Article
Behavioral Sciences
Arjan Blokland, Thibaut Sesia
Summary: This study compares the delay-dependent forgetting in two tasks in different rat strains and finds differences between them. It suggests that the forgetting curve of a specific strain should be tested before conducting treatment experiments in these tasks.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Behavioral Sciences
Keanan Augereau, Paola V. Migues, Oliver Hardt
Summary: Infusing the amnesic agent ZIP into the dorsal hippocampus disrupts long-term object location recognition memory, while infusing ZIP into the perirhinal cortex impairs long-term object identity recognition memory.
FRONTIERS IN BEHAVIORAL NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Xu-Dong Yu, Yan-Xin Mo, Zhiming He, James Reilly, Shao-Wen Tian, Xinhua Shu
Summary: The study investigated the effects of Urocanic acid (UCA) on memory consolidation and reconsolidation in a novel object recognition memory task. Results showed that immediate injection of UCA enhanced ORM memory performance, while injection 6 hours later did not have an effect.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Cell Biology
Shannon J. Moore, Victor A. Cazares, Stephanie J. Temme, Geoffrey G. Murphy
Summary: The calcium dysregulation hypothesis suggests that increased neuronal calcium concentration in the aging brain is responsible for learning and memory deficits. Researchers generated transgenic mice with increased expression of the L-type voltage-gated calcium channel, Ca(V)1.3, and found that this increase led to changes in neuronal physiology and cognitive function similar to those seen in aged animals.
Article
Behavioral Sciences
Qingyan Jiao, Xi Dong, Cunle Guo, Tongrui Wu, Feng Chen, Kai Zhang, Zengguang Ma, Yun Sun, Haiyan Cao, Chao Tian, Qi Hu, Nannan Liu, Yong Wang, Lijie Ji, Shutong Yang, Xinjun Zhang, Jie Li, Hui Shen
Summary: Sleep is crucial for important physiological functions, and sleep deprivation may impair learning and memory function. However, rapid eye movement sleep deprivation of different durations has varying effects on novelty-related object location memory and hippocampal synaptic plasticity in mice.
BEHAVIOURAL BRAIN RESEARCH
(2022)
Article
Cell Biology
Mar Puigdellivol, Stefan Milde, Anna Vilalta, Tom O. J. Cockram, David H. Allendorf, Jeffrey Y. Lee, Jacob M. Dundee, Katryna Pampuscenko, Vilmante Borutaite, Hugh N. Nuthall, Jack H. Brelstaff, Maria Grazia Spillantini, Guy C. Brown
Summary: The P2Y(6) receptor plays a key role in mediating microglial phagocytosis of neurons induced by A beta and tau, leading to neuronal and memory loss. Knockout of this receptor could potentially be beneficial in the treatment of neurodegenerative diseases.
Article
Behavioral Sciences
Fabian Vergara-Ovalle, Fructuoso Ayala-Guerrero, Carlos Rosas, Hugo Sanchez-Castillo
Summary: This study demonstrates that octopuses, like vertebrates, can differentiate between new and familiar objects through visual and tactile exploration. This new finding provides a guide for studying object recognition memory in octopuses and its developmental trajectory.
Article
Neurosciences
Anupam Sah, Maria Kharitonova, Katarzyna Mlyniec
Summary: Studies have shown that GPR39 knockout mice exhibit enhanced passive coping behavior, abnormal neuronal activity in specific brain regions, and resistance to traditional antidepressants. Imipramine partially reduces passive coping behavior by attenuating hyperactivity in the prefrontal cortex, but does not modulate abnormal brain activity in all regions. Antidepressant effects are suggested to be mediated through both GPR39-dependent and independent pathways in the brain.
Review
Behavioral Sciences
Owen Y. Chao, Susanne Nikolaus, Yi-Mei Yang, Joseph P. Huston
Summary: This review summarizes current studies on recognition memory in rodents, indicating that neuronal circuits connected to the medial prefrontal cortex and hippocampus play important roles in the recognition memory of objects and places.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2022)
Article
Behavioral Sciences
Qi Song, Youri G. Bolsius, Giacomo Ronzoni, Marloes J. A. G. Henckens, Benno Roozendaal
Summary: The study confirmed the effect of noradrenergic activation on both object recognition and object location memory in mice, providing a fundamental proof-of-principle for investigating the neural circuitry underlying noradrenergic and arousal effects on long-term memory in mice.
STRESS-THE INTERNATIONAL JOURNAL ON THE BIOLOGY OF STRESS
(2021)
Article
Biochemistry & Molecular Biology
Sravani Pulya, Ashutosh Mahale, Yamini Bobde, Ganesh Routholla, Tarun Patel, Swati, Swati Biswas, Vivek Sharma, Onkar P. Kulkarni, Balaram Ghosh
Summary: The novel HDAC3 inhibitor PT3 has shown excellent blood-brain barrier permeability and selectivity, enhancing long-term memory in mice. PT3 treatment increased H3K9 acetylation and upregulated the expression of multiple genes associated with memory formation. These findings suggest PT3 as a potential therapeutic candidate for age-related memory loss and disorders like Alzheimer's disease.
ACS CHEMICAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Anuck Sawangjit, Maximilian Harkotte, Carlos N. Oyanedel, Niels Niethard, Jan Born, Marion Inostroza
Summary: Memory consolidation is promoted by both sleep and wakefulness, but their effects on hippocampal and nonhippocampal representations differ. Sleep consolidation involves event-context binding, while wake consolidation tends to strengthen context-independent representations.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Yukako Yamane, Junji Ito, Cristian Joana, Ichiro Fujita, Hiroshi Tamura, Pedro E. Maldonado, Kenji Doya, Sonja Grun
Summary: In free viewing, the activity of neurons in different visual regions of the brain changes with repeated fixations on the same object, leading to reductions in firing rates and increased selectivity. The population activity for individual objects also becomes distinct.
Article
Behavioral Sciences
Hassina Belblidia, Thomas Freret, Marianne Leger, Pascale Schumann-Bard
Summary: This study investigated the effect of normal aging on temporal order memory and found that it is particularly vulnerable to the deleterious effect of aging.
BEHAVIOURAL BRAIN RESEARCH
(2023)
Article
Biochemistry & Molecular Biology
Dacheng Zhao, Jinwen He, Xiaobing Zhao, Xiaoyun Sheng, Zhiwei Feng, Xingwen Wang, Chengjun Zhang, Shenghong Wang, Bin Geng, Yayi Xia
Summary: The protein c-Fos and lncRNA GM15416 play important roles in regulating osteoblast cell death and osteogenesis. Overexpression of c-Fos leads to osteoblast apoptosis and osteoporosis, while decreased expression of lncRNA GM15416 helps prevent osteoporosis.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2024)
Editorial Material
Biochemistry & Molecular Biology
Christelle Jozet-Alves, Alexandra K. Schnell, Nicola S. Clayton
Article
Biochemistry & Molecular Biology
E. Ploux, T. Freret, J-M Billard
Summary: As people age, communication and plasticity between neurons weaken, with NMDAr activation playing a crucial role in brain plasticity. D-serine may contribute to mechanisms of physiological cognitive aging.
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
(2021)
Article
Chemistry, Medicinal
Francois-Xavier Toublet, Julien Lalut, Berenice Hatat, Cedric Lecoutey, Audrey Davis, Marc Since, Sophie Corvaisier, Thomas Freret, Jana Sopkova-de Oliveira Santos, Sylvie Claeysen, Michel Boulouard, Patrick Dallemagne, Christophe Rochais
Summary: Novel multitarget directed ligands are being developed in the field of Alzheimer's disease treatment to address the complexity of the disease. In this context, a new pleiotropic carbamate has been developed as a covalent inhibitor of BuChE and a precursor to a potent 5-HT6 receptors antagonist, showing promising in silico and in vitro results as well as first in vivo findings in restoring working memory.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Psychiatry
Valentine Bouet, Solenn Percelay, Elise Leroux, Boubacar Diarra, Marianne Leger, Nicolas Delcroix, Annie Andrieux, Sonia Dollfus, Thomas Freret, Michel Boulouard
Summary: The study introduces a new animal model combining genetic predisposition, early postnatal stress, and cannabinoid exposure, showing negative and cognitive symptoms similar to schizophrenia. This model offers relevance for researching new treatments and fits with the gene x environment interactions hypothesis.
SCHIZOPHRENIA RESEARCH
(2021)
Article
Agriculture, Dairy & Animal Science
Isabelle George, Noemie Lerch, Christelle Jozet-Alves, Sophie Lumineau
Summary: Lateralization refers to the dominance of one side of the body or brain in controlling motor or perceptual functions. Prenatal light exposure can influence visual lateralization in various species. While individual lateralization provides cognitive advantages, its impact on population level coordination is less clear. Studies suggest that intraspecific population-level lateralization may enhance coordination in social interactions, but in Japanese quail chicks, prenatal light exposure does not consistently induce lateralization nor influence social cohesion.
APPLIED ANIMAL BEHAVIOUR SCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Solenn Percelay, Jean-Marie Billard, Thomas Freret, Annie Andrieux, Michel Boulouard, Valentine Bouet
Summary: The study revealed dysregulations of functional properties and plasticity in hippocampal networks of 3-hit mice, potentially contributing to the pathophysiology of schizophrenia. Additionally, differences between males and females were observed, supporting the sexual dimorphism seen in the disorder.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Alexandra K. Schnell, Nicola S. Clayton, Roger T. Hanlon, Christelle Jozet-Alves
Summary: This study found that although cuttlefish may show changes in certain cognitive abilities with age, episodic-like memory function appears to be preserved in cuttlefish, suggesting that memory deterioration is delayed in this species.
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2021)
Article
Nutrition & Dietetics
Thomas Freret, Stacy Largilliere, Gerald Nee, Melanie Coolzaet, Sophie Corvaisier, Michel Boulouard
Summary: Anxiety is a common psychiatric disorder, and natural products may have comparable anxiolytic effects as benzodiazepines. However, the interaction of bioactive peptides with the gut-brain axis to sustain anxiolytic effects remains poorly understood.
Article
Environmental Sciences
Sofia Soloperto, Salima Aroua, Christelle Jozet-Alves, Christophe Minier, Marie-Pierre Halm-Lemeille
Summary: Regulatory assessment of chemical effects requires validated tests across different environments and organisms. This study developed a new exposure protocol using European sea bass larvae, assessing both traditional toxicological values and behavioral responses. Results showed the suitability of sea bass for early-life stage toxicity tests.
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
(2022)
Review
Biochemistry & Molecular Biology
Candice M. Roux, Marianne Leger, Thomas Freret
Summary: The hippocampus plays a crucial role in memory disorders, with 5-HT(4)Rs receptors emerging as potential new therapeutic targets. Activation of 5-HT(4)Rs may help in restoring or limiting hippocampal alterations associated with neurological diseases, though further research is needed to fully understand the mechanisms involved.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Lisa Poncet, Coraline Desnous, Ceprimecile Bellanger, Christelle Jozet-Alves
Summary: Research has found that, unlike other cephalopods, common octopuses have lower abilities in episodic-like memory and tend to use simpler foraging strategies. This difference may be linked to their distinct ecological environments and predatory constraints.
JOURNAL OF EXPERIMENTAL BIOLOGY
(2022)
Article
Clinical Neurology
Floriane Calocer, Huah Shin Ng, Feng Zhu, Yinshan Zhao, Olivier Dejardin, Emmanuelle Leray, Gilles Defer, Charity Evans, John D. Fisk, Ruth Ann Marrie, Helen Tremlett
Summary: The study found that lower socioeconomic status is associated with a higher mortality risk in persons with multiple sclerosis (PwMS).
MULTIPLE SCLEROSIS JOURNAL
(2023)
Article
Biochemistry & Molecular Biology
Candice M. Roux, Pierre Lecouflet, Jean-Marie Billard, Elise Esneault, Marianne Leger, Pascale Schumann-Bard, Thomas Freret
Summary: Acute hippocampal slice preparations have been commonly used in studying the anti-amnesic properties of drug candidates on long-term potentiation (LTP). Genetic background is crucial in experimental design, considering the availability of various transgenic mouse models. In this study, LTP was compared between inbred and outbred mice, showing reduced LTP magnitude in outbred mice due to lower responsiveness to theta-frequency during conditioning stimuli. Overall, this study highlights the importance of considering animal models in electrophysiological experiments.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Environmental Sciences
S. Soloperto, S. Olivier, A. Poret, C. Minier, M. P. Halm-Lemeille, C. Jozet-Alves, S. Aroua
Summary: The study aimed to expose European sea bass larvae to different concentrations of EE2 to investigate its effects on gene expression and behavior. The results showed that exposure to EE2 caused upregulation of certain genes, including cyp19a1b, gnrh2, and kiss1. Larvae exposed to the higher concentration of EE2 exhibited decreased growth and increased anxiety-like behaviors. The long-lasting effects of EE2 on behavior could potentially affect the development and fitness of exposed fish.
JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES
(2023)
Article
Biochemistry & Molecular Biology
Caroline Lahogue, Jean-Marie Billard, Thomas Freret, Valentine Bouet
Summary: The 5-HT6 receptors antagonist SB-271046 increases excitatory synaptic transmission and NMDAR activation at the CA3/CA1 hippocampal connections in mice. In male mice, this improvement is related to GABAAR antagonism, while in female mice it is not. Furthermore, the 5-HT6 receptors blockade has no significant effect on synaptic plasticity.