Journal
FITOTERAPIA
Volume 124, Issue -, Pages 73-79Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2017.10.018
Keywords
Alstonia scholaris; Monoterpenoid indole alkaloids; Scholarisines P-S; Nuclear factor-kappa B
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Funding
- Macao Science and Technology Development Fund [033/2015/A1]
- Teriary Education services office, Macau Special Administrative Region
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Four new monoterpenoid indole alkaloids (MIAs), scholarisines P-S (1-4), and 14 known MIAs (5-18) were isolated from the leaves of Aistonia scholaris (L) R. Br. (Apocynaceae). Their structures were elucidated by analyzing their HRESIMS data and NMR spectroscopic data. All of the isolated MIAs were evaluated for their Nuclear Factor-kappa B (NF-kappa B) inhibitory activity in HepG2-NF-kappa B-Luc cells. Among them, five compounds (4, 7, 8, 13 and 16) exhibited significant NF-kappa B inhibitory activity.
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