Article
Entomology
Yulong Wang, Zhen Liu, Xuebing Yin, Shihong Liu, Kai Wang, Rongjie Wan, Haoran Chen, Xinyang Li, Bo Huang
Summary: Entomopathogenic fungi have dynamic cell walls that adapt to environmental conditions. ss-1,3-Glucan recognition proteins activate insect immune systems. The immune response of Bombyx mori to different Beauveria bassiana strains was investigated, revealing differences at 12 h post-infection. Immunofluorescence assays showed an inverse relationship between ss-1,3-glucan content and fungal virulence. Injecting ss-1,3-glucan upregulated Bm ss GRP4 expression and reduced the virulence of high-virulence B. bassiana strains. Silencing Bm ss GRP4 resulted in the opposite virulence pattern. Interference with the CnA gene eliminated virulence differences between B. bassiana strains.
Article
Immunology
Wuren Huang, Ruijuan Tang, Shirong Li, Ying Zhang, Rongbing Chen, Liyuan Gong, Xuefei Wei, Yingyu Tang, Qiuning Liu, Lei Geng, Guoqing Pan, Brenda T. Beerntsen, Erjun Ling
Summary: Investigating the fixed-site infection method can help screen genes involved in penetrating the integument, revealing the mechanism of fungal infection. Melanization occurs before new hyphae penetrate the integument, and fungal infection induces epidermal cell proliferation.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Kohji Yamamoto, Satoshi Endo
Summary: This study characterized a new AKR, AKR2E8, in silkworms, which showed similar properties to human AKR1B1 and AKR1B10 and was found to play a major role in aldehyde detoxification in the midgut. The findings may aid in developing pest control methods for lepidopterans, such as silkworms, that damage crops.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Multidisciplinary Sciences
Andressa Katiski da Costa Stuart, Jason Lee Furuie, Thais Regiani Cataldi, Rodrigo Makowiecky Stuart, Maria Aparecida Cassilha Zawadneak, Carlos Alberto Labate, Ida Chapaval Pimentel
Summary: The use of microbial consortia in biological control has gained popularity, but little is known about the role of Beauveria bassiana in fungal consortia. This study investigates the metabolomics of a B. bassiana consortium and identifies biomarkers with antioxidant and anti-inflammatory properties. These metabolites suppress the insect's immune system and enhance the fungal virulence of the consortium. The study proposes an action model explaining the mortality of insects due to the metabolites secreted by the consortium.
Review
Microbiology
Haiyang Wang, Hui Peng, Wenjuan Li, Peng Cheng, Maoqing Gong
Summary: Excessive and long-term pesticide use is detrimental to the environment and increases pest resistance. Research and application of environmentally friendly entomopathogenic fungi are gaining momentum as a solution. Beauveria bassiana, in particular, is a widely studied biopesticide that produces toxins to parasitize and kill insect hosts, with promising prospects for future research and genetic engineering strategies for improvement.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Food Science & Technology
Yogita Lugani, Munish Puri, Balwinder Singh Sooch
Summary: Xylose reductase is an industrially important food enzyme that plays a crucial role in converting xylose into xylitol, with diverse applications in various industries.
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
(2021)
Article
Plant Sciences
Silvia Proietti, Gaia Salvatore Falconieri, Laura Bertini, Alberto Pascale, Elisabetta Bizzarri, Julia Morales-Sanfrutos, Eduard Sabido, Michelina Ruocco, Maurilia M. Monti, Assunta Russo, Kinga Dziurka, Marcello Ceci, Francesco Loreto, Carla Caruso
Summary: This study reveals that the interaction between tomato and the beneficial fungus Beauveria bassiana leads to changes in molecular pathways, metabolism, growth and defense hormones, and can effectively prevent necrotrophic infection. These findings are important for understanding the beneficial role of B. bassiana in tomato plants.
JOURNAL OF EXPERIMENTAL BOTANY
(2023)
Article
Green & Sustainable Science & Technology
Mohsen Mohamed Elsharkawy, Fatimah O. Alotibi, Abdulaziz A. Al-Askar, Muhammad Kamran, Said Behiry, Salam S. Alasharari, Fatma H. Galal, Muhammad Adnan, Ahmed Abdelkhalek
Summary: The research reveals that the new strain of Beauveria bassiana has pathogenicity to the larvae of Rhynchophorus ferrugineus, with its effectiveness increasing as the spore concentration rises. The study also found that the infected larvae experienced significant changes in their defensive and detoxifying enzyme activities. The lethal effect of B. bassiana resulted in elevated expressions of specific genes.
Article
Microbiology
Fangyuan Zhou, Yunxiao Gao, Mei Liu, Letian Xu, Xiaoqing Wu, Xiaoyan Zhao, Xinjian Zhang
Summary: This study investigated the response of associated microbiota to a pathogen in Delia antiqua, showing that bacterial microbiota instead of fungal microbiota played a crucial role in inhibiting the pathogen during invasion, stabilizing the associated microbiota. These findings deepen our understanding of the mechanisms maintaining microbiota stability.
FRONTIERS IN MICROBIOLOGY
(2021)
Review
Plant Sciences
Nathaniel M. Westrick, Damon L. Smith, Mehdi Kabbage
Summary: The article discusses how necrotrophic fungi overcome plant defense compounds to achieve successful pathogenesis, including strategies such as enzymatic detoxification and toxin sequestration and efflux. Efficient detoxification of host PDCs is critical for successful infection and often determines pathogen host range.
FRONTIERS IN PLANT SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Mubashir Aziz, Syeda Abida Ejaz, Nissren Tamam, Farhan Siddique
Summary: This study identifies theobromine and theophylline as strong inhibitors of AKR1B1 and AKR1B10, with potential anti-cancer activity against various tumor proteins. The findings contribute to the development and repurposing of AKR1B1/AKR1B10 inhibitors for the treatment of colon cancer and associated malignancies.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2023)
Article
Biochemistry & Molecular Biology
Ronghua Chen, Siwei Wang, Yue Sun, Haiqing Li, Shuqing Wan, Fei Lin, Hanhong Xu
Summary: Genes that participate in the degradation or isolation of glyphosate in plants have the potential to confer herbicide tolerance and low glyphosate residue in crops. The aldo-keto reductase (AKR4) gene in Echinochloa colona (EcAKR4) has been identified as a naturally evolved glyphosate-metabolism enzyme. This study compared the glyphosate-degradation ability of AKR4 proteins from maize, soybean, and rice, revealing that ZmAKR4 had the highest activity and OsAKR4-1 and OsAKR4-2 exhibited the highest activity among the AKR4 family in rice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Entomology
Rostislav Zemek, Jana Konopicka, Eva Jozova, Oxana Skokova Habustova
Summary: The study found that some strains of Beauveria bassiana are highly effective in killing Colorado potato beetle adults, recommending them for the development of a new biopesticide. This research highlights the importance of searching for perspective strains of entomopathogenic fungi among naturally infected hosts.
Article
Biochemistry & Molecular Biology
Kohji Yamamoto, Satoshi Endo
Summary: We studied the effects of green leaf volatiles emitted by plants on insects, focusing on AKR2E9, a potential insect-resistance gene in silkworms. We found that AKR2E9 might regulate the detoxification of toxic aldehydes in the midgut and antennae of silkworms.
ARCHIVES OF INSECT BIOCHEMISTRY AND PHYSIOLOGY
(2022)
Article
Microbiology
Qing Cai, Li Tian, Jia-Tao Xie, Qiu-Ying Huang, Ming-Guang Feng, Nemat O. Keyhani
Summary: The study characterized the histone deacetylase BbSir2 in the fungal insect pathogen Beauveria bassiana, revealing its role in histone deacetylation, asexual development, stress tolerance, and virulence. BbSir2 affects multiple pathways including carbon/nitrogen metabolism and cell cycle control, with critical targets identified as LysM effector proteins and benzoquinone oxidoreductase.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Genetics & Heredity
Zhi Yang, Hongyan Jiang, Xin Zha, Zhuoyue Lu, Zhibing Luo, Xuebing Li, Jing Zhao, Yongjun Zhang
FUNGAL GENETICS AND BIOLOGY
(2017)
Article
Zoology
Zhangjiang He, Xin Zhao, Zhuoyue Lu, Huifang Wang, Pengfei Liu, Fanqin Zeng, Yongjun Zhang
JOURNAL OF INVERTEBRATE PATHOLOGY
(2018)
Article
Microbiology
Xin Zhao, Xingju Yang, Zhuoyue Lu, Huifang Wang, Zhangjiang He, Guangyan Zhou, Zhibing Luo, Yongjun Zhang
ENVIRONMENTAL MICROBIOLOGY
(2019)
Article
Microbiology
Zhangjiang He, Xin Zhao, Yifei Gao, Nemat O. Keyhani, Huifang Wang, Juan Deng, Zhuoyue Lu, Yanze Kan, Zhibing Luo, Yongjun Zhang
ENVIRONMENTAL MICROBIOLOGY
(2020)
Article
Zoology
Zhangjiang He, Yulin Song, Juan Deng, Xin Zhao, Xu Qin, Zhibing Luo, Yongjun Zhang
JOURNAL OF INVERTEBRATE PATHOLOGY
(2020)
Article
Microbiology
Xin Zhao, Tingying Luo, Shuaishuai Huang, Ning Peng, Ying Yin, Zhibing Luo, Yongjun Zhang
Summary: Genomic data have identified a class of fungal specific transcription factors that regulate unique aspects of fungal gene expression. The novel fungal specific transcription factor BbStf1 was characterized in Beauveria bassiana as a negative regulator of antioxidant response, cell wall integrity, and virulence. The disruption of Bbstf1 resulted in increased tolerance to oxidative stress and cell wall perturbation, as well as altered gene expression patterns related to antioxidant enzymes and cell wall integrity-involved genes.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Microbiology
Zhuoyue Lu, Juan Deng, Huifang Wang, Xin Zhao, Zhibing Luo, Chenxi Yu, Yongjun Zhang
Summary: BbLac2 plays a multifunctional role during infection, detoxifying ROS, interfering with host PO activation, and masking pathogen associated molecular patterns to evade insect immune defenses.
ENVIRONMENTAL MICROBIOLOGY
(2021)
Article
Agronomy
Xu Qin, Xin Zhao, Shuaishuai Huang, Juan Deng, Xuebing Li, Zhibing Luo, Yongjun Zhang
Summary: Specific strains of Beauveria bassiana can be introduced as endophytes into host plants, promoting host plant growth, increasing resistance to microbial pathogens, and enhancing resistance to insect pests.
PEST MANAGEMENT SCIENCE
(2021)
Article
Agronomy
Xin Zhao, Yahui Jiang, Huifang Wang, Zhuoyue Lu, Shuaishuai Huang, Zhibing Luo, Liuyi Zhang, Ting Lv, Xiaohan Tang, Yongjun Zhang
Summary: The Fus3/Kss1 mitogen-activated protein kinase (MAPK) pathway and its target transcription factor, Ste12-like, are involved in penetration of host cuticle/pathogenicity in ascomycete pathogens. The interaction between BbSte12 and Bbmpk1 and their controlled virulence-associated traits during fungal infection were investigated. BbSte12 and Bbmpk1 participate in additional pathways for control of conidiation, growth and hyphal differentiation, as well as oxidative stress response besides regulating cuticle penetration via phosphorylation cascade.
PEST MANAGEMENT SCIENCE
(2023)