Design of selective histone deacetylase inhibitors: rethinking classical pharmacophore

Histone Deacetylase Inhibitors as Anticancer Drugs

(2017) Tomas Eckschlager et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Small Molecule Antagonists of the Interaction between the Histone Deacetylase 6 Zinc-Finger Domain and Ubiquitin

(2017) Rachel J. Harding et al.   JOURNAL OF MEDICINAL CHEMISTRY

Chidamide in the treatment of peripheral T-cell lymphoma

(2017) Thomas Chan et al.   OncoTargets and Therapy

Effect of clinically approved HDAC inhibitors on Plasmodium , Leishmania and Schistosoma parasite growth

(2017) Ming Jang Chua et al.   International Journal for Parasitology-Drugs and Drug Resistance

Structure-Based Design and Synthesis of Novel Inhibitors Targeting HDAC8 from Schistosoma mansoni for the Treatment of Schistosomiasis

(2016) Tino Heimburg et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural insights into HDAC6 tubulin deacetylation and its selective inhibition

(2016) Yasuyuki Miyake et al.   Nature Chemical Biology

Synthesis and Biological Investigation of Oxazole Hydroxamates as Highly Selective Histone Deacetylase 6 (HDAC6) Inhibitors

(2015) Johanna Senger et al.   JOURNAL OF MEDICINAL CHEMISTRY

Histone Deacetylase (HDAC) Inhibitor Kinetic Rate Constants Correlate with Cellular Histone Acetylation but Not Transcription and Cell Viability

(2013) Benjamin E. L. Lauffer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Potent and Selective Class IIa Histone Deacetylase (HDAC) Inhibitors as a Potential Therapy for Huntington’s Disease

(2013) Roland W. Bürli et al.   JOURNAL OF MEDICINAL CHEMISTRY

Selective class IIa histone deacetylase inhibition via a nonchelating zinc-binding group

(2013) Mercedes Lobera et al.   Nature Chemical Biology

Selective Histone Deacetylase 6 Inhibitors Bearing Substituted Urea Linkers Inhibit Melanoma Cell Growth

(2012) Joel A. Bergman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of HDAC Inhibitors That Lack an Active Site Zn2+-Binding Functional Group

(2012) Chris J. Vickers et al.   ACS Medicinal Chemistry Letters

Human HDAC isoform selectivity achieved via exploitation of the acetate release channel with structurally unique small molecule inhibitors

(2011) Lewis Whitehead et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Rational Design and Simple Chemistry Yield a Superior, Neuroprotective HDAC6 Inhibitor, Tubastatin A

(2010) Kyle V. Butler et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

HDAC family: What are the cancer relevant targets?

(2008) Olaf Witt et al.   CANCER LETTERS

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

(2008) Michael Haberland et al.   NATURE REVIEWS GENETICS