Article
Virology
Peng Lin, Dong-Yue Wen, Jin-Shu Pang, Wei Liao, Yu-Ji Chen, Yun He, Hong Yang
Summary: This study developed an overall survival prediction model based on protein expression profiles in HBV-infected nontumor liver tissues, demonstrating the feasibility of using protein expression profiles in nontumor liver tissues for survival prediction.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Medicine, General & Internal
Dali Zhang, Danni Feng, Minjuan Ren, Ying Bai, Zhenwen Liu, Hongbo Wang
Summary: This study found that chronic hepatitis B infection is not a risk factor for HCC recurrence after liver transplantation, but tumor characteristics play a crucial role. Patients with detectable HBV DNA before transplantation often have more advanced tumor characteristics and a higher risk of HCC recurrence.
ANNALS OF MEDICINE
(2022)
Article
Immunology
Jie Li, Hwai- Yang, Ming-Lun Yeh, Michael H. Le, An K. Le, Yee Hui Yeo, Chia-Yen Dai, Scott Barnett, Jian Q. Zhang, Jee-Fu Huang, Huy N. Trinh, Christopher Wong, Clifford Wong, Joseph K. Hoang, Ramsey Cheung, Ming-Lung Yu, Mindie H. Nguyen
Summary: This study found that concurrent FL in patients with CHB significantly reduces the risk of cirrhosis and HCC, as well as increases the rate of HBsAg seroclearance. Further research is needed to confirm these findings and investigate the underlying mechanisms of FL on CHB.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Review
Oncology
Eun-Sook Park, Mehrangiz Dezhbord, Ah Ram Lee, Bo Bae Park, Kyun-Hwan Kim
Summary: This article summarizes the mechanisms of liver regeneration and the potential disruption by HBV infection, providing insights for the prevention and treatment of liver failure caused by defective regeneration.
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Gastroenterology & Hepatology
Peter Schemmer, Patrizia Burra, Rey-Heng Hu, Christian M. Hueber, Carmelo Loinaz, Keigo Machida, Arndt Vogel, Didier Samuel
Summary: Chronic HBV infection is a major cause of HCC, with HBsAg playing a direct oncogenic role through various mechanisms. HBV-related HCC recurrence post-surgery may involve expansion of residual tumor cells and independent replication of HBV. The role of HBsAg in HCC development and recurrence post-surgical intervention has implications for immunotherapy.
LIVER INTERNATIONAL
(2022)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Lung-Yi Mak, Ka-Shing Cheung, Rex Wan-Hin Hui, Danny Ka-Ho Wong, James Fung, Man-Fung Yuen, Wai-Kay Seto
Summary: This prospective study found that enhanced liver fibrosis (ELF) in chronic hepatitis B patients before spontaneous HBsAg seroclearance was associated with hepatocellular carcinoma (HCC). Furthermore, a 97% reduction in ELF was found to significantly decrease the risk of HCC development in patients aged 50 or above after spontaneous seroclearance.
CLINICAL INFECTIOUS DISEASES
(2022)
Article
Gastroenterology & Hepatology
Jose Carlos Rodrigues Nascimento, Lianna C. Pereira, Juliana Magalhaes C. Rego, Ronaldo P. Dias, Paulo Goberlanio B. Silva, Silvio Alencar C. Sobrinho, Gustavo R. Coelho, Ivelise Regina C. Brasil, Edmilson F. Oliveira-Filho, James S. Owen, Pierluigi Toniutto, Reinaldo B. Oria
Summary: This study aimed to determine the impact of APOE alleles on outcomes in HCV-infected patients with liver cirrhosis following orthotopic liver transplantation. The results suggest that the E4 allele may protect against progression of liver fibrosis and degree of inflammation in these patients.
WORLD JOURNAL OF GASTROENTEROLOGY
(2021)
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
Article
Immunology
Zhiwei Liu, Chih-Jen Huang, Yu-Han Huang, Mei-Hung Pan, Mei-Hsuan Lee, Kelly J. Yu, Ruth M. Pfeiffer, Mathias Viard, Yuko Yuki, Xiaojiang Gao, Mary Carrington, Chien-Jen Chen, Allan Hildesheim, Hwai- Yang
Summary: The study found that an increase in the number of homozygous HLA class II loci is associated with an increased risk of chronic HBV infection and HBV-associated HCC. Specifically, HLA-DQB1 homozygosity is significantly associated with HCC risk.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Article
Oncology
Jian-Lv Huang, Xiang-Kun Wang, Xi-Wen Liao, Chuang-Ye Han, Ting-Dong Yu, Ke-Tuan Huang, Cheng-Kun Yang, Xiao-Guang Liu, Long Yu, Guang-Zhi Zhu, Hao Su, Wei Qin, Quan-Fa Han, Zheng-Qian Liu, Xin Zhou, Jun-Qi Liu, Xin-Ping Ye, Tao Peng
Summary: This study demonstrated that differential SOX4 expression is significantly upregulated in tumor tissue, and SOX4 is closely associated with overall survival and recurrence-free survival in HBV-associated HCC. SOX4 may impact TP53 metabolic processes, lymphocyte differentiation, and the insulin signaling pathway in HCC. The diagnostic and prognostic potential of SOX4 in HCC was also highlighted in this research.
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.