Review
Surgery
Shaoming Song, Haojie Jin, Qinghao Cheng, Shiyi Gong, Kun Lv, Ting Lei, Hongwei Tian, Xiaofei Li, Caining Lei, Wenwen Yang, Kehu Yang, Tiankang Guo
Summary: This study conducted a meta-analysis to compare the efficacy and safety of radiofrequency ablation combined with stent (RFA + Stent) and stent alone for unresectable malignant biliary obstruction (MBO). The results showed that RFA + Stent was associated with better overall survival, longer mean survival time, longer mean stent patency time, and higher stent patency at 6 months compared to stent alone. The incidence of adverse effects was similar between the two interventions.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Oncology
Yucheng Xiang, Sinan Lu, Yufeng Li, Zhenghao Liu, Weilin Wang
Summary: This meta-analysis demonstrated that biliary stent placement with I-125 seeds showed lower risk of stent occlusion and better mean survival compared with stent placement alone in patients with malignant biliary obstruction. Additionally, there was no significant difference in adverse events between the two groups.
Review
Radiology, Nuclear Medicine & Medical Imaging
Fulei Gao, Xiangzhong Huang, Yong Wang
Summary: This meta-analysis aimed to compare the therapeutic effect and safety of iodine-125 (125I) stent implantation with biliary stent placement in patients with malignant biliary obstruction (MBO) caused by different cancers. The results showed that 125I implantation can reduce the risk of death and stent occlusion, prolong survival and stent patency, without increasing complication risk.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Radiology, Nuclear Medicine & Medical Imaging
Fulei Gao, Xiangzhong Huang, Yong Wang
Summary: This meta-analysis aimed to evaluate the efficacy and safety of iodine-125 (I-125) stent implantation in patients with malignant biliary obstruction caused by different cancers. The results showed that I-125 seed implantation can reduce the risk of death and stent occlusion, prolong survival time and stent patency, and does not increase the risk of complications.
QUANTITATIVE IMAGING IN MEDICINE AND SURGERY
(2023)
Review
Gastroenterology & Hepatology
Mingxing Xia, Wenhao Qin, Bing Hu
Summary: Endobiliary radiofrequency ablation (RFA) is a promising technique for palliating malignant biliary strictures (MBS) that cannot be surgically resected. Clinical studies have shown that RFA can effectively prolong the survival of extrahepatic cholangiocarcinoma (CCA) and ampullary cancer, especially without distant metastasis. However, it does not confer a survival benefit in patients with nonprimary bile duct malignancies. Biliary RFA combined with systemic chemotherapy may have a synergistic effect on inoperable CCA, particularly in patients with locally advanced tumors.
DIGESTIVE ENDOSCOPY
(2023)
Article
Surgery
Ya-Lin Kong, Hong-Yi Zhang, Cheng-Li Liu, Xiao-Jun He, Gang Zhao, Cheng Wang, Ling-Hong Kong, Jing Zhao
Summary: The study evaluated the efficacy and safety of endobiliary radiofrequency ablation (RFA) combined with self-expandable metal stents (SEMS) placement for unresectable malignant obstructive jaundice. The results showed that this combined treatment was technically safe and feasible in improving quality of life and prolonging survival for these patients.
SURGICAL ENDOSCOPY AND OTHER INTERVENTIONAL TECHNIQUES
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Tomas Andrasina, Tomas Rohan, Jiri Panek, Petra Kovalcikova, Lumir Kunovsky, Lenka Ostrizkova, Vlastimil Valek
Summary: The study found that endobiliary radiofrequency ablation prior to metal stent insertion can increase stent patency in patients with cholangiocarcinoma, but no improvement in survival was observed in other types of malignant biliary stenosis.
EUROPEAN JOURNAL OF RADIOLOGY
(2021)
Review
Gastroenterology & Hepatology
Hayat Khizar, Yufei Hu, Yanhua Wu, Kamran Ali, Junaid Iqbal, Muhammad Zulqarnain, Jianfeng Yang
Summary: Radiofrequency ablation improves survival and stent patency time for patients with malignant biliary strictures (MBS) compared to stent-alone treatment. Adverse events can be limited with better techniques.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qing Gou, Lingeng Wu, Wei Cui, Zhiqiang Mo, Dejin Zeng, Liming Gan, Jian He, Qicong Mai, Feng Shi, Meng Chen, Zhonghai Sun, Yongdong Liu, Jingjing Wu, Xiumei Chen, Wenhang Zhuang, Rongde Xu, Weike Li, Qichun Cai, Jing Zhang, Xiaoming Chen, Jiaping Li, Zejian Zhou
Summary: Stent placement combined with intra-RFA and HAIC may improve stent patency time and overall survival for patients with Ad-BTCs and BO, with similar rates of adverse events related to biliary tract operation between the combination group and the control group.
EUROPEAN RADIOLOGY
(2021)
Article
Health Care Sciences & Services
Koji Takahashi, Hiroshi Ohyama, Yuichi Takiguchi, Motoyasu Kan, Mayu Ouchi, Hiroki Nagashima, Izumi Ohno, Naoya Kato
Summary: This study compared the use of SBS and PSIS in the treatment of unresectable hilar malignant biliary stricture. The results showed no significant differences in clinical success rate, adverse event rate, time to recurrent biliary obstruction, or overall survival between the SBS and PSIS groups, except for the significantly longer procedure time in the PSIS group.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Gastroenterology & Hepatology
Dongwook Oh, Junyong Chong, Tae Jun Song, Do Hyun Park, Sang Soo Lee, Dong-Wan Seo, Sung Koo Lee, Myung-Hwan Kim
Summary: This study retrospectively assessed the feasibility, efficacy, and safety of EB-RFA for malignant hilar obstruction (MHO). The results showed that SEMS placement after EB-RFA in MHO was not associated with improvement in the stent patency and patient survival. Further prospective randomized studies are necessary to establish the effectiveness of EB-RFA with stents in MHO.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
Review
Oncology
Jana Jarosova, Peter Macinga, Alzbeta Hujova, Jan Kral, Ondrej Urban, Julius Spicak, Tomas Hucl
Summary: Cholangiocarcinoma and pancreatic cancer are common causes of malignant biliary obstruction, which often cannot be surgically resected at late stages. For these cases, Radiofrequency ablation (RFA) may offer a promising modality for treatment, with potential positive impacts on survival and stent patency. Further studies with well-characterized patient populations are needed for routine clinical practice acceptance.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Gastroenterology & Hepatology
Dao-Jian Gao, Jian-Feng Yang, Shu-Ren Ma, Jun Wu, Tian-Tian Wang, Hang-Bin Jin, Ming-Xing Xia, Ying-Chun Zhang, Hong-Zhang Shen, Xin Ye, Xiao-Feng Zhang, Bing Hu
Summary: Additional RFA may improve overall survival and quality of life in patients with inoperable primary extrahepatic biliary cancer compared to stent placement alone.
GASTROINTESTINAL ENDOSCOPY
(2021)
Review
Gastroenterology & Hepatology
Zahid Ijaz Tarar, Umer Farooq, Mustafa Gandhi, Ghulam Ghous, Saad Saleem, Faisal Kamal, Zaid Imam, Laith Jamil
Summary: This study aimed to investigate the effect of radiofrequency ablation (RFA) on the overall survival (OS) and stent patency in patients with malignant biliary obstruction. The results showed that RFA treatment in addition to stent placement improved both OS and stent patency duration compared to stent placement only, with similar rates of adverse events and no serious adverse events or deaths related to RFA procedure.
EUROPEAN JOURNAL OF GASTROENTEROLOGY & HEPATOLOGY
(2023)
Article
Gastroenterology & Hepatology
Chuanfei Zeng, Yiling Zhang, Hui Yang, Junbo Hong
Summary: This review provides an overview of PEP prevention after stent implantation in patients with DMBS. The results show that PEP occurs more frequently in patients with SEMS compared to PS, and the incidence of PEP is slightly higher in covered stents than in USEMS. Prophylactic pancreatic duct stenting is recommended for patients receiving transpapillary FCSEMS placement.
EXPERT REVIEW OF GASTROENTEROLOGY & HEPATOLOGY
(2022)
Article
Gastroenterology & Hepatology
Azizullah Beran, Sachit Sharma, Sami Ghazaleh, Wade Lee-Smith, Muhammad Aziz, Faisal Kamal, Ashu Acharya, Douglas G. Adler
Summary: This meta-analysis explored the predictors of fecal microbiota transplantation (FMT) failure in patients with recurrent/refractory Clostridioides difficile infection (CDI). The study included 20 studies with a total of 4327 patients and found that FMT failed in 16.3% of the patients. Advanced age, severe CDI, inflammatory bowel disease, peri-FMT use of non-CDI antibiotics, prior CDI-related hospitalizations, inpatient status, and poor quality of bowel preparation were significant predictors of FMT failure.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Article
Gastroenterology & Hepatology
Muhammad Aziz, Hossein Haghbin, Manesh Kumar Gangwani, Simcha Weissman, Arti R. Patel, Manraj K. Randhawa, Luke B. Samikanu, Zakaria Abdullah Alyousif, Wade Lee-Smith, Faisal Kamal, Ali Nawras, Colin W. Howden
Summary: Erythromycin improved visualization during EGD, reduced the need for blood transfusion and repeat EGD, and shortened hospital stay.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Manesh Kumar Gangwani, Muhammad Aziz, Abeer Aziz, Fnu Priyanka, Simcha Weissman, Khiem Phan, Dushyant Singh Dahiya, Zohaib Ahmed, Amir Humza Sohail, Wade Lee-Smith, Faisal Kamal, Toseef Javaid, Ali Nawras, Benjamin Hart
Summary: Clostridium difficile Infection is a significant health problem with high morbidity and mortality. Fecal Microbiota Transplantation (FMT) is an alternative therapy with high success rate and low relapse rate. However, the efficacy of different types of FMT, such as fresh, frozen, and lyophilized, remains unclear. This review aims to consolidate the data and identify the most effective treatment.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Umer Farooq, Muhammad Aziz, Abdul Kouanda, Sun-Chuan Dai, Craig Munroe, Mustafa Arain, Douglas Adler
Summary: EUS-guided gallbladder drainage (EUS-GBD) is a rescue treatment for patients who fail EUS-BD and ERCP in the management of malignant biliary obstruction. This meta-analysis confirms that EUS-GBD is a safe and effective option for biliary drainage.
ENDOSCOPIC ULTRASOUND
(2023)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Ali Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Umer Farooq, Zahid Ijaz Tarar, Alec E. Faggen, Muhammad Aziz, Saurabh Chandan, Zohaib Ahmed, Abdul Kouanda, Sun-Chuan Dai, Craig A. Munroe, Douglas G. Adler
Summary: This meta-analysis evaluated the efficacy and safety of EUS-guided biliary drainage (EUS-BD) in the management of benign biliary obstruction. The results showed high success rates of technical success, clinical success, and a low rate of adverse events for EUS-BD. It concluded that EUS-BD is an effective and safe option for patients with benign biliary obstruction after a failed attempt at ERCP or when ERCP is not technically possible.
ENDOSCOPIC ULTRASOUND
(2023)
Review
Gastroenterology & Hepatology
Muhammad Aziz, Manesh Kumar Gangwani, Hossein Haghbin, Dushyant Singh Dahiya, Amir Humza Sohail, Faisal Kamal, Wade Lee-Smith, Douglas G. G. Adler
Summary: This study assessed the safety and efficacy of gastric per-oral endoscopic myotomy (G-POEM) compared to surgical techniques for managing refractory gastroparesis. The results showed that G-POEM had advantages in terms of procedural time and length of hospital stay compared to surgery. However, there were no significant differences in post-procedure symptoms and reduction in symptoms preoperatively and postoperatively.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Ali Khan, Wade M. Lee-Smith, Sachit Sharma, Ashu Acharya, Alec E. Faggen, Umer Farooq, Zahid Tarar, Muhammad Aziz, Todd Baron
Summary: This meta-analysis compared the efficacy and safety of early vs. late endoscopic treatment of pancreatic necrotic collections. The results showed no significant differences between the two groups in adverse events, resolution of necrotic collections, need for further interventions, direct necrosectomy, mortality, and mean number of endoscopic necrosectomy sessions.
ENDOSCOPY INTERNATIONAL OPEN
(2023)
Review
Gastroenterology & Hepatology
Zohaib Ahmed, Umair Iqbal, Muhammad Aziz, Syeda Faiza Arif, Joyce Badal, Umer Farooq, Wade Lee-Smith, Manesh Kumar Gangwani, Faisal Kamal, Abdallah Kobeissy, Asif Mahmood, Ali Nawras, Harshit S. Khara, Bradley D. Confer, Douglas G. Adler
Summary: A systematic review and meta-analysis comparing percutaneous endoscopic gastrostomy (PEG) and percutaneous radiological gastrostomy (PRG) showed that PEG is associated with lower 30-day mortality, tube leakage, and tube dislodgement rates compared to PRG.
GASTROENTEROLOGY RESEARCH
(2023)
Article
Medicine, General & Internal
Amna Iqbal, Manesh Kumar Gangwani, Azizullah Beran, Dushyant Singh Dahiya, Amir Humza Sohail, Wade Lee-Smith, Muhammad Aziz, Mona Hassan
Summary: Our network meta-analysis reveals increased mortality and antibiotic resistance with nosocomial SBP. We recommend clearly identifying such patients to manage accordingly and developing guidelines geared towards nosocomial infections to be able to optimally steer resistance patterns and reduce mortality.
AMERICAN JOURNAL OF THE MEDICAL SCIENCES
(2023)
Review
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Ali Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Umer Farooq, Amit Agarwal, Muhammad Aziz, Justin Chuang, Anand Kumar, Alexander Schlachterman, David Loren, Thomas Kowalski, Douglas Adler
Summary: This meta-analysis compared cold snare polypectomy (CSP) and cold forceps polypectomy (CFP) for resection of diminutive polyps. The study found that CSP had a significantly higher rate of complete resection of all diminutive polyps compared to CFP. There was no significant difference in the rates of complete resection of polyps <= 3 mm in size and polypectomy time between the groups. However, the rate of failure of tissue retrieval was significantly higher in the CSP group.
GASTROINTESTINAL ENDOSCOPY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Mona Hassan, Joyce Badal, Syeda Faiza Arif, Mohamad Nawras, Ahmad Nawaz, Muhammad Aziz, Anita Kottapalli, Wade Lee-Smith, Umer Farooq, Manesh Kumar Gangwani, Nooraldin Merza, Abdallah Kobeissy, Zohaib Ahmed
GASTROINTESTINAL ENDOSCOPY
(2023)
Meeting Abstract
Gastroenterology & Hepatology
Faisal Kamal, Muhammad Khan, Wade Lee-Smith, Sachit Sharma, Ashu Acharya, Umer Farooq, Zahid Ijaz Tarar, Muhammad Aziz, Manesh Kumar Gangwani, Anand Kumar, Alexander Schlachterman, David Loren, Thomas Kowalski
GASTROINTESTINAL ENDOSCOPY
(2023)
Review
Gastroenterology & Hepatology
Manesh Kumar Gangwani, Mohamad Nawras, Muhammad Aziz, Anooja Rani, Fnu Priyanka, Dushyant Singh Dahiya, Zohaib Ahmed, Amir Humza Sohail, Rahul Karna, Wade Lee-Smith, Faisal Kamal, Abdallah Kobeissy, Yaseen Alastal
Summary: This study compares the effectiveness of two anti-tumor necrosis factor agents, infliximab and adalimumab, in preventing postoperative recurrence of Crohn's disease. The results show that both drugs have similar efficacy in preventing endoscopic and clinical recurrence. Clinical decision-making should consider cost, side effects, tolerability, and patient preferences.
ANNALS OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Zohaib Ahmed, Joyce Badal, Manesh Kumar Gangwani, Ahmad Nawaz, Bryan Badal, Syeda Faiza Arif, Umer Farooq, Faisal Kamal, Toseef Javaid, Muhammad Aziz, Wade Lee-Smith, Asif Mahmood, Nooraldin Merza, Abdallah Kobeissy, Ali Nawras, Mona Hassan
Summary: Sarcopenia is significantly associated with an increased risk of post-TIPS hepatic encephalopathy and mortality. The presence of sarcopenia should be taken into account when considering the risks and benefits of performing TIPS in patients with cirrhosis. Further studies are needed to determine the clinical utility of important risk factors such as sarcopenia on post-TIPS outcomes.
INDIAN JOURNAL OF GASTROENTEROLOGY
(2023)
Review
Gastroenterology & Hepatology
Muhammad Aziz, Hossein Haghbin, Manesh Kumar Gangwani, Mohamad Nawras, Yusuf Nawras, Dushyant Singh Dahiya, Amir Humza Sohail, Wade Lee-Smith, Faisal Kamal, Aasma Shaukat
Summary: This study conducted a systematic review and meta-analysis to investigate the impact of increased withdrawal time on adenoma detection rate (ADR) during colonoscopy. The findings suggest that a 9-minute withdrawal time improves ADR and adenoma per colonoscopy (APC) compared to a 6-minute withdrawal time.
JOURNAL OF CLINICAL GASTROENTEROLOGY
(2023)