Journal
EXPERT REVIEW OF ANTI-INFECTIVE THERAPY
Volume 16, Issue 3, Pages 219-225Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/14787210.2018.1436967
Keywords
Mucosal leishmaniasis; miltefosine; pentoxifylline; immunotherapy; pentavalent antimony
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Introduction: Mucosal Leishmaniasis (ML) is a difficult to treat and severe form of Leishmaniasis. In general, more than 40% of subjects with ML have therapeutic failure upon the use of pentavalent antimony (Sb-v) at 20mg/kg/day during 30days. Additionally, Sb-v is a toxic drug that requires parenteral administration, and many patients will need several courses to be cured. In cases that cannot be treated or cured by Sb-v, the alternative is amphotericin B, another toxic and parenteral drug. As a consequence, many ML patients will be cured only after years of disease and may present several morbidities due to the aggressiveness of the disease or toxicity related to the treatment.Areas covered: We aimed to review clinical trials with Miltefosine or Sb-v associated with pentoxifylline in the treatment of ML.Expert commentary: There are few studies to define more effective and safer therapy in mucosal disease caused by Leishmania, with an urgent need to supporting and funding well designed trials. Miltefosine monotherapy, as well as pentoxifylline combined with Sb-v are promising therapeutic approaches to increase the cure rate of this neglected disease.
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