Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Vesa Oikonen, Hidehiro Iida, Pirjo Nuutila, Ele Ferrannini
Summary: This study aimed to assess whether [18F]FDG-PET can be used in the study of renal glucose metabolism in humans. The results showed that [18F]FDG-PET can still provide relevant physiological information on regional renal glucose uptake, as long as [18F]FDG uptake is corrected for tubular radioactivity.
METABOLISM-CLINICAL AND EXPERIMENTAL
(2023)
Article
Chemistry, Analytical
Siyang Liu, Ye Liu, Zhe Zhang, Xiaodong Wang, Yicheng Yang, Kai Sun, Jiangbo Yu, Daniel T. Chiu, Changfeng Wu
Summary: This study developed a near-infrared optical transducer to monitor glucose variations in cerebrospinal fluid, and observed abnormal glucose uptake in transgenic mice with brain tumors.
ANALYTICAL CHEMISTRY
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Qinming Zhang, Yi Liao, Xiawan Wang, Teng Zhang, Jianhua Feng, Jianing Deng, Kexin Shi, Lin Chen, Liu Feng, Mindi Ma, Le Xue, Haifeng Hou, Xiaofeng Dou, Congcong Yu, Lei Ren, Yao Ding, Yufei Chen, Shuang Wu, Zexin Chen, Hong Zhang, Cheng Zhuo, Mei Tian
Summary: The study developed a novel deep learning framework for accurate and efficient identification of epileptic foci in pediatric patients with temporal lobe epilepsy, outperforming traditional visual assessment and other analysis methods.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Medicine, Research & Experimental
Matteo Bauckneht, Cecilia Marini, Vanessa Cossu, Cristina Campi, Mattia Riondato, Silvia Bruno, Anna Maria Orengo, Francesca Vitale, Sonia Carta, Silvia Chiola, Sabrina Chiesa, Alberto Miceli, Francesca D'Amico, Giuseppe Fornarini, Carlo Terrone, Michele Piana, Silvia Morbelli, Alessio Signori, Paola Barboro, Gianmario Sambuceti
Summary: This study investigated the independent and additive prognostic value of PSMA and FDG gene expression in risk-stratification of prostate cancer (PCa). Machine learning analysis identified a predictive functional network involving glucose metabolism-related genes. Cellular experiments showed that increased proliferation and migration of PCa cells were associated with enhanced FDG uptake and decreased PSMA retention, indicating the prognostic value of FDG PET imaging.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Psychology, Clinical
Leigh Townsend, Toby Pillinger, Pierluigi Selvaggi, Mattia Veronese, Federico Turkheimer, Oliver Howes
Summary: This study investigates brain metabolism in patients with schizophrenia and finds evidence of lower glucose metabolism in the frontal cortex, supporting the hypothesis of hypofrontality in schizophrenia. However, there were no consistent alterations in other brain regions.
PSYCHOLOGICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Philip A. Corrado, Gregory P. Barton, Francheska C. Razalan-Krause, Christopher J. Francois, Naomi C. Chesler, Oliver Wieben, Marlowe Eldridge, Alan B. McMillan, Kara N. Goss
Summary: In this study, dynamic FDG PET-MRI was used to measure myocardial metabolic rate in young adults born term and preterm, and it was found that MMRglc was similar between the two groups at rest and decreased during hypoxia exposure. No differences in metabolic response to hypoxia were observed between term and preterm individuals.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Neurosciences
Alexander Cuculiza Henriksen, Markus Nowak Lonsdale, Dan Fuglo, Daniel Kondziella, Vardan Nersesjan, Lisbeth Marner
Summary: This study aimed to evaluate the quantification of cerebral glucose metabolic rate (CMRglc) using a Gjedde-Patlak plot and non-invasive image-derived input functions (IDIF) from the aorta, compared to the reference standard based on sampling the arterial input function (AIF). The results showed excellent agreement between the two methods.
Article
Geriatrics & Gerontology
Jiehui Jiang, Can Sheng, Guanqun Chen, Chunhua Liu, Shichen Jin, Lanlan Li, Xueyan Jiang, Ying Han
Summary: Exploring individual hallmarks of brain ageing is important. In this study, the age-related glucose metabolism pattern (ARGMP) is proposed as a potential index to characterize brain ageing in cognitively normal elderly individuals and predict high conversion risk into cognitive impairment.
Article
Clinical Neurology
Anita Nitchingham, Jarett Vanz-Brian Pereira, Eva A. Wegner, Vincent Oxenham, Jacqueline Close, Gideon A. Caplan
Summary: In this study, using FDG-PET, researchers found that patients with delirium showed hypometabolism in the bilateral thalami and certain cortical regions. The hypometabolism was correlated with delirium severity and performance on neuropsychological testing.
ALZHEIMERS & DEMENTIA
(2023)
Review
Biochemistry & Molecular Biology
Miikka-Juhani Honka, Eleni Rebelos, Simona Malaspina, Pirjo Nuutila
Summary: This review explores the use of PET in evaluating hepatic metabolism, haemodynamics, and cancer. F-18-FDG is the most commonly used tracer for assessing glucose uptake and endogenous glucose production. Other tracers such as F-18-FTHA, C-11-Palmitate, and C-11-Acetate have been applied for measuring fatty acid uptake rates, blood flow, and oxidation in the liver. O-15 labelled water is used for quantifying hepatic perfusion. The challenges and modelling approaches in utilizing PET for assessing hepatic metabolism are also discussed.
Article
Endocrinology & Metabolism
Eleni Rebelos, Andrea Mari, Miikka-Juhani Honka, Laura Pekkarinen, Aino Latva-Rasku, Sanna Laurila, Johan Rajander, Paulina Salminen, Hidehiro Iida, Ele Ferrannini, Pirjo Nuutila
Summary: This study confirms differences in renal cortical glucose uptake rates between people with obesity and healthy non-obese controls. Moreover, the negative correlations between renal cortical glucose uptake and free fatty acids, ketone bodies, and citrate suggest substrate competition in the renal cortex.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Article
Endocrinology & Metabolism
Cecilia Rapp, John Hamilton, Kaleigh Richer, Munawwar Sajjad, Rutao Yao, Panayotis K. Thanos
Summary: Alcohol misuse, particularly during adolescence, presents a serious health concern, as it is associated with negative effects on brain glucose metabolism (BGluM). This study utilized a binge drinking model in adolescent rats and found that all doses of ethanol led to decreased BGluM in multiple brain regions involved in sensory, motor, and cognitive processes. These findings highlight the detrimental effects of acute binge drinking on brain function and emphasize the need for further research on the long-term consequences and recovery after cessation of alcohol binge drinking.
METABOLIC BRAIN DISEASE
(2022)
Article
Geriatrics & Gerontology
Jiayu Liu, Lei Li, Yuan Li, Qian Wang, Ruen Liu, Hu Ding
Summary: The study found that STN-DBS surgery has a significant effect on the brain metabolism of patients with Meige syndrome, suggesting its importance as a treatment mechanism.
FRONTIERS IN AGING NEUROSCIENCE
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Xiaohui Zhang, Lin Chen, Han Jiang, Xuexin He, Liu Feng, Miaoqi Ni, Mindi Ma, Jing Wang, Teng Zhang, Shuang Wu, Rui Zhou, Chentao Jin, Kai Zhang, Wenbin Qian, Zexin Chen, Cheng Zhuo, Hong Zhang, Mei Tian
Summary: The hybrid nomograms combining RS with IPI significantly improved survival prediction in DLBCL. Radiomic analysis on MBV may serve as a potential approach for prognosis assessment in DLBCL.
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2022)
Article
Oncology
Xue Yang, Guangxia Yang, Ruojun Wang, Yanjuan Wang, Shengyi Zhang, Jian Wang, Chunjing Yu, Zeqin Ren
Summary: This study explored the correlation between the incidence rates of depression and anxiety and cerebral glucose metabolism in cancer patients. The results showed that patients with lung cancer had higher rates of depression and anxiety compared to other tumor patients, and their brain glucose metabolism was different in several areas. Poor pathological differentiation and advanced TNM stage were associated with higher depression and anxiety risk. The study revealed the correlation between brain glucose metabolism and emotional disorders in cancer patients.
FRONTIERS IN ONCOLOGY
(2023)