Advances in microwave-assisted synthesis and the impact of novel drug discovery

Microwave-assisted diastereoselective two-step three-component synthesis for rapid access to drug-like libraries of substituted 3-amino-β-lactams

(2018) Guido V. Janssen et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Design and synthesis of 1,4-substituted 1 H -1,2,3-triazolo-quinazolin-4(3 H )-ones by Huisgen 1,3-dipolar cycloaddition with PI3Kγ isoform selective activity

(2018) M. Srinivas et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Microwave-assisted synthesis of novel 5-substituted benzylidene amino-2-butyl benzofuran-3-yl-4-methoxyphenyl methanones as antileishmanial and antioxidant agents

(2018) Sanjeev R. Patil et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

1,2,4-Thiadiazolidin-3,5-diones as novel hydrogen sulfide donors

(2018) Beatrice Severino et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

PEG 400/Cerium Ammonium Nitrate Combined with Microwave-Assisted Synthesis for Rapid Access to Beta-Amino Ketones. An Easy-to-Use Protocol for Discovering New Hit Compounds

(2018) Giacomo Rossino et al.   MOLECULES

Efficient Access to Imidazo[1,2-a]pyridines/pyrazines/pyrimidines via Catalyst-Free Annulation Reaction under Microwave Irradiation in Green Solvent

(2018) R. Nishanth Rao et al.   ACS Combinatorial Science

Design and synthesis of a new series of 3,5-disubstituted isoxazoles active against Trypanosoma cruzi and Leishmania amazonensis

(2017) Rafael da Rosa et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Solution-phase microwave assisted parallel synthesis, biological evaluation and in silico docking studies of N , N ′-disubstituted thioureas derived from 3-chlorobenzoic acid

(2016) Muhammad Khawar Rauf et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Microwave assisted synthesis of novel acridine–acetazolamide conjugates and investigation of their inhibition effects on human carbonic anhydrase isoforms hCA I, II, IV and VII

(2016) Ramazan Ulus et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Regioselective copper-catalyzed N(1)-(hetero)arylation of protected histidine

(2016) Krishna K. Sharma et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Solvent- and catalyst-free synthesis of imidazo[1,2-a]pyridines under microwave irradiation

(2016) Dulin Kong et al.   JOURNAL OF CHEMICAL RESEARCH

A new type of power energy for accelerating chemical reactions: the nature of a microwave-driving force for accelerating chemical reactions

(2016) Jicheng Zhou et al.   Scientific Reports

Microwave-assisted synthesis and biological evaluation of 3,4-diaryl maleic anhydride/N-substituted maleimide derivatives as combretastatin A-4 analogues

(2015) Qi Guan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Design, microwave-mediated synthesis and biological evaluation of novel 4-aryl(alkyl)amino-3-nitroquinoline and 2,4-diaryl(dialkyl)amino-3-nitroquinolines as anticancer agents

(2015) Monika Chauhan et al.   BIOORGANIC CHEMISTRY

Microwave-assisted synthesis of the anticancer drug cisplatin, cis-[Pt(NH3)2Cl2]

(2015) Emanuele Petruzzella et al.   DALTON TRANSACTIONS

Mannich bases in medicinal chemistry and drug design

(2015) Gheorghe Roman   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

On the existence of and mechanism for microwave-specific reaction rate enhancement

(2015) Gregory B. Dudley et al.   Chemical Science

Solvent-Free Microwave-Assisted Synthesis of 2,5-Dimethoxyphenylaminotriazines

(2015) José R. Ramírez et al.   ACS Sustainable Chemistry & Engineering

Ethylene bis-imidazoles are highly potent and selective activators for isozymes VA and VII of carbonic anhydrase, with a potential nootropic effect

(2014) Bogdan Draghici et al.   CHEMICAL COMMUNICATIONS

Small Heterocycles in Multicomponent Reactions

(2014) Benjamin H. Rotstein et al.   CHEMICAL REVIEWS

Novel Microwave-Assisted Synthesis of the Immunomodulator Organotellurium Compound Ammonium Trichloro(dioxoethylene-O,O')tellurate (AS101)

(2014) M. Vázquez-Tato et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microwave-assisted synthesis and evaluation of acylhydrazones as potential inhibitors of bovine glutathione peroxidase

(2014) Felix Wilde et al.   MOLECULAR DIVERSITY

Syntheses of new tuberculosis inhibitors promoted by microwave irradiation

(2014) Maria De Rosa et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation

(2013) Barnali Maiti et al.   ACS Combinatorial Science

Microwave Effects in Organic Synthesis: Myth or Reality?

(2012) C. Oliver Kappe et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Microwave and continuous flow technologies in drug discovery

(2012) Sara Sadler et al.   Expert Opinion on Drug Discovery

One-pot multicomponent synthesis of medicinally important purine quinazolinone derivatives

(2012) Sanghapal D. Sawant et al.   TETRAHEDRON LETTERS

Synthesis, biological evaluation and X-ray crystallographic studies of imidazo[1,2-a]pyridine-based Mycobacterium tuberculosis glutamine synthetase inhibitors

(2012) Anneli Nordqvist et al.   MedChemComm

Fundamentals of green chemistry: efficiency in reaction design

(2011) Roger A. Sheldon   CHEMICAL SOCIETY REVIEWS

Microwave-assisted synthesis of small molecules targeting the infectious diseases tuberculosis, HIV/AIDS, malaria and hepatitis C

(2011) Johan Gising et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

An Integrated Synthesis–Purification System to Accelerate the Generation of Compounds in Pharmaceutical Discovery

(2011) Jill E. Hochlowski et al.   Journal of Flow Chemistry

Microwave-Assisted Multicomponent Reactions in the Heterocyclic Chemistry

(2010) Bo Jiang et al.   CURRENT ORGANIC CHEMISTRY

Microwave enhanced synthesis

(2009) Stephen Caddick et al.   TETRAHEDRON

CAN catalyzed synthesis of β-amino carbonyl compounds via Mannich reaction in PEG

(2008) Mazaahir Kidwai et al.   CATALYSIS COMMUNICATIONS