Article
Pharmacology & Pharmacy
Ling Zuo, Yang Hai, Ruoyu Zhang, Biao Zuo, Jiayu Tian, Pan Li, Xiumei Ke, Meng Wang, Li Ren, Xuezhi Li, Xuekuan Huang, Jianwei Wang
Summary: This study aimed to determine the therapeutic effect and pharmacological mechanism of icariin in PCOS rats. The results showed that icariin significantly improved ovarian function and reproductive endocrine disorders by regulating sex hormones, restoring the estrous cycle, and reducing ovarian morphological damage in PCOS rats. In addition, icariin also reduced weight gain and improved glucolipid metabolism in PCOS rats.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Nazia Begum, Kandavalli Manipriya, B. Veeresh
Summary: This study developed a new animal model by combining a high-fat diet with letrozole to better simulate polycystic ovary syndrome (PCOS). Compared to the letrozole-only model, this new model can better demonstrate metabolic anomalies observed in PCOS.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Amin Ullah, Mei-Jiao Wang, Jun-Pu Yang, Enoch Appiah Adu-Gyamfi, Armin Czika, Sanjay Kumar Sah, Qian Feng, Ying-Xiong Wang
Summary: This study investigated the expression pattern of inflammatory mRNA profiles in the ovarian tissues of a DHEA plus HFD-induced PCOS mouse model. The differentially expressed genes were found to be associated with PCOS inflammation and could potentially serve as therapeutic options against the disease.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Nutrition & Dietetics
Joanna Maria Pieczynska, Ewa Pruszynska-Oszmalek, Pawel Antoni Kolodziejski, Anna Lukomska, Joanna Bajerska
Summary: The study revealed that a high-fat, high-fructose diet can lead to metabolic/endocrine dysregulations in prepubertal female mice, exacerbating symptoms of Polycystic Ovarian Syndrome. It is important to be cautious of foods rich in simple sugars and saturated fats in the diet to reduce the risk of PCOS progression.
Article
Obstetrics & Gynecology
Fuensanta Navarro-Lafuente, Julian J. Arense-Gonzalo, Maria L. Sanchez-Ferrer, Maria T. Prieto-Sanchez, Ana Cutillas-Tolin, Jaime Mendiola, Evdochia Adoamnei, Esteban Gazabat-Barbado, Jesus Vioque, Alberto M. Torres-Cantero
Summary: This study suggests that higher intakes of specific fatty acids are related to some PCOS phenotypes.
REPRODUCTIVE BIOMEDICINE ONLINE
(2022)
Article
Endocrinology & Metabolism
Frank Gonzalez, Robert Considine, Ola A. Abdelhadi, Jiaping Xue, Anthony J. Acton
Summary: In PCOS, saturated fat intake triggers proatherogenic inflammation pathways, independent of obesity. This effect is more pronounced in PCOS combined with obesity compared to obesity alone. Abdominal adiposity and hyperandrogenism may contribute to perpetuating proatherogenic inflammation.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
(2021)
Article
Plant Sciences
Meng-fan Peng, Shuo Tian, Ya-gang Song, Cai-xia Li, Ming-san Miao, Zhen Ren, Ming Li
Summary: This study aimed to investigate the mechanism of TFEL intervention in a rat model of PCOS-IR, finding that TFEL can inhibit ovarian hyperplasia, regulate disorders of glucose and lipid metabolism, and improve the secretion of sex hormones by regulating the expression of signaling pathway-related proteins in the ovary and HPO axis.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Cell Biology
Xue-Ling Xu, Shou-Long Deng, Zheng-Xing Lian, Kun Yu
Summary: Female infertility is mainly caused by ovulation disorders, with polycystic ovary syndrome (PCOS) being the most prevalent. PCOS is associated with abnormal function of estrogen and estrogen receptors (ERs), affecting cellular activities. Selective estrogen receptor modulators (SERMs) like tamoxifen and clomiphene have shown clinical applications for subfertility with PCOS, but further understanding of the role of ER in PCOS is needed.
Article
Reproductive Biology
Jianmei Yang, Enli Wang, Mingmin Jiang, Yujun Tan, Fangfang Yao, Chenghong Sun, Lihong Pan, Ling Gao, Jingchun Yao
Summary: This study compared the characteristics of gut microbiota and metabolite profiles between polycystic ovary syndrome (PCOS) and orlistat-treated PCOS rats (ORL-PCOS), revealing that orlistat exerted a PCOS treatment effect by modifying the structure and composition of the gut microbiota, as well as the metabolite profiles of PCOS rats.
JOURNAL OF OVARIAN RESEARCH
(2023)
Article
Endocrinology & Metabolism
Alexandra E. Butler, Abu Saleh Md Moin, Zeljko Reiner, Thozhukat Sathyapalan, Tannaz Jamialahmadi, Amirhossein Sahebkar, Stephen L. Atkin
Summary: Proteomic analysis was conducted to investigate the mechanism of dyslipidemia in women with polycystic ovary syndrome (PCOS), and whether it is related to obesity and insulin resistance (IR) or intrinsic to PCOS. The analysis revealed altered levels of certain proteins associated with lipid metabolism in PCOS women, suggesting increased cardiovascular risk even in the absence of obesity and IR.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Yanan Liu, Mengke Li, Xue Lv, Kaiwen Bao, Xiao Yu Tian, Lei He, Lei Shi, Yi Zhu, Ding Ai
Summary: The study reveals that YAP protein is upregulated in metabolic syndrome and leads to the activation of the TGF beta pathway, resulting in arterial stiffness. It is found that YAP inhibits the dephosphorylation of Smads through removal of the ubiquitin chain. These findings are significant for the development of therapeutic targets for metabolic syndrome-associated arterial stiffness.
CIRCULATION RESEARCH
(2022)
Article
Endocrinology & Metabolism
Giuliane Barros de Melo, Jessica Furtado Soares, Thamyres Cristhina Lima Costa, Renata Ohana Alves Benevides, Caroline Castro Vale, Antonio Marcus de Andrade Paes, Renato Simoes Gaspar
Summary: The study suggests that a high-sucrose diet may lead to ovarian dysfunction in rats and be correlated with PCOS in women.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Youngjae Ryu, Yong Jin Kim, Yoon Young Kim, Jungwoo Kim, Sung Woo Kim, Hoon Kim, Seung Yup Ku
Summary: This study successfully established a PCOS model in mice using STZ, with findings indicating that low doses of STZ can induce PCOS features without causing diabetes features. Different doses of STZ treatment had varying effects on body weight, blood glucose levels, and hormone levels in mice.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Endocrinology & Metabolism
Shiqin Zhu, Zeyan Li, Cuiping Hu, Fengxuan Sun, Chunling Wang, Haitao Yuan, Yan Li
Summary: A systematic review and meta-analysis showed that women with PCOS have higher accumulations of visceral fat, abdominal subcutaneous fat, total body fat, trunk fat, and android fat compared to BMI-matched controls. However, when only studies using MRI or CT were considered, there were no significant differences in body fat distribution between PCOS and controls. Additionally, young and non-obese PCOS patients were found to be more likely to accumulate android fat.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Pharmacology & Pharmacy
Congshun Ma, Qianru Xiang, Ge Song, Xuefei Wang
Summary: Polycystic ovary syndrome (PCOS) is a reproductive endocrine disease with no specific drug treatment. Quercetin (QUR), a flavonoid, has potential therapeutic effects for PCOS patients. However, the mechanisms of QUR in PCOS patients remain unclear.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Obstetrics & Gynecology
Angelica Linden Hirschberg
Summary: Essential hyperandrogenism is prevalent among female elite athletes, possibly due to the beneficial effects of androgens on muscle mass, bone mass, and erythropoiesis. In addition to rare sex development differences, menstrual disorders in female athletes are often caused by acquired hypothalamic disturbances resulting from excessive energy expenditure in relation to energy intake, leading to low bone density and increased injury risk.
SEMINARS IN REPRODUCTIVE MEDICINE
(2022)
Editorial Material
Sport Sciences
Angelica Linden Hirschberg
Correction
Multidisciplinary Sciences
A. Kasielska-Trojan, J. T. Manning, M. Jablkowski, J. Bialkowska-Warzecha, A. L. Hirschberg, B. Antoszewski
SCIENTIFIC REPORTS
(2022)
Article
Biochemical Research Methods
Jona Elings Knutsson, Lena Ekstrom, Angelica Linden Hirschberg
Summary: Analyzing doping control samples from female athletes requires understanding non-doping factors like exercise, alcohol consumption, hormonal changes during menstrual cycle, and the effect of approved drugs. Serum samples are proposed as a complement to urine samples for doping testing. This study investigated the effect of combined oral contraceptives on serum steroid levels in 340 healthy females, finding that the glucuronide metabolites were unaffected while testosterone levels increased during the ovulation phase, suggesting the ratio of testosterone and androstenedione as a potential marker for doping with endogenous anabolic androgenic steroids in women.
DRUG TESTING AND ANALYSIS
(2023)
Article
Biochemical Research Methods
Alexander Andersson, Thomas Piper, Lena Ekstrom, Angelica Linden Hirschberg, Mario Thevis
Summary: Monitoring the urinary steroid profile in the athlete biological passport helps detect testosterone intake, but current research has mainly focused on male subjects, neglecting steroid concentration and variation in females. This study evaluates the usefulness of carbon isotope ratio (CIR) analysis in serum samples from female subjects. Results show significant depletion of CIR in two targeted steroid sulphates after 10 weeks of transdermal testosterone administration. Although the urinary athlete biological passport lacks sensitivity, CIR analysis of androsterone and epiandrosterone in serum can be used as a complementary method to confirm exogenous testosterone in women.
DRUG TESTING AND ANALYSIS
(2023)
Article
Endocrinology & Metabolism
Lea Tschaidse, Nicole Reisch, Wiebke Arlt, Aude Brac de la Perriere, Angelica Linden Hirschberg, Anders Juul, Ashwini Mallappa, Deborah P. Merke, John D. C. Newell-Price, Colin G. Perry, Alessandro Prete, D. Aled Rees, Nike M. M. L. Stikkelbroeck, Philippe A. Touraine, Helen Coope, John Porter, Richard John M. Ross, Marcus Quinkler
Summary: This study compared the renin-angiotensin-aldosterone system in patients with salt-wasting congenital adrenal hyperplasia (SW-CAH) receiving modified-release hydrocortisone (MR-HC) or standard glucocorticoid (GC) therapy. It was found that MR-HC therapy decreased 17-hydroxyprogesterone levels, reduced plasma renin activity, and increased serum sodium concentrations, while standard GC therapy did not have these effects.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Angelica Linden Hirschberg
Summary: Postmenopausal hyperandrogenism is commonly caused by polycystic ovary syndrome, leading to symptoms such as hirsutism and androgenic alopecia, as well as metabolic disorders like abdominal obesity, insulin resistance, and type 2 diabetes. Patients with serum testosterone levels exceeding 5 nmol/L should undergo further investigation to rule out tumors producing androgens from the ovaries or adrenal glands.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Letter
Sport Sciences
Angelica Linden Hirschberg
Article
Biology
Yu Pei, Sanjiv Risal, Hong Jiang, Haojiang Lu, Eva Lindgren, Elisabet Stener-Victorin, Qiaolin Deng
Summary: Excessive androgen production and obesity play a key role in the development of polycystic ovary syndrome (PCOS). Various mouse models, including prenatal androgenized, peripubertal androgenized, overexpression of nerve growth factor in theca cells, and diet-induced maternal obesity, were used to study PCOS. Transcriptome analysis revealed differentially expressed genes in the hypothalamus, adipose tissue, ovary, and oocytes, with the ovaries and adipose tissues showing the most significant changes. The Ms4a6e gene, found in all mouse models and in women with PCOS, suggests a conserved disease function in PCOS.
COMMUNICATIONS BIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Tina Ronn, Alexander Perfilyev, Josefine Jonsson, Karl-Fredrik Eriksson, Sine W. Jorgensen, Charlotte Brons, Linn Gillberg, Allan Vaag, Elisabet Stener-Victorin, Charlotte Ling
Summary: This study found an association between DNA methylation levels in adipose tissue and circulating lipid levels, and identified novel epigenetic changes associated with lipid levels. These findings provide insights into the relationship between dysregulation of circulating lipids and epigenetic mechanisms in adipose tissue, and have important implications for the study of metabolic syndrome.
HUMAN MOLECULAR GENETICS
(2023)
Article
Geriatrics & Gerontology
Panagiotis Anagnostis, Sarantis Livadas, Dimitrios G. Goulis, Silvia Bretz, Iuliana Ceausu, Fatih Durmusoglu, Risto Erkkola, Ivan Fistonic, Marco Gambacciani, Marije Geukes, Haitham Hamoda, Caoimhe Hartley, Angelica Linden Hirschberg, Blazej Meczekalski, Nicolas Mendoza, Alfred Mueck, Antonina Smetnik, Petra Stute, Mick van Trotsenburg, Margaret Rees, Irene Lambrinoudaki
Summary: Vitamin D deficiency is associated with various negative health outcomes such as osteoporosis, cardiovascular disease, cancer, infections, and neurodegenerative disease. However, the impact of vitamin D supplementation on non-skeletal outcomes needs further clarification, especially in postmenopausal women.
Article
Cell Biology
Sanjiv Risal, Congru Li, Qing Luo, Romina Fornes, Haojiang Lu, Gustaw Eriksson, Maria Manti, Claes Ohlsson, Eva Lindgren, Nicolas Crisosto, Manuel Maliqueo, Barbara Echiburu, Sergio Recabarren, Teresa Sir Petermann, Anna Benrick, Nele Brusselaers, Jie Qiao, Qiaolin Deng, Elisabet Stener-Victorin
Summary: The transgenerational effects of PCOS in female progeny are being investigated. This study examines whether sons born to mothers with PCOS transmit reproductive and metabolic phenotypes to their male progeny. The results show that PCOS-sons are more likely to be obese and have dyslipidemia, and a mouse model confirms that these dysfunctions are passed down to multiple generations. The study highlights the potential risk of transmission of reproductive and metabolic dysfunction through the male germline.
CELL REPORTS MEDICINE
(2023)
Review
Endocrinology & Metabolism
Meri Davitadze, Kashish Malhotra, Halimah Khalil, Meghnaa Hebbar, Chau Thien Tay, Aya Mousa, Helena PCOS SEva Team, Helena Teede, Leah Brennan, Elisabet Stener-Victorin, Punith Kempegowda
Summary: This systematic review and meta-analysis compared body image concerns among women with and without polycystic ovary syndrome (PCOS). The results showed that women with PCOS reported higher dissatisfaction with appearance evaluation and appearance orientation. They also had higher dissatisfaction with overweight preoccupation, lower body area satisfaction, and body weight classification compared to women without PCOS. These findings highlight the importance of addressing body image concerns in the clinical care of PCOS.
EUROPEAN JOURNAL OF ENDOCRINOLOGY
(2023)
Review
Endocrinology & Metabolism
Angelica Linden Hirschberg
Summary: Hyperandrogenism in women is associated with increased prevalence of cardiovascular risk factors and risk of cardiovascular disease. The relationship is independent of body mass index in premenopausal women, but dependent on obesity in postmenopausal women. The overall risk of cardiovascular disease in hyperandrogenic postmenopausal women is similar to controls. The reason for reduced cardiometabolic risk after menopause in hyperandrogenic women is not clear.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Meeting Abstract
Obstetrics & Gynecology
H. Lu, H. Jiang, C. Li, H. P. Pui, E. Lindgren, S. Risal, S. Torstensson, G. Eriksson, C. Ohlsson, A. Benrick, E. Stener-Victorin, Q. Deng
HUMAN REPRODUCTION
(2023)