Journal
FEBS LETTERS
Volume 592, Issue 3, Pages 446-458Publisher
WILEY
DOI: 10.1002/1873-3468.12974
Keywords
cancer; cellular proliferation; mir-17-92
Funding
- IRCC, IIT Bombay [13IRTAPSG005, 13IRCCSG008]
- DST [EMR/2014/000500]
- DBT [BT/PR11932/BRB/10/1315/2014]
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MicroRNAs associated with the mir-17-92 cluster are crucial regulators of the mammalian cell cycle, as they inhibit transcription factors related to the E2F family that tightly control decision-making events for a cell to commit for active cellular proliferation. Intriguingly, in many solid cancers, these mir-17-92 cluster members are overexpressed, whereas in some hematopoietic cancers they are down-regulated. Our proposed model of the Myc/E2F/mir-17-92 network demonstrates that the differential expression pattern of mir-17-92 in different cell types can be conceived due to having a contrasting E2F dynamics induced by mir-17-92. The model predicts that by explicitly altering the mir-17-92-related part of the network, experimentally it is possible to control cellular proliferation in a cell type-dependent manner for therapeutic intervention.
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