SecA: a potential antimicrobial target

Design, syntheses and evaluation of 4-oxo-5-cyano thiouracils as SecA inhibitors

(2015) Arpana S. Chaudhary et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Mechanisms of Rose Bengal inhibition on SecA ATPase and ion channel activities

(2014) Ying-Hsin Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reconstitution of functionally efficient SecA-dependent protein-conducting channels: Transformation of low-affinity SecA-liposome channels to high-affinity SecA-SecYEG-SecDF·YajC channels

(2013) Ying-hsin Hsieh et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Selective transport by SecA2: An expanding family of customized motor proteins

(2013) Barbara A. Bensing et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Design, Synthesis and Biological Evaluation of Rose Bengal Analogues as SecA Inhibitors

(2013) Jianmei Cui et al.   ChemMedChem

ADP-dependent Conformational Changes DistinguishMycobacterium tuberculosisSecA2 from SecA1

(2013) Nadia G. D'Lima et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phospholipids Induce Conformational Changes of SecA to Form Membrane-Specific Domains: AFM Structures and Implication on Protein-Conducting Channels

(2013) Zhipeng You et al.   PLoS One

Fluorescein Analogues Inhibit SecA ATPase: The First Sub-micromolar Inhibitor of Bacterial Protein Translocation

(2012) Ying-Ju Huang et al.   ChemMedChem

The bacterial Sec-translocase: structure and mechanism

(2012) J. A. Lycklama a Nijeholt et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors

(2011) Kenneth Segers et al.   ANALYTICAL BIOCHEMISTRY

Discovery of novel SecA inhibitors of Candidatus Liberibacter asiaticus by structure based design

(2011) Nagaraju Akula et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

SecA, a remarkable nanomachine

(2011) Ilja Kusters et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Traffic Jam at the Bacterial Sec Translocase: Targeting the SecA Nanomotor by Small-Molecule Inhibitors

(2011) Kenneth Segers et al.   CHEMISTRY & BIOLOGY

SecA Alone Can Promote Protein Translocation and Ion Channel Activity

(2011) Ying-hsin Hsieh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Clostridium difficileHas Two Parallel and Essential Sec Secretion Systems

(2011) Robert P. Fagan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dimeric SecA Couples the Preprotein Translocation in an Asymmetric Manner

(2011) Ying Tang et al.   PLoS One

Quaternary Structure of SecA in Solution and Bound to SecYEG Probed at the Single Molecule Level

(2011) Ilja Kusters et al.   STRUCTURE

In VitroActivities of Arylomycin Natural-Product Antibiotics againstStaphylococcus epidermidisand Other Coagulase-Negative Staphylococci

(2010) Peter A. Smith et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Divergent stalling sequences sense and control cellular physiology

(2010) Koreaki Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The first low μM SecA inhibitors

(2010) Weixuan Chen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors

(2010) Mi-Yeon Jang et al.   BIOORGANIC & MEDICINAL CHEMISTRY

SnapShot: Key Numbers in Biology

(2010) Uri Moran et al.   CELL

Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination

(2010) F. Perez et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Orientation of SecA and SecB in Complex, Derived from Disulfide Cross-Linking

(2010) Y. Suo et al.   JOURNAL OF BACTERIOLOGY

Daptomycin, a Bacterial Lipopeptide Synthesized by a Nonribosomal Machinery

(2010) Lars Robbel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Electron microscopic visualization of asymmetric precursor translocation intermediates: SecA functions as a dimer

(2010) Ying Tang et al.   Science China-Life Sciences

Characterization of Streptococcus gordonii SecA2 as a Paralogue of SecA

(2009) B. A. Bensing et al.   JOURNAL OF BACTERIOLOGY

Conformational Flexibility and Peptide Interaction of the Translocation ATPase SecA

(2009) Jochen Zimmer et al.   JOURNAL OF MOLECULAR BIOLOGY

Signal peptides are allosteric activators of the protein translocase

(2009) Giorgos Gouridis et al.   NATURE

Energy transduction in protein transport and the ATP hydrolytic cycle of SecA

(2009) A. Robson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Corynebacterium glutamicum possesses two secA homologous genes that are essential for viability

(2008) Michael Caspers et al.   ARCHIVES OF MICROBIOLOGY

Discovery of the first SecA inhibitors using structure-based virtual screening

(2008) Minyong Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Pandrug Resistance (PDR), Extensive Drug Resistance (XDR), and Multidrug Resistance (MDR) among Gram‐Negative Bacilli: Need for International Harmonization in Terminology

(2008) Matthew E. Falagas et al.   CLINICAL INFECTIOUS DISEASES

Maximal Efficiency of Coupling between ATP Hydrolysis and Translocation of Polypeptides Mediated by SecB Requires Two Protomers of SecA

(2008) Chunfeng Mao et al.   JOURNAL OF BACTERIOLOGY

Characterization of the Accessory Sec System of Staphylococcus aureus

(2008) I. R. Siboo et al.   JOURNAL OF BACTERIOLOGY

ATPase Activity of Mycobacterium tuberculosis SecA1 and SecA2 Proteins and Its Importance for SecA2 Function in Macrophages

(2008) J. M. Hou et al.   JOURNAL OF BACTERIOLOGY

Full-lengthEscherichia coliSecA Dimerizes in a Closed Conformation in Solution as Determined by Cryo-electron Microscopy

(2008) Yong Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the Isolated SecA DEAD Motor Suggests a Mechanism for Chemical–Mechanical Coupling

(2008) Stanley Nithianantham et al.   JOURNAL OF MOLECULAR BIOLOGY

SecA, the Motor of the Secretion Machine, Binds Diverse Partners on One Interactive Surface

(2008) Dylan B. Cooper et al.   JOURNAL OF MOLECULAR BIOLOGY

Antisense-Guided Isolation and Structure Elucidation of Pannomycin, a Substitutedcis-Decalin fromGeomyces pannorum

(2008) Craig A. Parish et al.   JOURNAL OF NATURAL PRODUCTS

A new twist on an old pathway – accessory secretion systems

(2008) Nathan W. Rigel et al.   MOLECULAR MICROBIOLOGY

Structure of a complex of the ATPase SecA and the protein-translocation channel

(2008) Jochen Zimmer et al.   NATURE

The Bacteria Fight Back

(2008) G. Taubes   SCIENCE

Protein Translocation Across the Bacterial Cytoplasmic Membrane

(2007) Arnold J.M. Driessen et al.   Annual Review of Biochemistry