Article
Biochemistry & Molecular Biology
Yaopeng Zhao, Jixia Wang, Tao Hou, Yancheng Yu, Han Zhou, Yang Han, Junxiang Cheng, Yanfang Liu, Chaoran Wang, Long Chen, Xinmiao Liang
Summary: A series of 2-(2,2-diarylethyl)-cyclamine derivatives were designed and synthesized as M3 mAChR antagonists, showing excellent selectivity and antagonistic activity. These novel compounds have the potential to be candidates for COPD drug development.
BIOORGANIC CHEMISTRY
(2023)
Review
Chemistry, Medicinal
Edouard Montigne, David Balayssac
Summary: This scoping review provides an overview of studies on peripheral neuropathic pain (PNP) in rodent models, exploring compounds targeting cholinergic neurotransmission. The results highlight the potential of cholinergic compounds for the management of neuropathic pain, emphasizing the need for clinical trials.
Review
Rheumatology
Vinicius Viana Abreu Montanaro, Julian Solis-Garcia del Pozo, Thiago Falcao Hora, Beatriz H. Leon, Carlos de Cabo, Javier Solera
Summary: Satoyoshi syndrome, a rare multisystem disease, is believed to have an autoimmune etiology. A systematic review of the available evidence supports this autoimmune hypothesis and reveals an association with other autoimmune diseases and various autoantibodies. Most patients showed improvement after treatment with corticosteroids, immunosuppressants, and immunoglobulins. These findings help advance our understanding of Satoyoshi syndrome by emphasizing the importance of further studies on the determination of autoantibodies in all patients.
Article
Multidisciplinary Sciences
Mihoko Kato, Irina Kolotuev, Alexandre Cunha, Shahla Gharib, Paul W. Sternberg
Summary: This study reveals the function of muscarinic receptor GAR-3 in epithelial cell migration in C. elegans, including receiving signals from cholinergic neurons, affecting migratory path, and determining migration direction. The experimental results suggest that the regulation of GAR-3 receptor in LC is accomplished by specific downstream signaling pathways, and there is a clear correlation between GAR-3 receptor activation level and LC migration direction.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Immunology
Akaluck Thatayatikom, Inyoung Jun, Indraneel Bhattacharyya, Kathleen Berg, Yun Jong Lee, Yoosik Kim, Abi Adewumi, Weizhou Zhang, Sthorn Thatayatikom, Ankit Shah, Casey Beal, Renee Modica, Melissa E. Elder, Seunghee Cha
Summary: The study aimed to evaluate the clinical validity of early Sjogren's syndrome autoantibodies for juvenile SS. Results showed that early SS autoantibodies had lower sensitivity and specificity, and could not effectively differentiate between JSS and non-JSS.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Gastroenterology & Hepatology
Yoko Igarashi-Hisayoshi, Eikichi Ihara, Xiaopeng Bai, Chika Higashi, Hiroko Ikeda, Yoshimasa Tanaka, Mayumi Hirano, Haruei Ogino, Takatoshi Chinen, Yasushi Taguchi, Yoshihiro Ogawa
Summary: This study investigated the region-specific role of the M-3 receptor in gastrointestinal motility using a novel positive allosteric modulator (PAM-369). The results showed that PAM-369 selectively potentiated the M-3 receptor without agonistic or antagonistic activity and increased small intestinal transit in mice. However, it had no effect on colonic transit. This study provides the first direct evidence of the different functional roles of the M-3 receptor between the small intestine and colon.
DIGESTIVE DISEASES AND SCIENCES
(2023)
Article
Rheumatology
M. Mona, S. Mondello, J. Y. Hyon, W. Saleh, K. Han, H-J Lee, Y-J Ha, E. H. Kang, Y. J. Lee, S. Cha
Summary: Anti-M3R has high specificity and sensitivity in Sjogren's syndrome, assisting in diagnosis and correlating with clinical manifestations.
CLINICAL AND EXPERIMENTAL RHEUMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Ujjwala Karmacharya, Prakash Chaudhary, Dongchul Lim, Sadan Dahal, Bhuwan Prasad Awasthi, Hee Dong Park, Jung-Ae Kim, Byeong-Seon Jeong
Summary: A new anticancer compound was discovered through structural modification of a parent compound, showing better activity against androgen-refractory cancer cells and being identified as a ligand to M3 muscarinic acetylcholine receptor. This compound demonstrated significant inhibition of carbachol-induced proliferation and NOX activity on cancer cells, suggesting its potential as a milestone in developing anti-cancer drugs against androgen-refractory prostate cancer.
BIOORGANIC CHEMISTRY
(2021)
Article
Biotechnology & Applied Microbiology
Wei Yang, Lijuan He
Summary: Hederagenin (HE) plays a protective role in inhibiting cell proliferation and improving fibrosis. The study reveals that HE protects against renal fibrosis by targeting the Muscarinic acetylcholine receptor M3.
Article
Rheumatology
Hiroyuki Nakamura, Tsutomu Tanaka, Thomas Pranzatelli, Youngmi Ji, Hongen Yin, Paola Perez, Sandra A. Afione, Shyh-Ing Jang, Corrine Goldsmith, Chang Yu Zheng, William D. Swaim, Blake M. Warner, Noriyuki Hirata, Masayuki Noguchi, Tatsuya Atsumi, John A. Chiorini
Summary: The study demonstrates that altering lysosome activity through the expression of LAMP3 in salivary gland epithelial cells can initiate an autoimmune response similar to SS, resulting in the production of autoantibodies and salivary dysfunction.
ANNALS OF THE RHEUMATIC DISEASES
(2021)
Article
Multidisciplinary Sciences
Miriam Scarpa, Colin Molloy, Laura Jenkins, Bethany Strellis, Rebecca F. Budgett, Sarah Hesse, Louis Dwomoh, Sara Marsango, Gonzalo S. Tejeda, Mario Rossi, Zeshan Ahmed, Graeme Milligan, Brian D. Hudson, Andrew B. Tobin, Sophie J. Bradley
Summary: Current treatments for neurodegenerative diseases like Alzheimer's disease have shown limited effectiveness, but activating the M1 receptor could potentially restore memory and slow disease progression. Recent research suggests that minimizing adverse reactions associated with M1 receptor activation can be achieved by ensuring proper phosphorylation and arrestin-dependent signaling. This approach shows promise for developing next-generation M1 receptor ligands with reduced side effects and improved neuroprotection.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Rheumatology
Gudny Ella Thorlacius, Lina Hultin-Rosenberg, Johanna K. Sandling, Matteo Bianchi, Juliana Imgenberg-Kreuz, Pascal Pucholt, Elke Theander, Marika Kvarnstrom, Helena Forsblad-d'Elia, Sara Magnusson Bucher, Katrine B. Norheim, Svein Joar Auglaend Johnsen, Daniel Hammenfors, Kathrine Skarstein, Malin V. Jonsson, Eva Baecklund, Lara A. Aqrawi, Janicke Liaaen Jensen, Oyvind Palm, Andrew P. Morris, Jennifer R. S. Meadows, Solbritt Rantapaa-Dahlqvist, Thomas Mandl, Per Eriksson, Lars Lind, Roald Omdal, Roland Jonsson, Kerstin Lindblad-Toh, Lars Ronnblom, Marie Wahren-Herlenius, Gunnel Nordmark
Summary: The clinical presentation of primary Sjogren's syndrome (pSS) varies widely. A multicentre study identified two patient subgroups based on the presence of SSA/SSB antibodies and genetic markers in the HLA region, with strong association signals found in HLA-DQA1 locus for the antibody-positive subgroup. Replication confirmed the association with MHC class I and II variants, indicating distinct clinical manifestations in pSS subgroups.
Article
Biochemistry & Molecular Biology
Haiying Zhang, Yanan Gao, Bin Liu, Haobin Jin, Li Fan, Xirui Yang, Qiang Gao, Yi Yu, Yueping Guo, Yan Liu
Summary: This study reveals the crucial role of M3R in reversing liver injury through the regulation of the Sp1/Gm2199/miR-212/ERK axis, which affects hepatocyte proliferation.
ACTA BIOCHIMICA ET BIOPHYSICA SINICA
(2022)
Article
Immunology
Yoko Sunami, Keizo Sugaya, Natsuki Miyakoshi, Osamu Iwazaki, Kazushi Takahashi
Summary: This study analyzed the autoimmune etiology of POTS in 24 patients, finding a significant association between persistent gastrointestinal symptoms and serum levels of anti-muscarinic acetylcholine receptor antibodies. However, no significant association was found between clinical features and autoantibodies against adrenergic receptors, angiotensin receptor 1, or endothelin receptor A. The results suggest that anti-mAChR antibodies may play an important role in a subgroup of POTS patients with persistent gastrointestinal symptoms.
IMMUNOLOGIC RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Aytan Musayeva, Subao Jiang, Yue Ruan, Jenia Kouchek Zadeh, Panagiotis Chronopoulos, Norbert Pfeiffer, Werner E. G. Mueller, Maximilian Ackermann, Ning Xia, Huige Li, Adrian Gericke
Summary: The study suggests that the M-3 receptor subtype plays a pivotal role in tear production, and its absence leads to ocular surface changes typical for dry eye disease (DED) at an advanced age. M3R(-/-) mice showed reduced tear volume, mild corneal epitheliopathy, decreased conjunctival goblet cell density, increased oxidative stress, and elevated mRNA expression levels for inflammatory cytokines and prooxidant redox enzymes at the age of 15 months.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
