Article
Gastroenterology & Hepatology
Federico Arguelles-Arias, Teresa Valdes Delgado, Belen Maldonado Perez, Jaime Gonzalez Antuna, Luisa Castro Laria
Summary: We evaluated the efficacy and safety of maintenance intravenous UST treatment in patients with inflammatory bowel disease who had a partial or loss of response to subcutaneous UST. The results showed that 43.5% of patients achieved clinical remission at week 12 and 82.6% of patients had a clinical response after 12 weeks of intravenous UST maintenance.
THERAPEUTIC ADVANCES IN GASTROENTEROLOGY
(2023)
Article
Immunology
Xinyue Wang, Di Wang, Juan Du, Yuqing Wei, Rui Song, Beibei Wang, Shuang Qiu, Bei Li, Leidan Zhang, Yongqin Zeng, Hongxin Zhao, Yaxian Kong
Summary: Aging leads to immune system dysfunction, particularly T cell defects. CD244 plays a significant role in T cell aging, while CD160 does not. Therefore, CD244 may serve as a therapeutic target for improving diseases and comorbidities associated with immune system aging.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pediatrics
Toshihiko Kakiuchi, Sakiko Kimura, Motohiro Esaki, Muneaki Matsuo
Summary: The efficacy and safety of ustekinumab in pediatric patients with Crohn's disease need further investigation. Careful distinction between true infusion-related reactions and allergic reactions is necessary to determine the appropriate course of treatment.
FRONTIERS IN PEDIATRICS
(2021)
Article
Biochemistry & Molecular Biology
Barbara Peruzzi, Enrica Urciuoli, Michela Mariani, Laura Chioma, Luigi Tomao, Ilaria Montano, Mattia Algeri, Rosa Luciano, Danilo Fintini, Melania Manco
Summary: Excess body weight is beneficial to bone health but leads to poor bone structure. This study found that children with obesity have a higher amount of circulating extracellular vesicles, which results in adipogenic differentiation in mesenchymal stromal cells and a reduction in differentiation markers in mature osteoblasts. Regular physical exercise can partially restore the bone phenotype by decreasing the levels of circulating extracellular vesicles in obese children.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Ecology
Victor Vazquez, Pablo Leon, Francisco J. L. Gordillo, Carlos Jimenez, Iniguez Concepcion, Kevin Mackenzie, Eileen Bresnan, Maria Segovia
Summary: The heavily calcified Emiliania huxleyi strain from the Norwegian Sea was cultured to investigate the effects of ocean acidification on growth performance, calcification, and physiological stress management. The study found that high pCO(2) affected cell growth rates, viability, and reactive oxygen species (ROS) accumulation, while low pH affected carbon uptake affinity. High CO2 had a greater impact on cell growth than low pH alone, suggesting metabolic imbalance induced by high CO2. However, calcification was not significantly reduced by either acidification method.
Article
Gastroenterology & Hepatology
Fernando Bermejo, Laura Jimenez, Alicia Algaba, Milagros Vela, Guillermo Bastida, Olga Merino, Alicia Lopez-Garcia, Luigi Melcarne, Iago Rodriguez-Lago, Saioa de la Maza, Abdel Bouhmidi, Manuel Barreiro-de Acosta, Pilar Lopez-Serrano, Marta Carrillo-Palau, Francisco Mesonero, Beatriz Orts, Daniel Bonillo, Alicia Granja, Ivan Guerra
Summary: Intravenous re-induction with ustekinumab is an effective and safe strategy that recovers the response in approximately half of the patients with refractory Crohn's disease who experience a loss of response. Re-induction can be attempted before switching out of the therapy class.
INFLAMMATORY BOWEL DISEASES
(2022)
Article
Gastroenterology & Hepatology
Jurij Hanzel, Jurij Zdovc, Tina Kurent, Nejc Sever, Katarina Javornik, Katja Tuta, Matic Kozelj, Natasa Smrekar, Gregor Novak, Borut Stabuc, Erwin Dreesen, Debby Thomas, Tomaz Vovk, Iztok Grabnar, David Drobne
Summary: This study found that serum concentrations of ustekinumab as early as 1 hour after intravenous infusion may be used to identify patients with Crohn's disease most likely to achieve endoscopic remission, which could optimize CD treatment.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2021)
Article
Multidisciplinary Sciences
G. Assante, A. Tourna, R. Carpani, F. Ferrari, D. Prati, F. Peyvandi, F. Blasi, A. Bandera, A. Le Guennec, S. Chokshi, V. C. Patel, I. J. Cox, L. Valenti, N. A. Youngson
Summary: The gut plays an important role in the pathology of COVID-19, acting as a route of infection and influencing the severity of the disease. Infection of the gut by SARS-CoV-2 leads to systemic changes that alter immune and inflammatory responses. Markers for gut inflammation and damage are increased in plasma as the severity of the disease worsens. However, levels of the gut cell death biomarker FABP2 are paradoxically reduced in moderate to severe cases of COVID-19.
SCIENTIFIC REPORTS
(2022)
Article
Biochemistry & Molecular Biology
Maria Zingariello, Paola Verachi, Francesca Gobbo, Fabrizio Martelli, Mario Falchi, Maria Mazzarini, Mauro Valeri, Giuseppe Sarli, Christian Marinaccio, Johanna Melo-Cardenas, John D. Crispino, Anna Rita Migliaccio
Summary: Inflammatory cytokine levels in bone marrow, rather than blood levels, are closely related to myelofibrosis in Gata1(low) mice, possibly through reshaping the HSC niche.
Article
Clinical Neurology
Alyssa A. Toorop, Zoe L. E. van Kempen, Maurice Steenhuis, Jessica Nielsen, L. G. F. Sinnige, Gert van Dijk, Christiaan M. Roosendaal, Edo P. J. Arnoldus, Elske Hoitsma, Birgit Lissenberg-Witte, Brigit A. de Jong, Bob W. van Oosten, Eva M. M. Strijbis, Bernard M. J. Uitdehaag, Theo Rispens, Joep Killestein
Summary: The study evaluated the change in natalizumab trough drug levels when switching from intravenous to subcutaneous administration. It was found that the drug levels were on average 55% lower with subcutaneous administration, leading to very low levels in some patients. Monitoring of trough drug levels is advised when switching to subcutaneous administration in patients with low intravenous drug levels, higher body mass index, or extended treatment intervals.
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
(2023)
Article
Endocrinology & Metabolism
Ning Sheng, Fei Xing, Jie Wang, Xin Duan, Zhou Xiang
Summary: The study aimed to evaluate the relationship between thyroid hormone and bone mineral density (BMD) in euthyroid adults. Data from the National Health and Nutrition Examination Survey 2007-2010 were analyzed, and 3,759 euthyroid participants were included. The results showed that T4 exhibited a negative correlation with BMD, and there was a nonlinear relationship between thyroid hormone and BMD.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Environmental Sciences
Jiaxin Shang, Yang Zhang, Yu Peng, Yihang Huang, Lu Zhu, Zhuoyi Wu, Jing Wang, Yixin Cui
Summary: The study found that vegetation in Northwest China experienced greening from 2000 to 2015, mainly influenced by precipitation and temperature, with population being the major factor under low precipitation gradients. Climate change was identified as the primary driver of vegetation change.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Article
Multidisciplinary Sciences
Momoka Nakashima, Kana Ishikawa, Aika Fugiwara, Kaiin Shu, Yoshimi Fukushima, Masaaki Okamoto, Hirotake Tsukamoto, Takahisa Kouwaki, Hiroyuki Oshiumi
Summary: HPV vaccine may induce inflammation but does not worsen mouse EAE, whereas circulating EV miR-451a levels are associated with EAE severity. Excessive glucose uptake increases EV miR-451a levels and exacerbates mouse EAE, suggesting that environmental factors play a larger role than the HPV vaccine in exacerbating autoimmune disorders.
SCIENTIFIC REPORTS
(2021)
Article
Chemistry, Applied
Young-Bo Song, Lisa M. Lamothe, Nardo Esmeralda Nava Rodriguez, David R. Rose, Byung-Hoo Lee
Summary: This study found that mammalian alpha-glucosidases fully hydrolyzed Isomaltooligosaccharides (IMOs) to glucose, although at a slow rate, while AMG could not fully hydrolyze IMOs due to its very low hydrolytic activity on alpha-1,6 linkages.
Article
Gastroenterology & Hepatology
Hisashi Shiga, Kunio Tarasawa, Rintaro Moroi, Motoki Makuuchi, Takahiro Takahashi, Yusuke Shimoyama, Masatake Kuroha, Yoichi Kakuta, Kiyohide Fushimi, Kenji Fujimori, Yoshitaka Kinouchi, Atsushi Masamune
Summary: Anti-TNF agents and UST appear to have comparable effectiveness for CD patients without prior use of biologics.
JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
(2022)
