Article
Oncology
Lin Liu, Cheng Peng, Yan Ruan, Qian Zhang
Summary: The natural compound lapiferin was found to promote the expression of P21 and inhibit proliferation while enhancing apoptosis of GSCC cells. This suggests lapiferin may have potent antitumor effects on GSCC and could be a potential therapeutic agent.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Tae Young Ryu, Jinkwon Lee, Yunsang Kang, Mi-Young Son, Dae-Soo Kim, Youn su Lee, Mi-Young Kim, Hyun-Soo Cho
Summary: Through analysis of RNA-seq results in renal cancer patients, we found that SUV420H2 is overexpressed in renal cancer and high SUV420H2 expression is associated with poor prognosis. Knockdown of SUV420H2 using siRNA can inhibit growth and induce apoptosis in the A498 cell line. Further experiments showed that DHRS2 is a direct target of SUV420H2 in the process of apoptosis. Results showed that co-treatment with siSUV420H2 and siDHRS2 could attenuate the growth suppression induced by SUV420H2 knockdown. Additionally, treatment with the SUV420H2 inhibitor A-196 induced apoptosis through upregulation of DHRS2. Taken together, our findings suggest that SUV420H2 may be a potential therapeutic target for the treatment of renal cancer.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2023)
Article
Cell Biology
Tao Ma, Yan Chen, Zhi-Gang Yi, Jia Liu, Yan-Hong Li, Jun Bai, Wen-Ting Tie, Mei Huang, Xiao-Feng Zhu, Ji Wang, Juan Du, Xiu-Qin Zuo, Qin Li, Fan-Li Lin, Liu Tang, Jing Guo, Hong-Wen Xiao, Qian Lei, Xiao-Li Ma, Li-Juan Li, Lian-Sheng Zhang
Summary: This study reveals that NORAD acts as an oncogene in multiple myeloma and exerts its effects through the BMP6/P-ERK1/2 axis. Knockdown of NORAD promotes apoptosis and induces cell cycle arrest, while inhibiting cell proliferation in multiple myeloma.
CELLULAR SIGNALLING
(2022)
Article
Oncology
Tianling Ding, Jie Hao
Summary: High expression of SIRT2 in multiple myeloma cell lines promotes cell proliferation, while knocking down SIRT2 inhibits cell proliferation, activates the RAS/ERK signaling pathway, and induces cell apoptosis and cell cycle arrest.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Oncology
Yuanbo Cui, Chunyan Zhang, Shanshan Ma, Zhe Li, Wenjie Wang, Ya Li, Yingchao Ma, Jiarui Fang, Yaping Wang, Wei Cao, Fangxia Guan
Summary: This study reveals that m6A demethylation of LncRNA LINC00022 by fat mass and obesity-associated protein (FTO) promotes tumor growth of ESCC. Clinically, LINC00022 was up-regulated in primary ESCC samples and predicted poor clinical outcome for ESCC patients. Mechanistically, LINC00022 directly binds to p21 protein and promotes its ubiquitination-mediated degradation, facilitating cell-cycle progression and proliferation.
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH
(2021)
Article
Oncology
Xiaohua Zhang, Tianying Zhang, Xiaojuan Han, Zhongying Qiu, Jianghong Cheng, Xingchun Gao, Xingchun Gou
Summary: The study showed that CACUL1 overexpression in glioma tissues promoted cell proliferation, suppressed apoptosis, and induced cell cycle arrest. Knockdown of CACUL1 hindered cell proliferation and induced apoptosis in glioblastoma cells, suggesting a potential oncogenic role for CACUL1 in gliomas.
CURRENT CANCER DRUG TARGETS
(2021)
Article
Biotechnology & Applied Microbiology
Qiang Wang, Liuming Zhang, Dejun Ji, Jingwen Qu, Jian Wang, Hao Zhang, Yongjun Li
Summary: This study investigated the regulation and function of CMTM3 in hair follicle stem cells. It was found that CMTM3 re-expression suppressed HFSC proliferation by inducing cell cycle arrest and apoptosis, while downregulation of CMTM3 promoted proliferation. Transcriptome analysis identified multiple genes and pathways involved in this process, suggesting a complex crosstalk between pathways and transcription factors mediated by CMTM3.
Article
Neurosciences
Jia Wang, Si-Fei Ma, Qi Yun, Wen-Jun Liu, Hong-Ru Zhai, Hou-Zhen Shi, Lan-Gui Xie, Jin-Jun Qian, Chun-Jie Zhao, Wei-Ning Zhang
Summary: This study explores the role of FOXG1 in Alzheimer's disease (AD) and its involvement in cell cycle regulation. By negatively regulating the levels of p21-activated kinase (PAK3), FOXG1 inhibits cell cycle reentry and reduces neuronal apoptosis and Aβ deposition. Increasing the level of FOXG1 may present a therapeutic strategy for AD.
JOURNAL OF ALZHEIMERS DISEASE
(2022)
Article
Multidisciplinary Sciences
Sook-Kyoung Heo, Eui-Kyu Noh, Hye Jin Seo, Yoo Jin Lee, SuJin Koh, Young Joo Min, Yunsuk Choi, Jae-Cheol Jo
Summary: Radotinib has been shown to induce apoptosis and inhibit cell proliferation in multiple myeloma cells by suppressing the activity and expression of STAT3 and JAK2 proteins. It also inhibits the growth of MM cells and related signaling proteins, making it a potential candidate for MM treatment.
Article
Biotechnology & Applied Microbiology
Tiangang Ma, Yanbing Hu, Yinxue Guo, Qinghua Zhang
Summary: The study demonstrates that miR-203 carried by extracellular vesicles from endothelial cells can inhibit the malignant phenotypes of NSCLC cells and delay tumor growth by targeting DTL and promoting p21 protein stability.
CANCER GENE THERAPY
(2022)
Article
Multidisciplinary Sciences
Meng Qu, Guoxin Zhang, Han Qu, Alexander Vu, Raymond Wu, Hidekazu Tsukamoto, Zhenyu Jia, Wendong Huang, Heinz-Josef Lenz, Jeremy N. Rich, Steve A. Kay
Summary: Hepatocellular carcinoma (HCC) is a global health challenge with increasing incidence worldwide. The circadian clock has been shown to play a key role in hepatocarcinogenesis, but the cellular and molecular mechanisms underlying the HCC-clock crosstalk are unknown. In this study, we found that HCC cells rely on the circadian clock transcription factors BMAL1 and CLOCK for cell growth, and down-regulation of these factors induces apoptosis and cell cycle arrest. Mechanistically, inhibiting BMAL1/CLOCK dysregulates cell cycle regulators Wee1 and p21, leading to tumor cell death. Our findings provide insights into the cellular impact of clock proteins in HCC oncogenesis and suggest a potential therapeutic approach based on modulation of the circadian clock.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Biochemistry & Molecular Biology
Ying Zhang, Shan Li, Xiangguo Cui, Yiliang Wang
Summary: This study explored the molecular mechanism of miR-944 mediated SPP1 in breast cancer progression and its regulatory effect on the PI3K/Akt pathway. The expression of miR-944 was decreased while that of SPP1 was increased in breast cancer tissues and cells. miR-944 negatively regulated the expression of SPP1 and inhibited breast cancer cell proliferation by blocking the PI3K/Akt pathway.
Article
Biochemistry & Molecular Biology
Rui Liu, Jiyu Miao, Yachun Jia, Guangyao Kong, Fei Hong, Fangmei Li, Meng Zhai, Ru Zhang, Jiaxi Liu, Xuezhu Xu, Ting Wang, Hui Liu, Jinsong Hu, Yun Yang, Aili He
Summary: This study investigated the expression levels and prognostic role of YTHDF2 in multiple myeloma (MM), and its effect on MM proliferation and cell cycle. The results showed that YTHDF2 was highly expressed in MM and was an independent prognostic factor for MM survival. Silencing YTHDF2 suppressed cell proliferation and caused cell cycle arrest. YTHDF2 promoted MM growth via the degradation of EGR1 and the subsequent activation of the EGR1/p21(cip1/waf1)/CDK2-cyclin E1 axis.
Article
Biochemistry & Molecular Biology
Dongxian Zhang, Wanling Lu, Nasser Samadi
Summary: This study reveals the significant role of KIF4A in lung cancer progression, and demonstrates that KIF4A inhibition can enhance the sensitivity of lung cancer cells to doxorubicin through targeting p21 and PI3K/AKT pathway.
CHEMICAL BIOLOGY & DRUG DESIGN
(2023)
Article
Cell Biology
Hao Wang, Zhinan Liu, Zhuo Sun, Dong Zhou, Hanyan Mao, Guohua Deng
Summary: In retinoblastoma, USP33 is upregulated and its downregulation leads to increased cell apoptosis, enhanced G1 phase arrest, and decreased tumorigenesis. Through modulation of the SP1/PI3K/AKT pathway, USP33 promotes the progression of retinoblastoma.