Review
Oncology
Guang Lu, Shikai Jin, Suwen Lin, Yuping Gong, Liwen Zhang, Jingwen Yang, Weiwei Mou, Jun Du
Summary: Peripheral T-cell lymphomas (PTCLs) are aggressive malignancies with poor prognoses. Novel targeted agents, such as histone deacetylase inhibitors (HDACis), are being investigated to improve treatment outcomes. HDACis, including romidepsin, belinostat, and chidamide, have shown efficacy and safety in PTCLs. More HDACis and combination therapies are being studied, and mutation analysis may provide insights into targeted therapies.
CLINICAL EPIGENETICS
(2023)
Article
Chemistry, Medicinal
Xing-Jie Zhang, Ming-Hui Liu, Yu-Sha Luo, Gui-Yan Han, Zhi-Qiang Ma, Fei Huang, Yuan Wang, Zhen-Yuan Miao, Wan-Nian Zhang, Chun-Quan Sheng, Jian-Zhong Yao
Summary: The synthesis of novel cytotoxic chlorin-based derivatives as dual photosensitizers and histone deacetylase inhibitors was investigated for biological activity. Compound 15e showed high phototoxicity, induced cell apoptosis in multiple organelles, and could be applied as a potential dual cytotoxic drug for PDT and chemotherapy.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Review
Chemistry, Multidisciplinary
Siddhartha Das Pramanik, Amit Kumar Halder, Ushmita Mukherjee, Dharmendra Kumar, Yadu Nandan Dey, R. Mogana
Summary: This review examines the role of HDACs in cancer treatment. While clinical trials with HDACi as monotherapy have had mixed results, combination therapy with other anticancer drugs has shown synergistic effects, increasing efficacy and decreasing toxicity.
FRONTIERS IN CHEMISTRY
(2022)
Article
Surgery
Ben E. Biesterveld, Ali Z. Siddiqui, Rachel L. O'Connell, Henriette Remmer, Aaron M. Williams, Alizeh Shamshad, William M. Smith, Michael T. Kemp, Glenn K. Wakam, Hasan B. Alam
Summary: Trauma is a leading cause of death among young people, and valproic acid treatment has been shown to improve survival in animal models of lethal trauma and attenuate the degree of acute kidney injury.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Yudibeth Sixto-Lopez, Jose Antonio Gomez-Vidal, Nuria de Pedro, Martiniano Bello, Martha Cecilia Rosales-Hernandez, Jose Correa-Basurto
Summary: HDAC6 has been identified as a molecular target for treating neurodegenerative disorders. Through a combination of computational design, molecular docking, and in vitro testing, a lead compound and a second series of compounds with improved neuroprotective effects were identified. The study highlights the potential of these compounds as HDAC6 inhibitors with neuroprotective properties.
JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS
(2022)
Article
Pharmacology & Pharmacy
Fengkun Lu, Lei Hou, Sizhen Wang, Yingjie Yu, Yunchang Zhang, Linhong Sun, Chen Wang, Zhiqiang Ma, Feng Yang
Summary: Studies have shown that the combination of epigenetic therapy and PD-1/PD-L1 blockade therapy can reverse immune escape, while lysosome activable polymeric vorinostat encapsulating PD-L1KD for the combination therapy of PD-L1-KD and HDACIs is an effective strategy to activate the immune system, inhibit tumor growth, and metastasis.
Review
Oncology
Fengyi Guo, Hongjing Wang
Summary: This review summarizes the classification and mechanisms of action of histone deacetylase and the clinical application of their inhibitors in ovarian cancer. Histone deacetylase inhibitors show promising potential as anti-cancer drugs, and combination therapy with other anticancer drugs for synergistic effects can improve efficacy.
FRONTIERS IN ONCOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Jie Wang, Feng Yun, Jiahui Sui, Wenpeng Liang, Dingding Shen, Qi Zhang
Summary: Epilepsy, a common and severe chronic neurological disorder, has been the subject of extensive research on post-translational modification (PTM) mechanisms, particularly protein acetylation modifications. Histone acetyltransferases (HATs) and histone deacetylases (HDACs) regulate acetylation, with HATs transferring acetyl groups to lysine residues and HDACs removing acetyl groups. Epilepsy is associated with the regulation of gene expression through histone acetylation and deacetylation, as well as the acetylation modification of non-histone substrates. HDAC inhibitors (HDACi) have been developed as potential antiepileptic drugs. This review summarizes the changes in acetylation modification during epileptogenesis, the application of HDACi in epilepsy treatment, and the underlying mechanisms. Further understanding of acetylation regulation will provide insights into the pathological mechanism of epilepsy and novel therapeutic ideas.
Article
Virology
Maria Del Carmen Rodriguez Rodriguez, Ines Garcia Rodriguez, Callum Nattress, Ahad Qureshi, Gunnel Hallden
Summary: This study demonstrates that inhibition of specific HDACs is a potential means to enhance OAd activity, supporting clinical translation.
Review
Cell Biology
Saikat Dewanjee, Jayalakshmi Vallamkondu, Rajkumar Singh Kalra, Pratik Chakraborty, Moumita Gangopadhyay, Ranabir Sahu, Vijaykrishna Medala, Albin John, P. Hemachandra Reddy, Vincenzo De Feo, Ramesh Kandimalla
Summary: Diabetes mellitus is a major manifestation of metabolic syndrome with increasing prevalence. Chronic hyperglycemia can lead to various vascular complications, being the major cause of morbidity and mortality in diabetic patients. Histone deacetylase (HDAC) plays a crucial role in regulating molecular activities in diabetes and could serve as a potential therapeutic target for developing novel intervention strategies.
Review
Biochemistry & Molecular Biology
Long Xu, Xiaoyu Yan, Jian Wang, Yuanxin Zhao, Qingqing Liu, Jiaying Fu, Xinyi Shi, Jing Su
Summary: This article provides an overview of ovarian cancer metastasis and the dysregulated expression of HDACs in ovarian cancer. It discusses the roles of HDACs in the regulation of ovarian cancer metastasis and highlights the importance of developing compounds that target HDACs in the future of ovarian cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Medicine, Research & Experimental
Nasreddine El Omari, Learn-Han Lee, Saad Bakrim, Hafiz A. Makeen, Hassan A. Alhazmi, Syam Mohan, Asaad Khalid, Long Chiau Ming, Abdelhakim Bouyahya
Summary: Romidepsin, a natural molecule produced by Chromobacterium violaceum bacterium, has been approved for its anti-cancer effect. It is a selective histone deacetylase (HDAC) inhibitor that modifies histones and epigenetic pathways. This review aims to highlight the specific molecular mechanisms responsible for HDAC inhibition by romidepsin, which can significantly improve the understanding of cancer cell disorders and pave the way for new therapeutic approaches using targeted therapy.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Oncology
Jinbing Xue, Gang Wu, Umer Ejaz, Fahad Akhtar, Xinyu Wan, Yong Zhu, Aixing Geng, Yadong Chen, Shuying He
Summary: LT-548-133-1 acts as a HDAC inhibitor and interferes with microtubule assembly, leading to cell cycle arrest in G2/M and ultimately apoptosis and proliferation inhibition in MCF-7 cells.
INVESTIGATIONAL NEW DRUGS
(2021)
Review
Biochemistry & Molecular Biology
Nikolaos Garmpis, Christos Damaskos, Anna Garmpi, Afroditi Nonni, Vasiliki E. Georgakopoulou, Efstathios Antoniou, Dimitrios Schizas, Panagiotis Sarantis, Alexandros Patsouras, Athanasios Syllaios, Christos Vallilas, Evangelos Koustas, Konstantinos Kontzoglou, Nikolaos Trakas, Dimitrios Dimitroulis
Summary: Colorectal cancer is a heterogeneous group of gastrointestinal tract tumors, and its pathogenesis involves multiple factors. Histone deacetylases have been found to be over-expressed in CRC and play an important role in its molecular pathophysiology.
CURRENT MEDICINAL CHEMISTRY
(2022)
Article
Genetics & Heredity
Miao Yan, Heng Cao, Kangjia Tao, Bing Xiao, Yifan Chu, Ding Ma, Xiaoyuan Huang, Yingyan Han, Teng Ji
Summary: This study explored the role of histone deacetylases (HDACs) in the tumor immune microenvironment of gynecologic tumors. Elevated HDAC expression was associated with poor prognosis and highly malignant cancer subtypes. Increased HDAC expression was linked to reduced infiltration of immune cells and negative associations with certain gene expression, while treatment with HDAC inhibitor and PD-1 antibody inhibited tumor growth and promoted immune microenvironment activation in a breast cancer model.
Article
Energy & Fuels
R. Reshmy, Vivek Narisetty, Ayon Tarafdar, Neena Bachan, Aravind Madhavan, Archana Tiwari, Preeti Chaturvedi, Sunita Varjani, Ranjna Sirohi, Vinod Kumar, Mukesh Kumar Awasthi, Parameswaran Binod, Joseph Amruthraj Nagoth, Raveendran Sindhu
Summary: The use of agricultural residue and nanomaterials for cellulase immobilization can improve efficiency at higher temperatures and reduce the cost of cellulose-assisted biofuel production. Immobilization techniques using cellulase with amino, chitosan, or polymeric functionalities enhance stability, activity, reusability, inhibition reduction, purification, and selectivity during enzymatic hydrolysis.
BIOENERGY RESEARCH
(2023)
Article
Energy & Fuels
Prangya Ranjan Rout, Mukesh Goel, Anee Mohanty, Daya Shankar Pandey, Nirmalya Halder, Sanjay Mukherjee, Shashi Kant Bhatia, Naresh Kumar Sahoo, Sunita Varjani
Summary: This review highlights the valorisation of wastewater during hydrothermal liquefaction (HTL) of biomass, focusing on the role of microalgae in wastewater utilization. The study findings suggest that the selection of appropriate technology is dependent on the characteristics of the microalgae. Recommendations for potential research opportunities are provided to improve the viability of HTL wastewater valorisation.
BIOENERGY RESEARCH
(2023)
Article
Energy & Fuels
Ankesh Ahirwar, Mohd Jahir Khan, Vandana Sirotiya, Megha Mourya, Anshuman Rai, Benoit Schoefs, Justine Marchand, Sunita Varjani, Vandana Vinayak
Summary: Haematococcus pluvialis is a potential source of natural astaxanthin with remarkable antioxidant properties. The high cost of extracting this pigment makes the cost of astaxanthin very high. Pulsed electric field (PEF) has been found to be a simple yet sensitive technique to permeabilize the thick cell wall of H. pluvialis and extract the pigment.
BIOENERGY RESEARCH
(2023)
Article
Food Science & Technology
Poonam Sharma, Khwaja Osama, Vivek Kumar Gaur, Alvina Farooqui, Sunita Varjani, Kaiser Younis
Summary: This study optimized the extraction of pectin from a novel source using ultrasound-assisted extraction and a five-factorial central composite design. The optimized conditions resulted in a yield of 35.58%. The extracted pectin can substitute up to 30% butter in cookies without altering sensory and physicochemical properties.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Article
Energy & Fuels
Monika Yadav, Venkatesh Balan, Sunita Varjani, Vinay Kumar Tyagi, Gaurav Chaudhary, Nidhi Pareek, Vivekanand Vivekanand
Summary: Converting biogenic waste to biogas through anaerobic digestion is a sustainable and environmentally friendly way of fuel production. Pretreatment methods are essential to overcome the recalcitrance of biomass and increase enzymatic efficiency. Biological pretreatment is desirable but longer duration needs to be addressed.
BIOENERGY RESEARCH
(2023)
Article
Food Science & Technology
Poonam Sharma, Khwaja Osama, Sunita Varjani, Alvina Farooqui, Kaiser Younis
Summary: Machine learning techniques were used to evaluate the effects of process parameters on pectin yield from Citrus limetta peel. The optimized conditions of microwave power, pH, and microwave time were determined as 600 W, 1, and 180 s respectively. Physicochemical analysis confirmed that the extracted pectin could be used as a food additive. Extracting pectin from Citrus limetta peel using microwave-assisted extraction (MAE) is an eco-friendly and efficient approach to transform waste into a versatile food additive.
JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE
(2023)
Review
Environmental Sciences
Swayansu Sabyasachi Mohanty, Shaili Vyas, Yamini Koul, Priya Prajapati, Sunita Varjani, Jo-Shu Chang, Muhammad Bilal, Konstantinos Moustakas, Pau Loke Show, Meththika Vithanage
Summary: Landfilling is the most commonly used method for disposing of municipal solid waste globally, but it leads to the formation of toxic leachate. This study aims to investigate the emerging concerns related to landfill leachate and the long-term priorities of stakeholders in implementing solutions to reduce its harmful effects. New effective and integrated leachate treatments have been developed due to the ineffectiveness of traditional methods and the emergence of new contaminants and regulations.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
Article
Environmental Sciences
Anwar Khursheed, Faris Mohammad A. Munshi, Abdulaziz Ibrahim Almohana, Abdulrhman Fahmi Alali, Mohab Amin Kamal, Shamshad Alam, Omar Alrehaili, Dar Tafazul Islam, Manish Kumar, Sunita Varjani, A. A. Kazmi, Vinay Kumar Tyagi
Summary: The reappearance of assimilated nitrogen and phosphorus in any biological process is a challenge to nutrient removal. A novel reactor configuration combining an anaerobic reactor and Anaerobic-Anoxic-Aerobic (A2O) SBR was tested for enhanced sludge and phosphorus removal. The reactor operated at low SRT for phosphorus assimilative uptake and resulted in a significant increase in phosphorus enrichment. However, the sludge reduction also occurred during the process. The success of the configuration lies in reconciling conflicting parameters of enhanced phosphorus uptake and sludge growth.
Review
Environmental Sciences
Aniket Naha, Sherly Antony, Soumitra Nath, Dhrubjyoti Sharma, Anamika Mishra, Devika T. Biju, Aravind Madhavan, Parameswaran Binod, Sunita Varjani, Raveendran Sindhu
Summary: Wastewater management is a growing concern for environmentalists globally, as the indiscriminate release of various wastes contributes significantly to water pollution. The development of reliable and sustainable technologies for fresh water supply is crucial, and synthetic biology offers promising solutions for refining existing wastewater treatment methods and designing novel ones.
ENVIRONMENTAL POLLUTION
(2023)
Review
Environmental Sciences
M. K. Manu, Liwen Luo, Reeti Kumar, Davidraj Johnravindar, Dongyi Li, Sunita Varjani, Jun Zhao, Jonathan Wong
Summary: Anaerobic digestion (AD) is a promising technology for diverting organic waste and producing clean energy. However, it is susceptible to external factors such as microplastic and chemical pollutants. This review assesses the impact of microplastic pollution on the AD process, including the pathways of microplastic entry, the effects of different types and concentrations of microplastics, and the risks to microbial communities and antibiotic resistance genes.
ENVIRONMENTAL POLLUTION
(2023)
Editorial Material
Environmental Sciences
Avelino Nunez-Delgado, Sunita Varjani, Yaoyu Zhou, Victoria Lopez-Ramon, Zhien Zhang, Manuel Sanchez-Polo, Marco Race
Summary: This article discusses the relationship between soil science and environmental research, as well as their importance in environmental protection. The editors invited researchers to submit high-quality manuscripts, receiving 171 submissions, with 27% accepted after peer-review. The editors believe that the papers included in this issue have scientific value and contribute to the field.
ENVIRONMENTAL RESEARCH
(2023)
Article
Environmental Sciences
Uttpal Anand, Tarun Pal, Alessandra Zanoletti, Suresh Sundaramurthy, Sunita Varjani, Anushka Upamali Rajapaksha, Damia Barcelo, Elza Bontempi
Summary: The World Health Organization (WHO) identified the variant B.1.1.529 of SARS-CoV-2 as a variant of concern, named Omicron, due to its multiple mutations that enhance its ability to spread globally and evade immunity, posing serious threats to public health.
ENVIRONMENTAL RESEARCH
(2023)
Editorial Material
Nanoscience & Nanotechnology
Pau-Loke Show, Kit Wayne Chew, Wee -Jun Ong, Sunita Varjani, Joon Ching Juan
BEILSTEIN JOURNAL OF NANOTECHNOLOGY
(2023)
Review
Green & Sustainable Science & Technology
Wangliang Li, Rohit Gupta, Zhikai Zhang, Lixia Cao, Yanqing Li, Pau Loke Show, Sunil Kumar, Vijaya Kumar Gupta, Kun-Yi Andrew Lin, Sunita Varjani, Stephanie Connelly, Siming You
Summary: High-solid anaerobic digestion (HSAD) is an effective method for disposing of organic waste and mitigating climate change through bioenergy recovery. However, HSAD faces challenges such as low biogas and methane yields, slow reaction rates, and inhibition due to mixing limitations. This article critically reviews recent progress in HSAD, focusing on transport phenomena and process modeling. It discusses hydrodynamic phenomena, biokinetic mechanisms, reactor simulations, advanced reactor designs, industrial applications, and key parameters for sustained HSAD operation. Further research on novel materials and the development of a generic simulation tool are needed for improving HSAD efficiency and scalability.
RENEWABLE & SUSTAINABLE ENERGY REVIEWS
(2023)
Article
Environmental Sciences
Shaili Vyas, Kusum Dhakar, Sunita Varjani, Reeta Rani Singhania, Preeti Chaturvedi Bhargava, Raveendran Sindhu, Parameswaran Binod, Jonathan W. C. Wong, Xuan-Thanh Bui
Summary: Many factors are involved in solid waste management, and recently, artificial intelligence techniques have gained attention as computational methods for solving these problems. This review aims to guide researchers in the field of solid waste management on the use of artificial intelligence, covering AI models, their benefits and drawbacks, effectiveness, and applications. The review discusses various AI technologies and their comparison with non-AI methodologies. It also explores the application of AI in different disciplines of solid waste management. The article concludes with the progress, challenges, and perspectives in implementing AI-based solid waste management.
SCIENCE OF THE TOTAL ENVIRONMENT
(2023)
