Chemical synthesis, characterisation and in vitro and in vivo metabolism of the synthetic opioid MT-45 and its newly identified fluorinated analogue 2F-MT-45 with metabolite confirmation in urine samples from known drug users

Pharmacological characterization of novel synthetic opioids (NSO) found in the recreational drug marketplace

(2018) Michael H. Baumann et al.   NEUROPHARMACOLOGY

Looking at flubromazolam metabolism from four different angles: Metabolite profiling in human liver microsomes, human hepatocytes, mice and authentic human urine samples with liquid chromatography high-resolution mass spectrometry

(2017) Ariane Wohlfarth et al.   FORENSIC SCIENCE INTERNATIONAL

Two fatalities associated with synthetic opioids: AH-7921 and MT-45

(2017) Helena Fels et al.   FORENSIC SCIENCE INTERNATIONAL

Misuse of Novel Synthetic Opioids

(2017) Matthew P. Prekupec et al.   Journal of Addiction Medicine

Identification of MT-45 Metabolites: In Silico Prediction, In Vitro Incubation with Rat Hepatocytes and In Vivo Confirmation

(2017) Camilla Montesano et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Use of LC-HRMS in full scan-XIC mode for multi-analyte urine drug testing - a step towards a ‘black-box’ solution?

(2017) N. N. Stephanson et al.   JOURNAL OF MASS SPECTROMETRY

Pooled human liver preparations, HepaRG, or HepG2 cell lines for metabolism studies of new psychoactive substances? A study using MDMA, MDBD, butylone, MDPPP, MDPV, MDPB, 5-MAPB, and 5-API as examples

(2017) Lilian H.J. Richter et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

New psychoactive substances: Studies on the metabolism of XLR-11, AB-PINACA, FUB-PB-22, 4-methoxy-α-PVP, 25-I-NBOMe, and meclonazepam using human liver preparations in comparison to primary human hepatocytes, and human urine

(2017) Lilian H.J. Richter et al.   TOXICOLOGY LETTERS

An Expanding World of Novel Psychoactive Substances: Opioids

(2017) Jolanta B. Zawilska   Frontiers in Psychiatry

Guilty by dissociation—development of gas chromatography–mass spectrometry (GC-MS) and other rapid screening methods for the analysis of 13 diphenidine-derived new psychoactive substances (NPSs)

(2016) Pierre M. Geyer et al.   ANALYTICAL AND BIOANALYTICAL CHEMISTRY

Acute skin and hair symptoms followed by severe, delayed eye complications in subjects using the synthetic opioid MT-45

(2016) A. Helander et al.   BRITISH JOURNAL OF DERMATOLOGY

Analysis of MT-45, a Novel Synthetic Opioid, in Human Whole Blood by LC–MS-MS and Its Identification in a Drug-Related Death

(2016) Donna Papsun et al.   JOURNAL OF ANALYTICAL TOXICOLOGY

Understanding the availability, prevalence of use, desired effects, acute toxicity and dependence potential of the novel opioid MT-45

(2014) Sindhu Siddiqi et al.   CLINICAL TOXICOLOGY

MT-45, a new psychoactive substance associated with hearing loss and unconsciousness

(2014) A. Helander et al.   CLINICAL TOXICOLOGY

Identification of two new-type designer drugs, piperazine derivative MT-45 (I-C6) and synthetic peptide Noopept (GVS-111), with synthetic cannabinoid A-834735, cathinone derivative 4-methoxy-α-PVP, and phenethylamine derivative 4-methylbuphedrine from illegal products

(2013) Nahoko Uchiyama et al.   Forensic Toxicology

Identification of novel psychoactive drug use in Sweden based on laboratory analysis – initial experiences from the STRIDA project

(2013) Anders Helander et al.   SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION