Article
Genetics & Heredity
Zhaoliang Lu, Hongyan Yu, Yufen Xu, Kaining Chen, Yueling Lin, Kun Lin, Yishuai Wang, Kaixiong Xu, Lanyan Fu, Weizhan Li, Huazhong Zhou, Bing Wei, Lei Pi, Di Che, Xiaoqiong Gu
Summary: The study revealed that the CC genotype of rs579501 is associated with an increased risk of sepsis, especially in children and male patients. Additionally, this genotype is significantly related to severe sepsis, mortality, and organ dysfunctions.
FRONTIERS IN GENETICS
(2022)
Article
Genetics & Heredity
Hyeon Woo Park, Young Ran Kim, Jeong Yong Lee, Eun Ju Ko, Min Jung Kwon, Ji Hyang Kim, Nam Keun Kim
Summary: This study analyzed the impact of HOTAIR polymorphisms on RPL in Korean women and found that rs4759314A>G and rs920778T>C were significantly associated with increased risk of RPL.
Article
Oncology
Chiara Corradi, Manuel Gentiluomo, Laszlo Gajdan, Giulia Martina Cavestro, Edita Kreivenaite, Gregorio Di Franco, Cosimo Sperti, Matteo Giaccherini, Maria Chiara Petrone, Francesca Tavano, Domenica Gioffreda, Luca Morelli, Pavel Soucek, Angelo Andriulli, Jakob R. Izbicki, Niccolo Napoli, Ewa Malecka-Panas, Peter Hegyi, John P. Neoptolemos, Stefano Landi, Yogesh Vashist, Claudio Pasquali, Ye Lu, Klara Cervena, George E. Theodoropoulos, Stefania Moz, Gabriele Capurso, Oliver Strobel, Silvia Carrara, Thilo Hackert, Viktor Hlavac, Livia Archibugi, Martin Oliverius, Giuseppe Vanella, Pavel Vodicka, Paolo Giorgio Arcidiacono, Raffaele Pezzilli, Anna Caterina Milanetto, Rita T. Lawlor, Audrius Ivanauskas, Andrea Szentesi, Juozas Kupcinskas, Sabrina G. G. Testoni, Martin Lovecek, Michael Nentwich, Maria Gazouli, Claudio Luchini, Raffaella Alessia Zuppardo, Erika Darvasi, Hermann Brenner, Cristian Gheorghe, Krzysztof Jamroziak, Federico Canzian, Daniele Campa
Summary: A new PDAC risk locus was identified, with genetic variation disrupting the binding between lncRNA and miRNA possibly affecting the development of PDAC.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Xiaocong Lin, Guodan Li, Xiuwen Yan, Weiyu Fu, Jie Ruan, Hang Ding, Huajun Yu, Xiaoyi Chen, Liubo Lan, Yong Dai, Kai Pan, Xinguang Liu, Haitao Zhang
Summary: This study identifies lncRNA BC002811 as a critical regulator in the development and progression of gastric cancer. BC002811 is upregulated in GC tissues and cell lines and its high expression is associated with reduced overall survival in GC patients. BC002811 promotes GC cell proliferation, migration, invasion, and inhibits apoptosis in vitro, and accelerates tumor growth and metastasis in vivo. It upregulates MMP2 and MMP9 and promotes GC cell metastasis by downregulating PTEN expression and blocking SOX2 binding to the PTEN promoter.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Oncology
Dechao Yuan, Jie Tian, Xiang Fang, Yan Xiong, Nishant Banskota, Fuguo Kuang, Wenli Zhang, Hong Duan
Summary: This study clarified the relationships between SNPs and osteosarcoma risk through a comprehensive meta-analysis, identifying significant associations in multiple genes and SNPs. The evaluation of epidemiological evidence provided useful information for future studies evaluating the risk of osteosarcoma.
FRONTIERS IN ONCOLOGY
(2022)
Article
Cell Biology
Zihao Chen, Yong Li, Bibo Tan, Fang Li, Qun Zhao, Liqiao Fan, Zhidong Zhang, Xuefeng Zhao, Yu Liu, Dong Wang
Summary: This study revealed that Lnc_ASNR is highly expressed in gastric cancer and promotes cell proliferation, migration, and invasion by regulating the miR-519e-5p/FGFR2 pathway. Lnc_ASNR functions as a ceRNA targeting miR-519e-5p, and its effects are closely related to epithelial-mesenchymal transition (EMT) in gastric cancer development.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Genetics & Heredity
Ze Li, Hui Gao, Yang Liu, Hongjiao Wu, Weiyuan Li, Yunce Xing, Zhi Zhang, Xuemei Zhang
Summary: The study identified that the variant genotypes of TLR4 rs7869402 and TLR4 rs7873784 reduced the risk of gastric cancer, especially among females, older subjects, non-smokers, and non-drinkers. No significant correlations were found between the other four SNPs and gastric carcinoma risk.
Review
Oncology
Ying Liu, Xiang Ao, Yu Wang, Xiaoge Li, Jianxun Wang
Summary: Gastric cancer is the third leading cause of cancer-related deaths worldwide, and chemotherapy is an important treatment method. However, most patients develop resistance to chemotherapy drugs. Recent studies have found that lncRNAs are involved in gastric cancer drug resistance and they regulate drug resistance through various mechanisms. Some lncRNAs have potential clinical applications.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Yifan Li, Lan Lu, Xu Wu, Qianxiu Li, Yueshui Zhao, Fukuan Du, Yu Chen, Jing Shen, Zhangang Xiao, Zhigui Wu, Wei Hu, Chi Hin Cho, Mingxing Li
Summary: This review summarizes the research progress on the roles of long non-coding RNAs (lncRNAs) in gastric cancer (GC), focusing on their involvement in Helicobacter pylori infection, GC metastasis, tumor microenvironment regulation, drug resistance, and associated signaling pathways. LncRNAs may serve as novel biomarkers for diagnosis and prognosis of GC and potential therapeutic targets.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Review
Cell Biology
Jihui Lee, Hara Kang
Summary: Sarcopenia is an age-related disease that can be regulated by alterations in the expression levels of non-coding RNAs, leading to muscle atrophy and dysfunction. Exercise can affect the expression patterns of non-coding RNAs involved in sarcopenia.
Review
Medicine, Research & Experimental
Bo Cao, Guoxiao Liu, Wang Zhang, Yajiao Shi, Bo Wei
Summary: Gastric cancer is a malignancy with high incidence and mortality rates globally, and non-coding RNAs, including circRNAs and lncRNAs, have been shown to play important roles in gastric carcinogenesis, serving as potential biomarkers for clinical diagnosis and prognosis. While significant progress has been made, there are still numerous issues to be addressed and further development is needed in this field.
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
(2021)
Article
Genetics & Heredity
Bo Pang, Fei Quan, Yanyan Ping, Jing Hu, Yujia Lan, Lin Pang
Summary: This study identified key lncRNAs involved in the development and progression of GBM through single-cell RNA-seq data analysis, revealing significant correlations with GBM invasion and poor survival of patients. The findings provide new insights into the molecular mechanisms underlying GBM invasion and potential therapeutic targets.
FRONTIERS IN GENETICS
(2021)
Review
Oncology
Gaurav Kumar Pandey, Chandrasekhar Kanduri
Summary: This article reviews the functional role and potential therapeutic applications of long non-coding RNA (lncRNA) in tumor development and discusses the extent of their decisive contribution to cancer development.
Review
Medicine, Research & Experimental
Sayedeh Azimeh Hosseini, Mohammad Hossein Haddadi, Hadis Fathizadeh, Foroogh Nemati, Hooman Mahmoudi Aznaveh, Farima Taraj, AmirArsalan Aghabozorgizadeh, Golmaryam Gandomkar, Elaheh Bazazzadeh
Summary: The frequent metastasis of gastric cancer poses challenges for effective treatment. In recent years, lncRNA has shown promise as a drug target in the treatment of gastric cancer, particularly in relation to cancer immunity, metabolism, and metastasis. This review provides an overview of the biological activities of lncRNAs in gastric cancer development and updates on the latest pathological activities, prognostic and diagnostic strategies, and therapeutic options for lncRNAs related to gastric cancer.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Genetics & Heredity
Haitao Luo, Dechao Bu, Lijuan Shao, Yang Li, Liang Sun, Ce Wang, Jing Wang, Wei Yang, Xiaofei Yang, Jun Dong, Yi Zhao, Furong Li
Summary: By analyzing full-length single-cell RNA sequencing data of T cells across different cancer types, a comprehensive catalog and functional repertoires of lncRNAs in human T cells were established. Overlooked lncRNAs expressed in T cells were identified, providing insight into the regulation of T cell functions and potential new biomarkers for cancer immunotherapies. The study offers a new perspective and resource for investigating T cell regulation in cancer immunity and developing novel cancer immunotherapies.
GENOMICS PROTEOMICS & BIOINFORMATICS
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.