Article
Oncology
Jiawen Zhao, Lei Zhang, Yingzhu Zhao, Nan Wu, Xi Zhang, Rong Guo, Huimeng Li, Chunxiang Li, Kai Zheng, Dequan Liu, Shicong Tang
Summary: This study investigated the role of lncRNA HOTAIR in breast cancer cells and its molecular mechanism. The results showed that high expression of HOTAIR was associated with cell proliferation, invasion, and migration in breast cancer, and HOTAIR regulated the expression of miR-1 and GOLPH3 genes.
CLINICAL & TRANSLATIONAL ONCOLOGY
(2023)
Article
Food Science & Technology
Pan Chao, Feng Yongheng, Zhou Jin, Zhu Yu, Yang Shiyong, Yang Kunxing, Ma Yong
Summary: This study revealed that in gastric cancer development, HOTAIR expression increases while miRNA-206 expression decreases. Knockdown of HOTAIR suppresses cell viability, increases apoptosis, inhibits invasion and migration by regulating miRNA-206, and suppresses CCND1 and CCND2 expression. HOTAIR targeting miRNA-206 and miRNA-206 targeting CCND1 and CCND2 play crucial roles in the antitumor effects in gastric cancer.
FOOD SCIENCE & NUTRITION
(2021)
Review
Cell Biology
Chunming Zhu, Xia Wang, Yuan Wang, Kefeng Wang
Summary: Chemotherapy is a significant treatment for advanced cancer, but drug-resistant tumors often relapse. The homeobox transcript antisense intergenic RNA (HOTAIR) has been found to play a role in tumor development and is associated with chemotherapy resistance. Therefore, understanding the biology and mechanism of HOTAIR in tumor behavior and its potential as a biomarker for predicting chemotherapy efficacy is crucial.
CELL DEATH DISCOVERY
(2022)
Review
Biochemistry & Molecular Biology
Wencheng Kong, Guang Yin, Sixin Zheng, Xinchun Liu, Akao Zhu, Panpan Yu, Jian Zhang, Yuqiang Shan, Rongchao Ying, Huicheng Jin
Summary: Gastric cancer is one of the most common malignant tumors in the world, with many genetic and epigenetic risk factors playing a significant role in its development. HOTAIR, as an important epigenetic factor, is involved in the development of gastric cancer through various mechanisms and has prognostic value.
Article
Biology
Qing Ma, Liuyi Yang, Karen Tolentino, Guiping Wang, Yang Zhao, Ulrike M. Litzenburger, Quanming Shi, Lin Zhu, Chen Yang, Huiyuan Jiao, Feng Zhang, Rui Li, Miao-Chih Tsai, Jun-An Chen, Ian Lai, Hong Zeng, Lingjie Li, Howard Y. Chang
Summary: This study demonstrates the significant role of human HOTAIR lncRNA in promoting breast cancer progression, including increased metastatic capacity and invasiveness in breast cancer cells, and alterations in the transcriptome and chromatin accessibility landscape.
Article
Medicine, Research & Experimental
Yi Wang, Yuqiu Li, Junpei Zhong, Miao Li, Youjia Zhou, Qing Lin, Siwen Zong, Wenting Luo, Jiayang Wang, Keqin Wang, Jie Wang, Lixia Xiong
Summary: Cav-1 in exosomes derived from breast cancer cells promotes lung metastasis by regulating intercellular communication and PMN formation.
Review
Oncology
Monica Cantile, Maurizio Di Bonito, Maura Tracey De Bellis, Gerardo Botti
Summary: This review describes the functional interaction between the lncRNA HOTAIR and microRNAs in human diseases, especially in cancer development, highlighting the crucial role of HOTAIR in modulating various cellular processes during cancer development. Experimental validation is needed to confirm the identified ncRNA-mediated sponge regulatory network, which could potentially lead to the development of new diagnostic and therapeutic tools for cancer patients.
Article
Chemistry, Analytical
Kimberley Clack, Narshone Soda, Surasak Kasetsirikul, Richard Kline, Carlos Salomon, Muhammad J. A. Shiddiky
Summary: In this study, we developed a novel and rapid method to detect HOTAIR sequences. The method showed high specificity and sensitivity in clinical samples, making it a potential tool for ovarian cancer diagnosis.
Article
Cell & Tissue Engineering
Xiaoxuan Zhang, Yan Zhang, Xin Qiu, Jing Cai, Zhenzhou Yang, Fangzhou Song
Summary: The study found that tumor cell-derived extracellular vesicles (T-EVs) can induce the transformation of normal lung fibroblasts (NFs) into cancer-associated fibroblasts (CAFs), and promote the metastasis of lung cancer cells by regulating inflammation levels, cell proliferation, invasion, and migration.
STEM CELLS INTERNATIONAL
(2022)
Article
Medicine, Research & Experimental
Ruifeng Pei, Le Zhao, Yiren Ding, Zhan Su, Deqiang Li, Shuo Zhu, Lu Xu, Wei Zhao, Wuyuan Zhou
Summary: This study reveals the promoting effect of HOTAIR in radioresistance of liver cancer stem cells (LCSCs). Mechanistically, HOTAIR recruits LSD1 to the MAPK1 promoter region, reduces the level of H3K9me2, and elevates ERK2 (MAPK1) expression. The JMJD6-BRD4 complex positively regulates HOTAIR transcription, ERK2 (MAPK1) expression, and maintains the stemness of LCSCs, ultimately promoting their radioresistance.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Biochemistry & Molecular Biology
Allison M. Porman, Justin T. Roberts, Emily D. Duncan, Madeline L. Chrupcala, Ariel A. Levine, Michelle A. Kennedy, Michelle M. Williams, Jennifer K. Richer, Aaron M. Johnson
Summary: This study reveals the regulatory role of m6A modification on the breast cancer-associated lncRNA HOTAIR. Methylated A783 on HOTAIR interacts with the m6A reader YTHDC1, promoting chromatin association of HOTAIR and driving proliferation and invasion of TNBC cells. The findings demonstrate how modification of a single base in an lncRNA can lead to distinct gene regulation mechanisms and cancer-associated phenotypes.
Review
Oncology
Laura Amicone, Alessandra Marchetti, Carla Cicchini
Summary: Epithelial-to-mesenchymal transition (EMT) is a cell differentiation process that gives epithelial cells the ability to move and invade, and its abnormal reactivation in cancer cells is crucial for metastasis. EMT is a dynamic program with various states, and the inverse transition, mesenchymal-to-epithelial transition (MET), is important for colonization of distant sites. Long non-coding RNAs (lncRNAs), specifically HOTAIR, play a critical role in regulating epithelial cell plasticity and EMT in tumors. This review focuses on the molecular mechanisms of HOTAIR expression and its functions in gene regulation and protein activities, as well as the challenges of targeting HOTAIR for therapeutic approaches against EMT.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2023)
Article
Chemistry, Multidisciplinary
Xuefei Zhang, Ming Liu, Fan Yang, Li Ma
Summary: Cryptotanshinone, a quinoid diterpene extracted from the root of Salvia miltiorrhiza Bunge, exhibits remarkable anticancer activities by inhibiting cell proliferation, inducing LDH release, ROS production, and apoptosis in A549 lung cancer cells. Its downregulation of lncRNA HOTAIR and p-Akt further contributes to its anticancer effect.
ARABIAN JOURNAL OF CHEMISTRY
(2021)
Review
Oncology
Lili Chen, Xinle Qian, Zhongqi Wang, Xiqiu Zhou
Summary: This review provides a summary of the molecular mechanism and role of HOTAIR in tumor invasion and metastasis, discusses its association with tumor metastasis through various pathways, and emphasizes its function in human malignant tumor metastasis.
Article
Health Care Sciences & Services
In-Jai Kim, Jeong-Yong Lee, Hyeon-Woo Park, Han-Sung Park, Eun-Ju Ko, Jung-Hoon Sung, Nam-Keun Kim
Summary: The study suggests that HOTAIR gene polymorphisms may serve as novel biomarkers for diagnosing coronary artery disease (CAD) and are closely associated with CAD susceptibility. Variations in genetic polymorphisms, genotype combinations, and haplotype analysis of HOTAIR are linked to disease occurrence and clinical factors contributing to disease susceptibility.
JOURNAL OF PERSONALIZED MEDICINE
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.