Toward organometallic antischistosomal drug candidates

Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis

(2014) Mathew Njoroge et al.   CHEMICAL REVIEWS

Human schistosomiasis

(2014) Daniel G Colley et al.   LANCET

Synthesis and Biological Evaluation of Organoruthenium Complexes with Azole Antifungal Agents. First Crystal Structure of a Tioconazole Metal Complex

(2014) Jakob Kljun et al.   ORGANOMETALLICS

In vitro and in vivo antischistosomal activity of ferroquine derivatives

(2014) Jennifer Keiser et al.   Parasites & Vectors

The Global Burden of Disease Study 2010: Interpretation and Implications for the Neglected Tropical Diseases

(2014) Peter J. Hotez et al.   PLoS Neglected Tropical Diseases

Schistosomiasis Chemotherapy

(2013) Sophie A.-L. Thétiot-Laurent et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Metalloantimalarials

(2013) Paloma F. Salas et al.   CHEMICAL REVIEWS

[(η6-Praziquantel)Cr(CO)3] Derivatives with Remarkable In Vitro Anti-schistosomal Activity

(2013) Malay Patra et al.   CHEMISTRY-A EUROPEAN JOURNAL

DMSO-Mediated Ligand Dissociation: Renaissance for Biological Activity ofN-Heterocyclic-[Ru(η6-arene)Cl2] Drug Candidates

(2013) Malay Patra et al.   CHEMISTRY-A EUROPEAN JOURNAL

Metal–drug synergy: new ruthenium(II) complexes of ketoconazole are highly active against Leishmania major and Trypanosoma cruzi and nontoxic to human or murine normal cells

(2013) Eva Iniguez et al.   JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY

In Vitro Metabolic Profile and in Vivo Antischistosomal Activity Studies of (η6-Praziquantel)Cr(CO)3 Derivatives

(2013) Malay Patra et al.   JOURNAL OF MEDICINAL CHEMISTRY

New approaches for understanding mechanisms of drug resistance in schistosomes

(2013) ROBERT M. GREENBERG   PARASITOLOGY

The drug and vaccine landscape for neglected diseases (2000–11): a systematic assessment

(2013) Belen Pedrique et al.   Lancet Global Health

Time to set the agenda for schistosomiasis elimination

(2012) David Rollinson et al.   ACTA TROPICA

Organometallic Compounds: An Opportunity for Chemical Biology?

(2012) Malay Patra et al.   CHEMBIOCHEM

The potential of organometallic complexes in medicinal chemistry

(2012) Gilles Gasser et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small organometallic compounds as antibacterial agents

(2012) Malay Patra et al.   DALTON TRANSACTIONS

Schistosomiasis

(2012) Bruno Gryseels   INFECTIOUS DISEASE CLINICS OF NORTH AMERICA

Searching for New Chemotherapies for Tropical Diseases: Ruthenium–Clotrimazole Complexes Display High in Vitro Activity against Leishmania major and Trypanosoma cruzi and Low Toxicity toward Normal Mammalian Cells

(2012) Alberto Martínez et al.   JOURNAL OF MEDICINAL CHEMISTRY

Ferrocenyl Derivatives of the Anthelmintic Praziquantel: Design, Synthesis, and Biological Evaluation

(2012) Malay Patra et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bioorganometallic Compounds with Antimalarial Targets: Inhibiting Hemozoin Formation

(2012) Maribel Navarro et al.   ORGANOMETALLICS

Challenges and Opportunities in the Development of Organometallic Anticancer Drugs

(2012) Christian G. Hartinger et al.   ORGANOMETALLICS

Metal-based anti-diabetic drugs: advances and challenges

(2011) Aviva Levina et al.   DALTON TRANSACTIONS

Efficacy of praziquantel and artemisinin derivatives for the treatment and prevention of human schistosomiasis: a systematic review and meta-analysis

(2011) Rong Liu et al.   Parasites & Vectors

Resolution of Praziquantel

(2011) Michael Woelfle et al.   PLoS Neglected Tropical Diseases

Praziquantel analogs with activity against juvenile Schistosoma mansoni

(2010) Yuxiang Dong et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Metabolite Profiling of Praziquantel and its Analogs During the Analysis of in vitro Metabolic Stability Using Information-Dependent Acquisition on a Hybrid Triple Quadrupole Linear Ion Trap Mass Spectrometer

(2010) Jiangeng Huang et al.   Drug Metabolism and Pharmacokinetics

Organometallic Anticancer Compounds

(2010) Gilles Gasser et al.   JOURNAL OF MEDICINAL CHEMISTRY

Enantioselective analysis of praziquantel and trans-4-hydroxypraziquantel in human plasma by chiral LC–MS/MS: Application to pharmacokinetics

(2009) Renata Monteiro Lima et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

(2009) Sandra D. Melman et al.   PLoS Neglected Tropical Diseases

Mefloquine—An Aminoalcohol with Promising Antischistosomal Properties in Mice

(2009) Jennifer Keiser et al.   PLoS Neglected Tropical Diseases

Drug Discovery for Schistosomiasis: Hit and Lead Compounds Identified in a Library of Known Drugs by Medium-Throughput Phenotypic Screening

(2009) Maha-Hamadien Abdulla et al.   PLoS Neglected Tropical Diseases

Bioorganometallic chemistry—from teaching paradigms to medicinal applications

(2008) Christian G. Hartinger et al.   CHEMICAL SOCIETY REVIEWS

Medicinal Organometallic Chemistry: Designing Metal Arene Complexes as Anticancer Agents

(2008) Anna F. A. Peacock et al.   Chemistry-An Asian Journal

New trends for metal complexes with anticancer activity

(2008) Pieter CA Bruijnincx et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Praziquantel: mechanisms of action, resistance and new derivatives for schistosomiasis

(2008) Michael J Doenhoff et al.   CURRENT OPINION IN INFECTIOUS DISEASES

Helminth infections: the great neglected tropical diseases

(2008) Peter J. Hotez et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferrocene Conjugates of Chloroquine and other Antimalarials: the Development of Ferroquine, a New Antimalarial

(2007) Daniel Dive et al.   ChemMedChem

Synthesis of “Trioxaquantel”® Derivatives as Potential New Antischistosomal Drugs

(2007) Sophie A.-L. Laurent et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY