Article
Hematology
Lars Glise, Mikael Rutberg, Liliana Haversen, Malin C. Levin, Max Levin, Anders Jeppsson, Jan Boren, Per Fogelstrand
Summary: This study identifies histidine protonation as an important component for electrostatic LDL binding to human coronary arteries. Our findings show that the local pH will have a profound impact on LDL's affinity for sulfated glycosaminoglycans, which may influence the retention and accumulation pattern of LDL in the arterial vasculature.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Jiawen Chen, Tianyu Sun, Yan You, Binbin Lin, Buling Wu, Jingyi Wu
Summary: This study explores the gene profile of extracellular proteoglycans and their glycosaminoglycan chains involved in dental epithelium-mesenchymal interactions. The results provide new insight into the roles of extracellular proteoglycans and their distinct sulfation underlying early odontogenesis.
Article
Biotechnology & Applied Microbiology
Martin C. Jordan, Lukas Hufnagel, Miriam McDonogh, Mila M. Paul, Jonas Schmalzl, Eva Kupczyk, Hendrik Jansen, Philipp Heilig, Rainer H. Meffert, Stefanie Hoelscher-Doht
Summary: This study compared the stability and strength of different fixation techniques for calcaneal beak fractures using synthetic bones. The results showed that the 6.5mm partial threaded cannulated screws and 5.0mm headless cannulated compression screws provided the best fixation strength and stability.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Review
Cell Biology
Noah Siddiqui, Kaori Oshima, Joseph A. Hippensteel
Summary: This review explores the pathophysiological changes caused by central nervous system injuries and emphasizes the importance of PGs and GAGs in these injuries. The article discusses the role of PGs and GAGs in acute injury and recovery, as well as potential therapeutic strategies.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2022)
Review
Chemistry, Applied
Jia-Xin Hao, Min-Juan Shen, Chen-Yu Wang, Jian-Hua Wei, Qian-Qian Wan, Yi-Fei Zhu, Tao Ye, Meng-Lin Luo, Wen-Pin Qin, Yu-Tao Li, Kai Jiao, Bin Zhao, Li-Na Niu
Summary: This review focuses on the potential mechanisms of proteoglycans-mediated biomineralization, including their roles in regulating cell proliferation and differentiation, collagen fibril aggregation, and mineral deposition. Proteoglycans play important roles in bone tissue engineering and as therapeutic targets for ectopic mineralization.
CARBOHYDRATE POLYMERS
(2022)
Article
Dentistry, Oral Surgery & Medicine
R. A. T. Noschang, D. Seebold, R. Walter, A. Rivera-Concepcion, I. A. Alraheam, M. Cardoso, P. A. Miguez
Summary: The study showed that SLRP proteins have positive effects on dentrin bonding and remineralization, with full proteoglycans containing GAGs significantly improving bonding over time.
Article
Biochemistry & Molecular Biology
Kazadi N. Mutoji, Mingxia Sun, Garrett Elliott, Isabel Y. Moreno, Clare Hughes, Tarsis F. Gesteira, Vivien J. Coulson-Thomas
Summary: After a corneal chemical injury, there were significant changes in the distribution of PGs, with an overall increase in CS and an increase in KS expression at a certain period, indicating the crucial roles of PGs and GAGs in maintaining corneal transparency.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Materials Science, Biomaterials
Serafina G. Lopez, Jongkil Kim, Lara A. Estroff, Lawrence J. Bonassar
Summary: In this study, the researchers removed proteoglycans (GAGs) from collagen gel-based tissue engineered constructs using chondroitinase ABC (cABC) and found that it improved collagen fiber alignment and mechanical properties without compromising compressive strength. The increased fiber organization also appeared to prevent the propagation of large defects under loading. This study provides a new method of modulating the extracellular matrix for improved collagen fiber formation and mechanical properties in tissue engineered constructs.
ACS BIOMATERIALS SCIENCE & ENGINEERING
(2023)
Article
Engineering, Biomedical
A. Ostadi Moghaddam, M. R. Arshee, Z. Lin, M. Sivaguru, H. Phillips, B. L. McFarlin, K. C. Toussaint, A. J. Wagoner Johnson
Summary: Glycosaminoglycans (GAGs) play a crucial role in modulating the interaction of collagen fibrils by promoting sliding through shear deformation. The molecular reconfiguration of GAGs is identified as a potential mechanism for their microscale, strain-dependent viscoelastic behavior.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Article
Cardiac & Cardiovascular Systems
Hien Luong, Sarojini Singh, Mallikarjun Patil, Prasanna Krishnamurthy
Summary: This study investigated cardiac structural and functional alterations as well as changes in myocardial glycosaminoglycan profile in mice exhibiting depression-like behavior. It found that depression in mice was associated with decreased BDNF protein expression, increased IL-6 mRNA expression, and structural changes in the heart. The study highlights the need for further research on the relationship between cardiac GAGs biology and myocardial remodeling underlying cardiovascular complications in patients with MDD.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2021)
Review
Cell Biology
Fredrik Noborn, Mahnaz Nikpour, Andrea Persson, Jonas Nilsson, Goran Larson
Summary: Chondroitin sulfate proteoglycans are a type of proteoglycan found on cell surfaces and in connective tissues, interacting with proteins involved in various pathophysiological processes. Recent advances in glycoproteomic methods have allowed for the identification of numerous novel chondroitin sulfate core proteins and attachment sites in humans and animal models, revealing greater structural complexity of CSPGs than previously perceived. These findings may challenge traditional notions of defining proteoglycans based on function or structural evidence.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Sport Sciences
Christoph Centner, Simon Jerger, Benedikt Lauber, Olivier Seynnes, Till Friedrich, David Lolli, Albert Gollhofer, Daniel Koenig
Summary: The study found that both LL-BFR and HL training resulted in comparable changes in patellar tendon stiffness, with no significant differences between the two groups. Increases in tendon cross-sectional area were also similar in both HL and LL-BFR. Muscle mass and strength increased significantly in both groups, with slightly higher changes in knee extension 1RM seen in LL-BFR.
MEDICINE & SCIENCE IN SPORTS & EXERCISE
(2022)
Article
Engineering, Biomedical
Jacqueline Solis-Cordova, Jennifer H. Edwards, Hazel L. Fermor, Philip Riches, Claire L. Brockett, Anthony Herbert
Summary: This study determined the contribution of glycosaminoglycans (GAGs) to the mechanical properties of porcine superflexor tendon (pSFT) in tension and compression. The results showed that GAGs significantly contribute to the compressive mechanical properties of pSFT, but not the tensile properties. The decellularisation process did not affect the content or function of GAGs in pSFT.
JOURNAL OF THE MECHANICAL BEHAVIOR OF BIOMEDICAL MATERIALS
(2023)
Review
Dentistry, Oral Surgery & Medicine
Yilin Chen, Qiuyue Guan, Xianglong Han, Ding Bai, Defu Li, Ye Tian
Summary: Proteoglycans are glycosylated proteins with various roles in periodontal tissue development, wound repair, immune response, and pathological processes. Study on the roles and expression patterns of proteoglycans in the periodontium can provide insight for treatments of periodontitis and gingival overgrowth. Further research and validation through genetically modified animal experiments are needed for a better understanding of periodontal proteoglycans.
JOURNAL OF PERIODONTAL RESEARCH
(2021)
Article
Veterinary Sciences
Zheng Huidan, Jinsu Kang, Namsoo Kim, Suyoung Heo
Summary: This study applied a polycaprolactone plate to tendon plating for the first time, compared its biomechanical properties with conventional methods, and evaluated the gap characteristics. The results showed that the 3LP + titanium plate group had the highest force values, and the biomechanical properties of the 3LP + a 2 mm PCL plate were similar to the 3LP + ES constructs. Gap formation was observed in all groups, with a higher frequency in the 3LP + 1.5 mm titanium plate group.
VETERINARY SCIENCES
(2023)
Review
Rehabilitation
Karenina Arrais Guida Modesto, Julia Aguillar Ivo Bastos, Marco Aurelio Vaz, Joao Luiz Quagliotti Durigan
Summary: This study investigated the effects of Kilohertz-frequency alternating current on muscle performance. Results showed that carrier frequencies up to 1 kHz elicited higher torque, while carrier frequencies between 2.5 and 5 kHz resulted in lower perceived discomfort. Shorter burst duty cycles (10%-50%) induced higher evoked torque and lower perceived discomfort. The study concludes that Kilohertz-frequency alternating current with carrier frequencies between 1 and 2.5 kHz and burst duty cycles less than 50% can generate greater evoked torque, while frequencies between 2.5 and 5 kHz along with burst duty cycles less than 50% can reduce perceived discomfort.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2023)
Article
Clinical Neurology
Larissa Santana, Emerson Fachin-Martins, David Lobato Borges, Jonathan Galvao Tenorio Cavalcante, Nicolas Babault, Frederico Ribeiro Neto, Joao Luiz Quagliotti Durigan, Rita de Cassia Marqueti
Summary: This study compared the association between neuromuscular function, motor function impairment, and muscle and tendon structures in individuals with spinal cord injury (SCI) and a non-disabled control group. The results showed that individuals with SCI had abnormalities in muscle and tendon structures, as well as a higher prevalence of neuromuscular electrophysiological disorders.
JOURNAL OF SPINAL CORD MEDICINE
(2023)
Article
Anatomy & Morphology
Damaris Helena Meneghetti, Leonardo Bagne, Stella Aparecida de Andrade Pinto, Cecilia Amelia de Carvalho Zavaglia, Maria Esmeria Corezola Amaral, Marcelo Augusto Maretto Esquisatto, Glaucia Maria Tech Dos Santos, Thiago Antonio Moretti de Andrade, Milton Santamaria, Guilherme Ferreira Caetano, Andrea Aparecida de Aro, Fernanda Aparecida Sampaio Mendonca
Summary: The combination of electrical stimulation and bone tissue engineering has been successful in bone regeneration. This study found that electrical stimulation combined with PCL + beta-TCP 5% scaffolds can control inflammation, promote blood vessel proliferation, and osteogenesis, making it a potentially promising strategy for bone defects regeneration.
ANATOMICAL RECORD-ADVANCES IN INTEGRATIVE ANATOMY AND EVOLUTIONARY BIOLOGY
(2023)
Article
Anatomy & Morphology
Henrique Mansur, Joao Luiz Quagliotti Durigan, Marcos de Noronha, Michael Kjaer, S. Peter Magnusson, Bruno Abdo Santana de Araujo, Rita de Cassia Marqueti
Summary: Increasing age affects morphologic changes in major tendons, but its effects on the cross-sectional area (CSA) of different ankle tendons are less understood. This study found significant differences in CSA among age groups and along different tendon regions. However, there were no differences in tendon CSA between sexes.
JOURNAL OF ANATOMY
(2023)
Article
Engineering, Electrical & Electronic
Alvaro Ventura, Leandro Gomes, Jonathan Cavalcante, Denis Vieira, Caio Victor Sousa, Rita de Cassia Marqueti, Nicolas Babault, Joao Luiz Durigan
Summary: This study aimed to investigate the changes in muscle architecture of quadriceps femoris constituents with sensor electrodes placed over VL and VM motor points during a neuromuscular electrical stimulation session. The results showed no difference in the muscle architecture changes when the electrodes were placed on VL and VM motor points. Therefore, clinicians can choose either VL or VM motor points for sensor electrode positioning and expect similar muscle architecture adaptation.
JOURNAL OF SENSORS
(2023)
Review
Cell Biology
Ivo Vieira de Sousa Neto, Ana Paula Pinto, Vitor Rosetto Munoz, Rita de Cassia Marqueti, Jose Rodrigo Pauli, Eduardo Rochete Ropelle, Adelino Sanchez Ramos da Silva
Summary: Physical training can improve mitochondrial health through PGC-1a signaling pathways. However, the impact of physical training on PGC-1a in different physiological systems with advancing age is not well understood. This review provides comprehensive information on the effects of exercise on PGC-1a signaling pathways in rodents and humans, addressing molecular mechanisms and highlighting the importance of further investigation in certain human tissues. PGC-1a functions as more than a transcriptional coactivator, playing a role in mitochondrial dynamics and various physiological processes.
AGEING RESEARCH REVIEWS
(2023)
Article
Medicine, Research & Experimental
Graziele F. Deriggi-Pisani, Uliana S. Stotzer, Rita C. Marqueti, Maria F. C. Rodrigues, Bruna G. Biffe, Karina A. Silva, Victor Fabricio, Clifford J. Rosen, Heloisa Sobreiro Selistre-de-Araujo
Summary: This study evaluated the effects of resistance training on bone properties, morphology, and bone extracellular matrix remodeling markers in an ovariectomy rat model. The results showed that resistance training could reverse the negative effects of ovariectomy on bone mineral density, stiffness, maximal load, and calcium content. Additionally, resistance training was effective in increasing trabecular thickness and cortical bone volume, improving bone resistance.
Article
Biophysics
Isabella da Silva Almeida, Leandro Gomes de Jesus Ferreira, Alvaro de Almeida Ventura, Henrique Mansur, Nicolas Babault, Rita de Cassia Marqueti, Joao Luiz Quagliotti Durigan
Summary: This study aimed to verify the reliability and agreement of the stimulus electrodiagnostic test (SET) in post-COVID-19 patients. The results showed high intra- and inter-rater reliability of SET measurements in assessing neuromuscular electrophysiological disorders (NED) in post-COVID-19 participants. The SET was found to be a reliable tool for evaluating NED in post-COVID-19 patients.
PHYSIOLOGICAL MEASUREMENT
(2023)
Article
Biology
Rebecca Salomao, Victoria Assis, Ivo Vieira de Sousa Neto, Bernardo Petriz, Nicolas Babault, Joao Luiz Quaglioti Durigan, Rita de Cassia Marqueti
Summary: The costs of COVID-19 worldwide have been enormous, and understanding biomarkers is crucial in reducing the disease burden. This review summarizes the role of increasing MMPs during SARS-CoV-2 infection and their association with complications and severity of COVID-19. Better understanding of MMPs could provide new insights into the symptoms, pathogenesis, and treatment of COVID-19.
Article
Rehabilitation
Isabel de Almeida Paz, Francesca Chaida Sonda, Matias Frohlich, Joao Luiz Quagliotti Durigan, Marco Aurelio Vaz
Summary: This study compared the effects of pulsed current and kilohertz frequency alternating current on healthy individuals. The results showed that pulsed current generated higher torque, had higher neuromuscular efficiency, and similar discomfort levels. Therefore, the study suggests that pulsed current is the best choice for clinicians to use in NMES-based protocols.
JOURNAL OF SPORT REHABILITATION
(2023)
Article
Critical Care Medicine
Luciana Vieira, Paulo Eugenio Silva, Priscilla Flavia de Melo, Vinicius Maldaner, Joao Q. Durigan, Rita de Cassia Marqueti, Otavio Nobrega, Sunita Mathur, Chris Burtin, Fabricio Barin, Wilcelly Machado-Silva, Sergio Ramalho, Gaspar R. Chiappa, Nadia Oliveira Gomes, Celso R. F. Carvalho, Graziella F. B. Cipriano, Gerson Cipriano
Summary: This study aimed to investigate the effects of early neuromuscular electrical stimulation (NMES) on muscle quality and size in patients with traumatic brain injury (TBI). The results showed that NMES intervention preserved muscle size and quality and maintained normal levels of signaling mediators of muscle growth and inflammation in TBI patients. Therefore, early NMES can be beneficial for TBI patients.
CRITICAL CARE RESEARCH AND PRACTICE
(2023)
