BCL6 as a therapeutic target for lymphoma

Discovery of Pyrazolo[1,5-a]pyrimidine B-Cell Lymphoma 6 (BCL6) Binders and Optimization to High Affinity Macrocyclic Inhibitors

(2017) William McCoull et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a B-Cell Lymphoma 6 Protein–Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach

(2017) Yusuke Kamada et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interferon γ is a STAT1-dependent direct inducer of BCL6 expression in imatinib-treated chronic myeloid leukemia cells

(2017) H S Madapura et al.   ONCOGENE

The CREBBP Acetyltransferase Is a Haploinsufficient Tumor Suppressor in B-cell Lymphoma

(2017) Jiyuan Zhang et al.   Cancer Discovery

Chemically Induced Degradation of the Oncogenic Transcription Factor BCL6

(2017) Nina Kerres et al.   Cell Reports

FBXO11 inactivation leads to abnormal germinal-center formation and lymphoproliferative disease

(2016) C. Schneider et al.   BLOOD

EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis

(2016) Wendy Béguelin et al.   CANCER CELL

The Expanding Role of the BCL6 Oncoprotein as a Cancer Therapeutic Target

(2016) Mariano G. Cardenas et al.   CLINICAL CANCER RESEARCH

Multi-tiered Reorganization of the Genome during B Cell Affinity Maturation Anchored by a Germinal Center-Specific Locus Control Region

(2016) Karen L. Bunting et al.   IMMUNITY

BCL6 locus is hypermethylated in angioimmunoblastic T-cell lymphoma

(2016) Shoko Nishizawa et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Rationally designed BCL6 inhibitors target activated B cell diffuse large B cell lymphoma

(2016) Mariano G. Cardenas et al.   JOURNAL OF CLINICAL INVESTIGATION

CREBBP Inactivation Promotes the Development of HDAC3-Dependent Lymphomas

(2016) Yanwen Jiang et al.   Cancer Discovery

Genome-wide Analysis Identifies Bcl6-Controlled Regulatory Networks during T Follicular Helper Cell Differentiation

(2016) Xindong Liu et al.   Cell Reports

Self-Enforcing Feedback Activation between BCL6 and Pre-B Cell Receptor Signaling Defines a Distinct Subtype of Acute Lymphoblastic Leukemia

(2015) Huimin Geng et al.   CANCER CELL

Lenalidomide Combined With R-CHOP Overcomes Negative Prognostic Impact of Non–Germinal Center B-Cell Phenotype in Newly Diagnosed Diffuse Large B-Cell Lymphoma: A Phase II Study

(2015) Grzegorz S. Nowakowski et al.   JOURNAL OF CLINICAL ONCOLOGY

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanisms

(2015) Katerina Hatzi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective targeting of BCL6 induces oncogene addiction switching to BCL2 in B-cell lymphoma

(2015) Thibault Dupont et al.   Oncotarget

Translocation of the proto-oncogene Bcl-6 in human glioblastoma multiforme

(2014) Simona Ruggieri et al.   CANCER LETTERS

The transcriptional modulator BCL6 as a molecular target for breast cancer therapy

(2014) S R Walker et al.   ONCOGENE

The Ansamycin Antibiotic, Rifamycin SV, Inhibits BCL6 Transcriptional Repression and Forms a Complex with the BCL6-BTB/POZ Domain

(2014) Sian E. Evans et al.   PLoS One

The BCL6 RD2 Domain Governs Commitment of Activated B Cells to Form Germinal Centers

(2014) Chuanxin Huang et al.   Cell Reports

Genetics of Follicular Lymphoma Transformation

(2014) Laura Pasqualucci et al.   Cell Reports

New effector functions and regulatory mechanisms of BCL6 in normal and malignant lymphocytes

(2013) Karen L Bunting et al.   CURRENT OPINION IN IMMUNOLOGY

MEF2B mutations lead to deregulated expression of the oncogene BCL6 in diffuse large B cell lymphoma

(2013) Carol Y Ying et al.   NATURE IMMUNOLOGY

Lineage-specific functions of Bcl-6 in immunity and inflammation are mediated by distinct biochemical mechanisms

(2013) Chuanxin Huang et al.   NATURE IMMUNOLOGY

Novel CTCF binding at a site in exon1A of BCL6 is associated with active histone marks and a transcriptionally active locus

(2013) A Batlle-López et al.   ONCOGENE

A Hybrid Mechanism of Action for BCL6 in B Cells Defined by Formation of Functionally Distinct Complexes at Enhancers and Promoters

(2013) Katerina Hatzi et al.   Cell Reports

Roles of BCL6 in normal and transformed germinal center B cells

(2012) Katia Basso et al.   IMMUNOLOGICAL REVIEWS

Bcl6 expression specifies the T follicular helper cell program in vivo

(2012) Xindong Liu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Burkitt lymphoma pathogenesis and therapeutic targets from structural and functional genomics

(2012) Roland Schmitz et al.   NATURE

Integrative Epigenomic Analysis Identifies Biomarkers and Therapeutic Targets in Adult B-Acute Lymphoblastic Leukemia

(2012) Huimin Geng et al.   Cancer Discovery

Pre-B cell receptor-mediated activation of BCL6 induces pre-B cell quiescence through transcriptional repression of MYC

(2011) R. Nahar et al.   BLOOD

BCL6-mediated repression of p53 is critical for leukemia stem cell survival in chronic myeloid leukemia

(2011) Christian Hurtz et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inactivating mutations of acetyltransferase genes in B-cell lymphoma

(2011) Laura Pasqualucci et al.   NATURE

BCL6 enables Ph+ acute lymphoblastic leukaemia cells to survive BCR–ABL1 kinase inhibition

(2011) Cihangir Duy et al.   NATURE

A Small-Molecule Inhibitor of BCL6 Kills DLBCL Cells In Vitro and In Vivo

(2010) Leandro C. Cerchietti et al.   CANCER CELL

Cytogenetic abnormalities in reactive lymphoid hyperplasia: byproducts of the germinal centre reaction or indicators of lymphoma?

(2010) Deborah W. Sevilla et al.   HEMATOLOGICAL ONCOLOGY

BCL6 repression of EP300 in human diffuse large B cell lymphoma cells provides a basis for rational combinatorial therapy

(2010) Leandro C. Cerchietti et al.   JOURNAL OF CLINICAL INVESTIGATION

DNA methylation prevents CTCF-mediated silencing of the oncogeneBCL6in B cell lymphomas

(2010) Anne Y. Lai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chronic active B-cell-receptor signalling in diffuse large B-cell lymphoma

(2010) R. Eric Davis et al.   NATURE

Integrated biochemical and computational approach identifies BCL6 direct target genes controlling multiple pathways in normal germinal center B cells

(2009) K. Basso et al.   BLOOD

The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL

(2009) W. Ci et al.   BLOOD

A purine scaffold Hsp90 inhibitor destabilizes BCL-6 and has specific antitumor activity in BCL-6–dependent B cell lymphomas

(2009) Leandro C Cerchietti et al.   NATURE MEDICINE

BCL6 suppression of BCL2 via Miz1 and its disruption in diffuse large B cell lymphoma

(2009) M. Saito et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bcl6 Mediates the Development of T Follicular Helper Cells

(2009) R. I. Nurieva et al.   SCIENCE

A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo

(2008) L. C. Cerchietti et al.   BLOOD

Structure of a BCOR Corepressor Peptide in Complex with the BCL6 BTB Domain Dimer

(2008) Alexandru F. Ghetu et al.   MOLECULAR CELL