Journal
FITOTERAPIA
Volume 128, Issue -, Pages 79-85Publisher
ELSEVIER
DOI: 10.1016/j.fitote.2018.05.006
Keywords
Phyllanthus glaucus; Cleistanthane diterpenoids; Bergenin; Anti-inflammation
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Funding
- Program for Changjiang Scholars of Ministry of Education of the Peoples Republic of China [T2016088]
- National natural Science Foundation for Distinguished Young Scholars [81725021]
- Innovative Research Groups of the National Natural Science Foundation of China [81721005]
- Academic Frontier Youth Team of HUST
- Integrated Innovative Team for Major Human Diseases Program of Tongji Medical College (HUST)
- Natural Science Foundation of Hubei Province of China [2015CFB638]
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Three new cleistanthane diterpenoids, phyllanglins A-C (1-3), a new natural product, 4-acetyl-bergenin (4), and three known compounds (5-7) were isolated from the roots of Phyllanthus glaucus. Their structures were elucidated by extensive spectroscopic data analyses and single-crystal X-ray diffraction. Phyllanglins A-C were unusual cleistanthane diterpenoids with phenylacetylene moieties, and a plausible biogenetic pathway was proposed to discuss the origins of them. All of the isolates were evaluated for their anti-inflammatory activities.
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