Article
Pharmacology & Pharmacy
Mihaela Gorcea, Majella E. Lane, David J. Moore
Summary: The purpose of this in vivo exploratory study was to investigate the conformational order and chain packing of human stratum corneum lipids in healthy face skin as a function of depth. The study found that the lipid order of the stratum corneum increases with depth in face skin, but shows significant differences compared to arm skin.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biology
Veronica Rego Moraes, Maisa Oliveira Melo, Patricia M. B. G. Maia Campos
Summary: Diabetes leads to increased production of AGEs, causing irreversible damage to collagen fibers and accelerated signs of skin aging. This study aimed to evaluate diabetic skin's characteristics and compare them to healthy skin.
Article
Pharmacology & Pharmacy
Victor Hugo Pacagnelli Infante, Marcella Gabarra Almeida Leite, Patricia M. B. G. Maia Campos
Summary: This study evaluated the film-forming properties of cosmetic formulations based on starches and Spirulina extract using reflectance confocal microscopy and other instrumental measurements. The formulations demonstrated effective film formation on both skin and hair surfaces, reducing water loss and providing protective effects.
Article
Chemistry, Multidisciplinary
Linda Cerofolini, Kristian Vasa, Elisa Bianconi, Maria Salobehaj, Giulia Cappelli, Alice Bonciani, Giulia Licciardi, Anna Perez-Rafols, Luis Padilla-Cortes, Sabrina Antonacci, Domenico Rizzo, Enrico Ravera, Caterina Viglianisi, Vito Calderone, Giacomo Parigi, Claudio Luchinat, Antonio Macchiarulo, Stefano Menichetti, Marco Fragai
Summary: Several protein-drug conjugates are currently used in cancer therapy, relying on covalently attached cytotoxic organic compounds or non-covalent interactions. Human transthyretin (TTR) has been identified as a potential carrier protein for cytotoxic drug delivery. This study demonstrates the importance of integrating multiple biophysical and structural techniques, such as microscale thermophoresis, X-ray crystallography, and NMR. Solid-state NMR is particularly valuable in revealing ligand binding effects and their impact on macromolecular complex stability.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Article
Multidisciplinary Sciences
Antoine Saint-Amand, Jonathan Lambrechts, Emmanuel Hanert
Summary: Estimating connectivity between coral reefs is essential for conservation efforts. Researchers assessed the impact of biophysical models resolution on connectivity estimates and found that higher resolution models produced more complex dispersal patterns with weaker connections. Fine-resolution models showed larger clusters of well-connected reefs and increased local retention. As a result, reef management recommendations should be made at scales coarser than the model resolution, not exceeding about 500 m.
SCIENTIFIC REPORTS
(2023)
Article
Chemistry, Medicinal
Gebhard Thoma, Rudolf O. Duthaler, Rudolf Waelchli, Alice Hauchard, Sandro Bruno, Ulrike Strittmatter-Keller, Anette Orjuela Leon, Sabine Viebrock, Reiner Aichholz, Karen Beltz, Kerri Grove, Shaila Hoque, Patrick J. Rudewicz, Hans-Guenter Zerwes
Summary: The JAK kinases JAK1, JAK2, JAK3, and TYK2 play key roles in cytokine signaling and are linked to many immune system-related diseases. Topical administration of JAK inhibitors has been considered to limit their action locally. CEE321, a clinical candidate disclosed here, is a potent pan JAK inhibitor with inhibitory effects on specific biomarkers related to atopic dermatitis.
JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Medicine, Research & Experimental
Panagiota Zarmpi, M. Alice Maciel Tabosa, Pauline Vitry, Annette L. Bunge, Natalie A. Belsey, Dimitrios Tsikritsis, Timothy J. Woodman, M. Begona Delgado-Charro, Richard H. Guy
Summary: Confocal Raman spectroscopy is a promising tool for quantifying drug uptake and clearance in the skin, providing valuable insights into local bioavailability. This research confirmed that Raman signals can be used to correct for signal attenuation and detect drug disposition, as well as distinguish between different formulations.
MOLECULAR PHARMACEUTICS
(2023)
Review
Chemistry, Multidisciplinary
Ming Qin, Guangsheng Du, Xun Sun
Summary: Research on mRNA-based therapies has flourished in the past two decades due to the advantages of mRNA. Various noninvasive delivery strategies have been developed to overcome intracellular barriers, with nasal and pulmonary delivery being the most studied areas. The advancement in noninvasive mRNA delivery is expected to accelerate the translation from experimental research to clinical applications.
ACCOUNTS OF CHEMICAL RESEARCH
(2021)
Review
Chemistry, Physical
Stephanie Andrade, Maria J. Ramalho, Joana A. Loureiro, Maria Carmo Pereira
Summary: Understanding how drugs interact with biological membranes is crucial for the pharmaceutical industry. In vitro lipid-based membrane models provide a simple alternative to study these interactions. Different lipid models and biophysical methodologies using liposomes are discussed for investigating drug-membrane interactions.
JOURNAL OF MOLECULAR LIQUIDS
(2021)
Article
Pharmacology & Pharmacy
Mike Walker
Summary: As the largest organ, the skin plays a crucial role in protecting the body and regulating various functions. However, aging and environmental factors contribute to the deterioration of the skin, leading to various issues and imposing a significant burden on individuals and the healthcare system.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Victor Hugo Pacagnelli Infante, Roland Bennewitz, Anna Lena Klein, Martina C. C. Meinke
Summary: The localization and quantification of Meissner corpuscles in glabrous skin using non-invasive optical microscopy techniques were reported. The local morphology above Meissner corpuscles was suggested to have a function in tactile perception.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biophysics
Jacob J. Kinnun, Haden L. Scott, Dima Bolmatov, C. Patrick Collier, Timothy R. Charlton, John Katsaras
Summary: Evidence for functional lipid domains has been accumulating for the past 50 years, despite initial ambiguity due to their highly dynamic nanoscopic structures. This review article discusses studies that have utilized techniques inherently sensitive to nanoscopic structural features, such as neutron scatting, nuclear magnetic resonance, and FRET. Additionally, potential future techniques, including cryoelectron microscopy, droplet interface bilayers, inelastic x-ray scattering, and neutron reflectometry, are mentioned to further enhance our understanding of the unique physicochemical properties of nanoscopic lipid domains.
BIOPHYSICAL JOURNAL
(2023)
Review
Dermatology
Maxim E. Darvin, Johannes Schleusener, Juergen Lademann, Chun-Sik Choe
Summary: Confocal Raman microspectroscopy is commonly used for noninvasive analysis of skin components and physiological parameters of the stratum corneum, and this paper summarizes recent results in this field.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2022)
Article
Dermatology
Richard Krombholz, Stefanie Fressle, Ines Nikolic, Ivana Pantelic, Snezana Savic, Milkica Crevar Sakac, Dominique Lunter
Summary: There is a limited number of suitable methods for skin penetration analysis of topically applied formulations, and they often lack spatial resolution. Good ex vivo models are crucial for testing skin penetration. This study compared different techniques for skin penetration analysis using caffeine as a hydrophilic model drug and tested the effect of 1,2-pentanediol on caffeine skin penetration.
EXPERIMENTAL DERMATOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jee-hyun Hwang, Haengdueng Jeong, Nahyun Lee, Sumin Hur, Nakyum Lee, Jeong Jun Han, Hye Won Jang, Wang Keun Choi, Ki Taek Nam, Kyung-Min Lim
Summary: The study found that the ex vivo live full-thickness porcine skin model is an excellent alternative to animal experiments for research on the safety and efficacy of cosmetic ingredients. Lactobionic acid showed the best improvement in skin barrier function, and the model could measure TEWL, confirming the significant skin barrier-protective effects of PHAs.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Dermatology
J. G. M. Logger, F. M. C. de Vries, P. E. J. van Erp, E. M. G. J. de Jong, M. Peppelman, R. J. B. Driessen
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Meeting Abstract
Dermatology
J. G. M. Logger, F. M. C. de Vries, P. E. J. van Erp, E. M. G. J. de Jong, M. Peppelman, R. J. B. Driessen
BRITISH JOURNAL OF DERMATOLOGY
(2020)
Article
Public, Environmental & Occupational Health
Wilbert van den Eijnde, Ronald Heus, Denise Falcone, Malou Peppelman, Piet van Erp
ANNALS OF WORK EXPOSURES AND HEALTH
(2020)
Article
Dermatology
Jade G. M. Logger, Malou Peppelman, Piet E. J. van Erp, Elke M. G. J. de Jong, Kim P. Nguyen, Rieke J. B. Driessen
Summary: This study evaluated the value of reflectance confocal microscopy (RCM) in monitoring Demodex mites, inflammation, and vascular parameters in rosacea during treatment. The results showed that treatment reduced inflammatory lesions and the number of mites, but had no significant impact on inflammatory cells, epidermal thickness, or vascular parameters. The study concludes that RCM, in its current form, has limited value for noninvasive follow-up of rosacea in clinical practice due to device limitations.
JOURNAL OF DERMATOLOGICAL TREATMENT
(2022)
Article
Immunology
S. Landman, V. L. de Oliveira, M. Peppelman, E. Fasse, E. van Rijssen, S. C. Bauland, P. van Erp, I Joosten, H. J. P. M. Koenen
JOURNAL OF IMMUNOLOGY RESEARCH
(2020)
Article
Dermatology
W. Woliner-van der Weg, M. Peppelman, Y. S. Elshot, M. B. Visch, M. B. Crijns, H. A. C. Alkemade, E. M. Bronkhorst, E. Adang, A. Amir, M. J. P. Gerritsen, P. E. J. van Erp, S. F. K. Lubeek
Summary: The study found that biopsy outperforms RCM in diagnosing and subtyping clinically suspected primary BCC. Patient satisfaction and preferences were good and highly comparable for both methods.
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Article
Dermatology
Jade G. M. Logger, Elke M. G. J. de Jong, Rieke J. B. Driessen, Piet E. J. van Erp
SKIN RESEARCH AND TECHNOLOGY
(2020)
Article
Dermatology
Jade G. M. Logger, Rieke J. B. Driessen, Elke M. G. J. de Jong, Piet E. J. van Erp
Summary: The GPSkin Pro is an accurate tool for measuring skin barrier impairment and monitoring barrier function in rosacea during treatment. It shows high accuracy in both healthy and impaired skin states, and is much more practical compared to previous skin barrier tools when used in clinical practice. Further validation of the GPSkin device in other inflammatory skin diseases is recommended.
SKIN RESEARCH AND TECHNOLOGY
(2021)
Letter
Dermatology
W. Woliner-van der Weg, M. Peppelman, P. E. J. vanErp, S. F. K. Lubeek
BRITISH JOURNAL OF DERMATOLOGY
(2021)
Review
Medicine, Research & Experimental
Sija Landman, Chiel van der Horst, Piet E. J. van Erp, Irma Joosten, Rob de Vries, Hans J. P. M. Koenen
Summary: Aza and DAC show promising potential in alleviating inflammatory disorders and preventing solid organ rejection and GvHD in pre-clinical animal models. Increasing Treg appears to be a common mechanism for preventing inflammatory disorders through Aza/DAC. However, the lack of essential methodological details in reported studies may lead to an overestimation of the true effects.
JOURNAL OF TRANSLATIONAL MEDICINE
(2021)
Article
Dermatology
Angelique N. Voorberg, Hanna Niehues, Jart A. F. Oosterhaven, Geertruida L. E. Romeijn, Ivonne M. J. J. Vlijmen-Willems, Piet E. J. Erp, Thomas H. A. Ederveen, Patrick L. J. M. Zeeuwen, Marie L. A. Schuttelaar
Summary: Hand eczema is a common inflammatory skin condition of the hands with unknown pathogenesis. Through RNA-sequencing analysis, this study found significantly elevated expression of genes/proteins related to keratinocyte host defense and inflammation in lesional skin of patients with vesicular hand eczema.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Gijs Rikken, Noa J. M. van den Brink, Ivonne M. J. J. van Vlijmen-Willems, Piet E. J. van Erp, Lars Pettersson, Jos P. H. Smits, Ellen H. van den Bogaard
Summary: Atopic dermatitis (AD) is a chronic inflammatory skin disease. Therapeutics targeting the aryl hydrocarbon receptor (AHR) have shown effectiveness in AD treatment. This study identified certain carboxamide derivatives as activators of the AHR signaling pathway, suggesting their therapeutic potential in inducing epidermal differentiation proteins and treating AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Dermatology
Mirjam J. Schaap, Ata Chizari, Tom Knop, Hans M. M. Groenewoud, Piet E. J. van Erp, Elke M. G. J. de Jong, Wiendelt Steenbergen, Marieke M. B. Seyger
Summary: This study demonstrated the potential of noninvasive whole field laser speckle contrast imaging in visualizing increased perilesional perfusion and perfusion inhomogeneity for predicting psoriatic lesion expansion. Patients found HAPI measurements to be fast, user-friendly, and important.
SKIN RESEARCH AND TECHNOLOGY
(2022)
Meeting Abstract
Dermatology
H. Niehues, G. Rikken, I. M. van Vlijmen-Willems, D. Rodijk-Olthuis, P. V. Erp, P. L. Zeeuwen, J. Schalkwijk, E. H. van den Bogaard
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Article
Dermatology
Mirjam J. Schaap, Finola M. Bruins, Xuehui He, Kadri Orro, Malou Peppelman, Piet E. J. van Erp, Elke M. G. J. de Jong, Hans J. P. M. Koenen, Ellen H. van den Bogaard, Marieke M. B. Seyger
Summary: Transdermal analysis patches (TAPs) can noninvasively measure skin-derived proteins in pediatric psoriasis patients, with the potential for patient-friendly monitoring in daily clinical practice.
SKIN PHARMACOLOGY AND PHYSIOLOGY
(2021)
Article
Dermatology
Matthew J. Davis, Gokul Srinivasan, Rachael Chacko, Sophie Chen, Anish Suvarna, Louis J. Vaickus, Veronica C. Torres, Sassan Hodge, Eunice Y. Chen, Sarah Preum, Kimberley S. Samkoe, Brock C. Christensen, Matthew R. Leboeuf, Joshua J. Levy
Summary: The development and application of AI algorithms are of great significance for the removal of cSCC, as they can improve operational efficiency and accuracy, especially for moderately and poorly differentiated tumors/ neoplasms. Further improvement is needed to maintain sensitivity to surrounding tissue and determine anatomical positioning.
EXPERIMENTAL DERMATOLOGY
(2024)
Article
Dermatology
Lingjing Chen, Qing Yu, Feiying Guo, Xuewen Wang, Zhenying Cai, Qiang Zhou
Summary: This study investigated the role and mechanisms of NTS in stress-induced hair growth inhibition. The results demonstrated that NTS effectively counteracted hair growth inhibition caused by stress and regulated the expression of multiple genes related to hair growth at the transcriptional level.
EXPERIMENTAL DERMATOLOGY
(2024)