Journal
FUTURE MICROBIOLOGY
Volume 13, Issue 7, Pages 785-798Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2017-0168
Keywords
2-ME; apoptosis; Bid; digital pathology; HIF-1 alpha; pulmonary tuberculosis
Categories
Funding
- Mexico Federal Funds [HIM/2008/015]
- CONACyT [FC 2015-1/115]
- Miembros del Patronato del HIM
Ask authors/readers for more resources
Aim: Investigate the role of hypoxia-inducible factor-1 alpha (HIF-1 alpha) in pulmonary tuberculosis (TB). Methods & results: A model of progressive pulmonary TB in BALB/c mice, immunohistochemistry and digital pathology were used. High HIF-1 alpha expression was observed during early TB in activated macrophages. During late TB, even higher HIF-1 alpha expression was observed in foamy macrophages, which are resistant to apoptosis. Blocking HIF-1 alpha during early infection with 2-methoxyestradiol worsened the disease, while during late TB, it induced macrophage apoptosis and decreased bacillary loads. Conclusion: HIF-1 alpha has a dual role in experimental TB. This finding could have therapeutic implications because combined treatment with 2-methoxyestradiol and antibiotics appeared to eliminate mycobacteria more efficiently than conventional chemotherapy during advanced disease.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available