Review
Biochemistry & Molecular Biology
Xiaoying Li, Qijun Wu, Baosen Zhou, Yashu Liu, Jiale Lv, Qing Chang, Yuhong Zhao
Summary: This study found that only 13 SNPs were strongly correlated with lung cancer risk based on systematic reviews and meta-analyses, providing valuable insights for further genetic studies.
FRONTIERS IN MOLECULAR BIOSCIENCES
(2021)
Article
Oncology
Jacqueline V. Aredo, Sophia J. Luo, Rebecca M. Gardner, Nilotpal Sanyal, Eunji Choi, Thomas P. Hickey, Thomas L. Riley, Wen-Yi Huang, Allison W. Kurian, Ann N. Leung, Lynne R. Wilkens, Hilary A. Robbins, Elio Riboli, Rudolf Kaaks, Anne Tjonneland, Roel C. H. Vermeulen, Salvatore Panico, Loic Le Marchand, Christopher I. Amos, Rayjean J. Hung, Neal D. Freedman, Mattias Johansson, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: The study revealed that smoking is a risk factor for second primary lung cancer (SPLC), and smoking cessation may reduce the risk of SPLC. Additionally, individuals who meet the U.S. Preventive Services Task Force's criteria at the diagnosis of initial primary lung cancer also have an increased risk of developing SPLC.
JOURNAL OF THORACIC ONCOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Maria Radanova, Mariya Levkova, Galya Mihaylova, Rostislav Manev, Margarita Maneva, Rossen Hadgiev, Nikolay Conev, Ivan Donev
Summary: There is a growing interest in studying single nucleotide polymorphisms (SNPs) in microRNA (miRNA) genes, as they may be associated with susceptibility, prognosis, and treatment response in colorectal cancer (CRC). These miRNA-SNPs could serve as non-invasive biomarkers for early detection of CRC. However, contradictory findings have been reported when different research groups investigated the same SNP in a gene for a specific miRNA, highlighting the need for more case-control studies involving participants from different ethnic backgrounds. According to our review, three miRNA-SNPs - miR-146a rs2910164, miR-27a rs895819, and miR-608 rs4919510 - appear to be promising prognostic, diagnostic, and predictive biomarkers for CRC.
Article
Oncology
Eunji Choi, Sophia J. Luo, Jacqueline Aredo, Leah M. Backhus, Lynne R. Wilkens, Chloe C. Su, Joel W. Neal, Loic Le Marchand, Iona Cheng, Heather A. Wakelee, Summer S. Han
Summary: Survivors of lung cancer have a high risk of developing second primary lung cancer (SPLC), but the impact of SPLC diagnosis on survival remains unclear. This study found that compared to patients with a single primary lung cancer, those with SPLC had significantly reduced overall survival. The effect of SPLC on reduced survival was more pronounced among patients with early-stage lung cancer and those who actively smoked at the time of diagnosis.
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE
(2022)
Article
Genetics & Heredity
Byung Woo Yoon, Hyun-Tae Shin, Je Hyun Seo
Summary: This study provides insights into the genetic differences in prostate cancer incidence among different ethnicities, using data on single-nucleotide polymorphisms associated with prostate cancer. The study reveals that the polygenic risk score, as well as certain genes such as AR, CDKN1B, and MAD1L1, are associated with ethnic differences in prostate cancer.
Article
Public, Environmental & Occupational Health
Meng Zhu, Jun Lv, Yanqian Huang, Hongxia Ma, Ni Li, Xiaoxia Wei, Mengmeng Ji, Zhimin Ma, Ci Song, Cheng Wang, Juncheng Dai, Fengwei Tan, Yu Guo, Robin Walters, Iona Y. Millwood, Rayjean J. Hung, David C. Christiani, Canqing Yu, Guangfu Jin, Zhengming Chen, Qingyi Wei, Christopher Amos, Zhibin Hu, Liming Li, Hongbing Shen
Summary: The study reveals that the role of genetic background contributes to the difference in smoking-related risk of lung cancer between European populations and East Asians. Chinese-specific and European-specific polygenic risk scores (PRSs) show differences, particularly in smoking-related genetic loci. The PRSs are consistently associated with lung cancer risk, with a stronger association observed in smokers of European populations. An interaction between genetic risk and smoking is significant in the UK population, but not in the Chinese population. The higher incidence of lung cancer in nonsmokers of East Asian ethnicity and ethnic differences in genetic factors contribute to the disparity in smoking-related risk of lung cancer.
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY
(2023)
Article
Oncology
Xinying Xu, Yuhang Liu, Huiyi Hu, Jinshen Wang, Yuxin Cai, Jun Xie, Mingqiang Kang, Fei He
Summary: This study identified several single-nucleotide polymorphisms (SNPs) of cancer stem cell-related genes that are potentially associated with the prognosis of lung cancer patients. Some genotypes were found to be associated with an increased risk of lung cancer death, while others were associated with a reduced risk of lung cancer death.
WORLD JOURNAL OF SURGICAL ONCOLOGY
(2023)
Review
Oncology
Robert Ulinski, Iwona Kwiecien, Joanna Domagala-Kulawik
Summary: Chronic obstructive pulmonary disease (COPD) is an independent risk factor for lung cancer, and both diseases share similarities in immunopathogenesis. Some elements of autoimmunity may be involved in the development of emphysema and its relation with malignant transformation. COPD complicates lung cancer diagnosis and treatment, and tobacco smoking remains the main cause of these tobacco-dependent diseases.
Article
Oncology
Hongyang Shi, Yonghong Zhang, Yu Wang, Ping Fang, Yun Liu
Summary: This study found that there is a potential association between CYP4F2 gene polymorphisms and lung cancer risk, and this association may be affected by gender and smoking status.
FRONTIERS IN ONCOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Sebastian Morales-Pison, Julio C. Tapia, Sarai Morales-Gonzalez, Edio Maldonado, Monica Acuna, Gloria M. Calaf, Lilian Jara
Summary: This study found that specific germline variants in driver genes MAP3K1, SF3B1, and SMAD4 contribute to the risk of breast cancer in the Chilean population.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Ngoc Minh Luu, Thi Tra Bui, Thi Phuong Thao Tran, Thi Huyen Trang Nguyen, Jin-Kyoung Oh
Summary: The study aimed to identify latent classes based on lifestyle behavior trajectories and investigate their association with cancer risk. The research found that only a small percentage of participants maintained a long-term healthy lifestyle, highlighting the importance of linking behavior combinations to cancer prevention.
SCIENTIFIC REPORTS
(2023)
Article
Oncology
Fan Wang, Yutao Li, Zhengxing Li, Zixiu Zou, Yongming Lu, Chang Xu, ZongXu Zhao, HuaiZhou Wang, Yi Wang, Shicheng Guo, Li Jin, Jiucun Wang, Qiang Li, GengXi Jiang, Fan Xia, Bo Shen, Junjie Wu
Summary: The study found that GPC5 rs2352028 is positively associated with lung cancer prognosis, with CT genotype patients having a better prognosis. In addition, older and early-stage patients with CT + TT genotype have a lower risk of death compared to those with CC genotype.
Article
Biochemistry & Molecular Biology
Daniela Valencia-Perez Rea, Ramces Falfan-Valencia, Ingrid Fricke-Galindo, Ivette Buendia-Roldan, Leslie Chavez-Galan, Karol J. Nava-Quiroz, Jesus Alanis-Ponce, Gloria Perez-Rubio
Summary: Tobacco smoking is the leading risk factor for respiratory diseases, and genes like CHRNA5 and ADAM33 are associated with nicotine addiction. This research aimed to evaluate the association of polymorphisms in rs16969968 (CHRNA5) and rs3918396 (ADAM33) with severe COVID-19. The study found a significant correlation between the GA + AA genotype of rs16969968 and higher erythrocyte sedimentation rate (ESR), as well as a positive correlation between fibrinogen and C-reactive protein.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Oncology
Randi M. Williams, Marisa Cordon, Ellie Eyestone, Laney Smith, George Luta, Brady J. McKee, Shawn M. Regis, David B. Abrams, Raymond S. Niaura, Cassandra A. Stanton, Vicky Parikh, Kathryn L. Taylor
Summary: This study found that lung cancer screening could serve as a teachable moment for smoking cessation, with individuals who were extremely worried about lung cancer being more motivated to quit smoking and more ready to quit within the next 30 days.
Article
Oncology
Dan Liu, Ya Gao, Lingling Li, He Chen, Lu Bai, Yanli Qu, Baosen Zhou, Ying Yan, Yuxia Zhao
Summary: The T allele of the rs799917 SNP in the BRCA1 gene is associated with a lower risk of lung cancer in the Han Chinese population in Liaoning Province, suggesting a potential protective factor against lung cancer.
Article
Multidisciplinary Sciences
Sonia Szymanska, Marcin Sikora, Katarzyna Hrynkiewicz, Jaroslaw Tyburski, Andrzej Tretyn, Marcin Golebiewski
Summary: The study assessed the diversity of endophytic bacteria in sugar and sea beet roots, and the influence of osmoprotectants during lyophilization on bacterial density, viability, and salt tolerance. Sea beet's endophytic microbiome is more diverse and salt resistant than its crop relative, and supplementing trehalose during lyophilization is more effective in enhancing bacterial community salt stress tolerance, viability, and density. This suggests the potential use of trehalose in formulating improved biofertilizers.
SCIENTIFIC REPORTS
(2021)
Article
Multidisciplinary Sciences
Monika Skorupa, Joanna Szczepanek, Justyna Mazur, Krzysztof Domagalski, Andrzej Tretyn, Jaroslaw Tyburski
Summary: The impact of salt shock and salt stress on DNA methylation in beets was determined, with different responses observed in sugar beet and halophytic beet plants. Changes in DNA methylation were found to be associated with salt tolerance and the transcriptomic response to salinity in beets.
Article
Nutrition & Dietetics
Wojciech J. Bilinski, Lukasz Szternel, Joanna Siodmiak, Przemyslaw T. Paradowski, Krzysztof Domagalski, Grazyna Sypniewska
Summary: Both vitamin D and insulin-like growth factor 1 play important roles in bone metabolism, and their interaction may influence bone turnover markers in prepubertal children. Low levels of 25-hydroxyvitamin D do not significantly impact bone turnover, and it may not be a reliable predictor of bone metabolism in children. Further research is needed to understand the specific mechanisms underlying the relationship between vitamin D, IGF-1, and bone turnover markers.
Article
Cell Biology
Andrzej Tretyn, Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Dorota Sandomierz, Joanna Dejewska, Karolina Ciechanowska, Aleksander Jarkiewicz-Tretyn, Wojciech Koper, Krzysztof Palgan
Summary: The study evaluated the antibody levels against SARS-CoV-2 virus and cellular immune response after the vaccination with mRNA vaccines. High levels of antibodies were observed in 98% of the vaccinated cohort, and all participants had protective T cells. The immune response is diversified, visible as early as 2-3 weeks after the first dose, and the level of protection significantly increased after the second dose, especially in pre-vaccine healthy subjects.
Article
Endocrinology & Metabolism
Wojciech J. Bilinski, Lukasz Szternel, Joanna Siodmiak, Magdalena Krintus, Przemyslaw T. Paradowski, Krzysztof Domagalski, Grazyna Sypniewska
Summary: The study found that impaired regulation of glucose metabolism and insulin resistance in childhood have adverse effects on bone turnover, particularly on bone resorption. Hyperglycemia significantly decreased bone resorption marker levels in boys but had no effect on girls, who showed higher bone formation than resorption. Insulin resistance significantly decreased bone resorption, especially in girls.
JOURNAL OF DIABETES AND ITS COMPLICATIONS
(2021)
Article
Medicine, General & Internal
Aleksander Zwierz, Krystyna Masna, Krzysztof Domagalski, Pawel Burduk
Summary: The purpose of this study was to analyze the long-term effects of a 12-week course of topical steroids on adenoid size, mucus, and middle ear effusion. The results indicated that there was no significant effect on adenoid size, mucus, and otitis media with effusion (OME) three to six months after finishing the treatment. Therefore, the decision of adenoidectomy and tympanostomy should not be procrastinated.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Medicine, General & Internal
Krystyna Masna, Aleksander Zwierz, Krzysztof Domagalski, Pawel Burduk
Summary: The study aimed to analyze seasonal differences in adenoid size and mucus levels via endoscopy, as well as changes in middle ear effusion via tympanometry. Results showed that thermal seasons did not influence the size of pharyngeal tonsils, but increased mucus coverage of adenoids and deterioration of middle ear function in winter may lead to seasonal clinical deterioration in children.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Immunology
Joanna Szczepanek, Monika Skorupa, Agnieszka Goroncy, Joanna Jarkiewicz-Tretyn, Aleksandra Wypych, Dorota Sandomierz, Aleksander Jarkiewicz-Tretyn, Joanna Dejewska, Karolina Ciechanowska, Krzysztof Palgan, Pawel Rajewski, Andrzej Tretyn
Summary: The study found that mRNA vaccines induce a stronger humoral response of the immune system, with the fastest decline in antibody levels over time.
Article
Plant Sciences
Agata Kucko, Aleksandra Bogumila Florkiewicz, Magdalena Wolska, Jakub Mietki, Malgorzata Kapusta, Krzysztof Domagalski, Emilia Wilmowicz
Summary: In this study, the researchers investigated the role of lipid-related enzymes and lipid-derived plant hormones in the flower abscission zone (AZ) of yellow lupine under drought conditions. They found that drought-induced lipid peroxidation in the AZ cells, leading to the upregulation of phospholipase D, lipoxygenase, and the accumulation of jasmonic acid (JA). They also observed the key steps of JA conjugation and signaling in response to drought stress. Overall, the activation of AZ during flower abscission is closely associated with lipid modifications and the induction of JA-related signaling pathways.
Review
Cell Biology
Joanna Szczepanek, Monika Skorupa, Andrzej Tretyn
Summary: miRNAs are not only markers of neoplastic disease initiation and progression, but also markers of response to anticancer therapy. Several miRNAs have been identified as biomarkers of drug resistance and have potential to sensitize cancer cells to therapy. The use of miRNAs in cancer treatment has been verified in clinical trials, showing great potential.
Article
Immunology
Monika Skorupa, Joanna Szczepanek, Agnieszka Goroncy, Joanna Jarkiewicz-Tretyn, Barbara Ptaszynska, Pawel Rajewski, Wojciech Koper, Krzysztof Palgan, Andrzej Tretyn
Summary: The characteristics of changes in anti-SARS-CoV-2 IgG within one year of vaccination in healthcare workers were investigated. It was found that booster doses significantly increased the levels of IgG antibodies and could have a real impact on restricting the further transmission of the virus.
Article
Medicine, General & Internal
Aleksander Zwierz, Krzysztof Domagalski, Krystyna Masna, Pawel Burduk
Summary: The study aims to assess the effectiveness of endoscopic examination in evaluating the size of the pharyngeal tonsil and determine the minimum necessary frequency of tests. Results showed that flexible endoscopic examination has high sensitivity and specificity in assessing the size of the pharyngeal tonsil.
Review
Biochemistry & Molecular Biology
Palgan Krzysztof, Tretyn Andrzej
Summary: Anaphylaxis is a life-threatening hypersensitivity reaction, often caused by drugs and food. Factors such as physical exercise, acute infections, drugs, alcohol, and menstruation can exacerbate the severity of the reaction. This review highlights the role of platelet-activating factor in the development of severe anaphylactic reactions, including anaphylactic shock.
Review
Biochemistry & Molecular Biology
Joanna Szczepanek, Monika Skorupa, Joanna Jarkiewicz-Tretyn, Cezary Cybulski, Andrzej Tretyn
Summary: Breast cancer demonstrates diverse epigenetic abnormalities that impact gene expression and tumor characteristics. Epigenetic alterations are crucial in cancer development and progression, and drugs targeting epigenetic modifications show promise for cancer treatment, including DNA methyltransferase inhibitors, histone-modifying enzymes, and mRNA regulators. However, currently, there is no effective standalone epigenetic drug therapy for breast cancer. Combining epigenetic drugs with conventional therapies has shown positive results, and targeting specific epigenetic changes may lead to more effective monotherapy options in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Medicine, General & Internal
Justyna Moppert, Krzysztof Domagalski, Sylwia Wrotek, Malgorzata Pawlowska
Summary: This study aimed to evaluate the predictive role of TNF-α, IL-6, s-ICAM-1, and EBV DNA load levels in hepatological complications of EBV infection in children. The findings revealed that elevated concentrations of IL-6, TNF-α, and s-ICAM-1 may indicate the risk of hepatitis with concomitant biliary pole damage.
JOURNAL OF CLINICAL MEDICINE
(2023)
