reconstructive prosthesis was designed with topological optimization and a lattice structure to enhance biomechanical and biological properties in the proximal tibia, which was validated through testing. The results showed improved mechanical performance and potential for next-generation applications in orthopedics surgery.
BIO-DESIGN AND MANUFACTURING
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
