Journal
FITOTERAPIA
Volume 127, Issue -, Pages 96-100Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.02.001
Keywords
Alkaloids; Xylopia vielana; Antiinflammatory activities
Categories
Funding
- Professor of Chang Jiang Scholars Program
- NSFC [81230090, 81520108030, 21472238]
- Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products [16DZ2280200]
- Scientific Foundations of Shanghai China [12401900801, 13401900103, 13401900101]
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Three new aporphine alkaloids, xylopialoids A-C (1-3), along with three known aporphine alkioids (4-6) and three other known compounds (7-9) were isolated from the roots of Xylopia vielana. Among these three new aporphine alkaloids, xylopialoid C (3) showed a special carbamido group directly connected to the nitrogen. The chemical structures of these nine compounds were determined by a combination of 1D and 2D NMR, MS, CD spectrum and Cu K alpha X-ray crystallographic analyses. All these six alkaloids were firstly tested for the inhibitory activities against the production of NO in RAW264.7 cells stimulated by lipopolysaccharide (LPS). Among these compounds, 4 showed a potential inhibitory activity against the production of nitric oxide with IC50 value of 1.39 mu M.
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