Article
Fisheries
Jiaqian Zhu, Yina Shao, Kaiyu Chen, Weiwei Zhang, Chenghua Li
Summary: Transglutaminases (TGases) play critical roles in innate immunity, with TGase2 involved in autophagy to help degrade protein aggregates. A novel TGase2-like gene, AjTGase2-like, was cloned from the sea cucumber Apostichopus japonicus, showing high conservation with vertebrate TGase2. AjTGase2-like was widely expressed and played a key role in immune response, acting as a positive regulator in sea cucumber autophagy.
FISH & SHELLFISH IMMUNOLOGY
(2021)
Article
Fisheries
Ye Li, Yancui Zhao, Xin Liu, Lei Yuan, Xiaoli Liu, Lei Wang, Hushan Sun
Summary: This study revealed the effects of lactic acid bacteria Lactobacillus on the intestinal microbiota and metabolism of sea cucumber, finding that M2-4 increased the relative abundance of potential probiotics, decreased potential pathogens, and promoted self-colonization in sea cucumber. Metabonomics analysis showed increased differential lipid metabolites and enriched lipid metabolism pathways, with significant impact on mTOR and PPAR signaling pathways, glutathione, and linoleic acid metabolism pathways.
Article
Fisheries
Yina Shao, Chengyang Wang, Tianyu Lu, Jianyang Jiang, Chenghua Li, Xuelei Wang
Summary: This study found that feeding Bacillus cereus LS2 could significantly improve the growth performance and immune parameters of sea cucumbers by activating specific pathways. Furthermore, LS2 diet could also influence the intestinal microbial composition of sea cucumbers by increasing the abundance of Actinobacteria and Bacteroidetes.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Yankai Wang, Jing Diao, Bei Wang, Xi Xu, Minjie Gui, Chenghua Li, Ming Guo
Summary: In this study, the second FADD gene in sea cucumber Apostichopus japonicus (AjFADD-2) was cloned and its potential function in innate responses was analyzed. It was found that AjFADD-2 was significantly induced in response to pathogen challenge and played a positive role in regulating apoptosis in coelomocytes.
FISH & SHELLFISH IMMUNOLOGY
(2022)
Article
Environmental Sciences
Mohamed Mohsen, Chenggang Lin, Yanming Sui, Hongsheng Yang
Summary: Sea cucumbers are affected by microplastic fiber transfer, but they can recover from the effects. Single transfer does not significantly impact their growth, but repetitive transfer decreases the growth rate.
ENVIRONMENTAL TOXICOLOGY AND CHEMISTRY
(2023)
Article
Fisheries
Ming Guo, Yankai Wang, Xianmu Fu, Wenjun Tao, Chenghua Li
Summary: This study discovered a circRNA, circ1149, which is closely related to skin ulcer syndrome in sea cucumber. It was found that circ1149 plays a significant role in pathogen-induced cell apoptosis in sea cucumbers. The study also identified miR-92a as a promoter of cell apoptosis through targeting Bax. Furthermore, circ1149 acts as a competing endogenous RNA by competing for miR-92a to suppress pathogen-induced cell apoptosis.
Article
Biotechnology & Applied Microbiology
Tomoyuki Shimazu, Mai Suzuki, Ryo Takasaki, Asuka Besshi, Yuna Suzuki, Yoichiro Iwakura
Summary: This study investigated the relationship between lactic acid bacteria (LAB) and innate immune receptors. The researchers found that C-type lectin receptors (CLRs) are involved in the immune-stimulating function of LAB. The interaction between LAB and CLRs can reduce the levels of certain cytokines and is only observed in heat-killed LAB. These findings contribute to a better understanding of the immunomodulatory effects of LAB.
PROBIOTICS AND ANTIMICROBIAL PROTEINS
(2023)
Article
Immunology
Tanjun Zhao, Liyuan Ren, Chengda Li, Li Liu, Yang Zou, Hanyu Yan, Yaoyao Zhan, Yaqing Chang
Summary: This study reveals the regulatory role of miR-7 in the pathogen-induced immune response in A. japonicus by targeting PAK1, highlighting its importance in immune regulation.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Environmental Sciences
Haona Wang, Hui Liu, Yanying Zhang, Lijie Zhang, Qing Wang, Ye Zhao
Summary: Microplastic pollution poses a major threat to marine biota, with both direct exposure to microplastics and leachates from them being toxic. The leachates of PVC microspheres were found to have higher toxicity on sea cucumber embryo development and larval growth, and the presence of phthalate esters in the leachates may contribute to their increased toxicity.
MARINE ENVIRONMENTAL RESEARCH
(2023)
Article
Fisheries
Huiyu Zhang, Qiwen Zhang, Yan Li, Zhenjiang Zech Xu, Xiaochang Huang
Summary: This study aimed to isolate potential probiotics from freshwater fish and evaluate their effects on the growth, immune response, and disease resistance of juvenile zebrafish. Three strains (Leuconostoc mesenteroides GL-5, Weissella hellenica GJ-1, and Pediococcus claussenii GJ-3) were identified with antagonistic activity against fish pathogens, high bile salt tolerance, and good hydrophobicity. Feeding zebrafish with these probiotics significantly promoted their growth and improved their immune response and disease resistance.
AQUACULTURE INTERNATIONAL
(2023)
Review
Fisheries
Azizza Mala, Subha Bhassu, Norhidayah Mohd Taufek, Najiah M. Sadali, Siran Wang, Elnour Mohamed, Adibi M. Nor
Summary: Aquaculture is important for Malaysia's national economy, but there are issues like organic pollution and contaminants in aquaculture farms. Lactic acid bacteria can help restore normal physiological state and increase productivity. However, research on using lactic acid bacteria as inoculants for seaweed silage is limited. By increasing their use, aquaculture can be more productive, safer, and environmentally friendly, contributing to long-term development.
AQUACULTURE REPORTS
(2023)
Article
Microbiology
Javier Feito, Diogo Contente, Manuel Ponce-Alonso, Lara Diaz-Formoso, Carlos Araujo, Nuria Pena, Juan Borrero, Beatriz Gomez-Sala, Rosa del Campo, Estefania Munoz-Atienza, Pablo E. Hernandez, Luis M. Cintas
Summary: Lactococcus lactis subsp. cremoris WA2-67 is a strain with multiple probiotic properties, including strong antimicrobial activity against fish pathogens, resistance to different environmental conditions, and absence of harmful genes and antibiotic resistance. These findings support its use as a probiotic in aquaculture.
Article
Biochemistry & Molecular Biology
Noriko Kawamoto-Miyamoto, Hiroshi Hosoda, Kazuyuki Miyoshi, Koji Nomoto
Summary: Lactic acid bacteria (LAB) cultured on food grade medium showed smaller cell size and higher yield, and exhibited a stronger ability to induce IL-12(p40) production. Furthermore, the concentration of glutamate in the medium influenced the cell size, yield, and the ability to induce IL-12 production. Therefore, regulating the concentration of glutamate is crucial for efficient culturing of functional LAB.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
(2022)
Article
Environmental Sciences
Mohamed Mohsen, Libin Zhang, Lina Sun, Chenggang Lin, Qing Wang, Shilin Liu, Jinchun Sun, Hongsheng Yang
Summary: The study found that dietary exposure to MFs did not significantly affect the growth and fecal production rate of sea cucumbers, but disrupted immunity and oxidative stress indices. These indices may serve as potential biomarkers of MF ingestion in sea cucumbers.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Food Science & Technology
Yueqi Zhou, Shumeng Wu, Yulu Peng, Yamei Jin, Dan Xu, Xueming Xu
Summary: The study assessed the influence of lactic acid bacteria on the physicochemical characteristics of low-salt fermented mackerel seasonings, with a focus on key volatile compounds and their formation pathways. The flavor of LAB-fermented mackerel seasonings was found to be superior to traditional fish sauce, with specific strains of LAB impacting the formation of flavor substances. Analysis of key odor-active compounds and their correlations with sensory characteristics revealed compounds like (E)-2-nonenal and (E,E)-2,4-decadienal playing a role in overall odor profile.
Article
Fisheries
Yingrui Li, Lin Su, Baoshan Guo, Shun Zhou, Chao Li, Yunji Xiu
Summary: Pathogens infection induces intestinal inflammatory processes. MicroRNAs in teleost serve as vital regulators in innate immunity responses against pathogen infection. MiR-144-5p is identified as negative regulator in teleost against bacterial infection. It down-regulates inflammation-related cytokines by targeting Hsp90 alpha, ultimately promoting bacterial infection.
Article
Fisheries
Hui Jun Huo, Tian Zhen Yang, Qing Zhu, Ning Yang, Chao Li
Summary: This study compared collectins from a range of vertebrates and found that they are widely distributed and conserved. The collectin from a marine teleost, the black rockfish, was analyzed in detail, revealing the need for further research on its sugar binding mechanism.
Article
Engineering, Environmental
Dandan Liang, Zeng Li, Guohong Liu, Chao Li, Weihua He, Jiannan Li, Yujie Feng
Summary: Periodic polarity reversal strategy can effectively cultivate bidirectional electron transfer biofilm and utilize the characteristics of biofilm to facilitate nitrate reduction.
CHEMICAL ENGINEERING JOURNAL
(2023)
Article
Fisheries
Min Cao, Qi Li, Xiantong Liu, Qiang Fu, Chao Li
Summary: Sebastes schlegelii is a fish species with high economic value, but the outbreak of diseases in its aquaculture industry has caused significant economic losses. Study of the fish immune system, particularly the immunoglobulin genes, can provide insights into the immune response to pathogens and contribute to the development of prevention and control methods. This study successfully identified and cloned the immunoglobulin heavy chain genes (sIgM, mIgM, sIgT, and mIgT) of S. schlegelii, revealing their high conservation during evolution.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xiaoyan Zhang, Haohui Yu, Ningning Wang, Chao Li
Summary: Evidence suggests that lncRNAs are involved in various immune responses in vertebrates. In the snakehead fish, immune-related lncRNAs play crucial roles in regulating immune responses against Nocardia seriolae infection. This study analyzed the transcription landscapes of lncRNAs and mRNAs in snakehead, revealing potential functions of lncRNAs in modulating mRNA expression levels and regulating downstream immune signaling pathways.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Xin Cai, Chengbin Gao, Alan J. Lymbery, Nicola J. Armstrong, Le Ma, Chao Li
Summary: Recently, the Gram-negative pathogenic bacterium Vibrio anguillarum has become a major obstacle to the turbot aquaculture industry due to its global distribution, wide host range, and potential devastating impacts. This study conducted comprehensive analyses of whole-transcriptome sequencing in turbot liver infected by V. anguillarum and found differential expression of circRNAs, miRNAs, and mRNAs. Interaction pairs between miRNA-circRNA and miRNA-mRNA were predicted and circRNA-related ceRNA regulatory networks were constructed. The study identified novel target genes for disease prevention and control in turbot.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Yiping Liu, Min Cao, Xu Yan, Xin Cai, Yuqing Li, Chao Li, Ting Xue
Summary: Cell-to-cell communication through gap junction channels is essential for coordinating cellular functions in multicellular tissues. This study identified 48 members of the gap junction protein family in Sebastes schlegelii, classifying them into connexin and pannexin types. The connexins were further divided into five subfamilies. The study also revealed the protein structure and interactions of GJs, and showed that GJ proteins were highly expressed in intestinal tissues and regulated after bacterial infection. The findings provide valuable insights for further understanding the function of GJ proteins in S. schlegelii.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Tong Cui, Peng Liu, Xuan Chen, Zhe Liu, Beibei Wang, Chengbin Gao, Zhongyi Wang, Chao Li, Ning Yang
Summary: This study identified nine caspase genes in turbot and found that they were expressed in various organs, especially in the intestine, kidney, blood, and gills. The expression patterns of these genes in mucosal tissues showed differences after bacterial infection, suggesting the crucial role of caspase genes in mucosal immune responses.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Fisheries
Chengbin Gao, Xin Cai, Le Ma, Peng Sun, Chao Li
Summary: In this study, the regulatory roles of circRNA-related ceRNA networks in the spleen immune system of black rockfish infected with A. salmonicida were investigated. The results revealed 39 differentially expressed circRNAs during the infection, which were significantly enriched in multiple immune-related pathways. These findings suggest a potential role of circRNA in the antibacterial immune response of fish.
FISH & SHELLFISH IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Chengbin Gao, Xin Cai, Le Ma, Ting Xue, Chao Li
Summary: In this study, the TNF alpha was characterized and its roles in the immune system of black rockfish during bacterial infections were explored. The results showed that Ss_TNF alpha was significantly up-regulated in the spleen and intestine after infections, while down-regulated in PBLs. The expression patterns of other inflammatory cytokines were also observed.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2023)
Article
Pediatrics
Mei Mei, Dan Dai, Zhuoyao Guo, Congcong Zhang, Jing Liu, Yuanyuan Qi, Xiaochuan Wang, Libo Wang, Liling Qian
Summary: This study retrospectively analyzed the clinical characteristics and underlying causes of 551 hospitalized children with recurrent pneumonia from January 2016 to January 2021 at the Children's Hospital of Fudan University. The majority (87.7%) of the children had underlying causes, with recurrent aspiration, primary immunodeficiency, and congenital heart diseases being the most common. Genetic defects were identified in about a quarter of the patients. Primary immunodeficiency, primary ciliary dyskinesia, bronchiolitis obliterans, and the age of >3 years at diagnosis were risk factors for severe outcomes. Aspiration and an abnormal family history were risk factors for rehospitalization.
PEDIATRIC PULMONOLOGY
(2023)
Article
Pediatrics
Lingyu Lai, Yong Lu, Zhimin Xi, Fang Liu, Liling Qian, Libo Wang, Quming Zhao
Summary: This article reports two cases of bronchial Dieulafoy's disease in children, causing recurrent massive hemoptysis. The disease was diagnosed through imaging examinations and bronchial arteriography, and was successfully treated with bronchial artery embolization, with no recurrence of hemoptysis.
TRANSLATIONAL PEDIATRICS
(2023)
