Article
Oncology
Brian De, Rituraj Upadhyay, Kaiping Liao, Tiffany Kumala, Christopher Shi, Grace Dodoo, Joseph Abi Jaoude, Kelsey L. Corrigan, Gohar S. Manzar, Kathryn E. Marqueen, Vincent Bernard, Sunyoung S. Lee, Kanwal P. S. Raghav, Jean-Nicolas Vauthey, Ching-Wei Tzeng, Hop Tran S. Cao, Grace Lee, Jennifer Wo, Theodore S. Hong, Christopher H. Crane, Bruce D. Minsky, Grace L. Smith, Emma B. Holliday, Cullen M. Taniguchi, Albert C. Koong, Prajnan Das, Milind Javle, Ethan B. Ludmir, Eugene Koay
Summary: Tumor-related liver failure (TRLF) is the leading cause of death in patients with intrahepatic cholangiocarcinoma (ICC). The role of liver radiotherapy (L-RT) for patients with extrahepatic metastatic disease (M1) remains undefined. This study aimed to compare outcomes for M1 ICC patients treated with and without L-RT.
Article
Oncology
Salvatore Gruttadauria, Floriana Barbera, Duilio Pagano, Rosa Liotta, Roberto Miraglia, Marco Barbara, Maria Grazia Bavetta, Calogero Camma, Ioannis Petridis, Daniele Di Carlo, Pier Giulio Conaldi, Fabrizio Di Francesco
Summary: Intrahepatic cholangiocarcinoma (iCCA) is a rare and aggressive liver tumor, with increasing incidence and mortality rates even after radical resection. Recent attention has focused on the disease, supporting liver transplantation as a viable treatment option. Genetic mutations activating signaling pathways have been linked to iCCA tumorigenesis, with a strong association found between Notch pathway mutations and tumor size. Efforts in molecular analysis may improve diagnostic capabilities and treatment protocols for better long-term survival in iCCA and HCC-iCCA patients.
Review
Oncology
Mackenzie Owen, Mina S. Makary, Eliza W. Beal
Summary: This review examines locoregional therapy approaches for intrahepatic cholangiocarcinoma and summarizes the current literature. Locoregional therapies include thermal ablation, transarterial chemoembolization, transarterial radioembolization, external beam radiotherapy, stereotactic body radiotherapy, hepatic arterial infusion of chemotherapy, irreversible electroporation, and brachytherapy. These therapies are effective in prolonging overall survival and further research is needed to determine their comparative efficacy and optimal treatment strategies.
Article
Medicine, General & Internal
Tim Reese, Gregor Pagel, Bettina A. Bause, York von Rittberg, Kim C. Wagner, Karl J. Oldhafer
Summary: For intrahepatic cholangiocarcinoma (iCCA), complex liver resections are justified in selected patients and survival rates are comparable to conventional liver resections. Survival in iCCA is affected by resection margins and UICC stage, rather than the complexity of the case.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Surgery
Michael J. Littau, Preston Kim, Sujay Kulshrestha, Corinne Bunn, Celsa Tonelli, Zaid M. Abdelsattar, Fred A. Luchette, Marshall S. Baker
Summary: The margin status has an impact on the overall survival in patients with intrahepatic and extrahepatic hilar cholangiocarcinoma. Negative resection is associated with improved overall survival.
Review
Oncology
Samuel J. Keltner, Christopher Hallemeier, Kyle Wang, Randa Tao, Shimul Shah, Julie Heimbach, Jordan R. Kharofa
Summary: The use of neoadjuvant radiation therapy for patients with unresectable hilar cholangiocarcinoma before liver transplantation varies greatly. Different radiation doses and fractionation schemes are utilized, with cumulative doses ranging from 40 to 110 Gy (EQD2). Further studies are needed to evaluate the efficacy and toxicity of these different approaches and provide better guidance for best practices.
AMERICAN JOURNAL OF CLINICAL ONCOLOGY-CANCER CLINICAL TRIALS
(2023)
Review
Gastroenterology & Hepatology
Xing Chen, Jinpeng Du, Jiwei Huang, Yong Zeng, Kefei Yuan
Summary: Intrahepatic cholangiocarcinoma (ICC) is a common type of primary liver cancer with increasing incidence. Due to the lack of specific manifestations and tools for early diagnosis, most patients are diagnosed at an advanced stage. Neoadjuvant and adjuvant therapies are necessary to improve the outcomes, but lag behind compared to other malignancies. Recent advances in neoadjuvant and adjuvant strategies for ICC are evaluated in this review.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2022)
Review
Oncology
Aditya Borakati, Farid Froghi, Ricky H. Bhogal, Vasileios K. Mavroeidis
Summary: Intrahepatic cholangiocarcinoma is an aggressive malignancy with limited treatment options. Surgical resection is often not feasible, and chemotherapy has limited benefit. Recent advances in stereotactic ablative radiotherapy offer a promising option for precise treatment and future research.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2022)
Article
Surgery
Robert R. McMillan, Milind Javle, Sudha Kodali, Ashish Saharia, Constance Mobley, Kirk Heyne, Mark J. Hobeika, Keri E. Lunsford, David W. Victor, Akshay Shetty, Robert S. McFadden, Maen Abdelrahim, Ahmed Kaseb, Mukul Divatia, Nam Yu, Joy Nolte Fong, Linda W. Moore, Duc T. Nguyen, Edward A. Graviss, A. Osama Gaber, Jean-Nicolas Vauthey, R. Mark Ghobrial
Summary: Intrahepatic cholangiocarcinoma (iCCA) has traditionally been considered a contraindication for liver transplantation (LT), but recent studies have shown positive outcomes for LT after neoadjuvant therapy. A center developed a protocol for neoadjuvant therapy and LT for locally advanced, unresectable iCCA patients in 2010. Patients who underwent LT had a high overall survival rate at 1, 3, and 5 years, with a higher than expected proportion of patients with genetic alterations in fibroblast growth factor receptor (FGFR) and DNA damage repair pathways. Further research is needed to determine criteria for LT in iCCA and factors predicting survival.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Article
Surgery
Sebastian Rademacher, Timm Denecke, Thomas Berg, Daniel Seehofer
Summary: In addition to conditioning measures in liver surgery, perioperative anti-tumor therapy is becoming increasingly important in cholangiocarcinoma (CCA). Resection and liver transplantation are still the only curative treatment approaches for non-distant metastatic stage CCA, but long-term results are unsatisfactory. Neoadjuvant therapy, including chemotherapy and local procedures, shows potential in achieving secondary operability and is justified for operable intrahepatic CCA with a high risk of recurrence. Multimodal therapy has a high potential in CCA and may increase in the future with the development of new therapeutic agents.
Article
Oncology
Stefan Stremitzer, Judith Stift, Johannes Laengle, Christoph Schwarz, Klaus Kaczirek, Robert P. Jones, Leonard M. Quinn, Stephen W. Fenwick, Rafael Diaz-Nieto, Graeme J. Poston, Hassan Z. Malik
Summary: Resection margin status is associated with different clinical outcomes in patients undergoing resection for hilar cholangiocarcinoma, with isolated positive circumferential margin potentially serving as a novel prognostic biomarker.
ANNALS OF SURGICAL ONCOLOGY
(2021)
Review
Medicine, General & Internal
Sudha Kodali, Akshay Shetty, Soumya Shekhar, David W. Victor, Rafik M. Ghobrial
Summary: Cholangiocarcinoma, a tumor arising from differentiation of cholangiocytes, can develop anywhere in the biliary tree. Early diagnosis allows for surgical resection, while late-stage intrahepatic cholangiocarcinoma cases may require chemotherapy, locoregional therapies, and radiation as treatment options.
JOURNAL OF CLINICAL MEDICINE
(2021)
Review
Gastroenterology & Hepatology
Gonzalo Sapisochin, Tommy Ivanics, Julie Heimbach
Summary: Cholangiocarcinoma is the second-most common primary liver malignancy. Liver transplantation can be considered for intrahepatic and extrahepatic cholangiocarcinoma in select patients based on disease stage and patient characteristics.
Review
Oncology
Riccardo Inchingolo, Fabrizio Acquafredda, Valentina Ferraro, Letizia Laera, Gianmarco Surico, Alessia Surgo, Alba Fiorentino, Stefania Marini, Nicola de'Angelis, Riccardo Memeo, Stavros Spiliopoulos
Summary: Hilar cholangiocarcinoma, also known as Klatskin tumor, is a rare and aggressive type of cancer with poor prognosis. Surgical resection, liver transplantation, radiotherapy, chemotherapy, and minimally invasive procedures are treatment options, but only a small percentage of patients are eligible for surgery or transplant at the time of diagnosis.
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
(2021)
Article
Oncology
Brian De, Hop S. Tran Cao, Jean-Nicolas Vauthey, Gohar S. Manzar, Kelsey L. Corrigan, Kanwal P. S. Raghav, Sunyoung S. Lee, Ching-Wei D. Tzeng, Bruce D. Minsky, Grace L. Smith, Emma B. Holliday, Cullen M. Taniguchi, Albert C. Koong, Prajnan Das, Milind Javle, Ethan B. Ludmir, Eugene J. Koay
Summary: The usage of liver radiotherapy has remained constant in the United States despite the increasing adoption of ablative liver radiotherapy, indicating a continued unmet need. Ablative liver radiotherapy is associated with longer survival compared to conventional radiotherapy.
Article
Immunology
M. M. Gonzales, D. Z. Valdes, R. Helmick, T. Taner, G. Vasdev
TRANSPLANTATION PROCEEDINGS
(2015)
Editorial Material
Surgery
D. Zamora-Valdes, C. B. Rosen, J. K. Heimbach, T. Taner
AMERICAN JOURNAL OF TRANSPLANTATION
(2016)
Review
Oncology
Daniel Zamora-Valdes, Timucin Taner, David M. Nagorney
Article
Gastroenterology & Hepatology
Daniel Zamora-Valdes, Kymberly D. Watt, Todd A. Kellogg, John J. Poterucha, Sara R. Di Cecco, Nicki M. Francisco-Ziller, Timucin Taner, Charles B. Rosen, Julie K. Heimbach
Article
Surgery
A. Espinosa-de-los-Monteros, I. Dominguez, D. Zamora-Valdes, T. Castillo, O. F. Fernandez-Diaz, H. A. Luna-Torres
Article
Gastroenterology & Hepatology
Ismael Dominguez-Rosado, Miguel Angel Mercado, Christopher Kauffman, Fernando Ramirez-del Val, Alejandro Elnecave-Olaiz, Daniel Zamora-Valdes
JOURNAL OF GASTROINTESTINAL SURGERY
(2014)
Letter
Surgery
Daniel Zamora-Valdes, Ismael Dominguez, Miguel A. Mercado
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2013)
Letter
Gastroenterology & Hepatology
Ismael Dominguez-Rosado, Daniel Zamora-Valdes, Miguel Angel Mercado
Article
Gastroenterology & Hepatology
Daniel Zamora-Valdes, Pilar Leal-Leyte, Peter T. W. Kim, Giuliano Testa
ANNALS OF HEPATOLOGY
(2017)
Letter
Surgery
Daniel Zamora-Valdes, Alan G. Contreras, Miguel A. Mercado
JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS
(2014)
Article
Gastroenterology & Hepatology
Eric Lopez-Mendez, Daniel Zamora-Valdes, Mariana Diaz-Zamudio, Oscar F. Fernandez-Diaz, Lourdes Avila
WORLD JOURNAL OF HEPATOLOGY
(2010)
Article
Gastroenterology & Hepatology
Nahum Mendez-Sanchez, Daniel Zamora-Valdes, Jose A. Flores-Rangel, Julio A. Perez-Sosa, Francisco Vasquez-Fernandez, Jezer I. Lezama-Mora, Genaro Vazquez-Elizondo, Guadalupe Ponciano-Rodriguez, Martha H. Ramos, Misael Uribe
LIVER INTERNATIONAL
(2008)
Review
Chemistry, Medicinal
Hector Baptista-Gonzalez, Norberto C. Chavez-Tapia, Daniel Zamora-Valdes, Misael Uribe, Nahum Mendez-Sanchez
MINI-REVIEWS IN MEDICINAL CHEMISTRY
(2008)
Article
Gastroenterology & Hepatology
Mario Vilatoba, Daniel Zamora-Valdes, Manuel Guerrero-Hernandez, Hector Romero-Talamas, Rafael P. Leal-Villalpando, Miguel A. Mercado
ANNALS OF HEPATOLOGY
(2011)
