Review
Biochemistry & Molecular Biology
Iwona Sudol-Szopinska, Nele Herregods, Andrea S. Doria, Mihra S. Taljanovic, Piotr Gietka, Nikolay Tzaribachev, Andrea Sabine Klauser
Summary: Over the past decade, imaging techniques for inflammatory arthritis in juvenile arthropathies have significantly improved, allowing for more accurate assessment and diagnosis. Ultrasound and magnetic resonance imaging have seen advancements in resolution, sensitivity, and diagnostic possibilities.
Article
Medicine, General & Internal
Monika Ostrowska, Emil Michalski, Piotr Gietka, Malgorzata Manczak, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study compared MRI findings between patients clinically suspected of Juvenile Idiopathic Arthritis (JIA) and patients with ankle arthralgia of unknown cause. The results showed that inflammatory features were observed on MRI, with tenosynovitis being significantly more common in JIA patients. However, the MRI summarized score did not effectively differentiate between JIA and non-JIA patients.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Rheumatology
Marta Mazzoni, Angela Pistorio, Francesca Magnaguagno, Stefania Viola, Alessia Urru, Gian Michele Magnano, Angelo Ravelli, Clara Malattia
Summary: The study found that many JIA patients still have subclinical synovitis and bone marrow edema on MRI despite being in clinical remission. These subclinical inflammations may indicate the risk of disease flare and joint deterioration, which could have important implications for the management of the disease.
ARTHRITIS CARE & RESEARCH
(2023)
Article
Pediatrics
Melike Mehves Kaplan, Tuba Kurt, Merve Cansu Polat, Muge Sezer, Zahide Ekici Tekin, Elif celikel, Vildan Gungorer, Niluefer Tekgoz, Cueneyt Karagol, Serkan Coskun, Nimet Oner, Banu Celikel Acar
Summary: The aim of this study was to assess the predictors of relapse in patients with oligoarticular juvenile idiopathic arthritis (oJIA) who achieved clinical remission off medication. A retrospective observational study was conducted on 126 patients who achieved remission off medication. The study found that the number of intraarticular corticosteroid injections (IACIs) and the length of follow-up were significantly related to relapse in oJIA patients who achieved remission off medication.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Pediatrics
Miladi Saoussen, Makhlouf Yasmine, Boussaa Hiba, Fazaa Alia, Ben Abdelghani Kawther, Laatar Ahmed
Summary: Musculoskeletal ultrasound (MSUS) is an important tool in pediatric rheumatology for detecting subclinical disease activity and treating patients during the window of opportunity. However, its role in assessing remission in JIA patients is not well-defined. This systematic review analyzes published literature on MSUS in JIA patients in remission, finding that abnormal MSUS findings, such as subclinical synovitis and Power Doppler signal, are common even in remission. Further studies are needed to better understand the implications and develop a standardized scoring system.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Article
Rheumatology
Lianne Kearsley-Fleet, Eileen Baildam, Michael W. Beresford, Sharon Douglas, Helen E. Foster, Taunton R. Southwood, Kimme L. Hyrich, Coziana Ciurtin
Summary: This analysis identified factors associated with successful cessation of biologics for remission in JIA as absence of uveitis, prior treatment with tocilizumab, and starting biologics earlier in the disease course.
Review
Biology
Federico Roggio, Luca Petrigna, Veronica Filetti, Ermanno Vitale, Venerando Rapisarda, Giuseppe Musumeci
Summary: Adolescent and Juvenile Idiopathic Scoliosis (AIS) is a three-dimensional spine deformity characterized by muscle alterations on the convex and concave sides of the scoliosis. Infrared thermography has shown promise as a non-invasive and radiation-free method for evaluating these alterations. This systematic review found that infrared thermography can objectively assess the thermal differences between the convex and concave sides of scoliosis, but further research is needed to establish it as a diagnostic tool.
JOURNAL OF THERMAL BIOLOGY
(2023)
Article
Medicine, General & Internal
Mateusz Kotecki, Piotr Gietka, Magdalena Posadzy, Iwona Sudol-Szopinska
Summary: This study evaluated the frequency of cervical spine lesions in 34 children with JIA, finding that 35% of patients were affected. X-ray was found to be superior in diagnosing AAS and SAS despite the advantages of MRI in imaging the atlanto-axial region.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Rheumatology
Jaymin Upadhyay, Jordan Lemme, Mariesa Cay, Hanne Van Der Heijden, Diana Sibai, Benjamin Goodlett, Jeffery Lo, Kacie Hoyt, Maria Taylor, Melissa M. Hazen, Olha Halyabar, Esra Meidan, Rudy Schreiber, Margaret H. Chang, Peter A. Nigrovic, Camilo Jaimes, Lauren A. Henderson, Kirsten Ecklund, Robert P. Sundel
Summary: This study utilized neuroimaging techniques to explore the pain-related neurobiological features in JIA patients, finding associations between pain severity and physical stress, cognitive function, and changes in brain structures regulating emotional pain processing. These preliminary findings suggest potential mechanisms by which pain may be dissociated from detectable joint pathology and persist independently of inflammation or treatment status.
SEMINARS IN ARTHRITIS AND RHEUMATISM
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Magdalena Posadzy, Anna Sowinska, Filip Vanhoenacker, Piotr Gietka, Ewa Zelnio, Iwona Sudol-Szopinska
Summary: Conventional radiography plays an important role in evaluating the residual value in children with arthralgia. Soft tissue swelling, osteoporosis, and joint space narrowing are more common in patients with Juvenile Idiopathic Arthritis (JIA) compared to those without inflammatory connective tissue disease.
JOURNAL OF THE BELGIAN SOCIETY OF RADIOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Tito Bassani, Andrea Cina, Dominika Ignasiak, Noemi Barba, Fabio Galbusera
Summary: A major clinical challenge in adolescent idiopathic scoliosis (AIS) is the difficulty of predicting curve progression at initial presentation. While previous research has focused on geometric parameters of the spine and descriptors of scoliotic curves, the contribution of biomechanical measurements was neglected, and ultimately did not enhance the prediction of curve progression.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2021)
Article
Pediatrics
Sabrina Gmuca, Maitry Sonagra, Rui Xiao, Elizabeth Mendoza, Kimberly S. Miller, Nina H. Thomas, Jami F. Young, Pamela F. Weiss, David D. Sherry, Jeffrey S. Gerber
Summary: Adolescents with fibromyalgia predominantly experience subjective dyscognition but more than 1/3 also experience objective dyscognition. Subjective dyscognition is independently associated with functional disability and anxiety.
FRONTIERS IN PEDIATRICS
(2022)
Article
Radiology, Nuclear Medicine & Medical Imaging
Vanessa Kristina Anna Koliogiannis, Martina Brandlhuber, Viktoria Messerschmidt, Robert Stahl, Carolin Melcher, Regina Schinner, Christof Birkenmaier, Jens Ricke, Andrea Baur-Melnyk
Summary: The EOS imaging system allows for accurate and consistent grading of osteoarthritis compared to conventional radiographs, particularly in evaluating joint space, osteophytes, and joint space narrowing parameters. Subchondral sclerosis of the lateral and medial femur condyle or tibia may sometimes not be as evident on EOS images.
EUROPEAN RADIOLOGY
(2021)
Article
Pediatrics
Merve Cansu Polat, Elif Celikel, Zahide Ekici Tekin, Vildan Gungorer, Tuba Kurt, Nilufer Tekgoz, Muege Sezer, Cueneyt Karagol, Serkan Coskun, Melike Mehves Kaplan, Nimet Oner, Banu celikel Acar
Summary: This study evaluated physical activity and health-related quality of life in children with oligoarticular juvenile idiopathic arthritis in remission, and found that they had lower scores in these aspects compared to healthy peers.
EUROPEAN JOURNAL OF PEDIATRICS
(2023)
Review
Orthopedics
Meghan Jardon, Erin F. Alaia
Summary: Imaging plays a crucial role in the diagnosis of musculoskeletal infection. Different imaging modalities have their own advantages and limitations. Radiography provides an overview of bones, ultrasound is useful for real-time guidance, CT is important in emergency situations, and MRI is the modality of choice for clear diagnosis of infection.
SKELETAL RADIOLOGY
(2023)
Article
Allergy
Arinna Bertoni, Sonia Carta, Chiara Baldovini, Federica Penco, Enrica Balza, Silvia Borghini, Marco Di Duca, Emanuela Ognio, Alessio Signori, Paolo Nozza, Francesca Schena, Patrizia Castellani, Claudia Pastorino, Carola Perrone, Laura Obici, Alberto Martini, Isabella Ceccherini, Marco Gattorno, Anna Rubartelli, Sabrina Chiesa
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2020)
Article
Rheumatology
Ellen Nordal, Angela Pistorio, Marite Rygg, Gabriella Giancane, Mohamad Maghnie, Natascia Di Iorgi, Kristina Flemming, Michael Hofer, Jose A. Melo-Gomes, Blanca E. R. G. Bica, Jurgen Brunner, Guenther Dannecker, Valeria Gerloni, Miroslav Harjacek, Hans-Iko Huppertz, Polyxeni Pratsidou-Gertsi, Susan Nielsen, Valda Stanevicha, Rebecca Ten Cate, Olga Vougiouka, Serena Pastore, Gabriele Simonini, Angelo Ravelli, Alberto Martini, Nicolino Ruperto
ARTHRITIS CARE & RESEARCH
(2020)
Article
Rheumatology
Hermine I. Brunner, Kabita Nanda, Mary Toth, Ivan Foeldvari, John Bohnsack, Diana Milojevic, C. Egla Rabinovich, Daniel J. Kingsbury, Katherine Marzan, Elizabeth Chalom, Gerd Horneff, Rolf-Michael Kuester, Jason A. Dare, Maria Trachana, Lawrence K. Jung, Judyann Olson, Kirsten Minden, Pierre Quartier, Mareike Bereswill, Jasmina Kalabic, Hartmut Kupper, Daniel J. Lovell, Alberto Martini, Nicolino Ruperto
ARTHRITIS CARE & RESEARCH
(2020)
Article
Pediatrics
Hermine I. Brunner, Nikolay Tzaribachev, Gabriel Vega Cornejo, Rik Joos, Elisabeth Gervais, Rolando Cimaz, Inmaculada Calvo Penades, Ruben Cuttica, Thomas Lutz, Pierre Quartier, Yash Gandhi, Marleen Nys, Robert Wong, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto
PEDIATRIC RHEUMATOLOGY
(2020)
Editorial Material
Rheumatology
Angelo Ravelli, Alberto Martini
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Hermine Brunner, Pierre Quartier, Ekaterina Alexeeva, Tamas Constantin, Isabelle Kone-Paut, Katherine Marzan, Rayfel Schneider, Nico M. Wulffraat, Vyacheslav Chasnyk, Irit Tirosh, Tilmann Kallinich, Jasmin Kuemmerle-Deschner, Carine Wouters, Bernard Lauwerys, Irina Nikishina, Maria Trachana, Olga Vougiouka, Alberto Martini, Daniel J. Lovell, Jeremy Levy, Eleni Vritzali, Nicolino Ruperto
ARTHRITIS & RHEUMATOLOGY
(2020)
Review
Pediatrics
Hermine Brunner, Robert Wong, Marleen Nys, Tzuyung D. Kou, Alyssa Dominique, Alberto Martini, Daniel J. Lovell, Nicolino Ruperto
Article
Microbiology
Pamela Vernocchi, Federico Marini, Giorgio Capuani, Alberta Tomassini, Giorgia Conta, Federica Del Chierico, Clara Malattia, Fabrizio De Benedetti, Alberto Martini, Bruno Dallapiccola, E. H. Pieter van Dijkhuizen, Alfredo Miccheli, Lorenza Putignani
Review
Rheumatology
Clara Malattia, Mirkamal Tolend, Marta Mazzoni, Jyoti Panwar, Margalit Zlotnik, Tarimobo Otobo, Logi Vidarsson, Andrea S. Doria
BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY
(2020)
Correction
Rheumatology
Aldo Naselli, Federica Penco, Luca Cantarini, Antonella Insalaco, Mariolina Alessio, Alberto Tommasini, Cristina Maggio, Laura Obici, Romina Gallizzi, Marco Cimmino, Sara Signa, Orso Maria Lucherini, Sonia Carta, Francesco Caroli, Alberto Martini, Anna Rubartelli, Isabella Ceccherini, Marco Gattorno
JOURNAL OF RHEUMATOLOGY
(2020)
Article
Rheumatology
Daniel J. Lovell, Hermine Brunner, Andreas O. Reiff, Lawrence Jung, Katerina Jarosova, Dana Nemcova, Richard Mouy, Christy Sandborg, John F. Bohnsack, Dirk Elewaut, Christos Gabriel, Gloria Higgins, Isabelle Kone-Paut, Olcay Y. Jones, Veronika Vargova, Elizabeth Chalom, Carine Wouters, Ivan Lagunes, Yanna Song, Alberto Martini, Nicolino Ruperto
Article
Rheumatology
Clara Malattia, Nicolino Ruperto, Silvia Pederzoli, Elena Palmisani, Angela Pistorio, Carine Wouters, Pavla Dolezalova, Berit Flato, Stella Garay, Gabriella Giancane, Chris Wells, Wendy Douglass, Hermine I. Brunner, Fabrizio De Benedetti, Angelo Ravelli
ARTHRITIS RESEARCH & THERAPY
(2020)
Meeting Abstract
Rheumatology
C. Malattia, M. Carpaneto, M. Mazzoni, C. Lavarello, E. Fueri, S. Marra, A. Ravelli, L. Nobili
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Meeting Abstract
Rheumatology
E. Cocchiara, E. Galli, A. De Fanti, C. Malattia, A. Ravelli, C. Salvarani
ANNALS OF THE RHEUMATIC DISEASES
(2020)
Article
Rheumatology
Gabriella Giancane, Joost F. Swart, Elio Castagnola, Andreas H. Groll, Gerd Horneff, Hans-Iko Huppertz, Daniel J. Lovell, Tom Wolfs, Troels Herlin, Pavla Dolezalova, Helga Sanner, Gordana Susic, Flavio Sztajnbok, Despoina Maritsi, Tamas Constantin, Veronika Vargova, Sujata Sawhney, Marite Rygg, Sheila K. Oliveira, Marco Cattalini, Francesca Bovis, Francesca Bagnasco, Angela Pistorio, Alberto Martini, Nico Wulffraat, Nicolino Ruperto
ARTHRITIS RESEARCH & THERAPY
(2020)