Review
Pharmacology & Pharmacy
Masahiko Terauchi, Atsushi Tamura, Yoshinori Arisaka, Hiroki Masuda, Tetsuya Yoda, Nobuhiko Yui
Summary: Research on regenerative treatment of oral tissues using cyclodextrin-based pharmaceutics and polyelectrolyte complexation shows great potential in enhancing the effectiveness and stability of treatments. These advanced techniques contribute to the progression of successful oral tissue regeneration.
Article
Oncology
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Summary: This study investigates the relationship between the formation of cyclodextrin (CD) and unesterified cholesterol (UC) complexes and their therapeutic effectiveness. The findings suggest that the solubility and molecular mechanisms of CD influence the formation and complexation capability of these complexes. The ability of CD derivatives to form 1:1 and 2:1 complexes is correlated with their therapeutic efficacy and toxicity, respectively. These findings highlight the importance of optimizing the molecular structure of CDs to overcome current treatment dilemmas.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Oncology
Yusei Yamada, Madoka Fukaura-Nishizawa, Asami Nishiyama, Akira Ishii, Tatsuya Kawata, Aina Shirakawa, Mayuko Tanaka, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Summary: This study found that cyclodextrins can be used to treat Niemann-Pick disease type C (NPC), but concerns about ototoxicity exist. By optimizing the molecular structure of cyclodextrins, this study suggests a way to overcome this dilemma.
CLINICAL AND TRANSLATIONAL MEDICINE
(2023)
Article
Biochemical Research Methods
Antony Cougnoux, Melissa R. Pergande, Fidel Serna-Perez, Stephanie M. Cologna
Summary: Niemann-Pick, type C (NPC) is a fatal lysosomal storage disorder with no FDA-approved therapy. 2-hydroxypropyl-beta-cyclodextrin (HP -b-CD) has shown promising results in reducing cholesterol storage and delaying neurodegeneration in cell culture and animal studies, but its mechanism of action is not well understood.
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2023)
Article
Pharmacology & Pharmacy
Yusei Yamada, Yoichi Ishitsuka, Yuki Kondo, Shuichi Nakahara, Asami Nishiyama, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Shunsuke Kamei, Tsuyoshi Shuto, Hirofumi Kai, Yuji Hayashino, Masatake Sugita, Takeshi Kikuchi, Fumio Hirata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Takahiro Seki, Tomoko Ohta, Yuki Kurauchi, Hiroshi Katsuki, Muneaki Matsuo, Katsumi Higaki, Kousaku Ohno, Shirou Matsumoto, Takumi Era, Tetsumi Irie
Summary: The study showed that HP-gamma-CD forms a stable 1:1 inclusion complex with cholesterol, and has almost equivalent therapeutic effects in treating NPC compared to HP-beta-CD. HP-gamma-CD has lower toxicity than HP-beta-CD, and demonstrates the same efficacy in treating NPC models.
BRITISH JOURNAL OF PHARMACOLOGY
(2021)
Article
Medicine, Research & Experimental
Yusei Yamada, Toru Miwa, Masaki Nakashima, Aina Shirakawa, Akira Ishii, Nanami Namba, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Yasuyo Okada, Atsushi Ichikawa, Katsumi Higaki, Ken Hayashi, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Yoshihide Ishikawa, Tomohito Kajii, Kyoko Tachii, Hiroki Takeda, Yorihisa Orita, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka
Summary: By comparing the two cyclodextrins, researchers found that G2-gamma-CD showed lower ototoxicity in treating NPC and was considered a cholesterol solubilizer with physicochemical properties and biocompatibility suitable for clinical application.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Biochemistry & Molecular Biology
Carsten Holzmann, Martin Witt, Arndt Rolfs, Veronica Antipova, Andreas Wree
Summary: In a mouse model of Niemann-Pick disease type C1 (NPC1), combination treatment (COMBI) and individual treatments with MIGLU or HPssCD were beneficial in terms of body and brain weight, with differences observed based on gender. While all treatments had some beneficial effects on evaluated parameters, locomotor activity reduction was not significantly improved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Kamil Wdowiak, Natalia Rosiak, Ewa Tykarska, Marcin Zarowski, Anita Plazinska, Wojciech Plazinski, Judyta Cielecka-Piontek
Summary: This study aimed to obtain hesperidin and hesperetin systems with HP-beta-CD, and evaluated their physicochemical properties and biological activities. The results showed significant improvement in solubility, permeability, and inhibitory activity, indicating the potential of HP-beta-CD as a carrier to enhance the biological activity and bioavailability of hesperidin and hesperetin.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Jorge L. Rodriguez-Gil, Laura L. Baxter, Dawn E. Watkins-Chow, Nicholas L. Johnson, Cristin D. Davidson, Steven R. Carlson, Arturo A. Incao, Kerri L. Wallom, Nicole Y. Farhat, Frances M. Platt, Ryan K. Dale, Forbes D. Porter, William J. Pavan
Summary: The study analyzed RNA-Seq data from 42 NPC1 patient-derived fibroblast cell lines and identified 485 HP beta CD-responsive genes, showing significant involvement in cholesterol and lipid biosynthesis pathways. Experimental results in mice suggested that a gene, GPNMB, may serve as a useful biomarker of treatment response in NPC1 disease.
HUMAN MOLECULAR GENETICS
(2021)
Article
Chemistry, Multidisciplinary
Mikhail P. Kurlykin, Mariya A. Golovina, Andrey V. Tenkovtsev
Summary: Functional polyrotaxanes of N-alkanoylpolyethyleneimine@ a-cyclodextrin type were synthesized by acylating the polypseudorotaxane precursor, a polyethylenimine@ a-cyclodextrin inclusion complex, with excess carboxylic acid anhydrides. During the reaction, a-cyclodextrin moieties were also completely O-acylated. The introduction of acyl groups into the polyethyleneimine backbone prevented the expulsion of a-cyclodextrin rings from this backbone.
MENDELEEV COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Madoka Fukaura, Yoichi Ishitsuka, Seiichi Shirakawa, Naoki Ushihama, Yusei Yamada, Yuki Kondo, Toru Takeo, Naomi Nakagata, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Yuki Kurauchi, Takahiro Seki, Hiroshi Katsuki, Katsumi Higaki, Muneaki Matsuo, Tetsumi Irie
Summary: The study investigated GPNMB as a potential biomarker for the therapeutic effect of HP-beta-CD in NPC mouse model, showing that HP-beta-CD inhibited cerebellar Purkinje cell damage and reduced GPNMB levels. However, intracerebral administration also decreased hepatic GPNMB expression and increased serum ALT levels in NPC mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Pharmacology & Pharmacy
Tetsumi Irie
Summary: Cyclodextrins can be used as carriers to treat lipid transport disorders such as Niemann-Pick disease. 2-Hydroxypropyl-beta-CD and 2-hydroxypropyl-gamma-CD are effective cholesterol shuttles for the treatment of NPC, with HPGCD showing a wider safety margin compared to HPBCD.
YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN
(2022)
Article
Clinical Neurology
Orsolya K. Albert, Katherine Friedmann, Rebecca Jaeger, Elizabeth Berry-Kravis
Summary: Intrathecal delivery of VTS-270 for the treatment of NPC1 has been performed on a biweekly schedule for over nine years at Rush University Medical Center. Out of 59 patients treated, 55.9% had no adverse events after LP, while 44.1% experienced adverse effects at some point. Overall, the rate of adverse events for LP infusion was very low.
PEDIATRIC NEUROLOGY
(2023)
Article
Chemistry, Physical
Li-Sheng Hao, Han-Xiao Wang, Yan-Si Wang, Ya-Qi Meng, Yan-Qing Nan
Summary: The inclusion complexation of surfactant with fi-cyclodextrin (fi-CD) is a research topic in supramolecular chemistry. Thermodynamic and molecular dynamics (MD) simulation studies provide valuable information about the synergism between cationic and anionic surfactants and the competition between inclusion complexation and mixed micellization. Experimental and simulation results indicate a stronger inclusion affinity of fi-CD with CTAB compared to SL, and a less competitive interaction between inclusion and mixed micellization when the composition approaches the equimolar ratio of CTAB and SL.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2023)
Article
Endocrinology & Metabolism
Tatiane Grazieli Hammerschmidt, Bruna Donida, Marco Raabe, Jessica Lamberty Faverzani, Franciele de Fatima Lopes, Andryele Z. Machado, Rejane G. Kessler, Luiza S. Reinhardt, Fernanda Poletto, Dinara J. Moura, Carmen R. Vargas
Summary: Niemann-Pick C disease (NPC) is a severe genetic disorder with no cure. Recent studies have found that beta-cyclodextrin (beta-CD) can reduce cholesterol accumulation in cells of NPC1 patients, and the combination with antioxidants can further improve the treatment effect.
METABOLIC BRAIN DISEASE
(2023)
Editorial Material
Nursing
Richard Gray, Dan Bressington, Martin Jones, David R. Thompson
JOURNAL OF ADVANCED NURSING
(2021)
Editorial Material
Nursing
Fiona Maxton, Philip Darbyshire, David R. Thompson
JOURNAL OF CLINICAL NURSING
(2021)
Article
Nursing
Wai Tong Chien, David R. Thompson, Sau Fong Leung, Daniel Bressington
Summary: This study found that social relationship-related quality of life is low among Asian inpatients with severe mental illness pre-discharge, and there is a weak correlation between functioning, quality of life, and symptoms. The study suggests that interventions beyond traditional focus on psychiatric symptoms, targeting social relationships, employment status, and physical health problems, may be needed to improve functioning levels in recently discharged individuals with severe mental illness.
JOURNAL OF PSYCHIATRIC AND MENTAL HEALTH NURSING
(2022)
Article
Public, Environmental & Occupational Health
Tina Habota, Jan Cameron, David R. Thompson, Chantal F. Ski
Summary: The study revealed significant prospective memory deficits in patients with chronic heart failure, but no significant differences were found in background cognitive tasks between groups. These PM impairments may impact patient engagement in HF self-care behaviors.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Polymer Science
Estefania Gonzalez Solveyra, David H. Thompson, Igal Szleifer
Summary: Protein adsorption onto nanomaterials is controlled by functionalizing their surface with polymers, and the efficiency depends on design parameters, surface curvature, and solution conditions. A comprehensive study analyzing the effect of these factors was conducted using molecular theory calculations.
Article
Education & Educational Research
Brittany M. Williams, David J. Thompson
Summary: This article examines the issues faced by higher education researchers and practitioners in addressing HIV/AIDS in the college context in the United States. The study finds limited focus on HIV/AIDS in college environments and an overemphasis on quantitative research methods. Additionally, researchers rarely discuss identity nuances and tend to focus on individual choices rather than systemic structures.
JOURNAL OF DIVERSITY IN HIGHER EDUCATION
(2022)
Article
Biochemistry & Molecular Biology
Zachary J. Struzik, Shruti Biyani, Tim Grotzer, Judith Storch, David H. Thompson
Summary: In this study, a robust pathway to optically pure PG is presented, utilizing triethyl ammonium H-phosphonate salt, instead of the currently unavailable commercially available optically pure material. The challenges in purification during the process have been addressed.
Article
Chemistry, Applied
Shruti A. Biyani, Corryn Lytle, Seok-Hee Hyun, Michael A. McGuire, Ranya Pendyala, David H. Thompson
Summary: This article presents a novel 5-step continuous flow synthesis for lorazepam, a widely used sedative. Each step was optimized and translated to continuous flow, resulting in over 99% pure lorazepam.
ORGANIC PROCESS RESEARCH & DEVELOPMENT
(2022)
Article
Cardiac & Cardiovascular Systems
Chantal F. Ski, Susie Cartledge, Dan Foldager, David R. Thompson, Suzanne Fredericks, Inger Ekman, Jeroen M. Hendriks
Summary: In a rapidly changing health and care landscape, it is important to acknowledge the need for integrated care with a patient-centered approach. Unfortunately, care systems are often fragmented and focused on the condition rather than the patient. To address this issue, the Science Committee of the Association of Cardiovascular Nursing and Allied Professions of the European Society of Cardiology has issued a statement on integrated care for those with cardiovascular disease. This statement outlines the evidence, challenges, and recommendations for practice, education, and research.
EUROPEAN JOURNAL OF CARDIOVASCULAR NURSING
(2023)
Article
Multidisciplinary Sciences
Shayak Samaddar, Debosreeta Bose, Bradley P. Loren, Joseph L. Skulsky, Olga Ilnytska, Zachary J. Struzik, Judith Storch, David H. Thompson
Summary: This study explores a new approach for treating Niemann-Pick Type C (NPC) using polyrotaxanes containing 2-Hydroxypropyl-β-cyclodextrin (HP-β-CD). The study found that polyrotaxanes can remove cholesterol from NPC patient cells, and the endcapping and threading efficiency of polyrotaxanes are directly related to cholesterol mobilization. Additionally, improving the solubility of the compounds can significantly enhance cholesterol mobilization.
Article
Toxicology
Giselle R. M. Bellia, Robert A. A. Bilott, Ning Sun, David Thompson, Vasilis Vasiliou
Summary: Current literature suggests that PFAS carbon chain length may affect its toxicity, and statistical modeling can be used to predict toxicity and improve the efficiency of PFAS regulation development. In this study, data analysis and predictive modeling were conducted, showing significant differences in mean values for 11 out of 15 health outcomes. Simple linear regressions were used for two health outcomes, yielding statistically significant results. Comparison between the results of an actual dataset and a theoretically generated dataset indicated no significant differences in the mean values of the two health outcomes. Therefore, predictive statistical modeling can be used to predict health outcomes for PFAS exposure.
TOXICOLOGY MECHANISMS AND METHODS
(2023)
Article
Acoustics
Eduardo Latorre Iglesias, David Thompson, Jorge Munoz Paniagua, Javier Garcia Garcia
Summary: At speeds above 300 km/h, aerodynamic noise from the bogie area in high-speed trains becomes significant. Component-based models are attractive for predicting aerodynamic noise due to their fast and cheap calculations. This study evaluates the feasibility of applying these models to predict the aerodynamic noise from bogies and adjusts the empirical constants using measurements in a wind tunnel.
Article
Engineering, Mechanical
Luis Baeza, Juan Giner-Navarro, Christopher Knuth, David J. Thompson
Summary: The study develops a wheelset model that considers both flexibility and rotation, and provides a global modeling method applicable to any coordinate system. Linear equations are derived in axisymmetric coordinates, allowing the calculation of natural frequencies in both fixed and rotating frames. The model is also applied to simulate the response of strain gauges in load-measuring wheelsets.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Engineering, Civil
Jiawei Wang, David Thompson, Giacomo Squicciarini
Summary: The study presents a semi-analytical model of railway track that accounts for vertical, lateral, and axial dynamics as well as the discrete supports provided by sleepers. The model includes torsion and warping effects on rail behavior and is validated through comparison with measurements. The results show that torsion and warping have a significant impact on the lateral behavior of the track.
PROCEEDINGS OF THE INSTITUTION OF MECHANICAL ENGINEERS PART F-JOURNAL OF RAIL AND RAPID TRANSIT
(2023)
Article
Biochemistry & Molecular Biology
Giulia Murbach-Oliveira, Kalpita Banerjee, Marcelo M. Nociari, David H. Thompson
Summary: A2E, a lipid bisretinoid, leads to vision impairment in eye diseases. Interaction between ethanolamine, acetic acid, and ATR plays a crucial role in high-yield A2E formation, with imine formation being a key step in the reaction. By optimizing reaction conditions, the yield and quality of A2E were significantly improved.
ACS BIO & MED CHEM AU
(2022)
