Pericytes: a double-edged sword in cancer therapy

Bevacizumab for the treatment of high-grade glioma: an update after Phase III trials

(2014) Mustafa Khasraw et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Imatinib disrupts lymphoma angiogenesis by targeting vascular pericytes

(2013) J. Ruan et al.   BLOOD

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

(2013) Rakesh K. Jain   JOURNAL OF CLINICAL ONCOLOGY

Pericyte Depletion Results in Hypoxia-Associated Epithelial-to-Mesenchymal Transition and Metastasis Mediated by Met Signaling Pathway

(2012) Vesselina G. Cooke et al.   CANCER CELL

Therapeutic angiogenesis due to balanced single-vector delivery of VEGF and PDGF-BB

(2012) Andrea Banfi et al.   FASEB JOURNAL

Regorafenib monotherapy for previously treated metastatic colorectal cancer (CORRECT): an international, multicentre, randomised, placebo-controlled, phase 3 trial

(2012) Axel Grothey et al.   LANCET

Pericyte Requirement for Anti-Leak Action of Angiopoietin-1 and Vascular Remodeling in Sustained Inflammation

(2011) Jonas Fuxe et al.   AMERICAN JOURNAL OF PATHOLOGY

Phase II Trials of Imatinib Mesylate and Docetaxel in Patients with Metastatic Non-small Cell Lung Cancer and Head and Neck Squamous Cell Carcinoma

(2011) Anne S. Tsao et al.   Journal of Thoracic Oncology

Targeting FGFR/PDGFR/VEGFR Impairs Tumor Growth, Angiogenesis, and Metastasis by Effects on Tumor Cells, Endothelial Cells, and Pericytes in Pancreatic Cancer

(2011) J. Taeger et al.   MOLECULAR CANCER THERAPEUTICS

Sunitinib Malate for the Treatment of Pancreatic Neuroendocrine Tumors

(2011) Eric Raymond et al.   NEW ENGLAND JOURNAL OF MEDICINE

Complexity of tumor vasculature in clear cell renal cell carcinoma

(2010) Chao-Nan Qian et al.   CANCER

Two is better than one: Benefits of VEGF and PDGF inhibition in ovarian cancer

(2010) Barbara Sennino   CANCER BIOLOGY & THERAPY

Angiopoietin-2 Interferes with Anti-VEGFR2-Induced Vessel Normalization and Survival Benefit in Mice Bearing Gliomas

(2010) S.-S. Chae et al.   CLINICAL CANCER RESEARCH

Doxorubicin Plus Sorafenib vs Doxorubicin Alone in Patients With Advanced Hepatocellular Carcinoma

(2010) Ghassan K. Abou-Alfa et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Continuous Sunitinib Treatment in Patients with Advanced Hepatocellular Carcinoma: A Swiss Group for Clinical Cancer Research (SAKK) and Swiss Association for the Study of the Liver (SASL) Multicenter Phase II Trial (SAKK 77/06)

(2010) D. Koeberle et al.   ONCOLOGIST

Stromal PDGFRβ Expression in Prostate Tumors and Non-Malignant Prostate Tissue Predicts Prostate Cancer Survival

(2010) Christina Hägglöf et al.   PLoS One

Heterogeneity of the Tumor Vasculature

(2010) Janice Nagy et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Prognostic Significance of Stromal Platelet-Derived Growth Factor β-Receptor Expression in Human Breast Cancer

(2009) Janna Paulsson et al.   AMERICAN JOURNAL OF PATHOLOGY

Contrasting Actions of Selective Inhibitors of Angiopoietin-1 and Angiopoietin-2 on the Normalization of Tumor Blood Vessels

(2009) Beverly L. Falcón et al.   AMERICAN JOURNAL OF PATHOLOGY

Platelet-Derived Growth Factor-B Normalizes Micromorphology and Vessel Function in Vascular Endothelial Growth Factor-A-Induced Squamous Cell Carcinomas

(2009) Wiltrud Lederle et al.   AMERICAN JOURNAL OF PATHOLOGY

Host-Derived Angiopoietin-2 Affects Early Stages of Tumor Development and Vessel Maturation but Is Dispensable for Later Stages of Tumor Growth

(2009) Patrick Nasarre et al.   CANCER RESEARCH

Pulmonary Vascular Destabilization in the Premetastatic Phase Facilitates Lung Metastasis

(2009) Y. Huang et al.   CANCER RESEARCH

Phase II, Multicenter, Uncontrolled Trial of Single-Agent Sorafenib in Patients With Relapsed or Refractory, Advanced Non–Small-Cell Lung Cancer

(2009) George R. Blumenschein et al.   JOURNAL OF CLINICAL ONCOLOGY

A New Target for Tumor Therapy

(2009) Rakesh K. Jain   NEW ENGLAND JOURNAL OF MEDICINE

Combined Anti-Angiogenic Therapy Targeting PDGF and VEGF Receptors Lowers the Interstitial Fluid Pressure in a Murine Experimental Carcinoma

(2009) Agnieszka Kłosowska-Wardęga et al.   PLoS One

Vascular Endothelial Growth Factor-A and Platelet-Derived Growth Factor-B Combination Gene Therapy Prolongs Angiogenic Effects via Recruitment of Interstitial Mononuclear Cells and Paracrine Effects Rather Than Improved Pericyte Coverage of Angiogenic Vessels

(2008) Petra Korpisalo et al.   CIRCULATION RESEARCH

Phase II Study of Imatinib in Patients With Recurrent Gliomas of Various Histologies: A European Organisation for Research and Treatment of Cancer Brain Tumor Group Study

(2008) Eric Raymond et al.   JOURNAL OF CLINICAL ONCOLOGY

A role for VEGF as a negative regulator of pericyte function and vessel maturation

(2008) Joshua I. Greenberg et al.   NATURE

Soluble receptor-mediated selective inhibition of VEGFR and PDGFR  signaling during physiologic and tumor angiogenesis

(2008) F. Kuhnert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pericyte coverage decreases invasion of tumour cells into blood vessels in prostate cancer xenografts

(2008) K Welén et al.   PROSTATE CANCER AND PROSTATIC DISEASES

Functions of Paracrine PDGF Signaling in the Proangiogenic Tumor Stroma Revealed by Pharmacological Targeting

(2008) Kristian Pietras et al.   PLOS MEDICINE