Article
Multidisciplinary Sciences
Akira Hirata, Keiko Mine, Ken Hayashi
Summary: Patients who undergo temporal inverted internal limiting membrane (ILM) flap technique for macular hole (MH) show good postoperative outcomes with improved visual acuity and closure of MH. The area of the ILM flap decreases significantly between 1 and 6 months postoperatively, with some patients experiencing flap contraction. Younger age and larger ILM flap area at 1 month postoperatively are correlated with ILM flap contraction.
SCIENTIFIC REPORTS
(2021)
Article
Ophthalmology
Nurullah Kocak, Volkan Yeter, Hakki Birinci
Summary: The study compares the outcomes of conventional ILM peeling and temporal inverted ILM flap technique for large full-thickness macular holes. The results suggest that the temporal inverted ILM flap technique is more effective in terms of hole closure rate, BCVA improvement, and restoration of the outer retinal layers.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Ji-Guo Yu, Jing Wang, Yi Xiang
Summary: The use of the inverted ILM flap technique in large MHs has shown higher anatomical closure rates and better postoperative visual outcomes compared to ILM peeling. Although the inverted ILM flap technique has significant advantages in the short term, no significant difference in visual recovery was found between the two techniques in the long term follow-up.
OPHTHALMIC RESEARCH
(2021)
Article
Medicine, General & Internal
Akari Kimura, Hisanori Imai, Yukako Iwane, Maya Kishimoto, Yasuyuki Sotani, Hiroko Yamada, Wataru Matsumiya, Akiko Miki, Sentaro Kusuhara, Makoto Nakamura
Summary: This new technique can effectively remove sub-internal limiting membrane hemorrhage without peeling the internal limiting membrane, resulting in improved visual acuity and prevention of full-thickness macular hole formation in patients with submacular hemorrhage caused by retinal arterial macroaneurysm rupture.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Ophthalmology
Xujia Liu, Jinqu Huang, Ruiqin Zhou, Zehua Jiang, Haoyu Chen, Weiqi Chen, Tsz Kin Ng, Zhenggen Wu, Guihua Zhang
Summary: This study evaluated the outcomes of ILM peeling and the inverted ILM flap technique for rhegmatogenous retinal detachment with macular hole. The inverted ILM flap technique had a higher Type 1 closure rate and similar rates of retinal reattachment and visual improvement compared to ILM peeling.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Rubina Rahman, Mohammad Waseem Sarfraz, Mohamad El-Wardani
Summary: The study compared the outcomes of inverted internal limiting membrane flap (ILMF) technique and complete ILM peeling (ILMP) in nonposturing surgery for large macular holes. Both techniques resulted in successful closure of the holes postoperatively, with ILMP showing statistically significant improvement in visual acuity compared to ILMF. Postoperative nonposturing did not compromise surgical success in both groups.
JOURNAL OF VITREORETINAL DISEASES
(2022)
Article
Ophthalmology
Remzi Avci, Aysegul Mavi Yildiz, Sami Yilmaz
Summary: This study compared the outcomes of conventional internal limiting membrane peeling with temporal inverted internal limiting membrane flap technique for large macular holes. The results showed that the flap technique had higher closure rates, better visual acuity improvement, and significantly higher rates of complete restoration of external limiting membrane and ellipsoid zone compared to the peeling technique.
EUROPEAN JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Nathalie Bleidissel, Julia Friedrich, Julian Klaas, Nikolaus Feucht, Chris Patrick Lohmann, Mathias Maier
Summary: The study demonstrates the favorable morphological and functional outcomes of the I-ILM flap technique in treating large idiopathic full-thickness macular holes, with a 100% closure rate and significant improvement in BCVA over a 12-month follow-up period. Better preoperative BCVA, complete restoration of ELM, higher MHI, and smaller MH base diameter are associated with greater improvements in BCVA.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Xunyi Gu, Zizhong Hu, Huiming Qian, Silvia Fransisca, Aime Mugisha, Jingfan Wang, Zhengyu Zhang, Weiwei Zhang, Jiangdong Ji, Qinghuai Liu, Ping Xie
Summary: In the treatment of macular hole retinal detachment in highly myopic eyes, the modified perfluorocarbon liquid-assisted inverted ILM flap technique was more effective in achieving macular hole closure and significantly improving visual acuity compared to standard ILM peeling.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Vishal Agrawal, Khushbu Jindal, Yogendra Dhakad, Priyanka Rathore, Kamlesh Khilnani
Summary: The multilayered inverted internal limiting membrane flap technique (ML-IILM) had significantly higher anatomical closure and better visual outcome compared to standard internal limiting membrane peeling in vitrectomy for large macular holes.
INDIAN JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Multidisciplinary Sciences
Changzhong Xu, Chao Feng, Mengyao Han, Junwen He, Rui Zhang, Tao Yan, Xiangyun Li, Yong Liu, Yanzi Li, Jianhua Wu
Summary: The study compared the efficacy of internal limiting membrane (ILM) flap covering and ILM flap insertion in treating highly myopic eyes with MHRD, showing similar results in retinal reattachment and MH closure between the two methods, with limited improvement in visual function. Factors such as longer axial length and higher choroidal atrophy were identified as risks for initial anatomical failure.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Ke Zhu, Boya Lei, Wenghang Wong, Juan Zhang, Yue Guo, Han Chen, Fang Song, Qing Chang, Gezhi Xu, Yanqiong Zhang
Summary: The study compared the anatomical and functional outcomes of using the ILM insertion technique or the inverted ILM flap technique in macular hole-associated retinal detachment. Results showed that the inverted ILM flap technique was more effective in achieving a higher MH closure rate and improving postoperative BCVA. Preoperative BCVA and the ILM flap technique were significant factors affecting visual outcomes in these patients.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Tadashi Mizuguchi, Masayuki Horiguchi, Sayaka Kakehi, Yasuki Ito
Summary: This study investigates the influence of an excess inverted internal limiting membrane flap on postoperative visual acuity and macular morphology in patients with idiopathic macular hole. The results showed that the postoperative morphology of the inverted ILM flap did not affect postoperative best-corrected visual acuity or central retinal thickness.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Lorenzo Iuliano, Eleonora Corbelli, Francesco Bandello, Marco Codenotti
Summary: This study compared the anatomical and functional outcomes of small and medium full-thickness macular holes (FTMHs) treated with internal limiting membrane (ILM) inverted flap (IF) or with the standard technique. The results showed that small FTMHs treated with IF had inferior foveal sensitivity and restoration of the external limiting membrane (ELM) and ellipsoid zone (EZ) compared to the standard technique at 6 months. However, there was no significant difference in best-corrected visual acuity (BCVA) improvement between the two techniques. Therefore, the surgical repair of small FTMHs with ILM IF may delay foveal structural repair and result in poorer visual sensitivity.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2023)
Article
Ophthalmology
Shuang Li, Lu Zhang, Ji-Guo Yu
Summary: This meta-analysis compared the outcomes of inverted internal limiting membrane (ILM) flap and ILM insertion techniques in the treatment of large macular holes (MHs). The results showed that there were no significant differences in MH closure rates and visual function outcomes between the two techniques. However, based on the results, postoperative best-corrected visual acuity and outer retinal layer reconstruction tended to favor the ILM flap technique. Further studies with larger sample sizes are needed to confirm the superiority of the ILM flap technique.
SEMINARS IN OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Zizhong Hu, Xunyi Gu, Huiming Qian, Kang Liang, Weiwei Zhang, Jiangdong Ji, Qin Chen, Qinghuai Liu, Ping Xie
Summary: This article provides supplemental digital content.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2022)
Article
Ophthalmology
Xunyi Gu, Zizhong Hu, Huiming Qian, Silvia Fransisca, Aime Mugisha, Jingfan Wang, Zhengyu Zhang, Weiwei Zhang, Jiangdong Ji, Qinghuai Liu, Ping Xie
Summary: In the treatment of macular hole retinal detachment in highly myopic eyes, the modified perfluorocarbon liquid-assisted inverted ILM flap technique was more effective in achieving macular hole closure and significantly improving visual acuity compared to standard ILM peeling.
RETINA-THE JOURNAL OF RETINAL AND VITREOUS DISEASES
(2021)
Article
Ophthalmology
Shan Sang, Jinxin Miao, Zizhong Hu, Songtao Yuan, Ping Xie, Qinghuai Liu
Summary: This study compared the protective effects of different contact lenses on the cornea, with results showing that XO lenses offer better corneal protection during vitreoretinal surgery, particularly in patients with PDR.
EYE & CONTACT LENS-SCIENCE AND CLINICAL PRACTICE
(2021)
Article
Medicine, Research & Experimental
Dan-Yang Chen, Ning-He Sun, Xiang Chen, Jun-Jie Gong, Song-Tao Yuan, Zi-Zhong Hu, Nan-Nan Lu, Jakob Korbelin, Kohji Fukunaga, Qing-Huai Liu, Ying-Mei Lu, Feng Han
Summary: Semaphorin 3G plays a crucial role in vascular remodeling and improvement of ischemic retinopathy by enhancing healthy vascular network formation and promoting diseased vasculature regression. Loss of Sema3G exacerbates pathological angiogenesis in retinal vasculature. Sema3G coordinates the functional interaction between beta-catenin and VE-cadherin, leading to increased beta-catenin stability and aiding in vascular remodeling.
JOURNAL OF CLINICAL INVESTIGATION
(2021)
Article
Computer Science, Artificial Intelligence
Yuhan Zhang, Xiwei Zhang, Zexuan Ji, Sijie Niu, Theodore Leng, Daniel L. Rubin, Songtao Yuan, Qiang Chen
Summary: The study developed an integrated time adaptive prediction model for predicting future GA growth locations. By integrating time factors to the BiLSTM models, the prediction accuracy was improved by almost 10%. The CNN-based refinement strategy effectively improved the prediction accuracy by removing wrong GA regions.
MEDICAL IMAGE ANALYSIS
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Chen Huang, Keren Xie, Yuhan Zhang, Mingchao Li, Songtao Yuan, Qiang Chen
Summary: The proposed fusion method combining SD-OCT and OCTA images is more effective for CNV visualization, providing a satisfying visual effect by integrating complementary information from multimodal images.
Article
Ophthalmology
Xiying Mao, Mingkang Chen, Yan Yu, Qinghuai Liu, Songtao Yuan, Wen Fan
Summary: In this study, a novel hemizygous nonsense mutation in the GPR143 gene was identified in a large Chinese family, causing poor visual acuity and isolated foveal hypoplasia without nystagmus. This expands the genetic mutation spectrum of GPR143 and suggests a unique manifestation of OA1 in this particular family.
Review
Cell Biology
Zhengyu Zhang, Aime Mugisha, Silvia Fransisca, Qinghuai Liu, Ping Xie, Zizhong Hu
Summary: Retinal diseases, leading causes of vision loss and blindness, involve complex pathogeneses such as angiogenesis, inflammation, immune regulation, fibrous proliferation, and neurodegeneration. Exosomes, as important mediators of cell communication, carry a variety of biomolecules and have the potential to be therapeutically effective in treating retinal diseases.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Optics
Xiang Zhang, Yang Liu, Chao Tao, Jie Yin, Zizhong Hu, Songtao Yuan, Qinghuai Liu, Xiaojun Liu
Summary: The proposed optical-acoustic combiner enhances acoustic focusing performance and detection sensitivity, while reducing optical disorders for improved resolution. In vivo experiments demonstrate the practicality of the combiner in biomedicine.
Article
Ophthalmology
Zizhong Hu, Xin Cao, Lu Chen, Yun Su, Jiangdong Ji, Songtao Yuan, Silvia Fransisca, Aime Mugisha, Wenjun Zou, Ping Xie, Qinghuai Liu
Summary: Following intravitreous injection of conbercept, VEGF-A levels in PDR eyes decreased rapidly, while PIGF levels decreased at day 2 and returned to baseline after 5 days. There was no increase in profibrotic cytokines post-injection.
ACTA OPHTHALMOLOGICA
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Loza Bekalo Sappa, Idowu Paul Okuwobi, Mingchao Li, Yuhan Zhang, Sha Xie, Songtao Yuan, Qiang Chen
Summary: This study introduces an improved CNN architecture called RetFluidNet to segment fluid abnormalities in AMD from SD-OCT images. The model integrates various pooling and connection operations to achieve best performance, showing significant improvement in accuracy and time efficiency.
JOURNAL OF DIGITAL IMAGING
(2021)
Article
Ophthalmology
Lu Chen, Weiwei Zhang, Ping Xie, Jiangdong Ji, Huiming Qian, Songtao Yuan, Qinghuai Liu, Zizhong Hu
Summary: The study found that the expression of vitreal cytokines is similar between patients with iERM and iMH, indicating that they can be used as healthy controls.
JOURNAL OF OPHTHALMOLOGY
(2021)
Article
Ophthalmology
Xinsheng Li, Jingfan Wang, Yan Wu, Xingxing Wang, Zhengyu Zhang, Zizhong Hu, Ping Xie
Summary: Vitrectomy with inverted fovea-sparing internal limiting membrane has shown high efficacy and safety in the treatment of eyes with myopic foveoschisis.
JOURNAL OF OPHTHALMOLOGY
(2022)
Article
Medicine, Research & Experimental
Yu Liu, Qin Yang, Haixin Fu, Jingfan Wang, Songtao Yuan, Xinsheng Li, Ping Xie, Zizhong Hu, Qinghuai Liu
Summary: Exosomes collected from the vitreous humor of proliferative diabetic retinopathy patients promote cell proliferation, migration, and tube formation ability of retinal endothelial cells via elevated miR-9-3p expression level. Muller glia cells are identified as the sole source of aberrantly expressed miR-9-3p, and their exosomes aggravate vascular dysfunction under high glucose conditions.
MOLECULAR THERAPY-NUCLEIC ACIDS
(2022)
Article
Ophthalmology
Tongfeng Cui, Hongyan Sun, Zizhong Hu, Yabo Shi, Jiang Zhu, Manman Jin, Bing Qin
Summary: This study used optical coherence tomography angiography (OCTA) to evaluate conjunctival vessels in patients with dry eye disease (DED). The results showed that the total number of conjunctival blood vessels increased in patients with DED, suggesting that conjunctival tissue hypoxia may be an important cause of dry eye disease.
JOURNAL OF OPHTHALMOLOGY
(2023)