Ryanodine channel complex stabilizer compound S48168/ARM210 as a disease modifier in dystrophin-deficient mdx mice: proof-of-concept study and independent validation of efficacy

Contractile efficiency of dystrophic mdx mouse muscle: in vivo and ex vivo assessment of adaptation to exercise of functional end points

(2017) Roberta Francesca Capogrosso et al.   JOURNAL OF APPLIED PHYSIOLOGY

Assessment of resveratrol, apocynin and taurine on mechanical-metabolic uncoupling and oxidative stress in a mouse model of duchenne muscular dystrophy: A comparison with the gold standard, α-methyl prednisolone

(2016) Roberta Francesca Capogrosso et al.   PHARMACOLOGICAL RESEARCH

Crosstalk between RyR2 oxidation and phosphorylation contributes to cardiac dysfunction in mice with Duchenne muscular dystrophy

(2015) Qiongling Wang et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Excess TGF-β mediates muscle weakness associated with bone metastases in mice

(2015) David L Waning et al.   NATURE MEDICINE

Standard Operating Procedures (SOPs) for Evaluating the Heart in Preclinical Studies of Duchenne Muscular Dystrophy

(2015) Dongsheng Duan et al.   Journal of Cardiovascular Translational Research

Angiotensin II modulates mouse skeletal muscle resting conductance to chloride and potassium ions and calcium homeostasis via the AT1 receptor and NADPH oxidase

(2014) Anna Cozzoli et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dual response of the KATP channels to staurosporine: A novel role of SUR2B, SUR1 and Kir6.2 subunits in the regulation of the atrophy in different skeletal muscle phenotypes

(2014) Antonietta Mele et al.   BIOCHEMICAL PHARMACOLOGY

Gene expression in mdx mouse muscle in relation to age and exercise: aberrant mechanical–metabolic coupling and implications for pre-clinical studies in Duchenne muscular dystrophy

(2014) Giulia Maria Camerino et al.   HUMAN MOLECULAR GENETICS

Long-term treatment with naproxcinod significantly improves skeletal and cardiac disease phenotype in the mdx mouse model of dystrophy

(2014) K. Uaesoontrachoon et al.   HUMAN MOLECULAR GENETICS

Src-dependent impairment of autophagy by oxidative stress in a mouse model of Duchenne muscular dystrophy

(2014) Rituraj Pal et al.   Nature Communications

An olive oil-derived antioxidant mixture ameliorates the age-related decline of skeletal muscle function

(2013) Sabata Pierno et al.   AGE

A pilot study of muscle plasma protein changes after exercise

(2013) Julia R. Dahlqvist et al.   MUSCLE & NERVE

Paracrine Effects of IGF-1 Overexpression on the Functional Decline Due to Skeletal Muscle Disuse: Molecular and Functional Evaluation in Hindlimb Unloaded MLC/mIgf-1 Transgenic Mice

(2013) Sabata Pierno et al.   PLoS One

Identification of Selective Inhibitors of the Potassium Channel Kv1.1-1.2(3)by High-Throughput Virtual Screening and Automated Patch Clamp

(2012) Sören J. Wacker et al.   ChemMedChem

Glucocorticoid-Treated Mice Are an Inappropriate Positive Control for Long-Term Preclinical Studies in the mdx Mouse

(2012) Arpana Sali et al.   PLoS One

Mitigation of muscular dystrophy in mice by SERCA overexpression in skeletal muscle

(2011) Sanjeewa A. Goonasekera et al.   JOURNAL OF CLINICAL INVESTIGATION

N-Acetylcysteine treatment of dystrophic mdx mice results in protein thiol modifications and inhibition of exercise induced myofibre necrosis

(2011) Jessica R. Terrill et al.   NEUROMUSCULAR DISORDERS

Enhancing translation: Guidelines for standard pre-clinical experiments in mdx mice

(2011) Raffaella Willmann et al.   NEUROMUSCULAR DISORDERS

Physiological Characterization of Muscle Strength With Variable Levels of Dystrophin Restoration in mdx Mice Following Local Antisense Therapy

(2010) Paul S Sharp et al.   MOLECULAR THERAPY

Chronic Systemic Therapy With Low-dose Morpholino Oligomers Ameliorates the Pathology and Normalizes Locomotor Behavior in mdx Mice

(2010) Alberto Malerba et al.   MOLECULAR THERAPY

Skeletal Muscle NADPH Oxidase Is Increased and Triggers Stretch-Induced Damage in the mdx Mouse

(2010) Nicholas P. Whitehead et al.   PLoS One

Leaky RyR2 trigger ventricular arrhythmias in Duchenne muscular dystrophy

(2010) J. Fauconnier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Multiple pathological events in exercised dystrophic mdx mice are targeted by pentoxifylline: outcome of a large array of in vivo and ex vivo tests

(2009) Rosa Burdi et al.   JOURNAL OF APPLIED PHYSIOLOGY

Preclinical drug trials in themdxmouse: Assessment of reliable and sensitive outcome measures

(2009) Christopher F. Spurney et al.   MUSCLE & NERVE

Hypernitrosylated ryanodine receptor calcium release channels are leaky in dystrophic muscle

(2009) Andrew M Bellinger et al.   NATURE MEDICINE

Mammalian animal models for Duchenne muscular dystrophy

(2009) Raffaella Willmann et al.   NEUROMUSCULAR DISORDERS

N-Acetylcysteine ameliorates skeletal muscle pathophysiology inmdxmice

(2008) Nicholas P. Whitehead et al.   JOURNAL OF PHYSIOLOGY-LONDON

Gentamicin treatment in exercised mdx mice: Identification of dystrophin-sensitive pathways and evaluation of efficacy in work-loaded dystrophic muscle

(2008) Annamaria De Luca et al.   NEUROBIOLOGY OF DISEASE

Towards developing standard operating procedures for pre-clinical testing in the mdx mouse model of Duchenne muscular dystrophy

(2008) Miranda D. Grounds et al.   NEUROBIOLOGY OF DISEASE