Article
Oncology
Xianning Lai, Sarah Kit Leng Lui, Hiu Yan Lam, Yuta Adachi, Wen Jing Sim, Natali Vasilevski, Nicola J. Armstrong, Stephanie Claire Bridgeman, Nathan Michael Main, Tuan Zea Tan, Janina E. E. Tirnitz-Parker, Jean Paul Thiery, Hiromichi Ebi, Alan Prem Kumar, Pieter Johan Adam Eichhorn
Summary: Despite limited overall responses of SHP2 inhibitors in RAS-dependent tumors, this study identifies SHP2 as a critical regulator of TGF beta activity and demonstrates its impact on migration, senescence, and cell survival. Combining SHP2 and TGF beta inhibitors may enhance tumor responses and improve patient outcomes.
NPJ PRECISION ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Zhengcheng Wang, Xiang Ao, Zhilin Shen, Luoquan Ao, Xiaofeng Wu, Chengxiu Pu, Wei Guo, Wei Xing, Min He, Hongfeng Yuan, Jianhua Yu, Ling Li, Xiang Xu
Summary: Chronic inflammation-induced metastases in cancer have been a significant obstacle in treatment. Recent studies have shown that TNF-alpha activates PI3K/Akt and p38 MAPK pathways to enhance CXCL10 transcription, promoting metastases in colon cancer cells. CXCL10, in turn, regulates EMT in colon cancer cells via the PI3K/Akt pathway, offering a new potential target for inhibiting colon cancer metastases.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2021)
Article
Oncology
Nannan Lv, Fei Liu, Lan Cheng, Feng Liu, Jinsong Kuang
Summary: TNF-α plays a key role in inducing EMT in papillary thyroid carcinoma (PTC) by affecting the expression of different transcription factors and signal pathways. The activation of different pathways did not show gene differences, with NF-kappa B inhibitors being able to reverse the expression of transcription factors.
Article
Biochemistry & Molecular Biology
Haibin Liu, Shengtao Sun, Bing Liu
Summary: The study aimed to investigate the neuroprotective role of Smurf2 in cerebral ischemic injury by inactivating the YY1/HIF1α/DDIT4 axis, showing that downregulation of Smurf2 and upregulation of YY1, HIF1α, and DDIT4 contribute to apoptosis and cerebral infarction in both MCAO mice and OGD-treated neurons.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Subhra Dash, Anirudha K. Sahu, Abhilasha Srivastava, Rajdeep Chowdhury, Sudeshna Mukherjee
Summary: Cytokines produced in the tumor microenvironment play a crucial role in cancer prognosis, with the interplay between TGF-beta and TNF-alpha being particularly important for understanding tumor development and progression.
Article
Oncology
Julia Berner, Lea Miebach, Marcel Kordt, Christian Seebauer, Anke Schmidt, Michael Lalk, Brigitte Vollmar, Hans-Robert Metelmann, Sander Bekeschus
Summary: This study explores the effects of medical gas plasma on tumor cells and their adaptation to oxidative stress. The researchers found that gas plasma can induce chronic oxidative stress adaptation in tumor cells, leading to regression of tumor growth. The study also investigated the cellular responses and molecular mechanisms involved in this adaptation process.
BRITISH JOURNAL OF CANCER
(2023)
Article
Immunology
Dong Zhang, Hui Yang, Xue-Li Dong, Jin-Tao Zhang, Xiao-Fei Liu, Yun Pan, Jian Zhang, Jia-Wei Xu, Zi-Han Wang, Wen-Jing Cui, Liang Dong
Summary: The TL1A/DR3 axis is closely associated with TNF-a expression in asthma and plays a role in exacerbating epithelial-mesenchymal transformation (EMT). Inhibiting or interfering with the TL1A/DR3 axis may have therapeutic potential for improving EMT in asthma.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Fanying Li, Hongxing Tang, Shaoji Zhao, Xinya Gao, Lixuan Yang, Jianbo Xu
Summary: Studies have shown that circRNAs play critical roles in cancer progression, mainly acting as microRNA sponges or interacting with RNA-binding proteins. More recently, it has been discovered that circRNAs can also encode proteins. In this study, the protein encoded by circular E-cadherin (circ-E-Cad), C-E-Cad, was found to have a significant impact on gastric cancer (GC) progression. C-E-Cad exerted tumor-promoting functions by regulating the PI3K/AKT pathway, and its expression level could be increased by the TGF-beta/Smad pathway.
MOLECULAR CARCINOGENESIS
(2023)
Review
Biochemistry & Molecular Biology
Fang-fang Dai, Min Hu, Yu-wei Zhang, Rong-hui Zhu, Li-ping Chen, Zhi-dian Li, Yan-jie Huang, Wei Hu, Yan-xiang Cheng
Summary: This study reviewed the effects of TNF-alpha disorder on pathological conditions during pregnancy and summarized the impact of anti-TNF-alpha drugs on adverse pregnancy outcomes. Intrauterine growth restriction, spontaneous abortion, and preterm birth were found to be the most common adverse pregnancy outcomes associated with anti-TNF-alpha drugs.
EXPERT REVIEWS IN MOLECULAR MEDICINE
(2022)
Article
Biology
Harini Narasimhan, Francesca Ferraro, Andreas Bleilevens, Ralf Weiskirchen, Elmar Stickeler, Jochen Maurer
Summary: This study demonstrates the effects of TNFα on primary triple-negative breast cancer stem cells, showing that TNFα stimulation increases the malignancy of stem cells and enhances their proliferation and invasive capacity. Additionally, TNFα can induce distinct cellular communication within the tumor microenvironment, leading to intra-tumoral stromal invasion and the formation of a pre-metastatic niche.
Review
Food Science & Technology
Masami Suganuma, Tatsuro Watanabe, Eisaburo Sueoka, In Kyoung Lim, Hirota Fujiki
Summary: Tip alpha, a unique Helicobacter pylori protein, contributes to gastric cancer development by stimulating TNF-α production through interaction with nucleolin. Its presence in American and Euro-Asian strains suggests its involvement in human gastric cancer, different from other pathogenic factors like CagA and VacA.
Article
Biochemistry & Molecular Biology
Marco Gasparella, Carola Cenzi, Monica Piccione, Valentina Noemi Madia, Roberto Di Santo, Valeria Tudino, Marco Artico, Samanta Taurone, Chiara De Ponte, Roberta Costi, Rosa Di Liddo
Summary: This study investigated the effects of a derivative of glucosamine called DCF001 on the proliferation and chondrogenic induction of stem cells under inflammatory stimuli. The results showed that DCF001 could regulate the expression of CD39, CD73, and TNF receptors, modulate the release of growth factors, and enhance the chondrogenic potential of stem cells. These findings suggest that DCF001 could be a valuable supplement for improving the outcome of cartilage repair using stem cells under inflammatory conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Hideki Kitaura, Aseel Marahleh, Fumitoshi Ohori, Takahiro Noguchi, Yasuhiko Nara, Adya Pramusita, Ria Kinjo, Jinghan Ma, Kayoko Kanou, Itaru Mizoguchi
Summary: TNF-alpha is a cytokine expressed by immune cells and is involved in host defense and bone-related cell functions. This review summarizes current research on the interaction between TNF-alpha and its receptors in bone cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Huanhuan Xu, Chunxia Gan, Zemin Xiang, Ting Xiang, Jin Li, Xueqin Huang, Xiangdong Qin, Titi Liu, Jun Sheng, Xuanjun Wang
Summary: The tumor necrosis factor alpha (TNF-a)-TNF-a receptor (TNFR) interaction is crucial in the development of autoimmune diseases like rheumatoid arthritis, making it an important target for drug discovery. This study found that (-)-Epigallocatechin-3-gallate (EGCG), a polyphenolic compound found in green tea, can bind to TNF-a, TNFR1, and TNFR2 and disrupt their interactions. This leads to inhibition of TNF-a-induced cell death and NF-kB signaling pathway, suggesting that regular consumption of EGCG in green tea could potentially be used as a therapeutic agent for TNF-a-associated diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Cell Biology
Xiaoliu Li, Jing Zhang, Qiang Wang, Lian Xiang, Jing Dong
Summary: This study aimed to investigate the expression of IL-11 in ischemic stroke patients and its correlation with rehabilitation training and prognosis. The results showed that patients in the rehabilitation training group had higher serum IL-11 levels and better prognosis compared to the control group. Serum IL-11 levels were found to be potential diagnostic biomarkers for poor prognosis in ischemic stroke patients. These findings suggest that IL-11, NIHSS score, and rehabilitation training are important factors for predicting the prognosis of ischemic stroke patients.
MEDIATORS OF INFLAMMATION
(2023)
Article
Oncology
Zijie Wang, Hengcheng Zhang, Haiwei Yang, Ming Zheng, Miao Guo, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobing Ju, Ruoyun Tan, Ji-Fu Wei, Min Gu
ANNALS OF TRANSLATIONAL MEDICINE
(2020)
Review
Medicine, General & Internal
Hengcheng Zhang, Ke Wang, Hao Chen, Li Sun, Zijie Wang, Shuang Fei, Ruoyun Tan, Min Gu
FRONTIERS IN MEDICINE
(2020)
Article
Medicine, Research & Experimental
Chuanjian Suo, Zeping Gui, Zijie Wang, Jiajun Zhou, Ming Zheng, Hao Chen, Shuang Fei, Min Gu, Ruoyun Tan
Summary: The study showed that bortezomib attenuated TNF-α-induced epithelial-mesenchymal transition and renal allograft interstitial fibrosis by inhibiting NF-κB/TNF-α/Akt/mTOR/p70S6 kinase/Smurf2 signaling and stabilizing the inhibitor of NF-κB protein.
Article
Multidisciplinary Sciences
Jianqiao Tian, Glenn Smith, Han Guo, Boya Liu, Zehua Pan, Zijie Wang, Shuangyu Xiong, Ruogu Fang
Summary: Alzheimer's disease is the leading cause of dementia, and evaluating retinal vasculature as a screening tool can help in early detection. The study found that utilizing machine learning techniques can accurately identify Alzheimer's disease, with a high classification accuracy.
SCIENTIFIC REPORTS
(2021)
Article
Immunology
Hengcheng Zhang, Zijie Wang, Jiayi Zhang, Zeping Gui, Zhijian Han, Jun Tao, Hao Chen, Li Sun, Shuang Fei, Haiwei Yang, Ruoyun Tan, Anil Chandraker, Min Gu
Summary: This study demonstrates that combined therapy of Belatacept and BTLA overexpression effectively attenuates acute rejection after kidney transplantation and prolongs kidney graft survival. The therapy reduces serum creatinine levels, inhibits mixed acute rejection, decreases DSA production, and modulates cytokine expression. The duration of elevated expression levels of CTLA-4 and BTLA differentially affects the immune response.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Zeping Gui, Chuanjian Suo, Zijie Wang, Ming Zheng, Shuang Fei, Hao Chen, Li Sun, Zhijian Han, Jun Tao, Xiaobin Ju, Haiwei Yang, Min Gu, Ruoyun Tan
Summary: The study identified that low expression of ATG16L in patients with chronic renal graft dysfunction (CAD) compared to non-CAD patients, and suppressed autophagic flux is a poor prognostic factor. Knockdown of ATG16L enhanced EndMT process in human renal glomerular endothelial cells (HRGECs). In rat renal transplant models of CAD, the abundance of ATG16L was accompanied by dynamic changes in autophagic flux during different stages of kidney transplantation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Yingyue Cao, Jianxiong Geng, Xin Wang, Qingwei Meng, Shanqi Xu, Yaoguo Lang, Yongxu Zhou, Lishuang Qi, Zijie Wang, Zixin Wei, Yan Yu, Shi Jin, Bo Pan
Summary: RBM10 functions as a tumor suppressor in LUAD by positively regulating the expression of CTNNBIP1 and inactivating the Wnt/beta-catenin pathway.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2022)
Article
Immunology
Xuzhong Liu, Kun Liu, Zeping Gui, Dengyuan Feng, Zijie Wang, Ming Zheng, Shuang Fei, Hao Chen, Li Sun, Zhijian Han, Xiaobing Ju, Hengcheng Zhang, Ruoyun Tan, Min Gu
Summary: The SNP rs10975519 on the IL-33 gene was found to be statistically associated with the development of renal allograft fibrosis in kidney transplant recipients. This process may be related to the IL-33-induced EMT and sustained activation of p38 MAPK signaling pathway.
JOURNAL OF IMMUNOLOGY RESEARCH
(2021)
Article
Immunology
Zeping Gui, Chuanjian Suo, Jun Tao, Zijie Wang, Ming Zheng, Shuang Fei, Hao Chen, Li Sun, Zhijian Han, Xiaobing Ju, Hengcheng Zhang, Min Gu, Ruoyun Tan
Summary: This study found that everolimus can attenuate the progression of renal allograft interstitial fibrosis and activate autophagy in vivo. It was observed that everolimus reduces expression of TNF-alpha-induced EMT through upregulation of autophagy. In addition, everolimus affects EMT by stabilizing I kappa B-alpha instead of the Akt pathway.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Genetics & Heredity
Shuang Fei, Zeping Gui, Dengyuan Feng, Zijie Wang, Ming Zheng, Hao Chen, Li Sun, Jun Tao, Zhijian Han, Xiaobing Ju, Min Gu, Ruoyun Tan, Xinli Li
Summary: This study identified SNP mutated genes and differentially expressed genes associated with proteinuria after kidney transplantation. Further investigation revealed that the mutation at rs3804099 of the TLR2 gene significantly influenced the occurrence of proteinuria. These findings provide insights into predicting proteinuria and suggest potential individualized therapy for patients after kidney transplantation.
FRONTIERS IN GENETICS
(2022)
Article
Energy & Fuels
Zijie Wang, Jun Yao, Hai Sun, Xia Yan, Yongfei Yang
Summary: This paper proposes a multi-continuum model considering coupled thermal-reactive compositional flow to simulate the in-situ conversion process in low-medium maturity shale oil reservoir. The accuracy of the multiple-interacting-continua model and compositional model is demonstrated and the impact of operation parameters on shale oil production is investigated through a series of case studies.
ADVANCES IN GEO-ENERGY RESEARCH
(2021)
Article
Mathematics, Interdisciplinary Applications
Zijie Wang, Jun Yao, Hai Sun, Lijun Liu, Xia Yan
Summary: The low-medium maturity shale oil in China has significant resource potential, but its complex occurrence state and reservoir characteristics make the extraction process challenging. In this paper, a coupled thermal-reactive compositional flow model and numerical solution method is proposed to accurately predict the production of fractured shale oil reservoirs, and the impact of key operation parameters and fractal parameters on shale oil exploitation is analyzed.
FRACTALS-COMPLEX GEOMETRY PATTERNS AND SCALING IN NATURE AND SOCIETY
(2022)
Article
Energy & Fuels
Wenhui Song, Jun Yao, Kai Zhang, Yongfei Yang, Hai Sun, Zijie Wang
Summary: This paper presents a pore network based model that takes into account multiple factors affecting the mass transport of multicomponent hydrocarbons in nanoporous shale, and provides a detailed understanding of the thermodynamic transport mechanisms of multicomponent hydrocarbons. The study reveals that the transport behavior of multicomponent hydrocarbons is governed by both fluid rheology and pore size.
JOURNAL OF PETROLEUM SCIENCE AND ENGINEERING
(2022)
Correction
Multidisciplinary Sciences
Jiayi Zhang, Hengcheng Zhang, Zijie Wang, Haiwei Yang, Hao Chen, Hong Cheng, Jiajun Zhou, Ming Zheng, Ruoyun Tan, Min Gu
SCIENTIFIC REPORTS
(2022)
Article
Engineering, Chemical
Tian Tian, Yannan Jia, Jianguo Wu, Jinlong Zhao, Kai Xu, Zijie Wang, Zheng Wang
Summary: The study found that metal-organic frameworks show excellent performance in removing antimony pollution from water, with the ability to quickly adsorb antimony even at low concentrations. The presence of coexisting ions slightly increased the adsorption of antimony, possibly due to the formation of an inner-sphere complex. By optimizing the adsorption conditions, the best removal efficiency can be achieved.
DESALINATION AND WATER TREATMENT
(2021)
Article
Genetics & Heredity
Xiangge Meng, Chengping Li, Yu Hei, Xiang Zhou, Guoli Zhou
Summary: The study used IVT-SAPAS sequencing to analyze the dynamic changes of APA sites during adipogenesis in bovine subcutaneous preadipocytes and intramuscular preadipocytes. The results showed that APA plays an important role in adipocyte differentiation, and UTR-APA switching genes have different trends, with intramuscular preadipocytes tending to use shorter 3'UTR for differentiation. TRIB3, WWTR1, and INSIG1 play important roles in intramuscular preadipocyte differentiation.
Article
Genetics & Heredity
S. Alizadeh, S. Khamse, N. Tajeddin, H. R. Khorram Khorshid, A. Delbari, M. Ohadi
Summary: This study identifies a specific genotype at a CG-rich trinucleotide short tandem repeat (STR) locus that is associated with late-onset neurocognitive disorders such as Alzheimer's disease (AD).
Article
Genetics & Heredity
Shougang Liu, Zhe Zhuang, Fanghua Liu, Xiuqing Yuan, Zeqiao Zhang, Xiaoqian Liang, Xinhui Li, Yongfeng Chen
Summary: This study investigated the effect and mechanism of RPL9 and TIFA in scalp psoriasis, and identified RPL9 as a potential therapeutic target for scalp psoriasis.
Article
Genetics & Heredity
Shiting Wang, Jiaqi Chen, Zhichao Jin, Ying Xing, Ruiping Wang
Summary: This study suggests a causal association between hair color and skin cancers, with light hair colors (red, blonde, and light brown) being associated with an increased risk and dark brown hair being associated with a decreased risk.
Article
Genetics & Heredity
Joseph Hawadak, Loick Pradel Kojom Foko, Rodrigue Roman Dongang Nana, Karmveer Yadav, Veena Pande, Aparup Das, Vineeta Singh
Summary: This study investigates the genetic diversity and natural selection of the Pfama-1 gene in Plasmodium falciparum isolates from Cameroon. The study finds a considerable nucleotide and haplotype diversity, as well as specific mutations in Cameroonian isolates. Positive diversifying selection and the identification of selected codon sites suggest the potential implication of these genetic variations in host immune pressure and parasite-binding complex modulation. The findings provide valuable baseline data for malaria vaccine design.
Article
Genetics & Heredity
Emily Biernat, Mansi Verma, Chhabi K. Govind
Summary: RSC is an essential ATP-dependent chromatin remodeling complex in Saccharomyces cerevisiae. It regulates nucleosome-depleted regions (NDRs) by sliding flanking nucleosomes away from NDRs. Depletion of RSC leads to nucleosome encroachment in NDRs and transcription initiation defects. The study compared the effects of catalytic-dead Sth1 and rapid depletion of Sth1 on transcription. Rapid depletion of Sth1 reduces recruitment of TBP and Pol II, while the catalytic-dead mutant exhibits a severe reduction in TBP binding but accumulates Pol II in coding regions. The results suggest a role for RSC in transcription elongation and termination processes.
Article
Genetics & Heredity
Yunxiao Wei, Yuhan Song, Muhammad Aamir Khan, Chengzhen Liang, Zhigang Meng, Yuan Wang, Sandui Guo, Rui Zhang
Summary: This study analyzed the GhTPP protein family in upland cotton for the first time and identified the important role of GhTPPA_2 in regulating sugar metabolism, improving soluble sugar accumulation, and drought stress tolerance.
Article
Genetics & Heredity
Yannan Geng, Rui Shao, Tiantong Xu, Lilong Zhang
Summary: A novel risk model based on SCUBE3, TNNC1, SPON1, SEPT12 and ULBP1 genes was developed for predicting PMOP risk, with higher risk score indicating higher risk of suffering from PMOP. Significant differences in signaling pathway activities were observed between the high-risk score group and the low-risk score group.
Article
Genetics & Heredity
Randy P. Williams, Corina Lesseur, Haoxiang Cheng, Qian Li, Maya Deyssenroth, Christopher D. Molteno, Ernesta M. Meintjes, Sandra W. Jacobson, Joseph L. Jacobson, Helen Wainwright, Ke Hao, Jia Chen, R. Colin Carter
Summary: The study suggests that heavy alcohol exposure during pregnancy may impact the proportion of fetal placental villi macrophages and increase the expression of inflammatory genes. Further research is needed to explore these effects and evaluate the potential functional roles of placental inflammation in FASD.
Article
Genetics & Heredity
Lvjing Luo, Lishuang Sun, Shu Li, Huiting Liu, Zhengyu Chen, Shi Huang, Yinyin Mo, Genliang Li
Summary: This study analyzed the expression of Ptpn1 and miR-124-3p in testicular tissues of mice and investigated their regulatory relationship. The results showed that Ptpn1 expression was up-regulated in adult mouse testis compared to juvenile mouse testis, while miR-124-3p expression showed an opposite pattern. Further analysis suggested that the down-regulation of miR-124-3p may contribute to the high expression of Ptpn1 in adult mouse testis.
Article
Genetics & Heredity
Gairui Li, Dan Zhao, Xiaolin Peng, Yashuang Zhao
Summary: MiRNA-22 shows potential as a candidate for early diagnosis of colorectal cancer (CRC). The study found higher miR-22 expression levels in the CRC and CRA groups, suggesting its potential as a biomarker for CRC early screening.
Article
Genetics & Heredity
Zhongqiu Zhu, Qianting Yang, Xiaoying Tian, Da Man, Jian Wang, Junfang Zhang, Bingshe Han
Summary: This study constructed a ceRNA network mediated by lncRNAs in cold-acclimated zebrafish ZF4 cells and revealed that upregulation of MSTRG3207 promotes apoptosis by sponging dre-miR-736 during cold acclimation.
Article
Genetics & Heredity
Weitao Chen, Denggao Xiang, Shang Gao, Shuli Zhu, Zhi Wu, Yuefei Li, Jie Li
Summary: Dam construction has negatively impacted the genetic diversity and structure of fish populations. This case study on the endangered Hemibagrus guttatus found low genetic diversity, high levels of inbreeding, and decreasing population size in fragmented populations. Genetic structure and differentiation were also observed, indicating the influence of dams on these fish populations.
Article
Genetics & Heredity
Pooja Singh, Debleena Guin, Bijay Pattnaik, Ritushree Kukreti
Summary: Through systematic literature review and meta-analysis, it was found that idiopathic pulmonary fibrosis is significantly associated with 222 polymorphisms in 118 genes. Four polymorphisms - rs35705950/MUC5B, rs2736100/TERT, rs2076295/DSP, and rs111521887/TOLLIP, exhibited substantial epidemiological evidence supporting their association with IPF risk.
Article
Genetics & Heredity
Jianping Zhang, Zhijun Cai, Fanzhe Feng, Yufeng Peng, Yi Cui, Yongiqing Xu
Summary: This study found that exosomes secreted by young BMSCs can promote the healing of tendon-bone interface after rotator cuff tears. These exosomes can improve extracellular matrix remodeling, osteogenic differentiation, angiogenesis, and stemness of tendon-derived stem cells (TDSCs). The exosomes from young BMSCs have better effects compared to those from aged BMSCs.
